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나이가 많은 환자에서 발생한 특발성망막앞막의 자연 분리 1예
노주희,김현아,박태관,온영훈.Ju Hee Noh. MD. Hyun A Kim. MD. Tae Kwan Park. MD. PhD. Young Hoon Ohn. MD. PhD 대한안과학회 2014 대한안과학회지 Vol.55 No.3
Purpose: To report a case of spontaneous separation of idiopathic epiretinal membrane in an elderly patient. Case summary: A 61-year-old male presented with decreased visual acuity in the right eye. He was diagnosed with idiopathic epiretinal membrane (ERM) in the right eye and posterior vitreous detachment (PVD) in both eyes. The patient underwent pars plana vitrectomy and ERM removal in the right eye. At postoperative 1 year, his vision in the right eye had improved, but idiopathic ERM developed in the left eye and visual acuity in the left eye decreased. Three years later, the ERM in the left eye resolved spontaneously and his vision increased. Conclusions: Herein we present a rare case of spontaneous separation of idiopathic ERM associated with a pre-existing PVD in an elderly patient and reviewed the available literatures regarding the possible mechanisms for the spontaneous separation of ERM in the presence of a pre-existing PVD. J Korean Ophthalmol Soc 2014;55(3):459-464
녹내장에서 파장가변 빛간섭단층촬영을 이용한 황반부 신경절세포층의 진단력
이응석(Eung Suk Lee),장지호(Jee Ho Chang),박태관(Tae Kwan Park),온영훈(Young Hoon Ohn),박가희(Ka Hee Park) 대한안과학회 2016 대한안과학회지 Vol.57 No.6
목적: 녹내장 환자에서 파장가변 빛간섭단층촬영(DRI OCT-1, Topcon Co., Tokyo, Japan)을 이용하여 황반부 신경절세포복합체 (macular ganglion cell complex, mGCC)와 황반 신경절세포 및 내망상층(macular ganglion cell inner plexiform layer, mGCIPL)의 두께를 분석해 보고 두 방법의 진단력을 확인해 보고자 한다. 대상과 방법: 2014년 8월부터 2015년 7월까지 본원에 내원한 109명 109안을 대상으로 파장가변 빛간섭단층촬영을 이용하여 mGCC와 mGCIPL의 두께를 측정하여 정상군, 초기, 진행된 녹내장군 간의 차이를 확인해 보고, 각각의 진단력, 민감도, 특이도를 구하여 유두주위 망막신경섬유층(circumpapillary retinal nerve fiber layer, cpRNFL) 두께 분석 방법과 비교해 보았다. 결과: 초기와 진행된 녹내장에 대한 area under the curve를 비교해 보았을 때 mGCC는 0.78과 0.99 cpRNFL과 유의한 차이가 없었으나 mGCIPL은 0.70으로 cpRNFL과 초기 녹내장을 진단하는 경우 cpRNFL의 진단력과 유의한 차이를 나타내었고(p=0.018),녹내장 진단에 대한 민감도와 특이도는 mGCC가 0.95와 0.97, mGCIPL은 0.92와 0.97로 측정되었다. 결론: 두 가지 방법 모두 녹내장을 진단하는 데 있어 높은 민감도와 특이도를 지닌 진단 방법이나, mGCC의 두께 분석 방법이 녹내장의 초기 변화를 감지하는 데 보다 나은 진단력을 가지고 있는 것으로 생각된다. <대한안과학회지 2016;57(6):941-950> Purpose: To evaluate diagnostic ability of macular ganglion cell complex (mGCC), macular ganglion cell inner plexiform layer (mGCIPL) measurements in glaucoma using swept source deep range imaging optical coherence tomography (DRI OCT-1, Topcon Co., Tokyo, Japan). Methods: From August of 2014 to July of 2015, 109 eyes of 109 subjects were assessed for the average thickness and sectional thickness of both mGCC and mGCIPL to determine whether there exists any significant difference among advanced stage glaucoma group, early stage glaucoma group and normal group in Swept source OCT. Comparisons were also made between the above measurements and circumpapillary retinal nerve fiber layer (cpRNFL) thickness measurements in their diagnostic accuracy, sensitivity, and specificity. Results: The diagnostic ability of mGCC based-mean thickness value (area under the curve [AUC] = 0.78/ 0.99) in detecting early stage glaucoma group as well as advanced stage group was not significantly different from that of cpRNFL thickness measurement. However, there was a significant difference in thickness between mGCIPL (AUC = 0.70) and cpRNFL in early stage glaucoma groups (p = 0.018). The sensitivities and specificities of mGCC were 0.95/0.97, and those of mGCIPL were 0.92/0.97, respectively. Conclusions: The two swept source OCT based methods measuring retinal ganglion cell layer thickness appeared to have a good diagnostic accuracy, high sensitivity and specificity in detecting glaucomatous eyes. Nevertheless, of the two methods, mGCC thickness measurement was more efficient in detecting early glaucomatous changes. J Korean Ophthalmol Soc 2016;57(6):941-950
저신장증 환아에서 인슐린양 성장인자-I 조절유전자의 점돌연변이에 관한 연구
김병준,박태관,장현하,정인경,김성운 경희대학교 유전공학연구소 1995 遺傳工學論文集 Vol.7 No.-
Aging is on the same line of birth, growth and death. So we analysed IGF-I promoter DNA profiles and sequences of normal short stature (NSS) patients for the purpose of comprehension of aging. We tested 52 NSS patients with DNA sampling. First we screened NSS DNAs with PCR (polymerase chain reaction) - SSCP (single strand confirmational polymorphism) method. We found only 1 patient out of 52 had abnormal SSCP band. Then we moved to subcloning of this PCR product into _(p)T7blue T-vector. We sequenced this DNA using antisense specific primer and 35S-dATP. Finally we confirmed two point mutations at the position of +8 and +74 from transcription initiation site. Next step for this study, we planned to transfection study for promoter function and gel retardation assay for new transcription factors.
가족성 저신장증 환아에서 인슐린양 성장인자 - 1 조절유전자의 점돌연변이
김진우,최영길,김영설,양인명,우정택,김성운,장현하,정인경,박태관 대한내분비학회 1996 Endocrinology and metabolism Vol.11 No.4
Background: FSS is a normal variants in Korea, but some of them had defect of noctumal GH pulse i.e. neurosecretory dysfunction. Although Korean children had strikingly got higher final height in the last decade. We are interested in what kinds of differences were existed in FSS group. Previous study showed theres no difference of GH related biochemical markers between normal and FSS group, like IGF-I, IGFBP-3 etc. We analyzed molecular difference in FSS group. Methods: We screened 23 FSS patients and 16 normal controls to IGF-I gene prornoter region with PCR-SSCP (single strand conformation polymorphisrn) method and sequenced 1 FSS patients who had abnormal SSCP band. Results: We found 1 out of 23 patients with abnormal SSCP band (none for 16 controls). Their IGF-I promoter gene were sequenced with modified Maxam-Gilbert method. One subject had 2 point mutations(+8 and +74). Conclusion: We found point mutations of IGF-I promoter in FSS group, This position was regarded as HNF(hepatic nuclear factor)-3 binding sites. We needed more study for the detection of its biological function according io linear growth with in vivo and in vitro study. (J Kor Soc Endoerinol 11:500~ 509, 1996)