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HTLV - I 의 불멸화에 의한 T 세포의 특성 및 한국인 악성 림프종과 Retrovirus 감염과의 관계
전호종(Ho Jong Jeon),서재홍(Chae Hong Suh),기근홍(Keun Hong Kee),김윤신(Yun Sin Kim),이미숙(Mi Sook Lee),정춘해(Choon Hae Chung),정종훈(Jong Hoon Jung),박영진(Young Jin Park),김향우(Hyang Woo Kim),아카키타다쯔(Tadaatsu Akagi) 대한내과학회 1995 대한내과학회지 Vol.49 No.3
Objectives: 1) The relationship between malignant T-cell lymphoma and retroviral infection was examined in sixty-two cases of non Hodgkin's lymphoma arising in nodal and extranodal site to presume the etiologic factors in the pathogenesis of T-cell lymphoma arising in Korean. 2) Human T-cell leukemia/lymphoma virus type I(HTLV-1) is known as an etiologic agent of adult T-cell leukemia/lymphoma(ATL), however, the precise role of the HTLV I on the genesis of ATL is unclear. To elucidate the mechanism of the leukemogenesis on the ATL, establishment of cell line harboring HTLV-I is indispensable. Methods: 1) Sixty- two cases of malignant lymphoma were examined with a battery of monoclonal and polyclonal antibodies directed to T-cell, B-cell and macrophage-lineage to determine the immunophenotypes. Reverse transcriptase activity and the pol gene region in HTLV-I were examined by RNA directed DNA polymerase assay and polymerase chain reaction. 2) Two helper T-cell lines, designated JP(JP-1 and JP-2), were established by co-culturing normal human cord leukocytes with a lethally irradiated HTLV-I-harboring human leukocytes cell line(MT-2). Results: 1) There are no evidence of retroviral infection including HTI.V-I in examined 7 cases of peripheral T-cell lymphama. 2) JP-1(interleukin 2 dependent) had a normal karyotype, and expressed the surface markers CD3+, CD4+, CD8-, CD19-, CD25+ and HLA-DR+. JP-2(IL-2 independent) had tetraploidy on the 22nd passage, and exhibited the surface markers CD3-, CD4+, CD8-, CD19-, CD25+ and HLA-DR+. T-cell receptor(TCR)-β chain gene was detected in these two cell lines by Southern blot hybridization techniques with (32)P-labelled DNA probe Jpconfirming T-cell nature. Jβ2 cells were all immunoreactive with anti-HTLV-1, p 19, p 24, gp46 and pX antibodies. The proviral genome of HTLV-1 was detected in these cell lines by Southern blot hybridization by the (32)P-labelled DNA probe, pHT-1 (M)3.9. Electron microscopy of JP 2 cells revealed a few of type C virus particles. Conelusion: 1) These results suggest that the evidence of retroviral infection as an etiological factors in the pathogenesis of T-cell lymphoma is poor. 2) HTLV-1 was transmitted from the infected human leukocyte cell line to human cord helper T-cells with the development of immortalized HTLV-1 producing T-cell lines, and IL-2 independent cell line(JP-2) lost their CD3 antigen, It is suspicious that there is the second factors to induce malignant transformation in the genesis of adult T-cell leukemia/lymphoma because of absence of the tumorigenecity in the JP cell lines harboring HTLV-1.
자궁경부의 상피내종양과 편평세포암종에서 cyclin E, bcl-2, p27, VEGF, p53 및 E-cadherin 발현양상
서재홍,양정원,성정희,오수섭,이미자 조선대학교 부설 의학연구소 2002 The Medical Journal of Chosun University Vol.27 No.2
Background and Objectives: Correlation of cyclin E, bcl-2, p27, VEGF, p53 and E-cadherin expression was analyzed in cervical intraepithelial neoplasia (CIN), carcinoma in situ (CIS), and microinvasive and invasive squamous cell carcinoma (SCC) according to human papilloma virus (HPV) inffection. Materials and Methods : (23 CIN 1, 28 CIN 2, 23 CIN 3), 18 CIS, and 24 SCC. Results: Expression of cyclin E was significantly higher in CIN 2, CIN 3, CIS and SCC than CIN 1 with or without HPV infection. Expression of bcl-2 was significantly higher in CIN 3 than SCC. There was no association between expression of p27 and VEGF and progression of CIN 1 to SCC. Expression of p53 was significantly high in CIN 3, CIS and SCC with or without HPV infection. Expression of the E-cadherin was significantly high in CIN 2, CIN 3, CIS and SCC with or without HPV infection. Conclusion: There was correlation between expression of cyclin E, b치-2, ㅔ53, E-cadherin and progression of CIN to SCC. It is suggested that cyclin E may play an important role in the neoplastic transformation of cervical squamous cell.
서재홍,임성철,기근홍 朝鮮大學校 附設 醫學硏究所 1991 The Medical Journal of Chosun University Vol.16 No.2
In gastric carcinomas including 20 cases of intestinal type and 20 cases of diffuse type, in adenoma (10 cases), and in metaplastic gastritis(10 cases), the presence of lactoferrin was investigated by immunohistochemistry. An evident reactivity for lactoferhn was encountered in intestinal type carcinomas, adenomas, and incomplete intestinal metaplasia. The problems in identifyng the steps in the pathogenesis of gastric cancer and in the calssification of its preneoplastic lesions led to a throughout analysis of the morphologic features of metaplastic gastritis, adenoma and adenocarcinoma of the gastric mucosa. Recently, several morphologic features with possible diagnostic significance have been identified among these parameters, several cytologic features seem to be of major importance for the quantitative analysis of the stepwise develop merit of malignancy. We have chosen to study nuclear and cytoplasm measurements as seen in gastric biopsied specimens. The results obtained were as follow: 1) Incomplete intestinal metaplasia, adenoma and intestinal type adenocarcinoma were stained with lactoferrin 2) Nuclear and cytoplasmic areas of incomplete metaplasia (50±14㎛_(2), 147±38㎛_(2)), Adenoma (56±16㎛_(2), 149±44㎛_(2)), Well differentiated adenocarcinoma(57±16㎛_(2), 152±48㎛_(2)), Moderate differentiated adenocarcinoma (44±14㎛_(2), 118±33㎛_(2)), Poor differentiated adenocarcinoma (54±16㎛_(2), 97±30㎛_(2)) and diffuse type adenocarcinoma (33±10㎛_(2) 434±124㎛_(2)) were noted. 3) Nuclear and cytoplasmic ratio of incomplete metaplasia(0.34±0.02), adenoma (0.38±0.02), well differentiated adenocarcinoma( 0.38±0.02), moderately differentiated adenocardnoma (0.37±0.02), Poor differentiated adenocarcinoma(0.56±0.01), and diffuse type adenocarcmoma (0.08±0.02) were noted.