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박철훈,김계엽,정현우,Park Cheol Hun,Kim Gye Yeop,Jeong Hyun Woo 대한동의생리학회 2004 동의생리병리학회지 Vol.18 No.6
This experimental study was designed to investigate the mechanism of Palmul-Tang(PMT) on the changes of cerebral hemodynamics in rats. The changes of cerebral hemodynamics in normal rats were as follows ; The PMT-induced increase in regional cerebral blood flow was significantly inhibited by pretreatment with indomethacin(1㎎/㎏, i.p.), an inhibitor of cyclooxygenase, and was inhibited by methylene blue(10㎍/㎏, i.p.), an inhibitor of guanylate cyclase. The PMT-induced dilation in pial arterial diameter was significantly inhibited by pretreatment with indomethacin and methylene blue. The PMT-induced increase in mean arterial blood pressure was significantly inhibited by pretreatment with indomethacin but was increased by methylene blue. This results were suggested that the mechanism of PMT was mediated by cyclooxygenase. The changes of cytokine production in cerebral ischemic rats were as follows ; In cytokine production of serum by drawing from femoral arterial blood after middle cerebral arterial occlusion 1hr, sample group was decreased IL-1β and TNF-α production compared with control group, IL-10 production of sample group was similar to that of control group, but sample group was significantly increased TGF-β production compared with control group. In cytokine production of serum by drawing from femoral arterial blood after reperfusion 1hr, sample group was significantly decreased IL-1β production compared with control group and decreased TNF-α production compared with control group. IL-10 production of sample group was similar to that of control group, but sample group was significantly increased TGF-β production compared with control group. In cytokine production of serum by drawing from femoral arterial blood after reperfusion 4 hrs, sample group was significantly decreased IL-1β production compared with control group, but IL-10 production of sample group was similar to that of control group. sample group was increased TNF-α and TGF-β production compared with control group. These results suggested that PMT had inhibitive effect on the brain damage by inhibiting IL-1β and TNF-α production, but by accelerating TGF-β production. The present author thought that PMT had an anti-ischemic effect through the improvement of cerebral hemodynamics and inhibitive effect on the brain damage.
CaCO<sub>3</sub>을 이용한 혼합매질분리막의 이산화탄소 투과도 향상
박철훈,정정표,이재훈,김종학,Park, Cheol Hun,Jung, Jung Pyo,Lee, Jae Hun,Kim, Jong Hak 한국막학회 2018 멤브레인 Vol.28 No.1
급진적인 산업발전에 따른 무분별한 이산화탄소 배출로 인하여 지구온난화, 이상 기후 등의 문제가 불거지고 있으며 이는 한 나라에만 국한되지 않은 국제적인 문제가 되었다. 위와 같은 문제를 해결하고자 본 연구에서는 이산화탄소에 대해 높은 친화도를 가지고 있는 PEGBEM-g-POEM 가지형 공중합체를 합성하였으며 $CaCO_3$염을 첨가하여 염의 중량에 따른 혼합매질분리막의 이산화탄소/질소 투과 성능을 관찰하였다. $CaCO_3$염이 고분자 중량 대비 50% 첨가되었을 때 최적의 이산화탄소/질소 분리 투과성능을 보였으며, 선택도는 염을 추가하기 전 44.7에서 45.42로 크게 변하지 않은 반면 이산화탄소 투과도는 염을 첨가하기 전 22.5 GPU에서 28.16 GPU로 약 25% 향상되었다. 이는 첨가한 염과 이산화탄소간의 상호작용으로 인하여 향상된 고분자 복합막의 이산화탄소에 대한 용해도에 기인하는 것으로 생각된다. 또한 염을 과량으로 첨가한 경우에는 고분자가 복합막의 표면을 충분히 메우지 못하여 계면결함이 생성되었으며 이로 인해 이산화탄소 기체 분리성능이 감소하였다. 기체분리성능 향상을 위해서는 적정량의 염 첨가가 필수적인 것으로 분석되었다. With vigorous development of petroleum and chemical industry, emission of carbon dioxide has attracted tremendous attention globally due to global warming problem and abnormal climate change. To address these problems, in this study, a PEGBEM-g-POEM graft copolymer with high $CO_2$ affinity was synthesized and $CaCO_3$ was incorporated to form mixed matrix membranes (MMMs) for enhancement of $CO_2$ permeance. By varying the addition weight of $CaCO_3$ in MMMs, high separation performance of $CO_2$ over $N_2$ was obtained. At 50 wt% loading of $CaCO_3$, the greatest separation performance was obtained with an enhanced $CO_2$ permeance from 22.5 to 28.16 GPU and slightly increased $CO_2/N_2$ selectivity from 44.7 to 45.42. It resulted from the increased $CO_2$ solubility of MMMs due to specific interaction between $CaCO_3$ and $CO_2$ molecules. Upon excess loading of $CaCO_3$, MMMs exhibited loss of $CO_2$ separation performance due to the formation of interfacial defects. Based on this result, it is considered that the proper addition of $CaCO_3$ is crucial for improvement of $CO_2$ separation performance.
박철훈 ( Park Cheol Hun ),권인 ( Kwon In ),이종건 ( Lee Jong Geon ),서경아 ( Seo Gyeong A ),임현우 ( Im Hyeon U ),김용욱 ( Kim Yong Ug ),이영 ( Lee Yeong ),나종구 ( Na Jong Gu ) 대한산부인과학회 2004 Obstetrics & Gynecology Science Vol.47 No.1
목적 : 임신 기간 동안 전반적 혹은 선택적 철분 투여에 대하여 논란의 여지가 있다. 이 연구의 목적은 임신 첫 삼분기의 ferritin치 측정이 예방적 철분 투여가 필요한 산모의 선별검사에 이용될 수 있는 지 알아보기 위한 것이다. 연구 방법 : 임신 첫 삼분기의 ferritin치 30 ㎍/L와 또한 철분 투여 여부를 기준으로 연구 대상을 4군으로 나누었다. Ferritin치 30 ㎍/L 이하인 군을 철분 투여한 22명과 투여하지 않은 13명으로 나누 Objective : It is controversial whether routine or selective iron supplementation during gestation is needed. The aim of this study is to evaluate whether screening with serum ferritin during the first trimester of pregnancy could be identify women who ne
당뇨병 임부의 신생아에서 발견된 미단부퇴행증후군 1 예
박철훈 ( Park Cheol Hun ),노덕영 ( No Deog Yeong ),김용욱 ( Kim Yong Ug ),김태응 ( Kim Tae Eung ),정재근 ( Jeong Jae Geun ) 대한산부인과학회 2004 Obstetrics & Gynecology Science Vol.47 No.2
The Caudal regression syndrome is characterized by sacrococcygeal or lumbosacrococcygeal agenesis, of variable extent, most often accompanied by multiple musculoskeletal abnormalities of the pelvis and legs. It is rare fetal complication of diabetic pregnancy. Although the exact teratogenic mechanism is not known, hyperglycemia appears to play a crucial role as a teratogen. Strict control of diabetes preconceptually and in early pregnancy is presumed to reduce the risk of occurrence. We report a case of caudal regression syndrome detected by pelvic radiography and MRI in the newborn of the diabetic mother.
임신 중기 양수천자 3,503예에 대한 세포 유전학적 분석: CUMC 경험 (2)
박인양 ( Park In Yang ),신종철 ( Sin Jong Cheol ),김석찬 ( Kim Seog Chan ),안현영 ( An Hyeon Yeong ),문희봉 ( Mun Hui Bong ),박철훈 ( Park Cheol Hun ),이희중 ( Lee Hui Jung ),이영 ( Lee Yeong ),나종구 ( Na Jong Gu ),김수평 ( Kim 대한산부인과학회 2004 Obstetrics & Gynecology Science Vol.47 No.1
목적 : 산전 유전진단을 위해 시행된 양수천자술을 이용한 염색체 분석의 검사 이유와 결과를 분석하여 임신 중기 양수천자술의 효용성과 적절한 검사 조건을 알아보고자 하였다. 연구 방법 : 가톨릭대학교 의과대학부속 강남성모병원 세포유전연구실에서 1997년 11월부터 2002년 11월까지 산전유전진단의 적응증이 있거나 유전상담 및 본인이 원하여 양수천자술에 의한 염색체 검사를 시행 받은 3,503예를 대상으로 하였다. 결과 : 총 대상 임신부 3,503예 중 Objective : To analyze chromosomal abnormalities according to patient`s age and indications of patients in midtrimester amniocentesis for prenatal genetic diagnosis. Methods : We retrospectively analyzed 3,503 cases of midtrimester prenatal genetic amnioc