흉추에 생긴 MRSA에 의한 신생아 골수염 1례

박은숙,신선희,김성구,윤혜선,Park, Eun Sook,Shin, Seon Hee,Kim, Sung Goo,Yoon, Hae Sun 대한소아감염학회 2002 Pediatric Infection and Vaccine Vol.9 No.2

골수염은 신생아에서는 드문 질환이며 신생아 중환자실 입원 환아 100명당 1~3명 정도에서 나타난다. 척추의 골수염은 이 중 1~2%를 차지하며 진단상의 어려움과 합병증으로 치료가 어렵다. 환아는 재태연령 34+2주, 출생체중 1.6 kg으로 생후 22일째 혈액 배양에서 MRSA가 발견되어 2주간 항생제 치료 후 다시 발열이 있어 입원치료 하였다. 자기 공명 영상상 흉추 7~8 부위의 골수염이 나타나 8주간의 vancomycin 정맥치료 결과 임상적, 방사선학적으로 호전되어 퇴원하였다. 저자들은 MRSA의 감염으로 척추의 골수염을 가진 신생아 1례를 경험하였기에 보고하는 바이다. Vertebral osteomyelitis represents only 1% to 2% of osteomyelitis and may pose a diagnostic conundrum, with disastrous consequences if diagnosis and therapy are delayed. We report a neonate with the unique association of vertebral osteomyelitis and MRSA infection. A 1-month-old boy was admitted to the hospital for evaluation of high fever and decreased oral intake. He was born at 34 wks, and his birth weight was 1.6 kg. We founded MRSA on his blood culture. Magnetic resonance imaging study showed findings of T7-T8 vertebral osteomyelitis. With 8 weeks of intravenous vancomycin treatment, the patient improved clinically and radiologically.

간호대학생의 입원아동 안전간호활동 인식 영향 요인

박은숙,오원옥,김미림,Park, Eunsook,Oh, Won-Oak,Kim, Mirim 한국아동간호학회 2017 Child Health Nursing Research Vol.23 No.4

Purpose: The purpose of this study was to identify the factors that affect nursing students' perception of pediatric safety nursing activities for children during hospitalization. Methods: The study sample included 304 nursing students who had participated in pediatric nursing practice. Data were analyzed using SAS 9.3 program. Results: Regression analysis showed that the model's explanatory power was 37%. Safety policy and procedure, safety priority, disaster experience, and knowing a place of refuge were factors affecting the perception of safety nursing activities for children during hospitalization. Conclusion: Findings show that safety policy and procedures and safety priority are major factors that affect the perception of safety nursing activities and indicate that effective education programs on safety policy and procedure and safety priority are necessary to improve the perception of safety nursing activities.

장애아 어머니의 불확실성, 사회적 지지 및 무력감

박은숙,오원옥,Park Eun Sook,Oh Won Oak 한국아동간호학회 1999 Child Health Nursing Research Vol.5 No.2

The purposes of this study were to measure the degree of perceived uncertainty, social support & powerlessness, to examine the relationship between the perceived uncertainty, social support & powerlessness and then to find the predictors of powerlessness in mother's of handicapped children. The subjects of this study consist of 102 mothers of handicapped children, registered at rehabilitation & handicapped children school. Data was collected from September 1998 to March 1999. The tools used in this study were Mishel's the Parents' Perception of Uncertainty Scale (28 item, 4 likert scale), Miller's Powerlessness measurement Scale(28 itewt 4 likert scale) & Cohen's Interpersonal Support Evaluation List (40 items, 4 likert scale). Data was analyzed by t-test, ANOVA, Duncan comparison, Pearson Correlation coefficient & Stepwise multiple regression Results of this study are summarized as follows : 1. Mothers perceived their uncertainty to be slightly high(Mn 2.50). The degree of perceived uncertainty by the four components were followed as : lack of clarity(2.69), unpredictability(2.56), ambiguity(2.56) & lack of information(2.46). The degree of perceived uncertainty of the mothers of handicapped children revealed to be influenced significantly by age of children, admission experience, disability types of children. 2. The degree of mothers' powerlessness was measured to be slightly high(Mn 2.14). The degree of perceived powerlessness of the mothers with handicapped children revealed to be influenced significantly by age of children, duration of illness admission experience,8E marital status of the mothers. 3. Mothers perceived their social support to be slightly high(Mn 2.71). The degree of perceived social support revealed to be influenced significantly by sex of children, married state of mothers. 4. Mothers' uncertainty was related positively to the mothers' powerlessness(r=.33, p=.0008). And also mothers' powerlessness was related inversely to social support(r=-.50, p=.0001). But, mothers' uncertainty was not related to social support significantly. 5. To analyze the variables which affect powerlessness, stepwise regression was implemented. As a result, about 61% of the powerlessness were explained by social support, marital status of the mothers and perceived uncertainty. Based upon these results, it is recommended that the nurses, who are caring handicapped children and their families, provide various support programs for them to overcome their difficulties. Also programs which decrease the uncertainty & powerlessness used social support multidimensionally & individually are recommended to be developed.

Recombinant Adeno-associated Virus-Mediated Gene Transfer in Homocystinuria Mice

박은숙,Park, Eun-Sook The Korean Society of Inherited Metabolic Disease 2005 대한유전성대사질환학회지 Vol.5 No.1

Homocystinuria is a metabolic disorder caused by a deficiency of cystathionine ${\beta}$-synthase (CBS). Patients with homocystinuria show clinical symptoms such as mental retardation, lens dislocation, vascular disease with life-threatening thromboembolisms and skeletal deformities. Generally, the major treatments for CBS deficiency include pharmacologic doses of pyridoxine or dietary restriction of methionine. However, there is no effective treatment for this disease up till today and gene therapy can be an attractive novel approach to treatment of the disease. We investigated whether a recombinant adeno-associated virus could be used as a CBS gene transfer vector to reduce the excessive homocysteine level in the homocystinuria mouse model. Recombinant adeno-associated virus vector encoding the human CBS gene (rAAV-hCBS), driven by EF1-a promoter, was infused into CBS-deficient mice ($CBS^{-/-}$) via intramuscular (IM) and intraperitoneal (IP) injection. IP injection was more efficient than IM injection for prolongation of lives and reduction of plasma homocysteine levels. After 2 weeks of gene transfer by IP injection, serum homocysteine level was significantly decreased in treated mice compared with the age-matched controls and the life span was extended about 1.5 times. Also, increased expression of CBS gene was observed by immunohistochemical staining in livers of treated $CBS^{-/-}$ mice and microvesicular lipid droplets was decreased in cytoplasm of liver. These results demonstrate the possibility and efficacy of gene therapy by AAV gene transfer in homocystinuria mice.

아동간호사의 공감정도에 관한 연구 -간호사와 입원아동 어머니를 대상으로-

박은숙,석민현,정경숙,Park Eun Sook,Suk Min Hyun,Jung Kyung Sook 한국아동간호학회 1997 Child Health Nursing Research Vol.3 No.2

Empathy is an essential factor for establishing therapeutic relationship. Especially for pediatric nursing, the nurses need to know how to perceive children's feeling and thought and to express her understanding about them affectively. So, empathy is considered as an important concept in pediatric nursing. This study was attempted to measure the empathic ability of pediatric nurses by pediatric nurses and mothers of hospitalized children. The subject of this study consisted of 83 pediatric nurses and 106 mothers of hospitalized children in 4 hospitals in Seoul and 1 hospital in Kyung-Gi. Data were collected from Jan. 14 to Feb. 6, 1997, by the questionnair method. The instrument for this study was the Empathic Construct Rating Scale : ECRS(60-item, 5 point scale). Data were analyzed by descriptive statistics, t-test and ANOVA. Results of this study are summarized as follows 1. Pediatric nurses perceived their empathic ability to be moderately high (Mn=3.71). The level of perceived empathic ability of the pediatric nurses showed no significance by general characteristics. 2. The mothers of hospitalized children perceived nurses' empathic ability to be moderate(Mn=3.27). The level of perceived nurses' empathic ability of the mothers of hospitalized children showed significant differences by the experience of hospitalization of the children and the age of the mothers. 3. The perceived nurses' empathic ability of the mothers was significantly low than of the pediatric nurses(t=6.50, P<.001). From the above results, it can be concluded, that the empathic ability of the pediatric nurses is not sufficient for caring children and mothers of ficiently. So, the pediatric nurses' empathic ability is needed to improve through facilitative relationship training as refreshment in-service education program.

뇌성마비의 재활

박은숙,Park, Eun-Suk 한국건강관리협회 1998 건강소식 Vol.22 No.10

원전종사자의 방사선 노출과 암사망 위험도와의 관련성에 대한 메타분석

박은숙,문기은,김한나,이원진,진영우,Park, Eun-Sook,Moon, Ki-Eun,Kim, Han-Na,Lee, Won-Jin,Jin, Young-Woo 대한예방의학회 2010 예방의학회지 Vol.43 No.2

Objectives: We conducted a meta-analysis to investigate the relationship between low external doses of ionizing radiation exposure and the risk of cancer mortality among nuclear power plant workers. Methods: We searched MEDLINE using key words related to low dose and cancer risk. The selected articles were restricted to those written in English from 1990 to January 2009. We excluded those studies with no fit to the selection criteria and we included the cited references in published articles to minimize publication bias. Through this process, a total of 11 epidemiologic studies were finally included. A publication bias was tested for using Egger's test. The homogeneity test was performed before the integration of each of the standardized mortality ratios (SMRs) and the result proved that the studies were heterogeneous. Results: We found significant decreased deaths from all cancers (SMR = 0.75, 95% CI = 0.62 - 0.90), all cancers excluding leukemia, solid cancer, mouth and pharynx, esophagus, stomach, rectum, liver and gallbladder, pancreas, lung, prostate, lymphopoietic and hematopoitic cancer. The findings of this meta-analysis were similar with those of the 15 Country Collaborative Study conducted by the International Agency for Research on Cancer. A publication bias was found only for liver and gallbladder cancer (p = 0.015). Heterogeneity was observed for all cancers, all cancers excluding leukemia, solid cancer, esophagus, colon and lung cancer. Conclusions: Our findings of low mortality for stomach, rectum, liver and gallbladder cancers may explained by the health worker effect. Yet further studies are needed to clarify the low SMR of cancers, for which there is no useful screening tool, in nuclear power plant workers.

JPEG 영상의 저작권 보호를 위한 Digital Watermarking 알고리즘

박은숙,우종원,이석희,허윤석,조기형,Park, Eun-Suk,Woo, Jong-Won,Lee, Seok-Hee,Heo, Yoon-Seok,Cho, Ki-Hyung 한국정보처리학회 2000 정보처리논문지 Vol.7 No.1

In this paper, we propose the method of embedding the encrypted digital watermark in quantization coefficient when we encode the image data in the process of JPEC. The proposed method is as following. After a DCT coefficient of each block is quantized, we arrange the quantization coefficient as on dimension with a zigzag scan and replace each block. By applying even-odd feature of frequency of the encrypted watermark to a quantization coefficient of some fixed domain of replaced each block and embedding it, we obtain the compressed image data by encoding after placing it in the order prior to replacement. The advantages of the proposed method here are as follows: We can embed many information keeping a secret as much as possible by using the algorithm of block replacement. We can control the amount of embedding of each use, as we embed the encrypted information by selecting some fixed domain of a quantization coefficient, we can fix the embedding data regardless of the image and the value of quantization. We verified the results by experiments and analyzed the efficiency of them in comparison with the former study. 본 논문에서는 암호화된 디지털 워터마크를 JPEG 부호화 과정 중 양자화 계수에 합성하는 디지털 워터마킹 방법을 제안한다. 제안된 워터마킹 방법은 다음과 같다. 먼저 각 블록의 DCT 계수를 양자화 한 후 지그재그 스캔으로 양자화 계수를 1차원으로 배열하여 각 블록을 치환한다. 치환된 각 블록의 일정 영역의 양자화 계수에 암호화된 워터마크를 주파수의 우기성을 적용, 합성한다. 합성이 끝난 후 치환되기 전 순서로 다시 복원하여 부호화 과정을 거쳐 압축된 영상데이터를 얻는다. 본 논문에서 제안된 방식은 합성 전 블록 치환 알고리즘을 사용함으로써 보안을 최대한 유지하면서 많은 정보를 합성할 수 있다. 또한 양자화 계수의 일정 영역을 선택하여 암호화된 정보를 합성하기 때문에 용도에 따른 합성량을 조절 할 수가 있고, 영상 및 양자화 값과 상관없이 합성 데이터를 고정시킬 수 있는 장점이 있다. 본 논문에서는 실험을 통해서 그 결과를 검증하고 기존 연구와의 비교 및 그에 따른 성능을 분석하였다.

에이즈 말기 환자의 증상과 돌봄의 실제

박은숙,Park, Eun-Suk 한국호스피스협회 2004 한국호스피스협회 Vol.75 No.-

에이즈 말기 환자의 증상과 돌봄의 실제

박은숙,Park, Eun-Suk 한국호스피스협회 2004 한국호스피스협회 Vol.78 No.-