다발성 용종의 형태로 발현된 위유암종(Gastric Carcinoid Tumor)의 수술적 치료 1예

안상현,김종원,이인규,이혁준,김우호,이건욱,양한광,Ahn, Sang-Hyun,Kim, Jong-Won,Lee, In-Kyu,Lee, Hyuk-Joon,Kim, Woo-Ho,Lee, Kuhn-Uk,Yang, Han-Kwang 대한위암학회 2007 대한위암학회지 Vol.7 No.2

위에 발생하는 유암종(carcinoid tumor)은 위저부에 있는 장크롬친화 유사 세포(enterochromaffine-like cell)의 증식에 의해 발생하는 종양이다. 위유암종은 모든 위 신생물의 2% 이내로 드문 질환이나 최근 발생률이 증가하고 있다고 한다. 저자들은 다발성 용종의 형태로 발현된 위유암종을 1예 경험한 바 있어 이를 보고하는 바이다. 29세 여자가 3년 전 실신을 주소로 외부병원을 방문하여 시행한 혈액검사 상 혈색소 6.0 g/dl로 측정되었다. 위내시경 상 출혈을 동반한 용종성 병변이 관찰되었고, 내시경적 결찰술로 지혈하였다. 당시 시행한 병리조직 검사 상 유암종으로 진단되었다. 추적 관찰 중 용종성 병변의 출혈로 인한 철결핍성 빈혈이 계속되어 본원으로 전원되었다. 위내시경 상 중체부에서 분문부에 걸쳐 20개 이상의 크기가 다양한 용종성 병변들이 관찰되었다. 혈색소 수치는 9.0 g/dl이었다. 출혈을 동반한 다발성 용종성 위유암종 진단 하에 위전절제술을 시행하였다. 조직검사 결과 위유암종으로 진단되었고 림프절 전이는 없었다. 수술 18개월 후 혈색소 12.8 g/dl로 측정되었고 복부 초음파 상 재발 소견은 없었다. 본 증례와 같이 위에 다발성으로 발생한 용종 형태의 유암종이 지속적인 출혈을 동반하여 만성적인 빈혈을 유발하는 경우 적극적인 수술적 치료를 고려해야 한다. Gastric carcinoid tumor is a neoplasm that arises from enterochromaffine-like (ECL) cells in the gastric fundus. It is a rare disease that comprises less than 2% of all gastric neoplasms; however its incidence has been recently increasing. We experienced one case of gastric carcinoid tumor that was revealed to be multiple polypoid lesions. A 29-year-old female patient visited a hospital three years ago due to syncope. The blood hemoglobin was measured as 6.0 g/dl. Gastroscopy revealed multiple polypoid lesions with bleeding; therefore endoscopic clipping was performed. The polyps were diagnosed as carcinoid tumor via endoscopic biopsy. She was transferred to our hospital because of persistent iron deficiency anemia that was caused by bleeding at the gastric polyps. Gastroscopy revealed more than twenty various-sized polypoid lesions from the mid-body to the antrum. The blood hemoglobin level was 9.0g/dl. Total gastrectomy was performed under the diagnosis of gastric carcinoid tumor with bleeding. All of the gastric polyps were diagnosed as carcinoid tumors, and any metastasis to the regional lymph nodes was not found. Eighteen months after operation, the blood hemoglobin was increased to 12.8g/dl with no evidence of recurrence. Surgical resection should be considered for treating gastric carcinoid tumor with continuous bleeding.

백호탕 추출물의 지방장벽 손상 개선을 통한 상피 내 Th2 분화 조절 효과

안상현,김기봉,정아람,Ahn, Sang Hyun,Kim, Ki Bong,Jeong, Aram 대한한방소아과학회 2021 대한한방소아과학회지 Vol.35 No.4

Objectives The purpose of this study is to confirm the regulate effect of T helper (Th) 2 differentiation that Baekho-tang extract may produce to improves skin lipid barrier damages. Methods Four-weeks-old NC/Nga mice were divided into four groups: control group (Ctrl, n=10), lipid barrier eliminated group (LBE, n=10), Dexamethasone treatment after lipid barrier elimination group (DxT, n=10), and Baekho-tang extract treatment group after lipid barrier elimination group (BHTT, n=10). Baeko-tang extract was administered for 3 days after removal of the skin fat barrier in BHTT group. Then, we identified changes in external symptoms of the skin, factors affecting skin barrier such as potential of hydrogen (pH), filaggrin (FLG), transepidermal water loss (TEWL) and Th2 differentiation factors like Interleukin (IL)-4, Kallikrein Related Peptidase 7 (KLK7) and protease activated receptor 2 (PAR-2) through our immunohistochemistry. Results After lipid barrier elimination, the reduction of morphological skin inflammations was less in BHTT group than in LBE group and DxT group. Also, pH and TEWL were significantly decreased with BHTT group. However, FLG was significantly increased in BHTT group compared to LBE, DxT, and Ctrl group. All kinds of Th2 differentiation factors (IL-4, KLK7 and PAR-2) were also decreased in BHTT compared to the LBE and DxT. Conclusions As a result of this study, BHT administration decreased pH, TEWL, and increased FLG, thus participating in recovering damaged skin barrier. Since Th2 differentiation factors were decreased as well, BHT's regulatory effect in sequential immune reactions may be a possible explanation of how it enhances recovery of the damaged lipid barrier.

천년 전의 별똥비

안상현,배현진,조혜전,정성욱,AHN SANG-HYEON,BAE HYUN JIN,CHO HYE JEON,JUNG SUNG-WOOK 한국천문학회 2002 天文學論叢 Vol.17 No.1

별똥에는 분산 별똥(sporadic meteors)과 별똥비(meteor shower)에 속하는 별똥이 있다. 우리는 $\ulcorner$고려사$\lrcorner$ $\ulcorner$천문지$\lrcorner$에 적혀 있는 별똥 기록을 조사하여 10세기에서 14세기까지 지구 공전 궤도 상의 별찌(meteoroids)의 분포에 대해서 연구하였다 먼저 $\ulcorner$고려사$\lrcorner$ 에 나오는 별똥 기록의 간지날짜를 점검하여 교정하고 간추려서 자료를 만들었다. 별똥이 나타난 날짜를 조사하여 고려 시대의 별똥별의 특징을 살펴보았다. 고려 시대 별똥 기록은 각 시기에 유행한 철학 사조의 영향과 전쟁과 내란 등의 영향으로 기록 수가 변하는 것으로 추정하였다. 그러나 평소에 떨어지는 분산 별똥들의 계절적 개수 변화는 매우 자연스러웠다. 우리는 일년 중 특정한 날짜에 별똥별이 많이 떨어지는 시기가 몇 개 있음을 발견하였다. 우리는 이것을 별똥비로 보고, 한국$\cdot$일본$\cdot$중국$\cdot$아랍$\cdot$유럽의 역사 기록에 나오는 별똥 소나기 기록을 모두 조사한 다음, 이것을 $\ulcorner$고려사$\lrcorner$의 별똥 기록에서 구한 별똥비와 비교하였다. 우리는 뚜렷한 별똥비 셋과 약한 별똥비 서넛을 확인할 수 있었다. 뚜렷한 세 별똥비는 사자자리 별똥비, 페르세우스 별똥비, 핼리혜성이 남기는 두 별똥비 등의 요즘 별똥비와 각각 일치함을 알아냈다 또한 나머지 약한 별똥비들도 오늘날 관측되고 있는 약한 별똥비와 대체적으로 일치함을 보았다. 결론적으로 고려시대의 별똥비의 활동성은 오늘날의 그것과 크게 다르지 않았다. 이것은 오늘날 활발한 별똥비들의 수명의 하한을 주는 결과이다. 이러한 연구를 통해 별똥 관측에 있어서 우리나라 옛 사람들이 남긴 관측 기록은 실제 자연의 모습을 그대로 읽어낼 수 있을 정도로 꾸준하고 정밀하고 정직한 것이었음을 알 수 있었다. 또한 그러한 좋은 유산을 현대 천문학에 유용한 연구 자료로서 활용할 수 있었다. The spatial distribution of meteoroids or cometary debris along the orbit of the Earth is investigated by analyzing the meteoric records in the Chronicle of the Koryo dynasty (918-1392) which is called Koryosa. Sporadic meteors in this period show the seasonal variation in number, which is similar to the current meteors. We also found that there are a few spikes showing large accumulation of records around the same dates. We regard these spikes as meteor showers in the Koryo period. We compared the dates of meteor showers with those compiled from the historical records around the world including Korea, Japan, China, Arab, and European countries. We discovered three prominent showers and four weak showers. The prominent ones are the Leonids, the Perseids, and the Aquarids and the Orionids pair. The last pair is the remnants of Halley's comet. The astronomical records written in the history book of the Koryo dynasty are turned out to be accurate and written in a steady manner. We can also see that those records can be useful to contribute the development of modern astronomy and astrophysics.

황련감초 하태독법과 프로바이오틱스의 대장점막 내 면역조절 효과 비교연구

안상현,차호열,김기봉,Ahn, Sang Hyun,Cha, Ho Yeol,Kim, Ki Bong 대한한방소아과학회 2017 대한한방소아과학회지 Vol.31 No.2

Objectives Hataedock is a treatment that dispels toxic heat and meconium which has been accumulated to the fetus from a pregnant mother via orally administering herbal extracts to a newborn baby. This study was conducted to compare the efficacy of Hataedock, with using the extract of Coptis japonica & Glycyrrhiza uralensis, to the early administration of probiotics for immunomodulation in the intestinal mucosa. Methods NC/Nga mice were divided into three groups; Control group (no treatment), CGT group (3-week-old mice given the extract of Coptis japonica & Glycyrrhiza uralensis), and MBT group (3-week-old mice given a Bifidobacterium). After 2 weeks, the intestinal mucosa tissues of each group of mice were observed. Immunohistochemical staining for IL-4, IL-13, CD40, $Fc{\varepsilon}RI$, $p-I{\kappa}B$, EGF, and VEGF in the intestinal mucosa was performed. Results CGT group showed 65% decrease in IL-4, 67% decrease in IL-13, 58% decrease in CD40, 72% decrease in $Fc{\varepsilon}RI$, 76% decrease in $p-I{\kappa}B$, 41% increase in EGF and 100% increase in VEGF compared to the control group. MBT group also showed 50% decrease in IL-4, 63% decrease in IL-13, 33% decrease in CD40, 53% decrease in $Fc{\varepsilon}RI$, 46% decrease in $p-I{\kappa}B$, 23% increase in EGF and 151% increase in VEGF compared to the control group. Conclusions These results suggest that both Hataedock, with using the extract of Coptis japonica & Glycyrrhiza uralensis, and early administration of probiotics were effective in regulating Th2, relieving inflammation and developing intestinal mucosal tissues. Hataedock with extract of Coptis japonica & Glycyrrhiza uralensis may be more effective for immunomodulation in intestinal mucosa than probiotics.

「 성경 」에 실린 별들의 동정 (同定)

안상현,박창범,유경로 ( Sang Hyun Ahn,Chang Bom Park,Kyung Loh Yu ) 한국과학사학회 1996 한국과학사학회지 Vol.18 No.1

습식법으로 제조한 인산형 연료전지 전극구조개선에 관한 연구

안상현,심재철,유덕영,이주성 ( Sang Hyun Ahn,Jae Cheol Shim,Duck Young Yoo,Ju Seong Lee ) 한국공업화학회 1997 응용화학 Vol.1 No.1

To increase performance of electrode in PAFC we try to change the electrode manufacturing method. In traditional method, dead catalyst is increased and the performance of electrode reduce. So we tried wetting process to reduce dead catalyst we made PTFE/C slurry and add Pt/C powders. In this case, the performance is better than the electrode made of traditional method.

황금 (Scutellaria baicalensis) 추출물의 ECS조절을 통한 아토피피부염 염증 완화 효과

안상현,김기봉,Ahn, Sang Hyun,Kim, Ki Bong 대한한방소아과학회 2021 대한한방소아과학회지 Vol.35 No.3

Objective The purpose of this study was to confirm the effect of Scutellaria baicalensis extract on skin damage recovery and inflammation relief in atopic dermatitis-induced mice through Endocannabinoid system (ECS) control. Methods 6-week-old Balb/C mice were divided into control group (Ctrl), atopic dermatitis induced group (ADE), palmitoylethanolamide (PEA) administered group after atopic dermatitis induced (PEAT), and Scutellaria baicalensis extract administered group after atopic dermatitis induced (SBT). Seven animals were assigned for each group. After drug administration for 3 weeks after inducing atopic dermatitis, Claudin and 8-OHdG were observed to confirm the recovery of the skin damage in each group. To confirm ECS regulation, CB1, CB2, and GPR55 were observed. To confirm the anti-inflammatory effect, Fc ε receptor, and MMP-9 was observed. Results Claudin positive reaction was significantly increased in SBT compared to ADE and PEAT. 8-OHdG positive reaction was significantly decreased in SBT compared to ADE and PEAT. CB1, CB2, and GPR55 positive responses were significantly increased in SBT compared to ADE and PEAT. Fc ε receptor and MMP-9 positivity were significantly decreased in SBT compared to ADE and PEAT. Conclusion It was confirmed that the Scutellaria baicalensis extract can reduce the inflammation of atopic dermatitis by restoring the structural damage of the skin lipid barrier through ECS activity.

두시 하태독법의 IL-4 활성 조절이 D. farinae 유도 아토피유사피부염 발병 조절에 미치는 효과

안상현,김재규,천진홍,김기봉,Ahn, Sang Hyun,Kim, Jae Kyu,Cheon, Jin Hong,Kim, Ki Bong 대한한방소아과학회 2017 대한한방소아과학회지 Vol.31 No.1

Objectives Hataedock method is a Korean medical therapy which removes fetal toxin by orally administering herbal decoction to neonates. This study was to observe skin damage and anti-inflammatory effect via regulating IL-4 activity in NC/Nga mice which were induced atopic dermatitis (AD)-like skin lesion by Dermatophagoides (D.) farinae after applying Douchi Hataedock method. Methods NC/Nga mice with 3 weeks of gestational age were used. Each 10 mice were allocated to the control group (Ctrl), the AD-induced group (AE), and the group which induced AD after administering Douchi extract (GT). After 4 weeks from administering Douchi extract to the mice, the primary AD was induced by applying D. farinae extract 6 times per week for 3 weeks and then the secondary AD was induced by the same method after 1 week from the primary AD induction. To identify the skin damage and anti-inflammatory effect, we observed LxR, IL-4, Fc ${\varepsilon}$ receptor, substance P, and $NF-{\kappa}B$. Results The GT group showed alleviation of skin injury and decrease in capillary angiogenesis. Stratum corneum damage, epithelial cell hyperplasia, lymphocyte infiltration, and capillary distribution relatively decreased in the GT group. LxR-positive reaction in the GT group were increased by 53% than that of the AE group. IL-4 production, $Fc{\varepsilon}$ receptor activity, and substance P-positive reaction in the GT group were decreased by 82%, 42%, and 82% respectively compare to those of the AE group. $NF-{\kappa}B$-positive reaction in the GT group were decreased by 15% compare to that of the AE group. Conclusions Hataedock method with Douchi extract alleviated AD via reducing inflammatory cytokines secreted at the early stage of AD. Thus, Douchi Hataedock method has a beneficial effect for the prevention and treatment of AD.

차량 애드혹 네트워크에서 차량 자체 정보를 기반으로 한 클러스터링 기법

안상현,임유진,Ahn, Sang-Hyun,Lim, Yu-Jin 한국정보처리학회 2011 정보처리학회논문지 C : 정보통신,정보보안 Vol.18 No.6

차량 애드혹 네트워크 환경에서 브로드캐스트 메시지 전송을 위한 효율적인 기법으로 클러스터링 기법이 있다. 대부분의 클러스터링 기법들은 안정적인 클러스터 구성을 위해 차량들 간에 정보를 교환하거나 이동성 정보를 계산하는 오버헤드를 야기한다. 이러한 오버헤드를 줄이기 위해 차량의 절대 속도를 기반으로 클러스터를 구축하는 CF-IVC[1]가 제안되었으나, CF-IVC의 경우 도로 혼잡 상황이나 운전자의 운전 행태를 고려하지 않음으로써 클러스터를 비효율적으로 구성하는 문제가 있다. 따라서 본 논문에서는 도로의 최고 제한 속도 및 도로 혼잡 상황을 고려한 차량 자체 정보 기반의 효율적인 클러스터 구축 기법을 제안한다. 제안 방식을 simple 플러딩 및 CF-IVC와 NS-2 시뮬레이션을 통해 비교함으로써 성능의 우수성을 입증한다. In the vehicular ad hoc network environment, the clustering mechanism is one of the efficient mechanisms to deliver broadcast messages. Most clustering mechanisms require message exchanges between vehicles to build stable clusters, which causes overhead. In order to reduce this overhead, CF-IVC [1] proposes the mechanism to construct clusters based on the vehicle speed. However, since CF-IVC does not consider the road traffic condition and the driver's behavior, it may result in inefficient clusters. Therefore, in this paper, we propose a mechanism to establish efficient clusters based on the vehicle local information with considering the road maximum speed limit and the road traffic condition. The performance of the proposed mechanism is validated by comparing with those of the simple flooding and CF-IVC through NS-2 simulations.

PKC 활성 조절을 통한 두시 하태독법의 항염증작용이 Mite 항원 유도 아토피유사피부염 발병 조절에 미치는 효과

안상현,김기봉,Ahn, Sang Hyun,Kim, Ki Bong 대한한방소아과학회 2016 대한한방소아과학회지 Vol.30 No.4

Objectives Hataedock (HTD) is an oral Korean herbal medical oral treatment that removes fetal toxic heat and meconium from new born babies. The purpose of this study is to evaluate whether Hataedock treatment of Duchi extracts has anti-inflammation effects in atopic dermatitis-like skin lesions in House Dust Mite-Induced NC/Nga Mice. Methods The mice were divided into 3 groups (n=10 per group) as follows: the control group (Ctrl group), AD-induced group (AE group), AD-induced with HTD treatment group (DT group). 3-week-old NC/Nga mice were introduced to Hataedock treatment, made of Duchi extract. After 4 weeks, House Dust Mite-Induced application was used six times per week for 3 weeks to induce the first atopic dermatitis, and second AD in 7 weeks after. To examine skin injuries and anti-inflammatory effect, PKC, MMP-9, iNOS immunohistochemistry were used. Results The alleviate effect of the skin damage and angiogenesis was observed in DT group. The damage of stratum corneum, hyperplasia, edema, infiltration of lymphocytes and distribution of capillary were decreased in DT group. Also, the study results suggested that Hataedock treatment made of Duchi extracts in DT group remarkably decreased skin damages by 51% (p < 0.001), as well as PKC by 91%, MMP-9 by 48% (p < 0.001), iNOS by 51% (p < 0.001). Conclusions Based on the study results, we observed that Hataedock treatment of Duchi extracts alleviates AD by diminishing various inflammatory cytokines, initial steps of AD development, in the skin lesions. Potential applications for prevention and treatment of atopic dermatitis are expected.