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다제내성결핵 균주에서 Reverse Hybridization Assay를 이용한 Fluoroquinolone, Kanamycin 신속 내성 검사의 유용성
박진수 ( Chin Su Park ),성낙문 ( Nack Moon Sung ),황수희 ( Soo Hee Hwang ),전재현 ( Jae Hyun Jeon ),원영섭 ( Young Sub Won ),민진홍 ( Jin Hong Min ),김천태 ( Cheon Tae Kim ),강형석 ( Hyung Seok Kang ) 대한결핵 및 호흡기학회 2012 Tuberculosis and Respiratory Diseases Vol.72 No.1
Multidrug-resistant tuberculosis (MDR-TB) is an increasing public health problem and poses a serious threat to global TB control. Fluoroquinolone (FQ) and aminoglycoside (AG) are essential anti-TB drugs for MDR-TB treatment. REBA MTB-FQ? and REBA MTB-KM? (M&D, Wonju, Korea) were evaluated for rapid detection of FQ and kanamycin (KM) resistance in MDR-TB clinical isolates. M. tuberculosis (n=67) were isolated and cultured from the sputum samples of MDR-TB patients for extracting DNA of the bacilli. Mutations in genes, gyrA and rrs, that have been known to be associated with resistance to FQ and KM were analyzed using both REBA MTB-FQ? and REBA MTB-KM?, respectively. The isolates were also utilized for a conventional phenotypic drug susceptibility test (DST) as the gold standard of FQ and KM resistance. The molecular and phenotypic DST results were compared. Sensitivity and specificity of REBA MTB-FQ? were 77 and 100%, respectively. Positive predictive value and negative predictive value of the assay were 100 and 95%, respectively, for FQ resistance. Sensitivity, specificity, positive predictive value and negative predictive value of REBA MTB-KM? for detecting KM resistance were 66%, 94%, 70%, and 95%, respectively. REBA MTB-FQ? and REBA MTB-KM? evaluated in this study showed excellent specificities as 100 and 94%, respectively. However, sensitivities of the assays were low. It is essential to increase sensitivity of the rapid drug resistance assays for appropriate MDR-TB treatment, suggesting further investigation to detect new or other mutation sites of the associated genes in M. tuberculosis is required.
박진수(Park, Jin-Soo),백지숙(Baek, Ji-Suk),양태현(Yang, Tae-Hyun),김창수(Kim, Chang-Soo),임성대(Yim, Sung-Dae),박구곤(Park, Gu-Gon) 한국신재생에너지학회 2009 한국신재생에너지학회 학술대회논문집 Vol.2009 No.06
This study presents preparation and characterization of composite membranes based on ionic liquids. The ionic liquids act as water in sulfonated membranes. On the behalf of ionic conduction through ionic liquid inside the membranes, non-aqueous membranes showed Arrenhius dependence on temperature with no external humidification. It was implied that hopping mechanism of proton was dominant in the ionic liquid based membranes. In addition, small angle X-ray (SAXS) studies provided the information on morphology of ionic clusters formed by the interaction between sulfonic acid groups of the polymers and ionic liquids. The SAXS spectra showed matrix peaks, ionomer peaks and Prodo's law for Nafion based composite membranes and only matrix peaks for hydrocarbon based ones. However, ionic conductivity and atomic force microscopy (AFM) images showed the clear formation of ionic clusters of the hydrocarbon based composite membranes. It implies for ionic liquid based high temperature membranes that it is important to use sulfonated polymers as solid matrix of ionic liquid which can form clear ionic clusters in SAXS spectra.
박진수,김윤배,Park, Jin-Soo,Kim, Yun-Bae 한국시뮬레이션학회 2010 한국시뮬레이션학회 논문지 Vol.19 No.3
The moving block bootstrap, the stationary bootstrap, and the threshold bootstrap are methods of simulation output analysis, which are applicable to autocorrelated data. These bootstrap methods assume the stationarity of data. However, bootstrap methods cannot work if the stationary assumption is not guaranteed because of seasonality or trends in data. In the simulation output analysis, threshold bootstrap method is the best in describing the autocorrelation structure of original data set. The threshold bootstrap makes the cycle based on threshold value. If we apply the bootstrap to seasonality data, we can get similar accuracy of the results. In this paper, we verify the possibility of applying the bootstrap to seasonal data.
박진수 ( Jin Soo Park ) 한국항행학회 2012 韓國航行學會論文誌 Vol.16 No.1
본 논문에서는 2.4GHz 대역에서 적용 가능한 무선 LAN용 모뎀을 설계?제안하였으며, 실제 PCB로 제작되어 데이터 송수신을 확인하였다. 본 논문에서 제안하고 있는 모뎀의 경우, 메인 프로그램을 처리하기 위해 기저대역처리용 프로세서는 처리속도, 동작전압과 신뢰성을 고려하여 현재 Wi-Fi모뎀에 많이 적용되고 있는 Ralink사의 RT2870을 사용하였다. RT2870은 현재 무선 LAN의 표준을 완벽히 지원하며, 다양한 변조방식을 지원하고 있으며, 2.4GHz와 5GHz대역을 모두 지원하는 칩이다. 또한 본 논문에서는 출력된 변조신호를 2.4GHz대역의 무선으로 전송하기 위하여 RF 처리용 칩인 RT2850을 적용하였으며, 40MHz 대역을 사용하여 2.422~2.462GHz의 무선 대역을 점유하도록 설계하였다. 제안된 모뎀은 저렴한 비용으로 향후 2.4GHz 대역의 무선인터넷 모뎀으로의 사용이 가능하며, 본 설계를 바탕으로 Wi-Fi기반의 개인통신기기 또는 무선 기반 POS시스템 개발에 적극 활용이 가능하다. 특히, 안드로이드 기반 개인용 무선단말기의 모뎀으로 적용이 가능하며 이를 이용하여 다양한 제품으로의 확대가 가능할 것으로 기대된다. In this paper, we propose a wireless modem, which used OFDM/64QAM method and the ISM band with 2.4GHz radio frequency. In this paper proposed the case of a modem, the main program to process the baseband processor, processing speed, operating voltage, and reliability should be ensured. So we have designed with Ralink`s RT2870, witch was used for Wi-Fi solution. The RT2870 provides full support for wireless LAN standard, and supports various modulation formats, 2.4GHz and 5GHz bands, both of which support chip. In this paper, we also output the modulated signal transmitted wirelessly to the 2.4GHz band RF RT2850 chip processing was applied and using 40MHz band 2.422 ~ 2.462GHz wireless bands were designed to occupy. By applying bi-directional transmission between wireless transmitter and receiver, it can be effectively connected with any kinds of wireless LAN with 2.4GHz ISM band. Therefore it could economically be used as peripheral equipments for POS system or personal wireless device based on Android platform.
외상 후 발생한 무지의 수근중수관절의 불안정성에 대한 인대 재건술
박진수(Jin Soo Park),김홍균(Hong Kyun Kim),정영기(Young Khee Jung),유정한(Jung Han Yoo),권인협(In Hyup Kwon),나중호(Jungho Rah) 대한정형외과학회 2008 대한정형외과학회지 Vol.43 No.1
무지 수근중수관절 외상 후 관절염의 소견없이 불안정성을 보이는 경우 요수근굴건을 이용한 Eaton과 Little의 인대 재건술을 시행할 수 있다고 알려져 있으며, 이 치료방법은 심부전방경사인대의 재건을 목적으로 하는 방법으로 최근에 심부전방경사인대 외에도 요배측 인대가 관절의 안정성에 중요한 역할을 하는 것으로 밝혀지고 있어 이에 저자들은 무지 수근중수관절의 불안정성을 보이는 3예를 치료하여 이를 보고하고자 한다. Eaton and Littler's ligament reconstruction is used to treat carpometacarpal instability of the thumb using the flexor carpi radialis tendon. This procedure involves a reconstruction of the deep anterior oblique ligament in patients with post-traumatic prearthritic unstable joints. According to a recent paper, the dorsoradial ligament as well as the deep anterior oblique ligament plays an important role in stabilizing the trapeziometacarpal joint. We report three cases of post-traumatic instability in a prearthritic thumb that was treated with Eaton and Littler's reconstruction using the flexor carpi radialis tendon.