소양(瘙痒)의 병인병기(病因病機)에 대한 연구

박승림 ( Seung Lim Park ),강정수 ( Jung Soo Kang ) 대전대학교 한의학연구소 2013 혜화의학회지 Vol.22 No.1

After studying the cause and mechanism of the itching with the perspective of chronic medical books including Neijing, and the annotators, the conclusions are as follows. 1. The itching, which has correlation with the heart, is the deficiency symptom(虛症). It is generated when the lung-metal(肺金) is infected by the fire pathogen(火邪) and developed to depression(鬱), because of the heart fire flaming upward of circuit year(歲火太過). The treatment is to make metal depression scatter(金鬱泄之). 2. The itching occurs between the dermis(膚) and the epidermis(皮). 3. The itching generates when the excess of yang exuberance(熱盛極) precede the transmission of the wind-heats(風熱), the wind-cold(風寒), and the wind-dampness(風濕). It causes the blood deficiency(血虛) and the blood stasis(血瘀) because of the skin dryness. 4. The itching usually generates during summer, causes the body fever(身熱) and the dermis pain(膚痛). When it becomes worse, it causes generalized itching and vesicles at the whole body(浸淫). 5. The itching is related to the spirit(魄), which works in unconsciousness and the movement of defense qi(衛氣) in night.

퇴행성 척추관 협착증의 임상적 고찰

박승림(Seung Rim Park),김명호(Myung Ho Kim),김형수(Hyoung Soo Kim),문경호(Kyoung Ho Moon),임석원(Seog Won Lim) 대한정형외과학회 1991 대한정형외과학회지 Vol.26 No.4

Poland 증후군

박승림(Seung Rim Park),김명호(Myung Ho Kim),김형수(Hyoung Soo Kim),문경호(Kyoung Ho Moon),임석원(Seog Won Lim) 대한정형외과학회 1991 대한정형외과학회지 Vol.26 No.5

Chitooligosaccharide가 생쥐의 간 기능에 미치는 영향

김세재,강소영,박승림,신태균,고영환,Kim, Se-Jae,Kang, So-Young,Park, Seung-Lim,Shin, Tae-Kyun,Ko, Young-Hwan 한국식품과학회 1998 한국식품과학회지 Vol.30 No.3

Chitin의 탈아세틸화로 얻어지는 화합물인 chitosan과 chitooligosaccharide는 다양한 생리활성 기능을 나타내므로 생물의학적인 응용에 많은 관심이 집중되고 있다. 본 연구는 수용성 chitooligosaccharide가 생쥐의 간 기능에 미치는 영향을 조사하기 위하여 수행되었다. 6주 동안 3% cholesterol를 식이한 생쥐에서는 혈장 cholesterol 함량이 증가하였으나, 1% chitooligosaccharide와 3% cholesterol을 함께 식이한 생쥐에서는 혈장 cholesterol 함량이 23% 정도 감소하였다. 그러나 혈장내 HDL-cholesterol과 간내 cholesterol 함량에는 유의한 차이가 없었다. 한편, 15% ethanol을 8주간 투여한 생쥐에서는 inflammation, necrosis, 지방구의 축적, GPT의 활성 증가 등 간 상해가 관찰되었다. 그와 반면에 0.5% chitooligosaccharide와 15% ethanol을 함께 투여한 생쥐에서는 ethanol에 의해 유발된 간 상해가 현저히 억제되어 지방구의 축적이 관찰되지 않았고, 혈장의 GPT 활성이 25%정도 감소하였다. 따라서, chitooligosaccharide가 생쥐에서 혈장 cholesterol 함량을 감소시키고, 알코올성 지방간을 예방하는 등 부분적인 기능이 있음을 보여주었다. Chitosan is the deacetylated product of chitin. Chitosan and its derivatives have many properties that make them attractive for a wide variety of health applications. This study was performed to investigate some effects of water soluble chitooligosaccharides on liver function in the mouse. The animals given the sterol diet containing 3% cholesterol for 6 weeks showed increase in plasma cholesterol level, which were lowered by 23% when they were fed on 1% chotooligosaccharide. While there was no significant change in liver cholesterol and plasma HDL-cholesterol levels. Continuous administration of 15% ethanol via drinking water to mice for 8 weeks elicited pathological alterations such as inflammation, necrosis, accumulation of lipid droplets in the liver and increase in GPT activity, while simultaneous administration of ethanol and chitooligosaccharide prevented remarkedly ethanol-induced liver injury; there was no observable lipid droplet and GPT activity was decreased by 25% in the liver. These results suggest that chitooligosaccharide play some roles in liver function, such as reducing the plasma cholesterol level and preventing alcoholic liver disease.

퇴행성 요추 측만증에서 후방 기기 고정술과 유합술 후에 발생한 근위부 인접 분절 질환

조규정(Kyu-Jung Cho),박승림(Seung-Lim Park),김명구(Myung-Gu Kim),윤영현(Yung-Hyun Yoon),이중선(Joong-Sun Lee),석세일(Se-Il Suk) 대한정형외과학회 2009 대한정형외과학회지 Vol.44 No.1

목적: 척추 기기 고정술 후 발생하는 인접분절질환의 위험인자로 환자의 나이, 기기 고정술 사용, 유합술의 범위, 시상면상 불균형 등이 보고되고 있다. 저자들은 퇴행성 요추 측만증 환자에 후방 기기 고정술을 시행한 후에 발생한 근위부 인접분절질환의 발생률과 위험인자를 연구하였다. 대상 및 방법: 감압술과 척추경 나사못 기기 고정술로 치료한 72명(평균 연령 64.8)을 평가하였고 평균 4.7년 추적 조사하였다. 25명에서는 하위 요추부에 후방 추체간 유합술을 추가로 시행하였다. 유합 구간은 평균 5.1구간이었다(범위 1-9구간). 상위고정척추는 제 9흉추에서 제 4 요추까지 다양하였으며, 원위고정척추는 제 5 요추 혹은 제 1 천추였다. 결과: 72명의 환자 중 17명(24%)에서 근위 분절에 인접분절질환이 발생하였다. 인접분절질환에는 압박골절(6명), 인접부 척추후만증(5명), 척추 협착증(4명), 통증을 동반한 추간판 간격 붕괴(2명)가 있었다. 수술전 요추측만각, 흉추 후만각, 관상면과 시상면의 수선은 인접분절질환의 발생과 연관성이 없었다. 근위부 인접분절질환의 발생은 유합 범위와 밀접한 관련이 있었으며, 상위고정척추가 요추인 군에서는 발생률이 38.5%이었던데 비해 흉추인 군에서는 6.1%로 나타나 의미 있는 차이를 보였다(p=0.001). Oswestry 점수는 인접분절질환이 없는 군에서 많이 호전되었다. 결론: 퇴행성 요추 척추 측만증에서 후방 기기 고정술 후 발생한 증상을 동반한 근위부 인접분절질환의 발생률은 24%였다. 근위 인접분절질환 발생의 위험 인자는 근위부 유합 범위로, 측만 변형이 남아 있는 요추부에서 유합을 멈추었을 때 인접분절질환이 많이 발생하였고, 측만 변형 전체를 포함하여 흉추부까지 유합하였을 때 인접분절질환의 발생률이 낮았다. Purpose: Adjacent segment disease (ASD) is major complication following spinal instrumentation and fusion. The purpose of the current study was to determine the prevalence and risk factors of proximal ASD following posterior instrumentation and fusion for degenerative lumbar scoliosis. Materials and Methods: Seventy-two patients (mean age 64.8 years) who had undergone decompression and fusion with pedicle screw instrumentation were evaluated. The average follow-up was 4.7 years. Twenty-five patients had additional interbody fusion at the lower lumbar spine. The average number of levels fused was 5.1 segments (range 1-9). The upper instrumented vertebrae ranged from T9 to L4. The lower instrumented vertebrae were L5 and S1. Results: Proximal ASD developed in 17 (24%) of 72 patients, including compression fractures (n=6), junctional kyphosis (n=5), spinal stenosis (n=4), and symptomatic disc collapse (n=2). The preoperative scoliotic angle, lumbar lordosis, thoracic kyphosis, and coronal and sagittal C7 plumb were not associated with the development of proximal ASD. There was a close correlation between the level of the upper instrumented vertebrae and the development of ASD (p=0.001). When fusion did not extend beyond the lumbar vertebra, ASD occurred in 15 (38.5%) of 39 patients. In contrast, when fusion extended up to the thoracic vertebrae, ASD occurred in 2 (6.1%) of 33 patients. The improvement in the Oswestry score was superior to the group without ASD (p=0.001). Conclusion: The prevalence of symptomatic ASD at the proximal segment was 24% after posterior instrumentation and fusion for degenerative lumbar scoliosis. The cephalad extent of fusion was the most significant risk factor for the development of proximal ASD.

무시멘트 인공 고관절 치환술후 대퇴 근위부 골밀도의 정량적 분석

강준순 ( Kang Jun Sun ),박승림 ( Park Seung Lim ),김형수 ( Kim Hyeong Su ),염승훈 ( Yeom Seung Hun ),이동주 ( Lee Dong Ju ),김신 ( Kim Sin ) 대한고관절학회 2002 Hip and Pelvis Vol.14 No.2

γ-Poly(glutamic acid)와 키토산 공중합체 필름의 물성

박승림,고영환 제주대학교 생명과학연구소 2001 제주생명과학연구 Vol.4 No.-

Chitosan was prepared from crab shells. γ-Poly(glutamic acid)(y-PGA) was purified from culture filtrate of Bacillus licheniformis ATCC9945a. γ-PGA-chitosan interpolymers were used to make than films. Tensile strength, extent of elongation, weight loss in water, and moisture gain under standard conditions of the films were determined. Tensile strength of the γ-PGA-chitosan interpolymer film was 85.5MPa and its extent of elongation was 12.5%. When the interpolymer film was suspended in distilled water at 20℃ for 24 hours, the weight loss was 6.8%, which was much lower than those of γ-PGA film 100% or chitosan film 47.7%. Moisture gain of the interpolymer film showed the similar tendencies to the case of the weight loss and it was only 18.4% by weight under standard conditions.

色彩治療와 韓醫學에서의 色의 適用

朴勝琳,姜政秀 대전대학교 한의학연구소 2003 한의학연구소 논문집 Vol.12 No.1

It has been believed that the human body can be effected by color, sound, smell, and taste - each of them is based on the original character. Out of these elements, the color can be a mediation that absorbs energy into human body and adapts it to the creatures whose life are definitely based on the solar energy. This thesis makes a study of the possibility of applying the color to the oriental medical science by researching the color psychology and therapy which are studied in the west medical science, the recognition and application of color developed from orientalism, and the opinion of color in the oriental medical science. Color therapy is one of the psychological treatment techniques that are able to recover and maintain the health with the rays of the sun rays and the color. The light and the color have its energy that may relax, harmonize, encourage, or excite a human being. This is because the wavelength and the vibration of each color will take effects to human body. The core energy of absorbing and distributing the color vibration is made in the 7 "chakras" in the body, which are the pith and marrow of bio-energy directly connected with the center of the nervous system. There are several methods in the color therapy - the treatment of solar ray, the color-bath, the water-therapy using color energy, the inducement of the solar energy into the body, the acupuncture, the therapy of crystal and jewel, and the self-suggestion dependent upon the color. The color therapy can help us to keep our balance by changing the emotion into the positive energy that will cure the disease with color. As a result, this method not only must be useful to cure physical disease, or develop into good health but also will be used in conforming itself to the mental disease. The color therapy mainly uses the eight colors, which are made by mixing Red, Yellow and Blue basic colors in the field. They are never used in the treatment, but they will go along with complementary colors. This rule is closely connected with the theory of yin and yang which lies at the root of oriental philosophy, and with the treatment principle of oriental medical science whose field is focused on the balancing the body mentally as well as physically. In the East, it is the Obangsaek - the color of blue, red, yellow, white, and black in the theory of yin and yang and the five elements that have been used in helping people having trouble with their health for a long time. In the view of the oriental medical science, these five colors attached the theory of five-elements have been very useful to the physiology, the pathology, or the diagnosis, and been applied to the medical treatment, combining themselves with a five-taste in medicinal herbs. Since the study of color and human physiology has been made in some different interest and fields these days, it goes to prove that the different function of color we couldn't have got before becomes very useful to the medical science. The color must be worth researching the diversity for applying itself to the oriental medical science.

Chitooligosaccharide가 생쥐의 간 기능에 미치는 영향

김세재,고영환,강소영,신태균,박승림 제주대학교 방사능이용연구소 1998 연구보고 Vol.12 No.-

Chitin의 탈아세틸화된 유도물인 chitosan과 chitooligosaccharides는 다양한 생리활성 기능을 나타내므로 생물 의학적인 응용에 많은 관심이 집중되고 있다. 본 연구는 수용성 chitooligosaccharide이 생쥐의 간 기능에 미치는 영향을 조사하기 위하여 수행되었다. 6주 동안 3% cholesterol를 식이한 생쥐에서는 혈장 cholesterol 함량이 증가하였으나, 1% chitooligosaccharide와 3% cholesterol을 함께 식이한 생쥐에서는 혈장 cholesterol 함량이 23% 정도 감소하였다. 그러나 혈장내 HDL-cholesterol과 간내 cholesterol 함량에는 유의한 차이가 없었다. 15% enthanol을 8주간 투여한 생쥐에서는 inflammation, necrosis, 지방구의 축적, GPT의 활성 증가등 간 상해가 관찰되었다. 그러나 0.5% chitooligosaccharide와 15% ethanol을 함께 투여한 생쥐에서는 ethanol에 의해 유발된 간 상해가 현저히 억제되어 지방구의 축적이 관찰되지 않았고, 혈장의 GPT 활성이 25% 정도 감소하였다. 따라서, chitooligosaccharide가 생쥐에서 혈장 cholesterol 함량을 감소시키고, 알코올성 지방간을 예방하는등 부분적인 기능이 있음을 보여주었다. Chitosan is the deacetylated product of chitin. Chitosan and its derivatives have many properties that make them attractive for a wide variety of health applications. This study was performed to investigate some effects of water soluble chitooligosaccharides on liver function in the mouse. The animals given the sterol diet containing 3% cholesterol for 6weeks showed increase in plasma cholesterol level, which were lowered by 23% when they were fed on 1% chotooligosaccharide. While there was no significant change in liver cholesterol and plasma HDL-cholesterol levels. Continuous administration of 15% ethanol via drinking water to mice for 8 weeks elicited pathological alterations such as inflammation, necrosis, accumulation of lipid droplets in the liver and increase in GPT activity, while simultaneous administration of ethanol and chitooligosaccharide prevented remarkedly ethand-induced liver injury; there was no observable lipid droplet and GPT activity was decreased by 25% in the liver. These results suggest that chitooligosaccharide play some roles in liver function, such as reducing the plasma cholesterol level and preventing alcoholic liver disease.

흰쥐에서 사염화탄소에 의해 유도된 간 상해에 미치는 키토산 올리고당의 영향

이영돈,박승림,강소영,김세재,박지권,고영환 제주대학교 생명과학연구소 1999 제주생명과학연구 Vol.2 No.-

Chitosan is the deacetylated product of chitin. Chitosan and its derivatives have many properties that make them attractive for a wide variety of health applications. We reported recently that water soluble chitooligosaccharides have hepatoprotective effect on ethanol induced liver injury in the mouse. The current study examined the effect of water soluble chitooligosaccharides on CC1₄-induced liver injury in rats. Male Sprague-Dawley rats were orally treated with CC1₄without or with administration of 5% chitooligosaccharides. After 5 weeks after CC1₄treatment, the histological sections and the expression of mRNA of interleukin-12(IL-12), hepatocyte growth factor(HGF), and tumor necrosis factor(TNF- ) were examined. The liver section of rats supplemented with chitooligosaccharides showed attenuated effects of the necrosis, steatosis, cirrhosis compared with those of non-supplemented rats. The level of TNF- mRNA in CC1₄-treated rats were higher than those in the rats supplemented with chitooligosaccharides, while the levels of IL-12 and HGF mRNA were higher in the rats supplemented with chitooligosaccharides than those of in CC1₄-treated rats. These findings suggested that water soluble chitooligosaccharides may have a hepatoprotective activity against CCl₄-induced liver injury in rats.