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위궤양의 발생기전에 대한 시험적 및 임상적연구 - Prednisolone 투여 백서의 위 Pepsin 의 성상에 관한 연구 -
박경남,기춘석,장호연,고재경 ( Kyung Nam Park,Choon Suhk Kee,Ho Yun Chang,Jai Kyung Koh ) 대한소화기학회 1980 대한소화기학회지 Vol.12 No.1
Because of its potent proteolytic nature, pepsin has been known to play an important role 'in ulcerogenesis of the stomach '>. The rate of pepsin secretion by stomach was reported to be stimulated by histamine'>, gastrin', pentagastrin >, caerulein >, secretin >, cholecystokinin> and glucocorticoids >, and inhibited by vagotomy>, histamin antag- .onists> and prostaglandins . It has been suggested that compounds which can timulate pepsin output may cause gastric ulcer and that drugs which exhibit antipeptic activity could be used as therapeutic agents for gastric ulcer. The introduction of glucocorticoids into medical practice with concomitant increase in the incidence of gastric ulcer made it clear that the adrenal glucocorticoids had a good deal to do with pepsin output and its activity-. However, no definite evidence for that tle pepsin secretion and its activity are affected by acute or chronic administration of glucocorticoids has been obtained in both experimental and clinical studies. In order to investigate the effect of glucocorticoids on pepsin activity in gastric juice, changes in the activity of pepsin vere observed in both basal a.nd gastopsin stimulated gastric juice collected from rats treated with prednisolone for fifteen days. Also studied were properties of pepsin in gastric juice to screen the compounds which specifically activate or inhibit the enzyme through the in vitro experiment .
Peutz - Jeghers 증후군에서 병발한 대장 선암종 1예
박경남(Kyung Nam Park),전규영(Kyu Young Jun),이성구(Sung Koo Lee),이종철(Jong Chul Rhee),박문향(Moon Hyang Park),이중달(Jung Dal Lee) 대한소화기학회 1985 대한소화기학회지 Vol.17 No.1
N/A The Peutz-Jeghers syndrome, characterized by pigmentation of the skin and mucous membranes and gastrointestinal polyposis of hamartomatous variety, has been well documented. There have been conflicting views, however, as to the frequency with which malignant change occurs in the polyp. There are insufficient data to establish this syndrome as a precancerous condition but documented cases of gastrointestinal cancer arising in this syndrome have been reported with an incidence of 2~3%. A case of Peutz-Jeghers syndrome with two descrete invasive adenocarcinom as arising in colonic polyps is reported with pertinent literature review. The patient was a 42 year old male admitted with symptoms of intestinal obstruction. He was found to have numerous polyps of variable size throughout the entire length of the colon and in part in the small intestine. He also had pigmentation of oral mucosa. Histologically the polyps were mostly hamartomatous and some were transformed into adenomatous in type with considerable cellular atypia. There were two descrete invasive Duke C adenocarcinomas arising in polyps on colectomy specimen.
HPLC 에 의한 암의 지표로서의 뇨중 Ribonucleoside 의 분리 및 정량에 대한 연구
박경남(Kyung Nam Park),한중수(Joong Soo Han),고재경(Jai Kyung Koh) 대한내과학회 1987 대한내과학회지 Vol.33 No.2
N/A Urine contains certain metabolic end products of nucleic acid metabolism including sma1l amounts of modified nucleosides. They are methylated or otherwise structurally transformed ribosyl purines and pyrimidines and are not recycled through the salvage pathway but are excreted in urine. Their measurement in urine provides an accurate indicatar of the metabolism of RNA, especially transfer RNA. Altered patterns of excretion of these compounds might offer a sensitive biomarker for diagnosis and treatment of cancer. In order to find out whether the urinary ribonucleosides could be used as tumor markers for the hepatocellular carcinoma or stomach cancer, analysis of urine samples from normal controls and patients with hepatocellular carcinoma and stomach cancer was performed using reversed-phase HPLC. For this study, a rapid and precise chromatographic method for the determination of ribonucleosides in urine by high-performance liquid chromatography has been developed, The ribonucleosides were first isolated with an affinity gel containing immobilized phenylboronic acid. Contents of pseudouridine, 5-methylcytidine, 1-methyladenosine, 7-methylguanosine, guanosine, 1-methylinosine and 1-methylguanosine were significantly increased in urine of patients with hepatocellular carcinoma. Among these elevated ribonucleosides, excretions of pseudouridine, 5-methylcytidine, 1-methylinosine and 1-methylguanosine were higher than the upper limits (mean+2SD) in control group providing positive rates above 78% (positive rates for the excretions of 5-methylcytidine and 1-methylinosine were 100 %). In patients with stomach cancer, urinary excretions of pseudauridine, cytidine, 5-methylcytidine, 7-methylguanosine and adenosine were significantly in- creased. Positive rates for those of pseudouridine and 5-methylcytidine were above 50o. The results suggest that urinary levels of pseudouridine, 5-methylcytidine, 1-methylinosine and 1-methylguaaosine for the hepatocellular carcinoma and those of pseudouridine and 5-methylcytidine for the stomach cancer are useful as diagnostic tumor markers.
위염 및 소화성 궤양의 병인과 Campylobacter pylori 와의 상관관계에 관한 연구
박경남(Kyung Nam Park),기춘석(Choon Suhk Kee),김정목(Jung Mogg Kim),정용훈(Yong Hoon Chung),김경희(Kyung Hee Kim),조양자(Yang Ja Cho),서인수(Inn Soo Suh),고영혜(Young Hyeh Ko),이중달(Jung Dal Lee) 대한내과학회 1988 대한내과학회지 Vol.34 No.5
N/A Campylobacter pylori (Cp) was investigated in connection with chronic gastritis and peptic ulcer by means of endoscopic biopsy, Cp was found in 7 of the 18 randomly selected normal persons and in 47 of the 72 patients with gastritis, duodentitis, or peptic ulcer. Differentiation between the normal persons and patients was made by subjective symptoms and endoscopy. However, according to the relationship between the occurrence of Cp and histological diagnosis of the patients, the control persons could be classified: 6 persons with normal histology and without Cp: 9 persons with active chronic gastritis (ACG), of which 7 persons had Cp: 3 persons with chronic gastritis (CG) and had no Cp. According to histological examination of the 72 patients, 7 were normal, 39 had ACG, 21 had chronic ulcer (CU). In the 39 ACG patients, Cp was isolated in 25 (64.1%) and demonstrated by Giemesa or Warthin-Starry silver stain in 32 (82.1%). In the 21 CG patients, Cp was isolated in 6 (28.6%) and seen in the tissue stain in 5 (23.8%). In the 5 CU patients, Cp was isolated in 5 (100.0%) ans seen in the tissue stain in 3 (60.0%). ~In the 7 patients with normal histology, Cp was isolated in one (14.3%) and seen in the tissue stain in one (14.3%). Therefore, Cp was detected in 47 (65.3%) biopsy samples of the 72 patients and zero (0%) of the 6 normal persons without inflammatory sings on the endoscopic or histologic studies (P< 0.005). These findings strongly implicate Cp as the cause of active chronic gastritis and chronic ulcer.
박경남 ( Kyung Nam Park ),최호순 ( Ho Soon Choi ),기춘석 ( Choon Suhk Kee ),이중달 ( Jung Dal Lee ),박문향 ( Moon Hyang Park ),홍일 ( Il Hong ),차호진 ( Ho Jin Cha ) 대한소화기학회 1987 대한소화기학회지 Vol.19 No.2
A teratorna (C'reek teratos [):IonsterJ and onkoma [a swelling]) is a true tumor or neoplasm composed of multiple tissues of kinds foreign to the parts in which it arises, take different forms, either solid or cystic, and arise in an immediately prexial median or paramedian location. The retroperitoneal teratoma is a rare condition in only 10% of all retroperitoneal primary neoplasms. Among 10%, the incidence of malignant degeneration has been reported to be from 6 to 10 percent and mature solid retropertioneal teratoma is about 90 percent. About 200 cases has been recorded since Morgargnis first description in 1961. A 24-year-old woman complained left upper guadrant palpable mass. Roentgen study revealed typical conglomerated frame-like calcification in left abdomen. In addition to reporting a case of mature solid retroperioneal teratoma, we will present a review of the literature available on this subject.
원발성간임의 (原發性肝癌) 초음파상에 (超音波像) 관한 연구
박경남(Kyung Nam Park),이창홍(Chang Hong Lee),기춘석(Choon Suk Kee),최웅환(Oung Whan Choi),이동후(Dontg Hoo Lee),이호채(Ho Chae Lee),김순길(Soon Gill Kim),민영일(Young Il Min) 대한소화기학회 1983 대한소화기학회지 Vol.15 No.1
N/A The gray- cale ultrasonographic app arances of histopathologically proven primary hepatoma in 61 patients were evaluated retrospectively. Our study has revealed four different ultrsonographic patterns of primary hepatoma: echogenic(39.4%), sonolucent(8.2%), mixed(31.0%) and diffuse parenchymal distortion(21.3%). Of 61 primary hepatoma examined, 19 cases exhibited encapsulation. Predominantly, the marginal Contour of mass was irregular rather than smooth. Most of cases represented downward convexity of the lower edge of the liver. Both of hump and marginal irregularity on the hepatic surface were exhibited in 54.1% and 59.0% respectively. Ultrasonography makes it possible to demonstrate not only the extrinsic compression of the vascularity by the tumor mass on intrahepatic vessels, inferior vena cava, and abdominal aorta, but also extrahepatic biliary obstruction. While 40.9% of cases were found to have a cites, splenomegaly was noticed in 31.1% In fact, ultrasonography is a useful screening method for imaging primry hepatorna with pecial regard of its noninva siveness and easy application to assess the nature and extent of the lesions.
Mallory - Weiss 증후군 32예 내시경적 관찰
박경남(Kyung Nam Park),이민호(Min Ho Lee),신동호(Dong Ho Shin),진봉재(Bong Jae Shin),신성현(Sung Hyun Yoon),기춘석(Choon Seok Kee) 대한소화기학회 1982 대한소화기학회지 Vol.14 No.1
N/A Hemorrhages from laceration of upper gastrointestinal mucosa after severe vomiting has been frequently reported as an important cause of UGI bleeding. For previous two decades, the Mallory-Weiss Syndrome has become more easily and accurately diagnosed together with the development of endoscope. A clinical observation of endoscopically proven Mallory-Weiss syndrome during 4 years from 1978 to 1981 was performed. The results were as follows; 1) The incidence of Mallory-Weiss syndrome was 7. 6% (32 cases) of 421 cases with upper gastrointestinal bleeding. 2) Male to female ratio was 2.6:1 and the average age of patients was 44. 3) The main predisposing factor was alcohol drinking(56.3%) and the antecedent symptoms were belching, nausea, and vomiting and the summated frequency of above three symtoms was 18.75% Patients without any previous symptoms occupied 18. 8%. 4) Frequency of identificaion of active bleeding was 80% when endoscopic examination was performed within 12 hrs from bleeding and the frequency was decreased together with long duration from the bleeding. And so there was no identifiable active bleeding when examination was performed after 48 hrs from bleeding 5) Cases of single laceration were 25 cases(78.1%) and the bleeding site was predominently esophagogastric junction 18(56%) and the side of laceration was mainly posterior wall (50%). G) Associated lesions were detected in 21 cases; gastritis, gastric ulcer, esophagitis, duodenal ulcer, esophageal varix, and duodenitis in order of frequency. 7) All patients were well treated only with conservative treatment; ice water irrigation, pitressin, and transfusion, etc.
위 (胃) 십이지장궤양환자에서 (十二指腸潰瘍患者) Madecassol ( centella asiatica ) 의 사용경험
박경남(Kyung Nam Park),신현성(Hyun Sung Shin),최일균(Il Gyun Choi),이민호(Min Ho Lee) 대한소화기학회 1982 대한소화기학회지 Vol.14 No.1
N/A In order to elucidate the effect of titrated extract of Centella Asiatica(TECA) on peptic ulcer, the drug was given to a total of 40 patients with peptic ulcer including 25 cases of gastric ulcer and 15 cases of duodenal ulcer. The results obtained were as follows: Of 15 patients with peptic ulcer including 9 cases of gastric ulcer and 6 cases of duodenal ulcer who received TECA alone, 14 cases(93%) exhibited a definite improvement in subjective symptoms and 11 cases(73%) showed healing of the ulcer under endoscopic and radiological observations. 2) Of 14 patients of peptic ulcer who received TECA along with antacid, 13 cases showed an improvement in subjective symptoms and 11 cases(78%) exhibited healing of the ulcer. 3) Of 11 patients with peptic ulcer who served as control, 5 cases exhibited an improvement in subjective symptoms, but there were no sign of healing in observation. 4) Activities of serum transaminases, content of blood urea nitrogen and concentrations of serum electrolytes in patients ivith peptic ulcer were determined before and after administration of the drugs and were observed to be unchanged.