항정신성 약물 사용에 따른 체중변화에 관한 연구

변은하,김상훈,김재민,박상학,김학열,박찬원 朝鮮大學校 附設 醫學硏究所 2002 The Medical Journal of Chosun University Vol.27 No.2

Objective : Weight gain is one of the common side effects of antipsychotics and it has been known that the quality of life is decreased by weight gain. Therefbre the purpose of this study is to compare weight gain among the antipsychotics, which are frequently used in the clinical practice. Methods : We performed a retrospective chart review of 124 patients with schizophrenia who were treated at least 12 weeks with typical antipsychotics (chlorpromazine and halopehdol) or atypical antipsychotics (risperidone, olanzapine, and clozapine). They were divided into three groups as treated with chlorpromazine (N=44), with haloperidol (N=60), and with atypical antipsychotics (N=20) and body weight and Body Mass Index (BMI) were compared at O (Baseline), 8 and 12 week between the three groups. Additionally, we examined possible correlations of changes in body weight with baseline factors. Results : 1) Significant change in body weight and BMI were found during 12 weeks in all groups, received different kinds of antipsychotics but there were no significant differences between three groups. 2) Weight gain was prominent within 8 weeks in the treatment, but not significant after then in all the three groups. 3) Lower body weight in baseline was correlated with more weight gain with the treatment with antipsychotics. Conclusions: Antipsychotics were associated with weight gain in patients with schizophrenia, Particularly in the early stage of treatment. Therefore to increase the quality of life and improve the compliance of medication in treatment of schizophrenia and other psychotic disorder, we must choice medication which are consistent with a individuality

아토피, 천식환자집 및 새집에서 실내공기 중 휘발성 유기용제 농도

변상훈(Sang Hoon Byeon),문경환(Kyong Whan Moon),최달웅(Dal Woong Choi),이은일(Eun Il Lee),오은하(Eun Ha Oh),김영환(Young Hwan Kim) 한국실내환경학회 2006 한국실내환경학회지 Vol.3 No.4

This study was undertaken to determine the concentrations of volatile organic compounds (VOCs) in the indoor air between houses of atopy, asthma patients and new houses. Total volatile organic compounds (TVOCs) in the indoor and outdoor air of normal houses were measured as 92.6 and 72.5 ㎍/㎥, respectively. TVOCs in the indoor and outdoor air of atopy patient"s houses were 152 and 42.1 ㎍/㎥. TVOCs in the indoor and outdoor air of asthma patient"s houses was 165 and 50.1 ㎍/㎥. TVOCs in the indoor and outdoor air of new houses was 158 and 78.3 ㎍/㎥. It was found that the concentrations of VOCs were higher in the indoor air of atopy, asthma patient"s and new houses than the normal houses. This suggests that the concentration of VOCs can influence atopy and asthma.

실내 공기 중 일부 알데하이드류에 대한 위해도 평가 - 일부 주택 및 아토피 환자 주택을 대상으로

문경환,변상훈,최달웅,이은일,오은하,김영환,Moon Kyong Whan,Byeon Sang Hoon,Choi Dal Woong,Lee Eun Il,Oh Eun Ha,Kim Young Whan 한국환경보건학회 2006 한국환경보건학회지 Vol.32 No.1

This study was undertaken to determine the concentrations of 15 aldehydes in air samples collected from 21 households including 9 atopy patient's homes and to assess the extent of exposure and risk for an individual due to inhalation. Of all the aldehydes identified in both indoor and outdoor environment, formaldehyde and acetaldehyde were the most abundant aldehydes, which were occupied $60\%\;and\;17\%$ of total amount, respectively. The geometric mean concentration of formaldehyde and acetaldehyde in indoor air were $170.5\pm1.9\;{\mu}g/m^3\;and\;47.3\pm1.5\;{\mu}g/m^3$, respectively. There existed a strong correlation between formaldehyde, acetaldehyde and other aldehydes. And the ratio of indoor and outdoor concentrations (I/O) exceeded 1.0 for almost every measured aldehydes except m-tolualdehyde... No associations were found between the level of aldehydes and either housing characteristics or living habits in most of the samples with only a few exception. And the concentrations of all aldehydes indoor air between atopy patient's homes and control homes were not significant(p>0.05). Formaldehyde and acetaldehyde exposures and risks were estimated by using the inhalation unit risk, mean concentrations and the 95th percentiles, and which were $2.6\times10^{-3}\;and\;1.1\times10^{-4}$, respectively. The mean and the 95th percentile risk estimates were 25 times higher for formaldehyde than for acetaldehyde in homes.

Emergence and settlement of Magnolia kobus in urban forests of Seoul, Korea

권오정,변지희,박은하,오충현 한국산림과학회 2019 Forest Science And Technology Vol.15 No.2

Magnolia kobus is a deciduous, broadleaved tree native to Jeju Island of Korea and Japan. The species has been introduced in mainland Korea as a landscape plant, and some individual plants have been found in forests of the mainland. The objective of the present study was to examine whether M. kobus individuals have spontaneously formed communities as part of a natural settlement process. Diameter at breast height (DBH), flower, fruit, and GPS coordinates were recorded for all M. kobus individuals in the study sites. Age of the trees was determined using an increment borer. A total of 158M. kobus individuals were identified. The reverse J-shaped Diameter at breast height distribution trend was confirmed. DBH and age of M. kobus samples were positively correlated, confirming that the distribution of individuals with varying DBH classes suggested an uneven-aged forest with the coexistence of trees from different generations. In all the survey sites, individuals of M. kobus with small DBH that did not reach inflorescence formation and fructification stages coexisted with individuals that flowered and produced fruits, which suggested the presence of overlapping generations of trees. Therefore, we concluded that M. kobus individuals were forming populations in the forests of mainland Korea.

주의력결핍 과잉행동장애의 실행기능 : 종합주의력검사와 스트룹검사, 아동 색선로검사, 위스콘신 카드분류검사의 관련성

서종만,김효원,여진영,변은하,정석훈 대한신경정신의학회 2012 신경정신의학 Vol.51 No.2

본 연구의 한계점으로는 첫째, 위에서 언급하였듯이ADHD군과 임상대조군만을 대상으로 하였고 정상대조군을포함하지 않았다. 둘째, 임상대조군에 다양한 진단을 가진아동청소년이 포함되었으며, 각각의 질환이 실행기능에 미치는 효과를 통제하지 못하였다. 그러나 실행기능에 직접적으로 관련된 것으로 알려진 틱장애나 학습장애를 가진 경우를 연구대상에서 제외하여 이러한 효과를 최소화하고자 하였다. 셋째, 정신장애의 진단과정에서 구조화된 진단면접도구가 사용되지 않았다. 본 연구와 같이 특정질환에서 신경인지기능 검사의 역할을 평가하는 연구에서는 진단의 정확성이 중요하기 때문에 Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime Version과 같은 구조화된 진단면접도구를 사용하는 것이 진단과정의 객관화에 도움이 될 수 있다. 이러한 한계에도 불구하고 본 연구는 많은 수의 표본을대상으로 종합주의력검사와 기존에 타당도가 알려져 있는실행기능검사의 결과를 ADHD 아동청소년과 ADHD가 아닌 아동청소년 사이에 비교하고 상관관계를 분석함으로써,ADHD의 실행기능을 평가하는데 있어서 종합주의력검사의타당도를 검증하였다는 점에서 의의를 지닌다. 본 연구의 결과를 바탕으로 약물연구, 유전학연구, 뇌영상연구 등 ADHD 에 대한 다양한 연구에 종합주의력검사를 활용할 수 있을것으로 생각된다. Objectives: The objective of this study was to investigate the relationship of the Comprehensive Attention (CAT), Stoop Color-Word (STROOP), Children’s Color Trails (CCTT), and Wisconsin Card Sorting Tests (WCST) in evaluating the executive function in attention-deficit/hyperactivity disorder (ADHD). Methods: A total of 197 children and adolescents with ADHD (mean age 10.4±3.2 years, 173 boys) and 62 without ADHD (mean age 11.8±3.5 years, 48 boys) have completed the Swanson, Nolan, and Pelham-IV questionnaire (SNAP-IV), and also the CAT, STROOP, CCTT and WCST. Results: The selective, sustained, divided attention and Flanker tests of the CAT significantly discriminated between the ADHD and non-ADHD groups. The results of the CCTT were significantly correlated with the results of the CAT only in the ADHD group. The results of the STROOP were associated with selective, sustained, divided attention and Flanker tests. The results of the WCST were significantly correlated with the scores of the Working Memory subtest of the CAT only in the non-ADHD group. Conclusion: The results of this study suggest that the CAT has strong discriminant validity and moderate concurrent validity. The CAT could be a tool for the evaluation of the executive function of ADHD.

천리안위성 1·2A호 지표면 알베도 상호 오차 분석 및 비교검증

우종호 ( Jongho Woo ),최성원 ( Sungwon Choi ),진동현 ( Donghyun Jin ),성노훈 ( Noh-hun Seong ),정대성 ( Daeseong Jung ),심수영 ( Suyoung Sim ),변유경 ( Yugyeong Byeon ),전우진 ( Uujin Jeon ),손은하 ( Eunha Sohn ),한경수 ( Kyung-so 대한원격탐사학회 2021 大韓遠隔探査學會誌 Vol.37 No.6

장기간에 걸친 전 지구적인 위성관측 지표면 알베도 자료는 전 지구 기후 및 환경의 변화 감시에 활발히 이용되고 있으며 그 활용도와 중요성이 크다. 우리나라의 경우 정지궤도위성 천리안위성 1호(Communication, Ocean and Meteorological Satellite, COMS) MI(Meteorological Imager) 센서와 천리안위성 2A호(GEO-KOMPSAT-2A, GK-2A) AMI (Advanced Meteorological Imager) 센서의 세대교체를 통해 지속적인 지표면 알베도 산출물의 확보가 가능하다. 그러나 COMS/MI 및 GK-2A/AMI의 지표면 알베도 산출물은 센서 및 알고리즘의 차이로 인해 산출물 간의 차이가 존재한다. 따라서 COMS/MI와 GK-2A/AMI 지표면 알베도 산출 기간을 확장하고 지속적인 기후변화 감시 연계성 확보를 위해 두 위성 산출물 간의 오차 분석이 선행되어야 한다. 본 연구에서는 COMS/MI 및 GK-2A/AMI 지표면 알베도 자료의 중복기간을 대상으로 지상관측자료 AERONET (Aerosol Robotic Network)와 타 위성자료 GLASS (Global Land Surface Satellite)와 함께 비교 분석하였다. 오차 분석 결과 AERONET과의 검증에서 COMS/MI의 평균 제곱근 오차(Root Mean Square Error, RMSE)가 0.043로 GK-2A/AMI의 RMSE인 0.015보다 높게 나타났다. 또한GLASS와 비교하였을 때 COMS/MI의 RMSE는 0.029로GK-2A/AMI의 0.038보다 낮게 나타났다. 이러한 오차특성을 이해하고 COMS/MI 및 GK-2A/AMI의 지표면 알베도 자료를 사용할 때 장기간 기후변화 감시에 적극적으로 활용할 수 있을 것이다. Global satellite observation surface albedo data over a long period of time are actively used to monitor changes in the global climate and environment, and their utilization and importance are great. Through the generational shift of geostationary satellites COMS (Communication, Ocean and Meteorological Satellite)/MI (Meteorological Imager sensor) and GK-2A (GEO-KOMPSAT-2A)/AMI (Advanced Meteorological Imager sensor), it is possible to continuously secure surface albedo outputs. However, the surface albedo outputs of COMS/MI and GK-2A/AMI differ between outputs due to differences in retrieval algorithms. Therefore, in order to expand the retrieval period of the surface albedo of COMS/MI and GK-2A/AMI to secure continuous climate change monitoring linkage, the analysis of the two satellite outputs and errors should be preceded. In this study, error characteristics were analyzed by performing comparative analysis with ground observation data AERONET (Aerosol Robotic Network) and other satellite data GLASS (Global Land Surface Satellite) for the overlapping period of COMS/MI and GK-2A/AMI surface albedo data. As a result of error analysis, it was confirmed that the RMSE of COMS/MI was 0.043, higher than the RMSE of GK-2A/AMI, 0.015. In addition, compared to other satellite (GLASS) data, the RMSE of COMS/MI was 0.029, slightly lower than that of GK-2A/AMI 0.038. When understanding these error characteristics and using COMS/MI and GK-2A/AMI’s surface albedo data, it will be possible to actively utilize them for long-term climate change monitoring.