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국내 10개 대학병원의 관동맥질환자의 고콜레스테롤혈증 치료 현황
성지동 ( Ji Dong Sung ),김상현 ( Sang Hyun Kim ),김영대 ( Young Dae Kim ),백상홍 ( Sang Hong Baek ),안영근 ( Young Keun Ahn ),임도선 ( Do Sun Lim ),조홍근 ( Hong Keun Cho ),채성철 ( Shung Chull Chae ),한기훈 ( Ki Hoon Han ),김효수 대한내과학회 2005 대한내과학회지 Vol.69 No.4
Background : Previous studies showed treatment gap phenomenon in the treatment of hyperlipidemia, meaning failure to adhere to the recommendation in the treatment guideline. In Korea, systematic research on this issue has never been done. This investigation was to estimate the hypercholesterolemia treatment gap in coronary artery disease (CAD) patients in tertiary care centers according to NCEP ATP-III guideline. Methods : Ten Korean educational hospital participated in the survey, reviewing medical record of 1,048 patients. Patients were enrolled when they were documented as having coronary artery disease by coronary angiography or stress tests or medical history of myocardial infarction, percutaneous coronary intervention or bypass surgery. Thirty or more medical records per each of 3 or more cardiologists were reviewed in each hospital. Sampling was done sequentially based on outpatient or inpatient list. Pharmacological treatment for hyperlipidemia included the first and last records of prescription. Baseline and the most recent lipid profiles were collected. Results : Findings from the survey was summarized as 10 to 50% rule: 10%: mean LDL-cholesterol reduction without lipid-lowering drug, 20%: LDL-cholesterol level at the treatment goal before any treatment, 30%: mean LDL-cholesterol reduction with lipid-lowering drug treatment, 40%: proportion of CAD patients without lipid-lowering drug, 50%: treatment goal achievement after treatment. Conclusions : Significant treatment gap exists in Korean cardiology practice in tertiary care centers. Systematic approach to reduce this gap is warranted.(Korean J Med 69:371-378, 2005)
좌심실 보조장치를 삽입한 환자에게 적용된 개별화된 운동 변인의 효과
서용곤 ( Yong Gon Seo ),성지동 ( Ji Dong Sung ),박원하 ( Won Hah Park ) 대한스포츠의학회 2016 대한스포츠의학회지 Vol.34 No.1
Left ventricular assist devices (LVADs) are a treatment option for patients with severe chronic heart failure. These patients are referred to an inpatient cardiac rehabilitation after implantation to improve an aerobic capacity and quality of life (QOL). Several studies have reported that an exercise therapy, which is a component of cardiac rehabilitation, improves exercise capacity and QOL. The LVADs were implanted successfully in a destination therapy in two Korean patients, and these patients were enrolled in the cardiac rehabilitation. After an individualized intervention, they were discharged from improved exercise functional capacity and QOL. This is the first report showing a benefit of the individualized exercise therapy using different parameters after LVADs implantation in Korea.
고콜레스테롤혈증 환자에서 내피의존성 혈관반응에 대한 스타틴과 비타민 C의 효과에 대한 연구
온영근(Young Keun On),성지동(Ji Dong Sung),채인호(In Ho Chae),김철호(Cheol Ho Kim),손대원(Dae Won Sohn),오병희(Byung Hee Oh),이명묵(Myoung Mook Lee),박영배(Young Bae Park),최윤식(Yun Shik Choi) 대한내과학회 2001 대한내과학회지 Vol.60 No.3
Background : Hypercholesterolemia is firmly established as a risk factor for the development of atherosclerosis. However the exact mechanism of hypercholesterolemia-related damage to the arterial wall and its relation to the atherosclerotic process are not well known. The endothelium plays an important role for the regulation of vascular tone and the endothelial function is impaired in the presence of risk factors early in the process of atherosclerosis. Assessment of endothelial function appears to be a valuable tool for the diagnosing and therapeutic monitoring of coronary artery disease. Lipid lowering agents and anti-oxidants are known to improve endothelial dysfunction in hypercholesterolemic patients, respectively. The purpose of this study is to investigate whether vitamin C has additional benefit on endothelial function of statin-treated hypercholesterolemic patients. Methods : The endothelial function was estimated using venous occlusion plethysmography (VOP) in 9 hypercholesterolemic patients and 11 healthy volunteers. The strain guage was connected to plethysmograph to record the forearm volume change. A rapid cuff inflator was used to inflate the arm cuff to 40 mmHg instantaneuosly thus occluding venous return from the forearm. The measurement of forearm volume change was repeated for 7 times each stage. The patients in the hypercholesterolemic (HC) group were treated with the statin, then examined again. The change of the forearm blood flow (FBF) was measured with the acetylcholine infusion through brachial artery and also with intra-arterial vitamin C. Results : Endothelium-dependent vasodilatation was significantly impaired in the HC group compared to the control group (15.9±0.9 mL/min/100mL forearm tissue, vs 8.9±0.6 mL/min/100mL forearm tissue, mean±standard error of mean, p<0.05). The FBF increased significantly after statin therapy (8.9±0.6 vs 25.2±1.4 mL/min/100mg forearm tissue, p<0.05). Vitamin C infusion in these patients results in additional improvement in FBF (25.2±1.4 vs 31.9±2.1, p<0.05). Conclusion : Endothelium-dependent vasodilatation was significantly impaired in the HC group compared to the control group. The FBF increased significantly after statin therapy. Vitamin C seems to have additional benefit on the endothelial function of statin-treated hypercholesterolemic patients.(Korean J Med 60:206-214, 2001)
한국인에서 다양한 진단기준에 따른 대사증후군의 유병률과 인슐린 저항성 반영의 차이
지재환 ( Jae Hwan Jee ),성지동 ( Ji Dong Sung ),최윤호 ( Yoon Ho Choi ),정재훈 ( Jae Hoon Chung ),민용기 ( Yong Ki Min ),이명식 ( Myung Shik Lee ),김광원 ( Kwang Won Kim ),이문규 ( Moon Kyu Lee ) 한국지질동맥경화학회(구 한국지질학회) 2006 韓國脂質學會誌 Vol.16 No.2
Objective: NCEP ATP III criteria, recent IDF and AHA/NHLBI criteria of metabolic syndrome (MetS) are useful to diagnose briefly MetS clinically, but exclude concept of insulin resistance in definition of MetS unlikely WHO criteria. We compared prevalence of MetS using various diagnostic criteria and evaluated if recent definitions of MetS reflect insulin resistance better than earlier criteria. Methods: Among 1,708 subjects aged 23~85 years (1,088 men; 620 women) who underwent medical checkup at health promotion center, we evaluated components of MetS with the basis of modified ATP III criteria using BMI≥25 kg/m2 instead of waist circumference (WC), classic ATP III criteria, IDF criteria, modified IDF criteria of Korea (IDF-K) using WC≥85 cm for women and AHA/NHLBI criteria, and calculated HOMA-IR in 708 subjects. Results: The prevalence of MetS according to AHA criteria was 25.3%, significantly higher than the other criteria (P<0.05) and that in IDF-K was 16.8%, significantly lower than the others, especially in women (P<0.001). In all criteria, prevalence of MetS increased significantly with aging in women (P<0.001) but decreased in 8th decade in men. Diagnosis of MetS showed positive relationships with HOMA-IR, and risk of HOMA-IR was higher in modified ATP III (OR 2.54, 95% CI 2.04~3.17) and AHA criteria (2.52, 2.03~3.14) in men, then high in classic ATP III (2.51, 1.64~3.85) and IDF criteria (2.65, 1.70~4.11) but lowest in modified ATP III criteria (1.88, 1.31~2.69) in women. Conclusion: In Koreans, according to AHA/NHLBI criteria, prevalence of MetS was higher than to the other criteria, and diagnosis of MetS reflected insulin resistance better than other criteria only in men.
온영근(Young Keun On),성지동(Ji Dong Sung),김효수(Hyo Soo Kim),김철호(Cheol Ho Kim),손대원(Dae Won Sohn),오병희(Byung Hee Oh),이명묵(Myoung Mook Lee),박영배(Young Bae Park),최윤식(Yun Shik Choi),서정돈(Jung Don Seo),이영우(Young Woo 대한내과학회 1996 대한내과학회지 Vol.50 No.1
Objectives: Identification of the coronary arterial lesion susceptible to accelerated progression of the atherosclerosis may provide important clinical information in the management of the patients with coronary artery diseases(CAD) or when revascularization procedures are planned especially in patients with multiple coroanry arterial lesions, We performed this study in order to evaluate 1) the changing pattems of coronary artery disease and 2) the possible factors for either progression or regression of the coronary arterial lesion in patients with angina pectors. Methods: 56 patients with angina pectoris who undertook repeated coronary arteriography (CAG) over an interval of 1 year or more were enrolled in the study. Patients who got PTCA, CABG, or thrombolytic therapy were excluded as well as vasospastic angina on initial coronary arteriography. Criteria for the progression and regression were the changes of the luminal narrowing of the coronary arterial segment by 20% or more, Results: Upon follow-up CAG, progression of the coronary arterial lesion was found in 55% of the patients, regression in 18% and no significant changes in 27%. Progression of the lesion was more frequently found in patients with multivessel disease and there was a tendency for new or prgressive lesion in the left anterior descending artery teritory than in any other coronary arteries. Among CAD risk factors, diabetes mellitus was more frequently associated with the progression of the coronary arterial lesion. Conclusion: The coronary arterial lesions in patients with angian pectoris are more frequently progressive rather than stationary or regressive, with a tendency for new or progressive lesion in the left anteior descending coroanry artery territory
건강한 한국 성인에서 lipoprotein lipase 유전자의 유전적 다형성이 혈중 지질농도와 체질량 지수에 미치는 영향
박진식(Jin Sik Park),성지동(Ji Dong Sung),채인호(In Ho Chae),김효수(Hyo Soo Kim),주재란(Jae Ran Ju),손대원(Dae Won Son),오병희(Byung Hee Oh),이명묵(Myoung Mook Lee),박영배(Young Bae Park),최윤식(Yun Shick Choi),이영우(Young Woo Lee) 대한내과학회 2000 대한내과학회지 Vol.58 No.1
Background : Lipoprotein lipase(LPL) plays a pivotal role in triglyceride-rich lipoprotein metabolism. It removes TG-rich lipoprotein from circulation by hydrolysing TG and produces active form of HDL. It also affects the development and maintenance of obesity by regulating the fatty acid metabolism of the adipose tissue. Many studies about the association of the genetic variation of LPL and dyslipidemia have been performed, but the results were not consistent. We tried to characterize the phenotypes of the LPL genetic variation in Korean. Methods : Healthy Korean adults (n=110) were genotyped for Hind III/Pvu II RFLP and Ser447Ter mutation of the LPL gene by PCR-digestion method. We investigated the association of the genetic variations with the lipids, the lipoprotein concentrations and the body mass index(BMI). Results : The allele frequencies of Hind III RFLP, Pvu II RFLP and Ser447Ter mutation were H1:H2=33%:67%, P1:P2=40%:60% and Ser447:Ter447=90%:10%. Ser447Ter mutation carriers had higher HDL cholesterol level than non-carriers (59±10mg/dl versus 53±11mg/dl, p=0.049) and the Pvu II RFLP is associated with increased body mass index.(P1P1:P1P2:P2P2 = 22.1±2.0 kg/m2: 23.5±2.7 kg/m2: 24.5±2.6 kg/m2, p=0.003) Conclusion : The genetic variations of the LPL gene in healthy Korean adult resulted in increased HDL cholesterol and increased BMI. These results were different from previous studies. This difference may reflect the racial difference from the diet and the linkage disequilibrium (Korean J Med 58:57-66, 2000)