LiCl-KCl 고온 용융염 내 UCl₃ 및 GdCl₃의 전기화학적 거동 연구

민슬기,배상은,박용준,송규석,Min, Seul-Ki,Bae, Sang-Eun,Park, Yong-Joon,Song, Kyu-Seok 한국전기화학회 2009 한국전기화학회지 Vol.12 No.3

Electrochemical behaviors of $U^{3+}$ and $Gd^{3+}$ were investigated in LiCl-KCl eutectic molten salt by using various electrochemical techniques. The electrodeposition and dissolution currents for uranium show the maximum at -1.51V and -1.35V, respectively while, for gadolinium,at -2.15V and -1.9V, respectively. In case of LiCl-KCl molten salt containing both of $U^{3+}$ and $Gd^{3+}$, the peak potential of electrodeposition of gadolinium shifts to more positive potential than in the solution without $U^{3+}$. The potentials in chronopotentiometric data suddenly dropped to negative value as soon as the reduction currents were applied and became constant at the potential around which the $U^{3+}$ and $Gd^{3+}$ are electrodeposited. The results of normal pulse voltammetry (NPV) and square wave voltammetry show that those methods can be used to qualitatively analyze the elements in the melts. Especially, the differentiation of NPV result was found to be useful for the separation of the peaks of which potentials are close each other. 본 연구는 고온화학공정에 사용할 전기화학적 센서 기술 개발의 사전 연구로서 고온 LiCl-KCl 공융염에 $UCl_3$나 $GdCl_3$를 녹여 $U^{3+}$와 $Gd^{3+}$의 전기화학 반응을 조사하였다. $U^{3+}$는 고온 LiCl-KCl 용융염내에서 -0.2V/-0.35 V에서 $U^{4+}$로의 산화/환원반응의, -1.51 V/-1.35 V에서 전착/해리 반응전류의 피크를 나타내었다. $Gd^{3+}$의 경우 -2.15 V에서 전착반응 피크를, -1.9 V에서 산화해리전류 피크를 나타내었다. $U^{3+}$와 $Gd^{3+}$의 혼합 고온 용융염에서는 $Gd^{3+}$의 전착 피크가 양의 전위로 이동하였다. 일정전류법의 결과는 시간이 지남에 따라 전위값이 일정해졌으며 그 전위값은 전해질 내 반응물의 환원전위값과 일치하였다. 노멀펄스전위법과 직각파전위법은 두 원소의 정성분석을 위한 좋은 전기화학적 방법론임을 보였으며 특히 노멀펄스전위곡선을 미분한 결과는 사용된 다른 방법에 비해 반응전류의 피크분리가 잘 일어났다.

하시모토 갑상선중독증 및 휘트르레 선종과 동반된 본태성 혈소판증가증

민슬기 ( Seul Ki Min ),공승진 ( Seung Jin Kong ),이호권 ( Ho Gwon Lee ),신동훈 ( Dong Hun Shin ),송헌호 ( Hun Ho Song ),이성진 ( Seong Jin Lee ),최문기 ( Moon Gi Choi ) 대한내과학회 2005 대한내과학회지 Vol.69 No.-

Hashitoxicosis, a rare cause of primary hyperthyroidism, is diagnosed by presence of thyrotropin receptor antibody, increased radioiodine uptake and histological finding of lymphoid follicle with lymphcytic infiltration. Thrombocytopenia associated with hyperthyroidism including hashitoxicosis is probably caused by increased destruction of platelets in reticuloendothelial phagocytic system although it is partially compensated by increased production of magakaryocytes in bone marrow. Because essential thrombocythemia in hyperthyroid state has not been reported, most cases of thrombocytosis developed in the treatment of hyperthyroidism are considered as secondary thrombocytosis without any further examination. We experienced fourty-seven year-old woman presenting with palpitation and anterior neck swelling. By endocrinological and histological examinations, she was diagnosed as hashitoxicosis and Hurthle cell adenoma. For evaluation of progressive thrombocytosis, bone marrow biopsy was performed, in which essential thrombocythemia was diagnosed. In summary, we report the first case of an essential thrombocythemia with hashitoxicosis and Hurthle cell adenoma. (Korean J Med 69:S856-S860, 2005)

간동맥 화학색전술에 의한 간세포암종 크기 감소 이후 간절제술을 시행한 환자

민슬기 ( Seul Ki Min ),김상균 ( Sang Gyune Kim ),김영석 ( Young Seok Kim ),이세환 ( Sae Whan Lee ),정승원 ( Soung Won Jeong ),장재영 ( Jae Young Jang ),김홍수 ( Hong Soo Kim ),김부성 ( Boo Sung Kim ) 대한간암학회 2011 대한간암학회지 Vol.11 No.1

Hepatocellular carcinoma (HCC) is the third most common cancer in korean population. Surgical management is the mainstay of HCC. Surgical resection and liver transplantation shows the best outcomes in well-selected patients. But few patients are possible to benefit from surgical resection or liver transplantation. The majority of cases of HCC are unresectable, but there are no proven treatment modalities for these cases. In small number of articles showed the favorable result of adjuvant chemotherapy, and transcatheter arterial chemoembolization (TACE) for unresectable HCCs. But there are some drawbacks, such as small number of sample size and variablity of study design at each studies. Hereby we report a patients of HCC, who was performed hepatectomy after tumor down sizing with TACE.

춘천 지역에서 발생한 쯔쯔가무시병의 임상적 특징

이호권 ( Ho Gwon Lee ),민슬기 ( Seul Ki Min ),공승진 ( Seung Jin Kong ),이수정 ( Su Jung Lee ),송헌호 ( Hun Ho Song ),윤종우 ( Jong Woo Yoon ),이명구 ( Myung Goo Lee ),신동훈 ( Dong Hoon Shin ),강성하 ( Sung Ha Kang ),이정열 ( Jeo 대한내과학회 2005 대한내과학회지 Vol.69 No.2

Background : Tsutsugamushi disease is an acute febrile disease in Korea. Some patients with tsutsugamushi disease have severe illness, which needs care in intensive care unit, and may die due to the disease. We analyzed the cases with tsutsugamushi disease who lived in Chuncheon and neighboring communities to find out clinical manifestations, laboratory findings especially in severe cases. Methods : We reviewed the clinical records of the 81 cases who were diagnosed as tsutsugamushi in Chuncheon Sacred Heart Hospital from April, 1997 to December, 2002. We analyzed the clinical and laboratory findings of the 81 cases, and the treatment results of 79 cases who recieved the treatment in this hospital. We also compared the characteristics of the patients between admission to general ward and intensive care unit (ICU). Results : Seventy three cases developed the disease in autumn. Seventy cases had fever. 58 cases had eschar in their bodies. With the doxycycline treatment, forty five cases subsided the fever within 48 hours, but in 13 cases, fever continued after 5 days of treatment. Twenty five cases were admitted to ICU, 8 cases among them were treated with ventilator, 3 cases died due to the multi-organ failure. When we compared the clinical characteristics of the patients admitted to ICU with those to general wards, leukocyte count, the level of BUN and creatinine were higher, the albumin level was lower in ICU patients than those of general ward patients. Conclusion : Tsutsugamushi disease can progress to severe disease, and be fatal to the patients. So it is necessary to diagnose early and treat carefully. We suggest that leukocyte count, BUN, creatinine, or albumin can be used to predict the prognosis.(Korean J Med 69:190-196, 2005)

갑상선기능항진증에 동반된 급성 E형 간염 2예

공승진 ( Seung Jin Kong ),민슬기 ( Seul Ki Min ),김익근 ( Ick Keun Kim ),구현철 ( Hyun Cheol Koo ),박인일 ( In Il Park ),한재필 ( Jae Pil Han ),이주용 ( Jue Yong Lee ),김대용 ( Dae Yong Kim ),이성진 ( Seong Jin Lee ),백광호 ( Gwan 대한소화기학회 2006 대한소화기학회지 Vol.47 No.1

연성 골수정을 이용한 소아 상완골 간부 골절의 치료

곽윤해(Yoon Hae Kwak),민슬기(Seul Ki Min),이용범(Yong Beom Lee),박건보(Kun-Bo Park) 대한정형외과학회 2012 대한정형외과학회지 Vol.47 No.4

목적: 소아 상완골 간부 골절은 일반적으로 비수술적으로 치료한 결과가 좋기 때문에 대부분 보존적 방법으로 치료하게 된다. 그러나 도수정복이 적절히 유지되지 않거나 개방성 골절 혹은 동반 골절이 있는 경우 등에 한하여 수술적 치료를 요하기도 한다. 본 연구에서는 소아 상완골 간부의 수술적 적응증이 되는 제한된 환아에 대하여 연성 골수정을 이용한 치료의 결과를 보고하고자 한다. 대상 및 방법: 2009년 3월부터 2011년 9월까지 소아 상완골 간부 골절의 발생 후 연성 골수정을 이용하여 수술을 시행한 환아 12명을 대상으로 후향적으로 연구하였다. 수술의 적응증은 개방성 골절, 적절한 정복을 유지할 수 없는 경우, 다발성 골절, 재골절 그리고 신경 손상등이었다. 모든 예에서 연성 골수정을 이용하였으며 골절의 발생 부위를 고려하여 전방 혹은 후방에서 2개의 골수정을 삽입하였다. 결과: 평균 15개월 동안 추시하였고 최종 추시까지 모든 환자에서 적절한 골유합을 얻었다. 수술 과정에서 신경 및 혈관 합병증은 발생하지 않았으며 수술 후 염증 소견도 관찰되지 않았다. 4명의 환아에서 골수정 삽입부의 자극을 호소하였고 이 중 두 명의 환아에서 통증 및 불편감을 호소하여 수상 후 6주에 내고정물을 제거하였다. 한 명의 환아에서 술 후 약 6개월경 근위 골수정 삽입부를 따라 비전위 골절이 발생하였다. 최종 추시에서 모든 환아에서 적절한 운동 범위를 회복하였고 수상 전 활동으로 복귀하였다. 결론: 소아의 상완골 간부 골절에서 연성 골수정을 이용한 고정법은 효과적인 방법으로서 수술적 고정을 요하는 환아에서 적절한 방법으로 사용될 수 있을 것으로 생각한다. Purpose: Most humeral fractures of children are treated satisfactorily with conservative method, thus surgical treatment is often reserved for limited conditions. In cases of an open fracture, inadequate reduction or multiple traumas, children with humeral shaft fractures require operative treatment. The aim of our study was to evaluate results and complications of pediatric humeral shaft fractures that were treated with flexible intramedullary nails. Materials and Methods: A retrospective study was performed for 12 patients who were treated operatively by flexible intramedullary nails between March 2009 and September 2011. Surgical indications were an open fracture, an inability to maintain an adequate reduction, concomitant fractures, refractures and combined radial nerve injury. All patients were treated with 2 titanium flexible intramedullary nails by antegrade or retrograde techniques, according to the site of the fractures. Results: The mean follow-up period was 15 months, and all patients achieved union status without major complications. There were no neurovascular injuries or infection during surgical procedures. However, 4 patients showed irritation at the insertion site of the nail, and 2 of them underwent early removal of nails at about 6 weeks due to skin lesions as well as pain and discomfort. One boy showed a fracture next to the proximal insertion site of the antegrade nail. All patients showed a full range of motion, and went back to daily life by the final follow-up. Conclusion: Flexible intramedullary nails are considered as a good option for the fracture of the pediatric humeral shaft. Surgeons should pay attention and use proper techniques to avoid complications.

위 정맥류 출혈에 대한 내시경적 정맥류 폐색술, 내시경적 정맥류 결찰술, 역행성 경정맥 위정맥류 폐색술 간의 치료효과 비교

김부성 ( Boo Sung Kim ),박재우 ( Park jae woo ),민슬기 ( Seul Ki Min ),김상균 ( Sang Gyune Kim ),김영석 ( Young Seok Kim ),배준용 ( Jun Yong Bae ),이종찬 ( Jong Chan Lee ),김홍수 ( Hong Soo Kim ),정승원 ( Soung Won Jeong ),장재영 대한소화기학회 2011 대한소화기학회지 Vol.57 No.5

Background/Aims: Endoscopic variceal obliteration (EVO), endoscopic variceal ligation (EVL), and balloon-occluded retrograde transvenous obliteration (BRTO) are used to manage gastric variceal bleeding. We compared the re-bleeding rates and survival times of these modalities. Methods: The study enrolled 103 patients with suspected gastric variceal bleeding between July 2001 and May 2009. For the management of gastric variceal bleeding, 52 patients underwent EVO; 36, EVL; and 15, BRTO. We evaluated their laboratory results and vital signs, and calculated the Child score, Child classification, and Model for End-stage Liver Disease score. Rebleeding was defined as new-onset hematemesis, hematochezia, melena, or endoscopically proven bleeding. Time-to-rebleeding and survival time were examined by Kaplan-Meyer analysis. A value of p<0.05 indicated statistical significance. Results: There were no significant differences in baseline characteristics among the three groups. The overall follow-up period averaged 65.13 months. During follow-up, rebleeding occurred in 17 patients (11 EVO, 5 EVL, and 1 BRTO). The times-to-rebleeding were 63.59, 75.79, and 51.41 months for EVO, EVL, and BRTO, respectively, and did not differ significantly (p=0.515). The median survival times were 77.42, 70.14, and 42.79 months, respectively, and also were not different significantly (p=0.978). Conclusions: There were no significant differences in the time-to-rebleeding or survival time among EVO, EVL, and BRTO. Further prospective, large-scale studies are needed. (Korean J Gastroenterol 2011;57:302-308)

골수정으로 치료한 대퇴골 전자간부 골절에서의 고정 실패에 대한 분석

장준동 ( Jun Dong Chang ),김태영 ( Tae Young Kim ),황지효 ( Ji Hyo Hwang ),민슬기 ( Seul Ki Min ),유제현 ( Je Hyun Yoo ) 대한골절학회 2012 대한골절학회지 Vol.25 No.3

목적: 대퇴골 전자간부 골절에서 골수정 삽입술 후 발생한 고정 실패의 양상 및 위험 인자들을 알아보고자 하였다. 대상 및 방법: 대퇴골 전자간부 골절로 골수정 삽입술을 시행 받고 최소 6개월 이상 추시 중 고정 실패가 발생하였던 14예를 대상으로 하였다. 수술 당시 평균 나이는 74.5세 (61∼86세)였고, 수술 후 고정 실패까지 기간은 평균 6.6주 (2∼10주)였다. 수술 전 3차원 컴퓨터단층촬영과 수술 전, 후 및 추 시상의 방사선 사진들을 대상으로 분석하였다. 결과: 고정 실패가 발생한 총 14예 중 AO 분류상 A1.2 4예, A2.1 3예, A2.2 5예, A2.3 2예로, 안정 골절이 7예, 불안정 골절이 7예였다. 총 14예 중 10예에서 대전자부 첨부에 분쇄상이 동반되었고 내측 및 전방 피질골의 해부학적 정복이 이루어지지 않았다. 지연 나사의 위치가 적절했던 10예 중 9예는 고전자부 골절 양상을 보였다. 고전자부 골절이었던 9예 중 7예는 근위 골편의 회전으로, 나머지 5예 중 4예는 내반 함몰로 인해 고정 실패가 발생하였다. 결론: 대퇴골 전자간부 골절 환자에서 골수정 삽입술 시 고전자부 골절 양상, 대전자 첨부 분쇄상, 내측 및 전방 피질골의 불완전한 정복이 고정 실패의 추가적인 위험 인자가 될 수 있을 것으로 생각한다. Purpose: To analyze the patterns of and risk factors for fixation failure after hip nailing in intertrochanteric (IT) hip fractures. Materials and Methods: Fourteen patients who sustained a fixation failure after hip nailing for IT hip fractures were enrolled in this study. The mean age at the index surgery was 74.5 years and the mean time to the fixation failure was 6.6 weeks. All of the serial radiographs up to the fixation failure and pre-operative 3-D computed tomography were analyzed. Results: According to AO classification, there were 7 stable fractures and 7 unstable ones. Of the total of 14 cases, 10 showed a comminution of the greater trochanter tip and incomplete anatomical reduction of the medial and anterior cortex at the fracture site. Of the 10 cases with appropriate position of the lag screw within the femoral head, 9 showed a high pertrochanteric fracture (HPF) pattern. The mechanism of the fixation failure was rotation of the femoral head in 7 of 9 cases with HPF and varus collapse of the proximal fragment in 4 of the other 5 cases. Conclusion: The HPF pattern, the comminution of the greater trochanter tip, and incomplete reduction of the medial and anterior cortex may be additional risk factors of fixation failure after treating IT hip fractures with hip nailing in.

춘천 지역에서의 위암 발생률에 관한 연구, 2000-2002년

김성중 ( Sung Jung Kim ),백광호 ( Gwang Ho Baik ),윤광희 ( Kwang Hee Youn ),송성욱 ( Sung Wook Song ),김동준 ( Dong Joon Kim ),김진봉 ( Jin Bong Kim ),민슬기 ( Seul Ki Min ),백일현 ( Il Hyun Baek ),박철희 ( Cheol Hee Park ),장현주 대한내과학회 2007 대한내과학회지 Vol.73 No.4

Background: Stomach cancer is the most common cancer in Korea, and it can be easily diagnosed by performing endoscopy. Helicobacter pylori (H. pylori) is associated with stomach cancer, and there has been much recent interest in the epidemiology of stomach cancer. Therefore, we estimated the incidence of stomach cancer in Chuncheon-si during 2000-2002. Methods: From July 1st, 2000 through June 30th, 2002, we investigated the subjects who were confined to be newly diagnosed cases living in Chuncheon-si. The data was collected from the medical records from all the medical facilities located in Chuncheon-si. Results: The total number of cases of newly diagnosed stomach cancer during this period (2000-2002) was 186 (117 males and 69 females). The annual crude incidence rate of stomach cancer was estimated to be 37.0 per 100,000 persons overall, and 47.0 and 27.2 in the males and females, respectively. The annual age standardized incidence rate for the Korean population was 33.7 per 100,000 persons overall, and 42.2 and 25.1 for the males and females, respectively. The major symptoms of stomach cancer patients were epigastric pain (61.8%) and weight loss (31.2%). The proportion of early gastric cancer was 34.9% (60 among 172 persons) of the cases of stomach cancer. 64 patients (74%) were H. pylori positive. Conclusions: We report here on the estimated incidence rate of the stomach cancer and the characteristics of the stomach cancer patients in Chuncheon-si during 2000-2002. This study has generated basic epidemiologic data to identify the effect of H. pylori eradication on the future incidence rate of stomach cancer.(Korean J Med 73:368-374, 2007)