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Concurrent upregulation of immune checkpoint molecule genes in colorectal cancer
방휘재,Sohn Joon Hyung,Kim Soo-Ki,KIM CHEOL SU,Cho Mee-Yon,Kim BoRa,An Sanghyun,Kim Kwangmin,Kim Youngwan 대한독성 유전단백체 학회 2023 Molecular & cellular toxicology Vol.19 No.3
Background A simultaneous gene expression pattern of immune checkpoint molecules might exist in colorectal cancer. This hypothesis has rarely been tested in human in vivo samples. Objective We investigated the gene expression patterns of immune checkpoint molecules in human colorectal cancer tissues using quantitative polymerase chain reaction (qPCR) with a focus on concurrent gene expression. Results We included 14 females and 16 males with a mean age was 68.5 years. The mean number of all immune checkpoint molecules did not diff er signifi cantly between normal and tumor tissues. Histological grade 3 tumors were more common in the PDCD1 -expressing group [3 (25.0%) vs. 0 (0%) ( p = 0.042)]. All six and four immune checkpoint molecules were expressed in eight and three PDCD1 -positive patients, respectively. Specifi cally, CD274 was expressed in 11 of 12 PDCD1 - positive patients, while LAG3 and IDO1 were expressed simultaneously in all patients expressing CD274 . Conclusion Colorectal cancers more commonly express multiple immune checkpoint molecules simultaneously than single molecules. This suggests that blocking multiple immune checkpoint pathways may serve as a potential strategy for immunotherapy.
노성훈,Masatoshi Nakagawa,최윤영,안지영,서상혁,신현백,방휘재,Shuangxi Li,김형일,정재호,형우진 연세대학교의과대학 2016 Yonsei medical journal Vol.57 No.5
East Asian surgeons generally report lower morbidity and mortality rates for gastrectomy with D2 lymphadenectomy than do surgeonsin Western countries; however, the disparity remains unexplained. The aim of this article was to determine the feasibility and safety regarding cases in which East Asian surgeons perform such procedures in Caucasian patients (CPs). Twelve CPs underwentgastrectomy with lymphadenectomy for gastric cancer at Yonsei University Severance Hospital, Seoul, Korea between June 2011 and April 2014. Procedures performed included total gastrectomy (7 of 12, 58%), distal gastrectomy (4 of 12, 33%), and completion total gastrectomy (1 of 12, 8%). Nine patients (75%) underwent D2 lymphadenectomy, and D1+ lymphadenectomy was performed in three others (25%). In four patients (33%), combined resections were carried out. The median values of surgical parameters were as follows: operative time, 266.5 min (range, 120–586 min); estimated blood loss, 90 mL (range, 37–350 mL); retrievedlymph node count, 37.5 (range, 22–63); and postoperative hospital stay, 13.7 days (range, 5–63 days). No mortality was encountered,although two patients (17%) experienced complications (both Clavien-Dindo classification grade IIIa anastomotic leakages), which were successfully managed by conservative treatment. In the hands of East Asian surgeons, mortality and short-term morbidity appears to be acceptably low in CPs subjected to gastrectomy with lymphadenectomy for gastric cancer.