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전이성 거세 저항 전립선암에서 Docetaxel 전신 화학요법의 최적의 횟수
안성훈(Sung Hoon Ahn),박승철(Seung Chol Park) 대한비뇨기종양학회 2013 대한비뇨기종양학회지 Vol.11 No.2
Metastatic prostate cancer is initially treated with androgen deprivation therapy, which induces rapid decrease in bone pain and decrease in serum prostate specific antigen level. However, most of cases with prostate cancer eventually progress to castration-resistant prostate cancer within a median of 18-24 months. Docetaxel-based systemic chemotherapy is now the standard treatment for CRPC, based on the results of 2 phase III studies. However, the optimal cycles of docetaxel-based systemic chemotherapy for CRPC has not been defined. Herein, we present two cases of castration-resistant prostate cancer treated by docetaxel-based systemic chemotherapy and reviewed recent literatures.
상부 위장관 이물에 대한 임상적 고찰 : 내시경적 진단과 적출
안성훈(Sung Hoon Ahn),허정욱(Jung Wook Hur),강영우(Young Woo Kang),이준호(Jun Ho Lee),박승국(Seoung Kook Park),박태원(Tae Won Park),강진무(Chin Moo Kang) 대한소화기학회 1993 대한소화기학회지 Vol.25 No.5
N/A Today upper gastrointestinal (UGI) endoscopy is widely used in diagnosis and management of foreign bodies. A clinical study of 76 cases with the foreign bodies in the upper gastrointestinal tract diagnosed by flexible UGI endoscopy in Dangsan Hospital from January 1982 to December 1992 was performed. Foreign bodies were common in male (rate 1,6: 1) and in 6th decade (28 cases, 36.8%). Bezoar was the most common foreign body (57 cases, 75.0%) and foreign bodies were mostly lodged in stomach (50 cases, 65.8%). Endosopic removal or destruction was successful in 31 cases (35.4%) including all 19 cases other than bezoar. 52 cases (68.4%) hacl combined diseases, 17 cases (22.4%) had past history of operation and 9 cases (11.8%) had history nf ingestion of foreign bodies. In conclusion, UGI endoscopy and endoscopic removal is required to diagnose and manage foreign bodies in UGI tract
간 , 담도 및 췌장 : 한국 임산부에서의 황달에 관한 임상적 고찰
안성훈(Sung Hoon Ahn),박승국(Soong Kook Park),허정욱(Jung Wook Hur),강영우(Young Woo Kang),김경목(Kyung Mok Kim),한승범(Seung Bum Han) 대한소화기학회 1987 대한소화기학회지 Vol.19 No.2
N/A The jaundice in pregnancy generally is devided to peculiar liver disease and intercurrent disease to pregnancy. Its diagnosis and management are the matter of importance to clinician in view of complications of parturition, fetus and neonate. The clinical studies, however, on this field are scarce in this country. We analysed 19537 obstetric medical charts of Korean pregnant women admitted in the department of obstetrics & gynecology, Dongsan medical center in a period of ten years from January 1977 to December 1986. Serum bilirubins were checked in 1357 cases among the 19537 charts. The results were as follows; 1) The incidence of chemical jaundice in pregnancy was 3.5% (48 cases) in 1357 serum bilirubin checked. 2) The associated clinical conditions were 18 cases (37.5%) of toxemia at most, 6 cases (12.5%) of cholestasis of pregnancy, 3 cases (6.3%) of acute viral hepatitis and 18 cases (37.5%) of unknown cause of jaundice. 3) 15 cases (31.2%) of maternal postpartum hemorrhage, 5 cases (10.4%) of prematurity were considered as the complications of jaundice in pregnancy. The incidence of prematurity, fetal distress, perinatal mortality in jaundice group were statistically significant compared to that of Korean general group of pregnancy. For more detail study on jaundice in pregnancy we think prospective study including hepatitis marker, liver function test, liver biopsy and analysis of causes of jaunidce in pregnancy is necessary in all cases of pregnant women.
Role and Vision of Appropriate Technology
안성훈(Sung-Hoon Ahn),독고석(Seok Dockko),추원식(Won-Shik Chu),장수영(Sooyoung Chang),이우성(Woo Sung Lee),유영제(Young Je Yoo),윤제용(Jeyong Yoon) 적정기술학회 2017 적정기술학회지(Journal of Appropriate Technology) Vol.3 No.1
Appropriate technology was previously defined as a low technology to help and promote the poverty issue by using cheap, simple and local material. However, this definition has been expanded as a technology which empowers general capability with a focus on ‘sustainability,’ a keyword in this present era, as well as creating a market-centered social value. In this special issue, the role and vision of appropriate technology of Republic of Korea is suggested in agreement with the changing circumstances. Five major issues are discussed: Korean ODA program, correspondence to the UN agenda, national industries and unemployment, utilizing retired personnel in the field of science and technology, and education using appropriate technology. In this regard, the role and vision of appropriate technology as an optimal technology is suggested. 저렴하고 간단한 현지 재료로 구현할 수 있는 기술 정도로 정의되었던 빈곤문제 해결을 위한 적정기술은 ‘지속가능성(sustainability)이라는 시대적 상황과 더불어 시장지향성 사회적 가치창출을 통한 총체적 역량강화라는 일반적인 기술로 그 의미가 확장되고 있다. 본 논문에서는 급변하는 시대적 상황과 진화하는 적정기술에 따라 한국의 적정기술이 나아가야 할 방향과 비전을 다음과 같이 5개의 주요 이슈의 관점에서 제시 하고자 한다. 한국형 ODA (Official Development Assistance) 프로그램, UN 아젠다에 대한 대응, 국내 산업과 실업, 은퇴 과학기술자 인력 활용, 적정기술을 통한 중·고등교육 등은 본 논문에서 적정기술을 최적화하는데 주요 이슈로써 논의될 것이다.
간경변증환자에서 고농도 분지형 아미노산제제 투여후 혈중 아미노산과 간기능 검사상의 변화 - 일반 아미노산제제와 비교조사 -
안성훈 ( Sung Hoon Ahn ),박승국 ( Soong Kook Park ),박원대 ( Won Dae Park ),한승범 ( Seung Beum Han ),이수형 ( Soo Hyeong Lee ),허정욱 ( Jeug Wook Hur ) 대한소화기학회 1987 대한소화기학회지 Vol.19 No.1
N/A This study was done to compare the therapeutic effect of enriched branched chain amino acid (BCAA) infusion to regular amino acid infusion for the decompensated liver cirrhosis. Enriched BCAA solution (Pamisol) was given to 30 patients and regular amino acid solution (Salviamine) was given to 8 patints. The changes of plasma amino acid concentrations and liver profiles in before and 7 days after amino acid infusion daily 1,000 ml were compared. The results were as follow. 1) In the group of patients given enriched BCAA infusion, the plasma concentrations of valine, leucine, isoleucine (BCAA) increased (p<0.001), while the phenylalanine, tyrosine (aromatic amino acid: AAA) decreased (p<0.001). 2) In the group of patients given regular amino acid infusion, both BCAA and AAA concentrations increased (p+0.001). 3) In the group of patients given enriched BCAA infusion, total protein increased (p<=0.01), total bilirubin decreased (p<=0.01), prothrombin time shortened (p<0.05), and blood ammonia decreased (p< 0.01). 4) In the group of patients given regular amino acid infusion, only total protein increased (p < 0.01) but, bilirubin, prothromoin time and blood ammonia remained no significant changes. 5) The molar ratio of BCAA/AAA more improved in the enriched BCAA infusion than regular amino acid.
각종 간질환에서의 (肝疾患) 혈청 (血淸) High Density Lipoprotein - Cholesterol 의 변동
안성훈(Sung Hoon Ahn),박승국(Seung Kook Park),허정욱(Jung Wook Hur),이호찬(Ho Chan lee),김정철(Jung Chul Kim),정태호(Tai Ho Chung) 대한소화기학회 1984 대한소화기학회지 Vol.16 No.1
N/A In patients with liver disease, abnormalities of cholesterol metabolism has been suspected. Hence concentrations of cholesterol in whole serum, and cholesterol concentrations in the high density lipoprotein fraction of serum was measured after the precipitation of low density and very low density lipoproteins with sodium phosphotungstate-13Mg in l patients with liver cirrhosis, 10 patients with acute hepatitis, 10 patients with chronic hepatitis, 7 patients with hepatoma, 5 patients with obstructive jaundice, and 24 healthy control subjects. Total cholesterol concentrations in patients with hepatic cirrhosis were significantly lower than control, but in patients with chronic hepatitis, and obstructive jaundice, total cholesterol concentrations were slightly higher than control. High density lipoprotein cholesterol concentrations in various liver disease were significantly lower than control, and their ratios of high density lipoprotein cholesterol to total cholesterol were also significantly low.