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배양된 정상 갑상선세포에서 LECTIN 에 의한 HLA - DR 항원 발현에 관한 연구
박성기(Sung Ki Park),이명식(Myung Shik Lee),조보연(Bo Youn Cho),고창순(Chang Soon Koh),이문호(Mun Ho Lee),차창룡(Chang Young Cha),황응수(Eung Soo Hwang),오승근(Seung Keun Oh) 대한내과학회 1988 대한내과학회지 Vol.35 No.5
N/A Although it has been suggested that HLA-DR Ag expression in thyrocytes by nonspecific immune stimuli such as lectin may play an important pathogenetic role in autoimmune thyroid diseases, its precise mechanism has not been established. The purpose of this study is to investigate a part of the mechanism and features of lectin-induced expression of HLA-DR antigenicity in cultured normal thyrocytes. By an indirect immunofluorescence method using monoclonal anti-HLA-DR Ab, this study was performed to assess the effects of various lectins, as well as the effects of culture duration, cyclosporine, prostaglandin E₂, and gamma-interferon on HLA-DR Ag expression in cultured normal thyrocytes, and also to compare cytoplasmic and surface expression of HLA-DR Ag. The results were summarized as follows: 1) In 5 separate experiments with normal thyrocytes cultured with 10 mg/ml leucoagglutinin, HLA-DR Ag was detected on the 2nd day of culture. The expression rate increased to a maximum on the 7th to 9th day of culture and decreased thereafter. 2) The positivity of HLA-DR Ag expression by T-cell specific mitogenic lectins was 60% in the cultured cells with 2 mg/ml phytohemagglutinin, 60% in those with 10 mg/ml concanavalin A, and 50% in those with 10 mg/ml leucoagglutinin on the 7th day of culture, There were no significant changes of HLA-DR Ag expression in higher concentrations. HLA-DR Ag was expressed in 40% of cultured thyrocytes with 100 mg/ml pokeweed mitogen but HLA- DR Ag expression was not induced by lipopolysaccharide, which is not a T-cell mitogenic lectin. 3) Leucoagglutinin-induced expression of HLA-DR Ag was reduced by cyclosporine which suppresses secretion of lymphokines from T-lymphocyte, but not by prostaglandin E₂, which suppresses HLA-DR Ag expression in macrophages. 4) Gamma-interferon-induced expression of HLA-DR Ag was not reduced by cyclosporine. 5) HLA-DR Ag expression was not induced by hormones such as TSH, insulin and hydrocortisone. 6) In normal thyrocytes cultured with concanavalin A or leucoagglutinin, the HLA-DR Ag expression rates in the cytoplasm and cell surface were nearly similar. These results, that HLA-DR Ag expression was induced by T-cell mitogenic lectin but suppressed by cyclosporine (inhibitor of gamma-interferon synthesis in T-lymphocyte) and that the expression rates in the cytoplasm and cell surface were nearly similar suggest that the T-lymphocyte is involved in lectin-induced expression of I-ILA-DR Ag in cultured normal thyrocytes and that HLA-DR Ag is produced in the cytoplasm of thyrocytes.
박성기 ( Park Sung-ki ),제성준 ( Zae Sung-zoon ) 부산대학교 과학교육연구소 2021 교사교육연구 Vol.60 No.4
이 연구는 체육고등학교에 근무하는 주지 교과 교사들의 교직 생활에서 경험하고 있는 고민과 갈등을 심층적으로 분석하여 체육고등학교만의 문화적 특성을 도출하여 체육고등학교에 대한 이해를 넓히는 데 그 목적이 있다. 이를 위해 A광역시 소재의 B체육고등학교에 근무하는 주지교과 교사 2명을 대상으로 교직 생활에 대해 문화기술적 연구(Ethnography)로 실시하였다. 관찰, 문서, 면담을 통해 자료를 수집하여 귀납적 범주 분석을 실시하였다. 체육고등학교에 근무하기 전 학교 밖에서 바라본 시선에서 주지 교과 교사로서 업무와 수업의 부담이 적고 학교 생활에 있어서도 편하게 지낼 수 있는 학교라는 인식을 하고 있었다. 이를 바탕으로 자신들의 편의를 위해 체육고등학교를 지망하여 근무를 시작하게 되었다. 하지만 자신들이 가지고 있던 이미지와는 다르게 근무를 하면서 담임 교사, 교과 교사, 조직구성원의 측면에서 많은 어려움을 겪고 있었다. 담임교사 측면에서는 기본생활 습관이 부족한 학생들과 운동부 감독 교사들이 담임 위의 담임으로의 인식, 진로 진학 지도 차원의 어려움이 도출되었다. 교과 교사 측면에서는 수업에 대한 기본 태도의 부족, 중학생 수준의 낮은 기초 학력 수준, 교재 연구의 어려움이 나타났으며 조직 구성원으로서는 무임승차, 우리는 소수, 소통이 없는 교사 문화로 인한 어려움이 나타났다. 이 연구는 향후 체육고등학교에 근무하는 주지 교과 교사를 위해 교직 문화 적응에 대한 정보를 제공할 수 있을 것으로 기대한다. 또한 체육고등학교 문화에 관한 이 연구는 체육고등학교만이 가지고 있는 교육적 문제점의 일부를 드러내기 때문에 나아가 체육고등학교의 교육 정책 수립 및 효과적인 교육과정 운영의 기초 자료가 될 것이라 기대해본다. The purpose of this study was to broaden the understanding of physical education high schools by deriving cultural characteristics unique to physical education high schools through in-depth analysis of the worries and conflicts the intellectual subject teachers working in physical education high school are experiencing. For this, an ethnography study was conducted on the school life of two intellectual subject teachers working at B Physical Education High School located in A metropolitan city. An inductive category analysis was performed by collecting data through participatory observations, school documents, open-ended questionnaires, and interviews. Before working in the physical education high school, the intellectual subject teachers thought they could have a comfortable school life with less burden of work and classes. Based on this assumption they decided to go to a physical education high school for their convenience and started working. However, contrary to their expectations, they experienced a lot of difficulties as homeroom teachers, subject teachers, and members of the school. This study provides information on the adaptation to school culture for intellectual subject teachers assigned to physical education high schools. In addition, since the results reveal some of the educational problems that physical education high schools especially have, this study can serve as a basic data for establishing educational policies and effective curriculum for physical education high schools.
원위 경골 골절에 대한 단계적 최소 침습적 금속판 고정술
박성기 ( Sung Ki Park ),오창욱 ( Chang Wug Oh ),오종건 ( Jong Keon Oh ),김경훈 ( Kyung Hoon Kim ),민우기 ( Woo Kie Min ),박병철 ( Byung Chul Park ),정원주 ( Won Ju Jeong ),인주철 ( Joo Chul Ihn ) 대한골절학회 2010 대한골절학회지 Vol.23 No.3
목적: 개방성 창상 또는 연부 조직 손상을 동반한 원위 경골 골절을 단계적 최소 침습적 금속판 고정술로 치료하고 결과를 평가하였다. 대상 및 방법: 원위 경골 골절 환자 20예 (평균 연령, 47.8세)를 대상으로 하였다. AO 분류상 A형 4예, C형 16예였고 8예의 개방성골절이 포함되었다. 가교 외 고정 후 평균 23.9일에 최소 침습적 금속판 고정술을 시행하였다. 최종 추시 때 골유합 및 정렬에 대한방사선적 평가를 하였고, 족관절 운동 범위 및 AOFAS (American Orthopedic Foot & Ankle Society) 점수로 기능적 평가를 하였다. 결과: 20예 중 17예 (85%)에서 평균 21.3주 (범위, 12∼28주)에 일차 골유합을 얻었고 3예의 불유합에서 골 이식이 필요하였다. AOFAS 점수는 평균 88.5점 (범위, 67∼92점이었고, 족관절 운동 범위는 평균 49.2도 (족저 굴곡 37.4도, 족배 굴곡 11.8도)였다. 합병증으로서 경도의 부정정렬 2예, 갈퀴 족 변형 1예, 비골 신경병증 1예가 있었다. 60세 이상의 환자에서 AOFAS 점수가 낮았으나, 골절 형태 등의 다른 인자들은 결과에 영향을 미치지 않았다. 결론: 개방성 골절을 포함한 연부 조직 손상을 동반한 원위 경골 골절에서 단계적 최소 침습적 금속판 고정술은 심부 감염과 연부조직 합병증을 감소시키고 만족스러운 결과를 얻을 수 있을 것으로 생각된다. Purpose: To assess the result of staged minimally invasive plate osteosynthesis (MIPO) for distal tibial fracture with an open wound or injured soft tissue. Materials and Methods: In 20 patients (mean age, 47.8 year-old) with distal tibial fractures, there were 4 type A fractures and 16 type C fractures based on the AO classification system. Eight of the 20 patients had open fractures. MIPO was performed on average 23.9 days after bridging external fixation. At the final follow-up, we assessed the radiological results of bone union and alignment. Functional results were also evaluated by measuring the degrees of ankle motion and the American Orthopedic Foot & Ankle Society (AOFAS) scores. Results: Seventeen of 20 cases (85%) achieved primary union at an average of 21.3 weeks. There were 3 cases of nonunion requiring a bone graft. The mean AOFAS score was 88.5 (range, 67∼92) and the average range of ankle motion was 49.2o (plantarflexion: 37.4o, dorsiflexion: 11.8o). Complication included 2 cases of minor mal-alignment, 1 case of claw toe and 1 case of peroneal neuropathy. Patients over the age of 60 had lower functional results. Additional factors did not affect the final results. Conclusion: Staged MIPO may achieve satisfactory results in distal tibial fractures with soft tissue compromise, decreasing deep infections and soft tissue complications.
99mTc - DISIDA 간담도 스캔상 담도폐쇄로 진단된 환자의 임상적 특성 - 초음파 검사상 정상 소견을 보인 9예를 중심으로 -
박성기(Sung Ki Park),변종훈(Jong Hoon Byun),양수현(Soo Hyun Yang),박봉철(Bong Chul Park),채동호(Dong Ho Che) 대한핵의학회 1992 핵의학 분자영상 Vol.26 No.1
N/A To evaluate the role of hepatobiliary (DISIDA) scan in the diagnosis of biliary obstruction, we studied the clinical characteristics of 9 cases with biliary obstructuon, whose hepatobiliary scans and ultrasonography were not concordant (normal ultrasonography and abnormal hepatobiliary scan). The results were as follows; 1) The main chief complaints (89%) were abdominal pain, especially in RUQ area. The levels of serum bilirubin were elevated in 67% of patients (normal∼5.9 mg/dl) and those of alkaline phosphatase were elevated in 78% of patients (normal∼724 U/L). 2) The final diagnoses were CBD stones (67%), tumor (22%) and 3 cases were associated with C. sinensis. 3) The major obstruction sites were in distal CBD (89%). From the above results we concluded that hepatobiliary scan is a useful diagnostic method of biliary obstruction, especially in distal CBD lesion and early stage, in spite of normal ultrasonography.
99mTc - phytate 간스캔을 이용한 간 경변증의 예후 평가
박성기(Sung Ki Park),변종훈(Jong Hoon Byun),양수현(Soo Hyun Yang),박봉철(Bong Chul Park),채동호(Dong Ho Che),조준구(Jun Koo Cho),송태원(Tae Won Song) 대한핵의학회 1991 핵의학 분자영상 Vol.25 No.1
N/A To evaluate the prognostic significance of 99mTc-phytate liver scintigraphy in patients with cirrhosis, we measured the grade of extrahepatic uptake (EHU) of 99mTc-phytate, from 0 (absent EHU) to 5 (irnportant EHU), according to the relative distribution of the radiotracer among liver, spleen and bone marrow. The results were as follows: 1) EHU score was correlated to the Pugh score (r=0.64) and to survival. 2) The ROC curve on an observed status of death was superior for EHU score. In conclusion, 99mTc-phytate liver scintigraphy may be a useful prognostic method in patients with liver cirrhosis.