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박의주 ( Eui Ju Park ),장재영 ( Jae Young Jang ),정승원 ( Soung Won Jeong ),이세환 ( Sae Hwan Lee ),김상균 ( Sang Gyune Kim ),김영석 ( Young Seok Kim ),김홍수 ( Hong Soo Kim ),김부성 ( Boo Sung Kim ),진소영 ( So Young Jin ),황지영 대한간암학회 2014 대한간암학회지 Vol.14 No.1
Recently, detection of an incidental hepatic tumor has rapidly increased with the introduction of multi-modality imaging techniques. And then, it is very important to determine whether these tumors are malignant or benign lesions. In some cases, differentiation from other hepatic tumors such as focal nodular hyperplasia or hepatic adenoma and hepatocellular carcinoma can be extremely diffi cult, both clinical and radiologic finding. Therefore, it is suggested that combination of multi-modality imaging study than using only a single imaging test. Despite advanced imaging studies such as computed tomography (CT), magnetic resonance imaging (MRI), contrast enhanced ultrasonography, and positron emission tomography (PET) showed a high sensitivity and specificity, role of liver biopsy is still remained to confirm the diagnosis. The use of liver biopsy in the diagnosis of hypervascular hepatic tumors is controversial. However if the tumors was shown rapid growth tendency and heterogeneous radiological appearance, liver biopsy or surgical resection should be considered to provide final diagnosis and prompt curative treatment. We report a case of a hepatocelluar carcinoma showing similar radiologic characteristics to focal nodular hyperplasia in patients without high risk factors of hepatocelluar carcinoma.
박의주 ( Eui Ju Park ),김양기 ( Yang Ki Kim ),복진현 ( Jin Hyun Bok ),이영목 ( Young Mok Lee ),김기업 ( Ki Up Kim ),어수택 ( Soo Taek Uh ),박영길 ( Young Kil Park ) 대한결핵 및 호흡기학회 2008 Tuberculosis and Respiratory Diseases Vol.65 No.6
결핵균은 공기를 매개로 전파되고 결핵균에 노출된 시간과 최초의 노출 정도가 전파의 위험을 증가 시키는 중요한 인자로 알려져 있다. 활동성 폐결핵 환자와 함께 생활하는 가족 내에서 감염이 현저히 증가하는데 이는 결핵균에 노출되는 기회 및 시간이 증가하기 때문이다. 하지만 고식적인 접촉자 조사만으로는 흔히 결핵 발생률을 과소평가할 수 있기 때문에 접촉자 조사와 결핵균의 유전형 조사를 병행하는 것이 감염의 위험이 높은 집단을 선별해내고 발생빈도 및 전염경로를 밝히는 데 보다 효과적인 것으로 보고되고 있다. 이에 접촉자 조사와 결핵균의 유전형 조사를 통해 가족 내 결핵균 전파를 증명한 1예를 보고하는 바이다. (Tuberc Respir Dis 2008;65:512-516)
Child class C의 조기 간세포암 환자와 Child class A의 진행성 간세포암 환자에서의 생존 비교
박의주 ( Eui Ju Park ),장재영 ( Jae Young Jang ),정승원 ( Soung Won Jeong ),추진우 ( Jin Woo Choo ),김진녕 ( Jin Nyoung Kim ),권순하 ( Soon Ha Kwon ),이병무 ( Byoung Moo Lee ),이세환 ( Sae Hwan Lee ),김상균 ( Sang Gyune Kim ),차 대한간암학회 2013 대한간암학회지 Vol.13 No.2
Background/Aims: The prognosis of hepatocellular carcinoma (HCC) is affected by stage as well as liver function. We analyzed the survival outcome of early stage HCC in Child class C patients and advanced HCC in Child class A patients. Methods: Among 453 HCC patients with good performance status Group A included 33 consecutive Child class C patients with early stage (I II) HCC and Group B included 45 consecutive Child class A patients with advanced stage (III IV) HCC. We investigated the clinical characteristics cirrhotic complications and prognostic factors related with survival in each group and compared overall survival between two groups. Results: Age prothrombin time total bilirubin and Model for End-Stage Liver Disease (MELD) scores were significantly higher in Group A. Male sex platelet count albumin sodium (Na) hepatitis B virus alpha fetoprotein (AFP) and portal vein thrombosis were significantly higher in Group B. Complications of cirrhosis such as variceal bleeding ascites and hepatic encephalopathy were increased in Group A (P<0.05). Patients with an elevated AFP (>400 ng/mL) tended to exhibit poor survival as it increased in Group A (P=0.084). MELD scores>15 (Hazard ratio[HR] 17.84 95% confidence interval [CI] 3.70-85.93 P<0.001) stage IV (HR:3.27, 95% CI 1.10-9.75 P=0.033) and absence of HCC treatment (HR: 3.70 95% CI 1.06-12.50, P=0.040) were independent poor prognostic factors in Group B. Median overall survival was 24.6 months (95% CI 10.6-38.4) for Group A and 13.5 months (95% CI 4.6-22.3) for Group B (P=0.278). In the HCC treatment group there were no significant differences of median overall survival between Group A and Group B respectively (27.1 vs. 15.7 months P=0.338). In patients with conservative treatment Group A and Group B had a significantly different median overall survival of 13.6 and 2.5 months respectively (P=0.012). In patients of Group B median overall survival was significantly higher in patients who received treatment of HCC compared to those who did not respectively (15.7 vs. 2.5 months P<0.001). Conclusions: Overall median survival was not different between both groups. However in Child class A patients with advanced stage HCCs the cumulative median survival was higher in patients who received treatment of HCC compared to those who did not. Therefore advanced stage HCC patients with good liver function should be considered for HCC treatments.
메탄-수소 대향류확산화염에서 H₂와 H의 선호확산을 통한 화학적 효과에 관한 연구
박정(Jeong Park),권오붕(Oh Boong Kwon),이의주(Eui Ju Lee),윤진한(Jin Han Yun),길상인(Sang In Keel) 대한기계학회 2007 大韓機械學會論文集B Vol.31 No.12
Numerical study on preferential diffusion effects in flame structure in CH4-H2 diffusion flames is conducted with detailed chemistry. Comparison of flame structures with mixture-averaged species diffusion and suppression of the diffusivities of H2 and H was made. Discernible differences in flame structures are displayed with three species diffusion models. The behaviors of maximum flame temperatures with those species diffusion models are not explained by scalar dissipation rate but by the nature of chemical kinetics. It is seen that the modifcation of flame structure is mainly due to the preferential diffusion of H2 and thereby the nature of chemical kinetics. It is also found that the behaviors of major species with the three species diffusion models are addressed to the nature of chemical kinetics, and this is evident by examining importantly contributing reaction steps to the production and destruction of those chemical species.
도축 소에 있어서 육안적 검사 방법에 따른 간질 감염 실태조사
박배근 ( Bae Keun Park ),홍의주 ( Eui Ju Hong ),류시윤 ( Si Yun Ryu ),정배동 ( Bae Dong Jung ),김지민 ( Ji Min Kim ),김현철 ( Hyeon Cheol Kim ) 한국동물위생학회 2015 韓國家畜衛生學會誌 Vol.38 No.4
This study was conducted to investigate the prevalence of fascioliasis in slaughtered cattle in Kangwon (Wonju, Hoengseong, Hongcheon, Cheorwon, Pyeongchang) province and Daejeon from October to December in 2014. From the total 10,780 examined cattle, 0.54% (58/10,780) were found to be positive for fascioliasis by postmortem macroscopic inspection. The Fasciola spp. infection rates were higher in the most Daejeon (1.83%, 41/2,240), followed by Hoengseong (0.40%, 15/3,714) and Hongcheon (0.22%, 2/901). It was not infected in the other regions. The outward appearances of Fasciola spp. infected livers looked almost normal and the worms were all parasitize in the main hepatic duct.
이서인(Seo In Lee),홍의주(Eui Ju Hong),김현철(Hyeon Cheol Kim),류시윤(Si Yun Ryu),박배근(Bae Keun Park) 한국예방수의학회 2020 예방수의학회지 Vol.44 No.4
The present study investigated the intra-vitam larval migration of Anisakis pegreffii, which is naturally infected, from the intestine to the viscera and the musculature of live spotty-bellied greenling, Hexagrammos otakii, under the different seawater temperatures. The results showed that the increase in the ratio of larval migration from the intestine to the viscera correlated with the increase in the water temperature in the aquarium. The intra-vitam larval migration ratios from the intestine to the viscera were 60% (63/105) at 15°C, 1.64% (3/183) at 12°C, 1.16% (2/172) at 9°C and 1.42% (2/141) in the control group (7.5°C). The free larvae showed no, slight and strong movement at 9°C, 12°C and 15°C, respectively, in saline water, and the larvae were present in a coiled state at 9°C and 12°C. The results suggest that temperature plays an important role in the intra-vitam larval migration of A. pegreffii. In addition, the free larval behavior of A. pegreffii in vitro increased with increase in temperature. Therefore, to prevent human anisakiasis caused by the consumption of raw fish, it is important that the temperature of the aquarium must be maintained below 12°C, which is the critical temperature zone.
B형간염 바이러스의 잠재 감염 만성 C형간염에서 B형간염 바이러스 잠재 감염
장재영 ( Jae Young Jang ),박의주 ( Eui Ju Park ) 대한소화기학회 2013 대한소화기학회지 Vol.62 No.3
Occult HBV infection is defined as the presence of HBV DNA in the liver (with or without detectable or undetectable HBV DNA in the serum) of individuals testing negative for HBsAg. Studies on occult HBV infection in hepatitis C patients have reported highly variable prevalence, because the prevalence of occult HBV infection varies depending on the hepatitis B risk factors and methodological approaches. The most reliable diagnostic approach for detecting occult HBV detection is through examination of liver DNA extracts. HCV has been suspected to strongly suppress HBV replication up to the point where it may be directly responsible for occult HBV infection development. However, more data are needed to arrive at a definitive conclusion regarding the role of HCV in inducing occult HBV infection. Occult HBV infection in chronic hepatitis C patients is a complex biological entity with possible relevant clinical implications. Influence of occult HBV infection on the clinical outcomes of chronic hepatitis C may be considered negative. However, recent studies have shown that occult HBV infection could be associated with the development of hepatocellular carcinoma and contribute to the worsening of the course of chronic liver disease over time in chronic hepatitis C patients. Nevertheless, the possible role of occult HBV infection in chronic hepatitis C is still unresolved and no firm conclusion has been made up until now. It still remains unclear how occult HBV infection affects the treatment of chronic hepatitis C. Therefore, in order to resolve current controversies and understand the pathogenic role and clinical impacts of occult HBV infection in chronic hepatitis C patients, well-designed clinical studies are needed. (Korean J Gastroenterol 2013;62:154-159)
양측 가슴벽에 동시에 발생하고 일측의 덩어리는 피부로 진행된 원발성 신경집종
김철 ( Chul Kim ),박상모 ( Sang Mo Park ),박의주 ( Eui Ju Park ),정은정 ( Eun Jung Jung ),장원호 ( Won Ho Jang ),김양기 ( Yang Ki Kim ),이영목 ( Young Mok Lee ),김기업 ( Ki Up Kim ),김현조 ( Hyun Zo Kim ),황정화 ( Jung Hwa Hwang 대한결핵 및 호흡기학회 2008 Tuberculosis and Respiratory Diseases Vol.65 No.4
Neurilemmomas are benign nerve sheath tumors derived from Schwann cells that rarely occur in the chest wall. Neurilemmomas of the chest wall are usually solitary lesions that bulge toward the pleural cavity. Neurilemmomas are confirmed histologically based on the presence of Verocay bodies, Antoni A and Antoni B tissue patterns and S-100 protein. Bilateral neurilemmomas in the chest wall are extremely rare, as are those that grow in the subcutaneous tissue but not the pleural area. We report here a case of bilateral chest wall neurilemmomas in which the tumors bulged out to the skin and were palpable. (Tuberc Respir Dis 2008;65:318-322)
전성란 ( Seong Ran Jeon ),어수택 ( Soo Taek Uh ),김기업 ( Ki Up Kim ),이영목 ( Young Mok Lee ),김양기 ( Yang Ki Kim ),정은정 ( Eun Jung Jung ),김지연 ( Ji Yon Kim ),박의주 ( Eui Ju Park ) 대한결핵 및 호흡기학회 2008 Tuberculosis and Respiratory Diseases Vol.64 No.2
Tracheomegaly is a distinctive condition that presents with marked dilation of the trachea. Spontaneous pneumomediastinum is the result of alveolar rupture with dissection of the airway along the bronchus and into the mediastinum. Tracheomegaly and recurrent spontaneous pneumomediastinum are rare complications of pulmonary fibrosis when combined with rheumatoid arthritis. We present a case of tracheomegaly and recurrent spontaneous pneumomediastinum that was precipitated by repeated respiratory infection and chronic cough in a patient with pulmonary fibrosis that was associated with rheumatoid arthritis. (Tuberc Respir Dis 2008;64:144-148)