우량체 보험의 위험평가

박성수,Park, Sung-Soo 한국생명보험의학회 2000 保險醫學會誌 Vol.19 No.-

Alteration of Biochemical Responses in Activated Human Neutrophils by ATP and Adenosine

박성수,이정수,Park, Sung-Soo,Lee, Chung-Soo The Korean Society of Pharmacology 1990 대한약리학잡지 Vol.26 No.1

안정 상태 및 활성화된 중성 백혈구에서 ATP는 superoxide 라디칼 생성을 자극하였으나 adenosine은 약간 억제하였다. ATP에 대한 활성화된 중성 백혈구의 반응이 안정상태의 중성 백혈구에서보다 크게 나타났다. 칼슘이 제거된 반응액에서 superoxide 라디칼 생성에 대한 adenosine의 억제효과가 관찰되었으나 ATP는 영향을 주지않았다. Superoxide 라디칼 생성에 대한 ATP의 자극 효과는 adenosine에 의하여 용량에 따라 억제되었다. ATP와 adenosine은 NADPH oxidase 활성도에 영향을 주지 않았다. ATP 또는 adenosine에 의한 superoxide 라디칼 생성의 변경은 다른 triphosphate nucleotide나 nucleoside에 의한 것보다 현저하였다. 활성화된 중성 백혈구에서 ATP와 ADP는 칼슘이온의 흡수를 더 자극하였고 세포질 유리 칼슘농도를 증가시켰으나, adenosine은 칼슘이온의 이동을 억제하였다. APT에 의한 세포질 유리 칼슘이온 농도의 증가는 verapamil에 의하여 효과적으로, tetrodotoxin에 의하여 약간 억제되었다. ATP에 노출된 활성화된 중성 백혈구에서의 superoxide 라디칼 생성에 대한 verapamil 과 tetrodotoxin의 억제 효과는 ATP의 영향이 없는 활성화된 중성 백혈구에서보다 크게 나타났다. Tetraethylammonium chloride는 superoxide 생성에 뚜렷한 영향을 미치지 못했다. CCCP, 2,4-dinitrophenol, diphenylhydantoin과 procaine은 활성화된 중성 백혈구에서 superoxide 라디칼의 생성을 억제하였다. 이들 가운데 CCCP만이 ATP의 자극 효과를 억제하였다. ATP는 활성화된 중성 백혈구에서의 sulfhydryl기의 손실을 더 자극하였으나 adenosin의 영향은 관찰되지 않았다. 이상의 결과로부터 중성 백혈구의 기능적 반응은 부분적으로 purine에 의하여 조절될 것으로 시사되었다. ATP와 adenosine은 칼슘 흡수와 그리고 아마도 세포막 인산화 반응 및 용해성 sulfhydryl기의 산화에 대한 영향을 통하여 활성화된 중성 백혈구의 반응을 더 변경 시킬 수 있을 것으로 추정된다. In both resting and opsonized zymosan activated neutrophils, ATP stimulated superoxide generation, whereas adenosine inhibited it slightly. The superoxide generation in activated neutrophils to ATP was greater than that of resting neutrophils. In $Ca^{++}$ free medium, inhibitory effect of adenosine on superoxide generation was detectable, whereas ATP did not have any effect. The stimulatory effect of ATP on superoxide generation was inhibited by adenosine in a dose dependent manner. Neither ATP nor adenosine had any effect on NADPH oxidase acitivity. Effects of ATP or adenosine on superoxide generation were more prominent than that by other triphosphate nucleotides or nucleosides. ATP and ADP further stimulated $Ca^{++}$ uptake and increased cytosolic free $Ca^{++}$ level in neutrophils activated by opsonized zymosan, but adenosine inhibited a $Ca^{++}$ mobilization. Verapamil effectively and tetrodotoxin slightly inhibited an increase of cytosolic free $Ca^{++}$ level induced by ATP. Inhibitory effect of either verapamil or tetrodotoxin on superoxide generation in the ATP plus opsonized zymosan-activated neutrophils was greater than in the cells activated by opsonized zymosan alone. Tetraethylammonium chloride had no apparent effect on superoxide generation. CCCP, 2,4-dinitrophenol, diphenylhydantoin and procaine all inhibited superoxide generation in neutrophils activated by opsonized zymosan. Among these, CCCP only inhibited a stimulatory effect of ATP. ATP further stimulated a loss of sulfhydryl groups in activated neutrophils, whereas adenosine had no effect on it. These results suggest that functional responses of neutrophils may be regulated at least partly by purines. ATP and adenosine may further after functional responses of activated neutrophils through their effect on $Ca^{++}$ uptake, membrane phosphorylation and oxidation of soluble sulfhydryl groups.

턱교정 수술에 있어 흡수성 고정판 및 나사 사용에 대한 임상적 연구

박성수,최진영,Park, Sung-Soo,Choi, Jin-Young 대한악안면성형재건외과학회 2009 Maxillofacial Plastic Reconstructive Surgery Vol.31 No.2

Objectives : The titanium fixation system has been used in orthognathic surgery for fixation of bone segments usually, but the biodegradable fixation system was developed and also being used. The strongest point in the biodegradable system is that no extra operation should be needed to remove fixation materials. In spite of this merit, oral & maxillofacial surgeons hesitate to use this system in fracture or orthognathic surgery. In this study, as we got some clinical experiences, we'd like to report the result of clinical study using the biodegradable fixation system in orthognathic surgery. Patients and Methods : A total of 35 patients composed of 17 males and 18 females with 25 osteotomies in maxilla and 34 osteotomies in mandible were fixated with the biodegradable fixation system(Inion $CPS^{(R)}$). We investigated methods of stabilization, fixation time, and complications on the basis of the method as above. Results : Four 2mm thick L shaped plates with 7 holes of which 1 hole was removed were fixed in maxilla with six $2.0{\times}7mm$ screws. Three $2.5{\times}16{\sim}18mm$ screws were used to fix superior ramus area and one mandibular angle area in mandible. It took about 27.4 minutes in maxilla, 25.3 minutes in mandible to perform the fixation which took longer time than the titanium system(9.5 minutes in maxilla, 8 minutes in mandible). Generally, there was no problem except 9 cases in which there were some complications. Conclusions : In most cases, the biodegradable fixation system can be used without problem in usual orthognathic surgery. But, this system is inferior to the titanium fixation one in some respects such as fixation time, size, and physical property. Some supplementations for such weak points as aforementioned should be needed for the universal use of biodegradable materials.

Borrmann 제4형 위암의 치료성적

박성수,김성훈,김승주,김종석,목영재,Park, Sung-Soo,Kim, Sung-Hoon,Kim, Seung-Joo,Kim, Chong-Suk,Mok, Young-Jae 대한위암학회 2003 대한위암학회지 Vol.3 No.4

Purpose: The prognosis for Borrmann type 4 gastric cancer is dismal although therapies for gastric cancer have been developed. We investigated the outcomes for Borrmann type 4 gastric cancers compared to those for other types of cancer. Materials and Methods: Between 1993 and 2000, 777 patients with advanced gastric cancer underwent surgical resection at the Department of Surgery, Korea University Hospital. The clinicopathologic features of 138 patients with Borrmann type 4 carcinomas of the stomach were retrospectively reviewed from the database of gastric cancer. The results were compared with those of 639 patients with other types of gastric carcinomas. Results: Patients with Borrmann type 4 carcinomas tended to be younger and to have larger tumors. The location, the depth of invasion, lymph node metastasis, and distant metastasis were significantly different between the two groups. Patients with Borrmann type 4 carcinomas had a more advanced stage than patients with other types of carcinomas. The analysis of the treatment factors revealed that total gastrectomies were more frequent in the group with Borrmann type 4 carcinomas and that the curative resection rate of patients with Borrmann type 4 gastric carcinomas was lower than that of patients with other types of gastric carcinomas (P<0.001). The 5-year survival rate for Borrmann type 4 gastric cancer was $19.4\%$ and that for other types was $52.9\%$ (P=0.001). In curative cases, the 5-year survival rates were $32.8 \%$ for patients with Borrmann type 4 gastric carcinomas and $63.4\%$ for other types of carcinomas (P=0.001). Conclusion: Borrmann type IV gastric cancer has more advanced features and a poorer prognosis than other types of gastric cancer. Improving the prognosis for patients with Borrmann type 4 gastric cancer requires early detection and a curative resection.

진단시의 혈압변화 - 재측정에 의한 초기혈압의 변화에 대해 -

박성수,이신휘,Park, Sung-Soo,Lee, Shin-Whi 한국생명보험의학회 1998 保險醫學會誌 Vol.17 No.-

삼성생명의 지방을 비롯한 총 7개 의무실에서 1997년 11월 1일부터 11월 30일까지 동일 진단시에 5-10분 이상의 시간 간격을 두고 혈압측정을 2회 실시한 757예에 대해 측정치의 변화를 검토하여 다음과 같은 결과를 얻었다. 1) 진단시의 혈압은 1회 측정치 보다 2회 측정치가 낮게 나타났다. 2) 혈압치의 저하율은 조건체 상당의 혈압치를 나타낸 고혈압치군과 고연령층에서 높게 나타났다. 3) 고혈압치군 436예중에서는 170예(39.0%)가 무조건체로까지 혈압이 하강하였다. 4) 중증의 고혈압으로 보험가입이 거절된 27예의 경우는 현저한 혈압의 하강은 없었다. 이상의 결과로 진단시에 일정간격의 시간차를 둔 혈압의 재측정이 계약확대의 관점과 혈압측정의 정확성 측면에서 진사실무에 적용하는 것이 필요하다.

의료비 보장보험의 언더라이팅

박성수,Park, Sung-Soo 한국생명보험의학회 2001 保險醫學會誌 Vol.20 No.-

반안면왜소증 환자의 안면비대칭 해소를 위한 늑연골 이식 및 악교정 수술의 동시 이용: 증례보고

박성수,서진원,최진영,Park, Sung-Soo,Suh, Jin-Won,Choi, Jin-Young 대한악안면성형재건외과학회 2010 Maxillofacial Plastic Reconstructive Surgery Vol.32 No.4

A 31-year-old woman with hemifacial microsomia presented to the Department of Oral and Maxillofacial Surgery, Seoul National University Dental Hospital. The patient was previously treated with distraction osteogenesis device to elongate right maxilla and mandibular ramus. But, the result was not satisfactory, to correct residual facial asymmetry due to hemifacial microsomia we planned costochondral graft for reconstruction of ramus and condyle, Le Fort I osteotomy and sagittal split ramus osteotomy for facial asymmetry. The right mandibular condyle and ramus was reconstructed with right eleventh costochondral graft via submandibular approach. Using costochondral graft and orthognathic surgery the facial asymmetry in hemifacial microsomia patient was corrected. 1-stage treatment consists of costochondral graft and orthognathic surgery can achieve function and esthetics at the same time, is timesaving to both patient and surgeon.

Type II Cell 분리체로부터 Surfactant 인지질의 분비를 매개하는 신호변환 기전

박성수,Park, Sung-Soo 대한결핵및호흡기학회 1996 Tuberculosis and Respiratory Diseases Vol.43 No.2

Secretion of surfactant phospholipid can be stimulated by a variety of agonists acting via at least three different signal transduction mechanisms. These include the adenylate cyclase system with activation of cAMP-dependent protein kinase; activation of protein kinase C either directly or subsequent to activation of phosphoinositide-specific phospholipase C and generation of diacylglycerols and inositol trisphosphate; and a third mechanism that involves incresed $Ca^{2+}$ levels and a calmodulin-dependent step. ATP stimulates secretion via all three mechanisms. The protein kinase C pathway is also coupled to phopholipase D which, acting on relatively abundant cellular phospholipids, generates diacylglycerols that further activate protein kinase C. Sustained protein kinase C activation can maintain phosphatidylcholine secretion for a prolonged period of time. It is likely that interactions between the different signaling pathways have an important role in the overall physiological regulation of surfactant secretion.

조기사망(早期死亡)에 대한 분석(分析) - '97. 1. 1${\sim}$'97. 6. 30의 조기사망건(早期死亡件) -

박성수,이신휘,Park, Sung-Soo,Lee, Shin-Whi 한국생명보험의학회 1998 保險醫學會誌 Vol.17 No.-

삼성생명의 97년 상반기('97.1.1${\sim}$'97.6.30)에 발생한 조기사망건에 대한 분석을 하였다. 조사대상은 계약시 진단을 받고 가입한건중 계약일로부터 1년 이내에 사망한 사람을 대상으로 하였으며 자살과 불의의 사고에 따른 건은 제외했다. 조기사망은 진단건수 90,934건 중 26건(20명)이 발생하였으며 이는 100,000건당 29건이었다. 성별로는 남성 21건, 여성 5건으로 남성에서 높은 발생률을 나타내었으며 40대(代)이상 연령층에서 반수 이상을 차지하였다. 사인은 일반국민을 대상으로 한 사망원인과 일치하여 악성신생물이 가장 많았고 이어서 심질환, 뇌혈관질환의 순서였으며, 악성 신생물 중에서는 특이하게도 간암이 위암보다 더 많았다.

의학적 위험선택

박성수,Park, Sung-Soo 한국생명보험의학회 1999 保險醫學會誌 Vol.18 No.-