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Characterization of Monoclonal Antibodies against Human Leukocyte Common Antigen (CD45)
신향미,이기형,송형근,조운동,이건국,이선화,이경미,지길용,윤상순,구지혜,이호창 대한면역학회 2011 Immune Network Vol.11 No.2
Background: The leukocyte common antigen (CD45) is a transmembrane-type protein tyrosine phosphatase that has five isoforms. Methods: We generated seven murine mAbs against human CD45 by injecting cells from different origins, such as human thymocytes, PBMCs, and leukemic cell lines. By using various immunological methods including flow cytometry, immunohistochemistry, and immunoprecipitation, we evaluated the reactivity of those mAbs to CD45 of thymus as well as tonsil lysates. Furthermore, we transiently transfected COS-7 cells with each of gene constructs that express five human CD45 isoforms respectively, and examined the specificities of the mAbs against the transfected isoforms. Results: In case of thymocytes, lymphocytes, and monocytes, all the seven mAbs demonstrated positive reactivities whereas none was reactive to erythrocytes and platelets. The majority of immune cells in formalin-fixed paraffin-embedded thymus and tonsil tissues displayed strong membranous immunoreactivity, and the main antigen was detected near 220 kDa in all cases. Among the mAbs, four mAbs (AP4, DN11, SHL-1, and P6) recognized a region commonly present in all the five isoforms. One mAb, YG27, recognized four isoforms (ABC, AB, BC, and O). Two mAbs, P1 and P14, recognized the isoforms that contain exon A encoded regions (ABC and AB). Conclusion: In this study, we confirmed that AP4, DN11, SHL-1, YG27 and P6, are mAbs reactive with the CD45 antigen whereas P1 and P14 are reactive with the CD45RA antigen.
Plexiform Fibrohistiocytic Tumor of the Neck- A Case Report -
신향미 대한병리학회 2005 Journal of Pathology and Translational Medicine Vol.39 No.3
Plexiform fibrohistiocytic tumor (PFT) is a rare, low-grade soft tissue tumor that occurrs primarily in children and young adults. The most common location of PFT is the upper extremity, and there are very few reports of PFT in the neck. We report here on a case of PFT presenting as a painless subcutaneous nodule in the neck of a 46-year-old woman. Histologically, this subcutaneous tumor was composed of a plexiform proliferation of histiocyte-like cells and fibroblast- like cells along with a few multinucleated osteoclast-like giant cells. Immunohistochemically, the tumor cells were positive for vimentin, CD68 and smooth muscle actin (SMA).
신향미,성노현 충북대학교 의학연구소 2000 忠北醫大學術誌 Vol.10 No.2
융모막혈관종은 태반에서 발생하는 가장 흔한 양성 종양으로 대개는 크기가 작고 태반체 속에 묻혀 있으며 증상이 없기 때문에 발견되지 않는 경우가 많다. 그러나 드물게 종양이 큰 경우에는 태반의 태아면 또는 모체면쪽으로 돌출하며 양수과다, 조산 등을 나타낼 수 있다 한편 이 종양은 비교적 흔한 종양임에도 불구하고 그 기원세포는 명확히 밝혀지지 않았다. 저자들은 27세 경산부의 태반에서 조산의 원인이 된 장경 8 cm의 융모막혈관종 1예를 경험하고 cytokeratin 18과 CD34에 대한 항체를 이용한 면역조직화학검사로써 융모막혈관종은 융모막반과 고정융모의 혈관에서 기원했을 가능성을 밝혔다. Chorangioma is the most common benign tumor of the placenta. A case of unusually large chorangioma associated with premature delivery is presented. At 26 weeks of gestation, a 27-year-old woman delivered a female infant. The placenta weighed 650 gm and a large, solid mass, measuring 8 cm in diameter, was seen on fetal surface of the placenta protruding into amniotic cavity. Microscopically, the tumor was composed of numerous capillary-sized vessels separated by inconspicuous stroma. Immunohistochemically, tumor cells showed staining for CD34, vimentin, alpha smooth muscle (α-SM) actin and cytokeratin 18. The blood vessels within the chorionic plate and anchoring villi stained for cytokeratin 18, but the vasculature of the terminal villi lacked cytokeratins. In these results, the chorangioma originate most likely from blood vessels of the chorionic plate and anchoring villi.
신향미(HM Shin),전권희(GH Chun),문인근(IG Moon),안영준(YJ Ahn),황호원(HW Hwang) 대한산부인과학회 1994 Obstetrics & Gynecology Science Vol.37 No.4
Primary ovarian pregnancy is a rare form of ectopic pregnancy. However, improved diagnosis of acute hemoperitoneum of ovarian origin may reveal a higher incidence than reported earlier. We have experienced two cases of ovarian pregnancy and report with a brief review of literature concerned.
자궁경부 상피내병변에서 HPV와 p53 단백의 변화에 대한 면역조직화학적 소견
기근홍,황철기,신향미 조선대학교 부설 의학연구소 2000 The Medical Journal of Chosun University Vol.25 No.1
Background and Objectives : p53 is a tumor suppressor gene. Loss of function of the p53 tumor suppressor gene implicated in a wide variety of human tumors. Many mechanisms are involved in p53 dysfunction. One of the mechanisms is binding of oncogenic virus such as human papillomavirus (HPV). HPV infection are strongly linked to the development of cervical neoplasia including cervical intraepithelial neoplasia (CIN) of uterine cervix The purpose of this study is to investigate the relationship between aberrant p53 expression and presence of HPV DNA in CIN of the uterine cervix. Materials and Methods : In the present study, the author analyzed 35 cases of paraffin-embedded CIN, including 10 cases of grade 1, 10 cases of grade Ⅱ, and 15 cases of grade Ⅲ CIN by the immunohistochemistry and in situ hybridization. Results : Overall positive rate of HPV DNA type 16 and type 18 was 74.3% (26 cases) and 65,7% (23 cases), respectively. Nuclear accumulation of p53 was found in 22 cases (62.9%) of all CIN. In negative cases of HPV DNA type 16, the p53 was positive in 18 cases and negative in 8 cases. In positive cases of HPV DNA type 18, the p53 was positive in 16 cases and negative in 7 cases. In negative cases of HPV DNA type 16, the pS5 was positive in 6 cases and negative in 6cases. Conclusion : This results suggest that HPV infection may contribute to the DNA damage associated with the accumulation of aberrant p53 protein, and then closely relate to the progression of cervical neoplasms. But, alteration of p53 Protein levels and presence of HPY DNA was not an exclusive markers of cervical tumorigenesis.
김윤환,오장근,신향미,문태현,김정범,김영생,Kim, Yoon-Hwan,Oh, Jang-Gun,Shin, Hyang-Mi,Moon, Tae-Hyun,Kim, Jeong-Beom,Kim, Young-Saeng 대한기관식도과학회 2009 大韓氣管食道科學會誌 Vol.15 No.2
Myxoma is a benign mesenchymal neoplasm that can occur in the head and neck. Laryngeal myxoma is extremely rare and easily confused with a laryngeal polyp. The common clinical presentation is hoarseness, dysphonia, dyspnea and dysphagia depending on their size and location. Treatment for laryngeal myxoma is complete surgical excision with surrounding normal tissue. To our knowledge, 11 laryngeal myxomas have been reported in the English literature, and all patients except only 1 case were male. We report the second female case of myxoma on a vocal cord with a review of literature.
기능성 부갑상선암종 : A case report 1예 보고
송형근,이옥준,신향미,오태근,궁성수,윤효영 충북대학교 의과대학 충북대학교 의학연구소 1998 忠北醫大學術誌 Vol.8 No.1
부갑상선에 생기는 악성종양은 매우 드물며 이중 기능성 부갑상선암종이 대부분을 차지한다. 현재까지 270예가 보고 되었으며 국내에서는 5예뿐이다. 53세 여자의 부갑성선 기능항진증과 재발성 췌장염을 동반한 부갑상선암종 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Parathyroid carcinoma is a rare endocrine tumor, reported to be less than 1% of patients with primary hyperparathyroidism. Patients with parathyroid carcinomas are often symptomatic, have markedly elevated calcium levels. and have a palpable neck mass. They are equally distributed between the sexes. The diagnosis is suspected when the tumor is large, parathyroid hormone levels are high, and a palpable mass is present in the neck. Parathyroid carcinoma is often misdiagnosed preoperatively, suspected intraoperatively, and only confirmed postoperatively. We experienced a case of hyperfunctioning parathyroid carcinoma associated with recurrent pancreatitis in a 52 year old female, which was confirmed microscopically. The tumor showed : 1) blood vessel invasion ; 2) a trabecular pattern, and 3) intervening thick fibrous bands.