황기와 행인(杏仁)이 면역세포(免疫細胞)의 Apoptosis 및 Nitric Oxide에 미치는 효과(效果)

정현우,문한주,Jeong Hyun-Woo,Moon Han-Ju 대한한의학방제학회 1998 大韓韓醫學方劑學會誌 Vol.6 No.1

The purpose of this research was to investigate effects of Astragali Radix(AR) and Armeniacae Semen(AS) on T-lymphocytes and peritoneal macrophages in mice. The proliferation of thymocytes and splenocytes were teated using macroplate-reader. The apoptosis and sub-population of T-lymphocytes were tested using a flow cytometer. Nitric oxide production was tested using a Griess reagents. The result were obtained as follow; 1. AR increased the proliferation of thymocytes and splenocytes. 2. AS decreased the proliferation of thymocytes and splenocytes. 3. AR and AS decreased No production fron peritoneal macrophages 4. AR and AS were accelerate T-lymphocytes apoptosis. 5. AR and AS increased $T_C$ cells population, but decreased $T_H$ cells population of T-lymphocyte.

죽력(竹瀝)이 T-lymphocytes 및 복강(腹腔) Macrophage에 미치는 영향(影響)

정현우,강성용,한종현,이원석,오찬호,은재순,Jeong, Hyun-Woo,Kang, Sung-Yong,Han, Jong-Hyun,Lee, Won-Suk,Oh, Chan-Ho,Eun, Jae-Soon 대한한방내과학회 1997 大韓韓方內科學會誌 Vol.18 No.2

The purpose of this research was to investigate effects of Bambusae Caulis in Liquamen(BCL) on T-lymphocytes and peritoneal macrophages in mice. The apoptosis and subpopulation of T-lymphocytes were tested using a flow cytometer. The phagocytic activity of mouse peritoneal macrophage was tested using a luminometer. Nitric oxide production was tested using a Griess reagents. BCL induced T-lymphocytes apoptosis. BCL increased $T_H$ cells population and decreased $T_C$ cells population of T-lymphocyte, but did not affect splenocytes subpopulation. BCL increased nitric oxide production and phagocytic activity of peritoneal macrophage in mice. These results suggest that BCL regulates the immune system in consequence of an increase in helper T cell population and macrophages activation.

직접 수열 확산 방식 기반 다중 밴드 FSK 신호의 성능 분석 및 실험 결과

정현우,신지은,정지원,Jeong, Hyun-Woo,Shin, Ji-Eun,Jung, Ji-Won 한국음향학회 2021 韓國音響學會誌 Vol.40 No.4

본 논문에서는 수중 통신에서 은밀성과 성능 향상을 위해 직접 수열 확산 방식 기반 다중 밴드 기법을 사용한 부 대역 Frequency Shift Keying(FSK) 신호의 효율적인 송수신 구조를 제시하였다. 은밀성적인 측면에서는 Pseudo Noise(PN) 부호의 chip을 직접 곱하는 직접 수열 대역 확산 방식을 적용하였으며, 성능적인 측면에서는 다중 경로 특성, 도플러 확산 등으로 인한 성능 감쇠를 극복하기 위해 다중 밴드, 터보 등화, 각 밴드별 가중치 알고리즘을 적용하였다. 시뮬레이션 결과를 바탕으로, 송수신기 사이의 거리가 약 300 m ~ 500 m인 호수에서 기동 실험을 하여 대역확산 신호의 chip 수를 8개, 32개로, 다중 밴드 수는 4개 일 때의 성능을 분석하였으며, chip 수가 증가할수록, 터보 등화 기법 적용 시 반복횟수가 증가할수록 성능이 향상되었고, 다중 밴드에서 프리엠블 오류율을 분석하여 밴드 별 가중치를 적용 시 더 많은 패킷 전송 성공률을 나타냈다.

수중 음향 통신에서 주파수 편이 변조 신호의 프리엠블 오류율을 이용한 주파수 이득 조절 연구

정현우,정지원,김완진,Jeong, Hyun-Woo,Jung, Ji-Won,Kim, Wan-Jin 한국음향학회 2022 韓國音響學會誌 Vol.41 No.2

The main characteristics of the underwater acoustic channel have varying multipath and fast fading. Especially, Frequency Shift Keying (FSK) signals with multiple frequency bands caused loss of information bits allocated on the specific frequencies due to selective fading phenomenon. Therefore, this paper proposes frequency gain control algorithm based on preamble error rates. The proposed algorithm estimates optimal gain value in the range of preamble error rate with less than 10 % for specific faded frequency. By employing turbo equalized FSK signals with rate of 1/3, the experiment was conducted on a lake in Munkyeong city with distance of 300 m to 500 m. The result confirms that packets are decoded successfully by applying proposed algorithm as increasing number of iterations.

한국과 일본의 복지용구 품목 비교 연구

정현우,염호준,박상수,Jeong, Hyun-Woo,Yeom, Hojun,Park, Sangsoo 국제문화기술진흥원 2022 The Journal of the Convergence on Culture Technolo Vol.8 No.6

Korea's long-term care insurance for the elderly, which started in 2008, is a borrowed one from gaeho insurance, which started eight years earlier. Both countries have a policy of welfare equipment benefit systems to support the lives of the elderly who are intellectually and mentally weakened. In this study, we attempted to compare and examine the welfare equipment items in Korea with those in Japan and find out the characteristics of the items in Korea and Japan. In Korea, loitering-detection device, posture changing devices, and incontinence underwears were registered as welfare devices before Japan, and in Japan, automatic urine disposal systems, wheelchair electric assist device, position converters, and lifts for handicapped person were designated as welfare devices before Korea. In addition, the Japanese Ministry of Health, Labor and Welfare has announced the designation of the excretion prediction support device as a welfare device. If Korea and Japan cooperate to develop welfare equipment items together, it will be of great help in improving the quality of life of the elderly in both countries in a super-aged society.

계지작약지모탕(桂枝芍藥知母湯)이 Ajuvant 투여로 유발된 풍습성(風濕性) 동물병태모델에 미치는 실험적 연구

정현우,Jeong, Hyun-Woo 대한한의학방제학회 2012 大韓韓醫學方劑學會誌 Vol.20 No.1

The purpose of this study explain the experimental effects of Guizhishaoyaozhimu-Tang (桂枝芍藥知母湯) that have clinical efficacy in rheumatoid Arthritis. Materials of present study were Guizhishaoyaozhimu-Tang freeze dried powder (GSZT), Sprague-dawley rats (300 g or so, male), various kinds of needing experimental studis. In order to study the therapeutic effects of GSZT, this Prescription (GSZT 500 mg/kg, 1,000 mg/kg) were administered per oral to the rats with the arthritis induced by Freund's complete adjuvant ($0.2m{\ell}/kg$), several experimental items were measured and compared each other ; that is body weight, rate of edema, analgesic effect by hot plate method, WBC, total protein, TNF-${\alpha}$, IL-10 and expression and localization of H&E, COX-2 staining in synovial tissues from rat with rheumatoid arthritis by immunohistochemical staining using polyclonal COX-2 antibodies. Rats were divided into four groups. Normal group was not treated with Freund's complete adjuvant and treated with DDW 1.0 $m{\ell}$, Control group was treated with Freund's complete adjuvant 0.2 $m{\ell}/kg$ and DDW 1.0 $m{\ell}$, Sample A group was treated with Freund's complete adjuvant 0.2 $m{\ell}/kg$ and GSZT (500 $mg/m{\ell}$) $1.0m{\ell}$, Sample B group was treated with Freund's complete adjuvant 0.2 $m{\ell}/kg$ and GSZT (1,000 $mg/m{\ell}$) 1.0 $m{\ell}$. 0 was day that did not start experiment, 14 was day that confirmed rheumatism induced by Freund's complete adjuvant, 28 was day that completed experiment. The following results were obtained in this study ; Sample A group was increased in body weight, escape time and paw licking time statistical significance compared with Control group, and were decreased in edema, WBC, total protein, TNF-${\alpha}$ with statistical significance compared with Control group. Sample B group was increased in escape time with statistical significance compared with Control group, and were decreased in edema, WBC, total protein with statistical significance compared with Control group. Sample A and Sample B groups were increased in IL-10 compared with Control group, and Sample B group was decreased in TNF-${\alpha}$ compared with Control group. And, Control, Sample A and Sample B groups were showed considerable reduction of positive expression in comparison to Normal group. Especially, Sample B group was most significantly reduction of positive expression than the other groups. From above results, I suggest that GuizhiShaoyaoZhimu-Tang can be used for curing rheumatoid arthritis.

천문동(天門冬)이 항암(抗癌) 및 면역세포(免疫細胞)에 미치는 영향(影響)

정현우,조영임,Jeong, Hyun Woo,Cho, Young-Lim 대한한의학방제학회 1997 大韓韓醫學方劑學會誌 Vol.5 No.1

동의학(東醫學)에서는 질병의 발생에 대하여 정기(正氣)의 강약(强弱)에 그 관건(關鍵)이 있다하였다. 그리하여 모든 질병의 치료에 있어서도 정기(正氣)의 회복에 중점을 두는 부정법(扶正法)이나 거사법(祛邪法)을 사용하면서도 정기(正氣)에 손상(損傷)을 입히지 않도록 많은 관심을 기우리고 있다. 암(癌)의 치료 또한 정기(正氣)가 얼마만큼 보충되는가에 따라 항병능력(抗病能力)이 항진(亢進)된다할 수 있을 것이다. 현재 국내외적(國內外的)으로 악성종양(惡性腫瘍)을 치료하기 위하여 다방면으로 연구를 하고 있으며, 또한 실제로 사용하고 있는 치료방법들로는 수술요법(手術療法) 방사선요법(放射線療法) 면역료법(免疫療法) 화학요법(化學療法)등이 있지만 아직까지는 미흡한 상태라 할 수 있을 것이다. 현재 일반적으로 항암제(抗癌劑)를 이용한 화학요법(化學療法) 등이 사용되고 있고, 면역료법(免疫療法)을 위한 많은 방법들이 연구되고 있어 본 저자(著者)들은 천문동(天門冬)이 면역세포(免疫細胞)의 증식(增殖)을 촉진시켜주면서 항암작용(抗癌作用)이 있을 것으로 사료(思料)되는 바 피부암세포(皮膚癌細胞)인 A431 cell line과 골수암세포(骨髓癌細胞)인 KHOS-NP cell line에 천문동(天門冬)을 투여(投與)하여 암세포(癌細胞)의 증식(增殖)을 살펴보고, 면역세포(免疫細胞)인 T cell과 B cell의 증식(增殖)을 살펴보았다. 또한 복강내(腹腔內) macrophage에서 분비되는 NO의 양(量)을 In vitro와 In vivo실험(實驗)을 통하여 살펴보았고, T cell의 apoptosis 및 subpopulation의 양(量)을 관찰하였다. 이 결과(結果) 천문동(天門冬)은 A431 cell 및 KHOS-NP cell에 항암작용(抗癌作用)을 보였고, T-cell의 증식(增殖)을 촉진시켰으며, 마우스 복강내(腹腔內) macrophage에서 분비(分泌)되는 NO의 양(量)을 감소시켜고, T cell의 apoptosis에 있어서는 대조군(對照群)에 비하여 유의성(有意性)있게 증가(增加)시켰으며, subpopulation에서는 $T_H$ cell을 증가(增加)시켰다. 그리하여 천문동(天門冬)은 항암작용(抗癌作用) 뿐만아니라 면역세포(免疫細胞)의 증식(增殖)에도 관여하는 약물(藥物)로 인정(認定)할 수 있을 것으로 사료(思料)된다. To investigate effect of water extract of Asparagi Tuber(天門冬) on human cancer cell-lines and immunocytes, this research estimated proliferation of A431 cell line, KHOS-NP cell line, mouse thymocytes and mouse splenocytes, Nitric Oxide(NO) from macrophage, apoptosis and subpopulation of the mouse thymocytes. The result were obtained as follows ; 1. Asparagi Tuber inhibited the proliferation of A431 cell line. 2. Asparagi Tuber inhibited the proliferation of KHOS-NP cell line. 3. Asparagi Tuber accelerated the proliferation of mouse thymocytes. 4. Asparagi Tuber inhibited the proliferation of mouse splenocytes. 5. Asparagi Tuber $100{\mu}g/m{\ell}$ inhibited the production of NO from macrophages in vitro, being compared NPS+IFN treated group. 6. Asparagi Tuber inhibited the production of NO from macrophages in vivo, being compared LPS+IFN treated group. 7. Asparagi Tuber accelerated the induction of apoptosis of the mouse thymocytes. 8. In subpopulation Asparagi Tuber increased $T_H$ of the mouse thymocytes, but decreased $T_C/T_S$ of the mouse thymocytes.

滋陰健脾湯加枳殼·天麻가 腦虛血動物의 腦血流力學 變動 改善에 미치는 작용기전

정현우(Jeong Hyun Woo) 한의병리학회 2003 동의생리병리학회지 Vol.17 No.5

한계상태설계법에 따른 보의 설계전단강도 안전성

정현우(Jeong, Hyun-Woo),이재훈(Lee, Jae-Hoon),최진호(Choi, Jin-Ho),황도규(Hwang, Do-Kyu),배재준(Bae, Jae-Joon) 한국콘크리트학회 2012 한국콘크리트학회 학술대회 논문집 Vol.2012 No.11

滋陰健脾湯이 局所腦血流量, 平均血壓, 心筋收縮力에 미치는 作用機轉

정현우(Hyun Woo Jeong),김희성(Hee Seong Kim),양기호(Gi Ho Yang) 한의병리학회 2002 동의생리병리학회지 Vol.16 No.3