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간경변증환자에서 고농도 분지형 아미노산제제 투여후 혈중 아미노산과 간기능 검사상의 변화 - 일반 아미노산제제와 비교조사 -
안성훈 ( Sung Hoon Ahn ),박승국 ( Soong Kook Park ),박원대 ( Won Dae Park ),한승범 ( Seung Beum Han ),이수형 ( Soo Hyeong Lee ),허정욱 ( Jeug Wook Hur ) 대한소화기학회 1987 대한소화기학회지 Vol.19 No.1
N/A This study was done to compare the therapeutic effect of enriched branched chain amino acid (BCAA) infusion to regular amino acid infusion for the decompensated liver cirrhosis. Enriched BCAA solution (Pamisol) was given to 30 patients and regular amino acid solution (Salviamine) was given to 8 patints. The changes of plasma amino acid concentrations and liver profiles in before and 7 days after amino acid infusion daily 1,000 ml were compared. The results were as follow. 1) In the group of patients given enriched BCAA infusion, the plasma concentrations of valine, leucine, isoleucine (BCAA) increased (p<0.001), while the phenylalanine, tyrosine (aromatic amino acid: AAA) decreased (p<0.001). 2) In the group of patients given regular amino acid infusion, both BCAA and AAA concentrations increased (p+0.001). 3) In the group of patients given enriched BCAA infusion, total protein increased (p<=0.01), total bilirubin decreased (p<=0.01), prothrombin time shortened (p<0.05), and blood ammonia decreased (p< 0.01). 4) In the group of patients given regular amino acid infusion, only total protein increased (p < 0.01) but, bilirubin, prothromoin time and blood ammonia remained no significant changes. 5) The molar ratio of BCAA/AAA more improved in the enriched BCAA infusion than regular amino acid.