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박현정,안상건,김정상,Park, Hyun-Jeong,Ahn, Sang-Gun,Kim, Jeong-Sang 한국식품영양과학회 2007 한국식품영양과학회지 Vol.36 No.4
흰쥐 우측요부에 RK3E-ras cell주입으로 7일 이내에 종양이 발달하는 것을 관찰하고, 단삼 추출물을 제조하여 항종양 효과를 관찰하고자 1주 후부터 2주 동안 육종 부위에 투여 후 종양의 크기와 무게를 측정하고 조직학적인 관찰을 통하여 암세포의 발달과 암전이 유무를 살펴보았다. 암종의 크기는 대조군에 비하여 단삼 추출물을 투여한 실험군에서 현저히 감소(p<0.01)하였으며, 암종의 중량 또한 실험군에서 현저히 감소(p<0.01)하였다. 조직학적 관찰 결과 종양을 둘러싸고 있는 섬유막은 대조군에 비하여 실험군에서 발달 해 있었으며, 암세포의 밀도는 실험군에 비하여 대조군에서 높았다. 간조직을 관찰한 결과 대조군의 간문맥 주변에서 전이된 것으로 보이는 암세포들이 다수 관찰되었다. 이와 같은 결과를 토대로 단삼 추출물이 항종양효과가 있다고 사료된다. The present study was carried out to investigate the antitumor activity of Salvia miltiorrhiza (SM) herbal extract in rat tumor model. We used a new tumor animal model for the invasion and metastasis of cancer using genetically k-ras-induced rat kidney cells (RK3E-ras). We observed tumor as early as 7 days after the injection of RK3E-ras cells in subcutaneous of Sprague-Dawley rats. All of the rats developed tumor mass at the inoculated site. After 7 days, the experimental groups were divided into two: saline control and injected with SM (200 mg/kg) groups. We investigated tumor's weight, size and hepatic metastasis of each group. Injection of SM herbal extract every other day for 14 days significantly inhibited tumor growth. Histologically, the tumors were undifferentiated carcinoma showing multifactorial necrosis and hemorrhage; also, the tumor invaded into hepatoportal region. Treatment with SM herbal extract caused significant inhibition of tumor cell proliferation. Our data showed that SM herbal extract is effective in controlling the tendency of tumor cell proliferation and metastasis by injection of RK3E-ras cells. These findings provided the potential value of SM as a novel antitumor agent candidate.
조지호 ( Ji Ho Jo ),김수관 ( Su Gwan Kim ),김학균 ( Hak Kyun Kim ),문성용 ( Seong Young Moon ),오지수 ( Ji Su Oh ),윤정훈 ( Jung Hoon Yoon ),안상건 ( Sang Gun Ahn ) 조선대학교 치의학연구원 2010 Oral Biology Research (Oral Biol Res) Vol.34 No.1
Objective. This study was performed to investigate the clinical and histopathologic features of chronic osteomyelitis and its treatment in Korean. Subject and Method. A total of 30 patients (mean age: 50.5 years old, 16-81 years old) were examined in this retrospective study. In a treatment protocol used for 30 patients, chronic osteomyelitis of the jaws was treated by surgical intervention and 2 weeks of intravenous antibiotics, followed by 6 weeks of oral antibiotics. Surgical therapy consisted of decortication or sequestrectomy and saucerization of the affected bone. A successful outcome was defined as the resolution of symptoms after surgery and 8 weeks of antibiotic therapy. Failure was defined as a case requiring a second surgery and 8 additional weeks of antibiotic therapy. Result. After application of the treatment protocol, successful outcome was seen in most patients. Some patients were treated successfully with a second surgery and 8 additional weeks of antibiotic therapy. Conclusion. According to this study, surgery followed by antibiotic therapy for at least 8 weeks is an effective method for treating chronic osteomyelitis of the jaws.
윤정훈,김도경,안상건,김수관 大韓顎顔面成形再建外科學會 2003 Maxillofacial Plastic Reconstructive Surgery Vol.25 No.1
We reviewed a series of 22 traumatic bone cysts of the jaws experienced during the 21-year period between 1982 and 2002 at the Chosum University Dental Hospital. The study group consisted of 13 females (59.1%) and 9 males (40.9%). The patient's mean age was 25.2 years, with peak incidence occuring in the first and second decade. Most traumatic bone cyst was located in the posterior mandible. Radiographically, well-defined round radiolucent (9 cases) or scalloped appearance (8 cases) were the predominant type, whereas 2 cases were ill-defined. A provisional clinical diagnosis was varied, only 9 of which were correct. Histopathologically, all the biopsy specimen composed of loose fibrous connective tissue accompanied by inflammatory reaction (13 cases), giant cells (9 cases). In addition, calcifications (6 cases) and new bone formation (5 cases) in the cyst wall were also observed. Taken together, correlative analysis of histopathologic and clinico-radiographic features is essential for definitive diagnosis and management.
치성 각화낭에서 매복치 동반 여부에 따른 Ki-67 발현 비교
박철우,김도경,안상건,김수관,윤정훈 大韓顎顔面成形再建外科學會 2003 Maxillofacial Plastic Reconstructive Surgery Vol.25 No.1
Odontogenic keratocysts(OKCs) are frequently associated with erupted or impacted tooth. In such instances, the radiographic features simulate those of a dentigerous cyst. The purpose of this study was to evaluate a comparative immunohistochemical expression of Ki-67 as a proliferative marker in the OKC associated with or without impacted tooth. In addition, we have also been investigated with regard to the proliferative activity comparing the unilocular and multilocular varieties of the OKC. The material for this study consisted of thirty-two cases of OKCs (OKC with impacted tooth, n=16; OKC without impacted tooth, n=16) and ten cases of dentigerous cysts as a comparison. The results revealed that the proliferative activity of OKCs with impacted tooth was higher than those of dentigerous cysts. However, there was no correlation between Ki-67 immunoreactivity and association with or without impacted tooth in 32 cases of OKCs. In addition, this present study showed that there was no correlation between the unilocular and multilocular varieties of the OKCs imn proliferative activity.