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손우찬,김형진,이영순 한국독성학회 1991 Toxicological Research Vol.7 No.1
Complexities of testis structure and function are emphasized in morphometrical and genotoxic evaluation by statistical analysis. F-344 rats were treated with azinphos methyl, cyclophosphomide, and dichlorvos. And Brdu was injected with intrapertionially before sacrifice. The existence and degree of DNA damage were measured by Brdu labeling index which represented relative amount of Brdu incorporated in DNA, morphometric change was evaluated by the relative length of tubular diameter in circular seminiferous tubules and the number of spermatogonia per Sertoli cell in stage IX seminiferous tubules.
독성병리 Peer Review의 중요성과 실제적 접근방법
손우찬(Woo-Chan Son),김배환(Bae-Hwan Kim),장동덕(Dong-Deuk Jang),한범석(Beom-Seok Han),양기화(Ki-Hwa Yang),이영순(Yong-Soon Lee) 한국독성학회 2004 Toxicological Research Vol.20 No.1
Evaluation of toxicological pathology is to some extend subjective judgments by pathologist and the accuracy of pathologist’s works is based on the individual training and experiences. It has been required to establish a peer review system for toxicologic pathology and these review system has been employed by various practice of toxicological pathology. It would be pointed out that the possible causes of drifts in pathology are due to 1) lack of knowledge or experience of individual pathologists, 2) poorly maintained consistence of grading among animals in study, 3) different interpretation of findings between pathologists, or 4) pathology data processing. Example cases of diagnostic errors and current practice of peer review including tissue selection criteria, documentation and problem resolution for short-term and carcinogenicity studies were introduced. For sound regulatory<br/> system and high integrity of practice in toxicological pathology, current approaches of peer review system were reviewed.