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임신 중 환경오염물질 2-Bromopropane에 노출된 마우스의 모독성 평가
허정두(Jeong-Doo Heo),김충용(Chung-Yong Kim),강성철(Chen-Zhe Ziang),서정은(Jeong-Eun Suh),정문구(Moon-Koo Chung),김무강(Moo-Kang Kim),신동호(Dong-Ho Shin),김종춘(Jong-Choon Kim) 한국실험동물학회 2004 Laboratory Animal Research Vol.20 No.1
2-Bromopropane (2-BP), a halogenated propane analogue, is a substitute for chlorofluorocarbones (CFCs). The present study was carried out to investigate the potential adverse effects of 2-BP on pregnant dams after maternal exposure during the gestational days (GD) 6 through 17 in ICR mice. The test chemical was administered subcutaneously to pregnant mice at dose levels of 0, 500, 1000, and 1500 ㎎/㎏/day. All pregnant females were subjected to autopsy on GD 18. Treatment-related clinical signs, as evidenced by dose-dependent increases in the incidence and severity of rough fur, swelling, induration, crust formation, and ulceration at the injection sites, were observed at dose levels of above 1000 ㎎/㎏/day. Maternal body weight on GD 18 and maternal body weight gain for the intervals GD 6-17 (treatment period) were suppressed at a dose level of 1500 ㎎/㎏ in a dose-dependent manner, but not statistically significant. Hematological investigations revealed a dose-dependent decrease in the number of platelet at a dose level of 1500 ㎎/㎏. Fetal body weights of both sexes in the 1500 ㎎/㎏ group were also decreased in a dose-dependent manner. There were no adverse effects on mortality, food consumption, organ weights, and reproductive findings except for decreased fetal body weight in any treatment group. Based on these results, it was concluded that the 12-day repeated subcutaneous dose of 2-BP resulted in an increased incidence of clinical signs, suppressed maternal body weight, reduced platelet count and decreased fetal body weight at a dose level of 1500 ㎎/㎏/day in pregnant mice. In the present experimental conditions, the no-observed-adverse-effect level of 2-BP was considered to be 500 ㎎/㎏ for dams.
기니픽을 이용한 BR92021 ( 정제 브이아이 장티푸스 백신 ) 의 항원성 평가
정태천(Tae Cheon Jeong),김갑호(Kap Ho Kim),배주현(Ju Hyun Bae),구희경(Hee Kyoung Gu),서정은(Jeong Eun Suh),박종일(Jong Il Park),차신우(Shin Woo Cha),임상민(Sang Min Lim),정한선(Hahn Sun Jung),김상린(Sang Lin Kim) 한국응용약물학회 1999 Biomolecules & Therapeutics(구 응용약물학회지) Vol.7 No.3
To study the antigenicity of BR92021(Vi polysaccharide typhoid vaccine), active systemic anaphylaxis and passive cutaneous anaphylaxis were tested in guinea pigs. The groups were as follows: group I(low dose, 30 ㎕/kg), group II(high dose, 300 ㎕/kg), group III(300 ㎕/kg plus complete Freund`s adjuvant), group IV(positive control, ovalbumin plus complete Freund`s adjuvant) and group V(saline-treated control). Male Hartley guinea pigs at 7 weeks of age were sensitized subcutaneously with the test article or saline three times per week for three weeks(i.e., total 9 times). For groups III and IV, animals were sensitized subcutaneously with either the test article or ovalbumin plus complete Freund`s adjuvant once per three week for 6 weeks(i.e., total 3 times). Twelve days after the last sensitization, the blood was collected from the sensitized animals for the passive cutaneous anaphylaxis test. In addition, the sensitized animals were subjected to the active systemic anaphylaxis test on fourteen days after the 1st sensitization by an intravenous challenge with either the test article or ovalbumin. In group I, mild(1/5) or moderate(4/5) symptoms of anaphylactic shock were observed. In group II, no sign(1/5), moderate(3/5) and severe(1/5) symptoms were observed. In group III, four animals of 5 revealed moderate signs and one of 5 showed no signs of anaphylactic shock. In group IV, all 5 animals showed severe signs of shock. In group V, one of 5 revealed moderate and four of 5 showed no signs. The necropsy findings related to the active systemic anaphylaxis were observed in most animals of groups I to V. In the passive cutaneous anaphylaxis test, the antiserum was diluted 10- to 5120- fold and was injected intradermally on the clipped back of recipient animals, followed by an intravenous challenge with either the test article or ovalbumin. No animals in groups I, II, III and V showed the positive reaction, whereas all animals in group IV, the positive control, showed the positive reaction at the dilution range of x1280 to x5120. Our results indicate that the test article, BR92021, may have weak antigenic potential in male guinea pigs.
프로야구 관중의 응원만족도가 팀 일체감 및 재관람의도에 미치는 영향
조우정(Cho, Woo-Jeong),김애랑(Kim, Ae-Rang),서정은(Suh, Jung-Eun) 한국체육과학회 2012 한국체육과학회지 Vol.21 No.1
The purpose of this study was to examine the influence of pro-baseball spectators’ cheering satisfaction on team identification and repurchase intentions. The spectators who watched the games of 2011 pro-baseball league in Bu-San, Dae-Gu and Gwang-Ju were selected as samples of this study. A total of 436 questionnaires were collected. The collected data were analyzed through frequency analysis, exploratory factor analysis, independent samples t-test, one-way ANOVA and regression analysis. The findings of this study were as follows. First, there was a statistically significant difference in pro-baseball spectators’ cheering satisfaction between the groups of different gender. Second, there was a statistically significant difference in pro-baseball spectators’ cheering satisfaction with respect to the frequency of watching games. Third, cheering satisfaction were found to affect the team identification of pro-baseball spectators. Fourth, cheering satisfaction were also found to affect the repurchase intentions of pro-baseball spectators. Lastly, team identification was found to be an influence factor for the repurchase intentions of pro-baseball spectators.
Single dose toxicity study of CKD-602, a new camptothecin anticancer agent, in Beagle dogs
김종춘,신동호,박승춘,손우찬,차신우,한정희,배주현,서정은,정문구,Kim, Jong-Choon,Shin, Dong-Ho,Park, Seung-Chun,Son, Woo-Chan,Cha, Shin-Woo,Han, Junghee,Bae, Joo-Hyun,Suh, Jeong-Eun,Chung, Moon-Koo The Korean Society of Veterinary Science 2004 大韓獸醫學會誌 Vol.44 No.1
The present study was carried out to investigate the potential acute toxicity of CKD-602 by a single intravenous dose in Beagle dogs. The test chemical was administered intravenously to male and female Beagle dogs at dose levels of 0.3, 0.5, or 2.5 mg/kg. Mortalities, clinical findings, and body weight changes were monitored for the 14-day period following the administration. At the end of 14-day observation period, all animals were sacrificed and complete gross postmortem examinations were performed. All males and females of the 2.5 mg/kg dose group were found dead between the fourth and seventh day after the injection. Treatment related clinical signs, including vomiting, anorexia, mucous stool, diarrhea, and no stool were observed. Decrease or suppression of body weight was observed in a dose-dependent manner. In autopsy, dark red discoloration of the gastrointestinal tract, atrophy of the thymus, paleness of the spleen, sporadic dark red spots of the lung and petechia of the heart were observed in dead animals of the 2.5 mg/kg dose group. There were no specific adverse effects on males and females of the 0.3 and 0.5 mg/kg dose groups, except for the transient clinical signs such as anorexia, vomiting, and mucus/no stool. On the basis of the results, it was concluded that a single intravenous injection of CKD-602 to Beagle dogs resulted in increased incidence of abnormal clinical signs and death, decreased body weight, and increased incidence of abnormal gross findings. The absolute toxic dose of this chemical was 2.5 mg/kg for both genders. The $LD_{50}$ value was 1.1 mg/kg (95% confidence limit not specified) for both genders. The no-observed-effect level (NOEL) was considered to be below 0.3 mg/kg for both genders.
Sibutramine의 신규 염인 Sibutramine Mesilate Hemihydrate의 랫드와 비글견에 대한 단회 경구투여 독성
한수철(Su-Cheol Han),차신우(Shin-Woo Cha),서정은(Jeong-Eun Suh),서귀현(Kwee-Hyun Suh) 한국실험동물학회 2004 Laboratory Animal Research Vol.20 No.4
This study was to investigate single-dose toxicities of sibutramine mesilate hemihydrate (SIBMS), a new salt of sibutramine, in Sprague-Dawley (SD) rats and beagle dogs. The test article was administrated once by gavage to rats at dose levels of 43.1, 86.3, 172.5 and 345.0 ㎎/㎏/day, and to beagle dogs at dose levels of 23.0 and 43.0 ㎎/㎏/day, respectively. For comparison, sibutramine hydrochloride monohydrate (SIBCH) used clinically as anti-obesity agent was administrated to SD rats at dose levels of 37.5, 75.0, 150.0 and 300.0 ㎎/㎏/day and at dose levels of 20.0 and 40.0 ㎎/㎏/day to beagle dogs. In rats, deaths, temporary body weight loss, increased locomotive activity and salivation were observed and the approximate lethal dose of SIBMS was 345.0 ㎎/㎏ for males and 172.5 ㎎/㎏ for females and those of SIBCH was 300.0 ㎎/㎏ for males and 150.0 ㎎/㎏ for females, respectively. In beagle dog, death, temporary body weight loss, vomiting, salivation, hyperemic conjunctiva, anorexia and lacrimation were found. The toxic effect dose of SIBMS were 46.0 ㎎/㎏ and those of SIBCH were 40.0 ㎎/㎏ for both sexes.