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단일 3차 의료 기관의 약물 유발 아나필락시스 발생 현황
문일주 ( Il Joo Moon ),박혜정 ( Hye Jung Park ),김성렬 ( Sung Ryeol Kim ),고범석 ( Beom Seok Koh ),임동우 ( Dong Woo Leem ),박경희 ( Kyung Hee Park ),이재현 ( Jae Hyun Lee ),박중원 ( Jung Won Park ) 대한내과학회 2015 대한내과학회지 Vol.88 No.3
Background/Aims: Drug-induced anaphylaxis (DIA) is a severe, acute, and potentially life-threatening condition. In Korea, only a few well-documented cases of DIA have been described. Therefore, the aim of this study was to investigate the clinical characteristics, causes, and management of DIA in a single Korean medical institute. Methods: This was a retrospective medical record review of all DIA patients who visited the in-patient, out-patient, and emergency departments of our hospital from January 1 2006 to October 30 2013. Results: Among 605 cases of anaphylaxis, 167 were drug-induced. The culprit drugs were contrast agents (43 cases, 25.7%), antibiotics (38, 22.8%), non-steroidal anti-inflammatory drugs (35, 21.0%), anti-cancer drugs (22, 13.2%), parenteral vitamins (9, 5.4%), ranitidine (6, 3.6%), and neuromuscular blockers (3, 1.8%). The most common organ-specific symptoms/signs were cardiovascular (74.3%), cutaneous (71.3%), respiratory (55.7%), and gastrointestinal manifestations (19.2%). In most cases, DIA was treated with antihistamines (77.2%) and systemic corticosteroids (76.5%); the use of epinephrine was considerably less frequent (35.3%). Conclusions: In our institution, contrast agents were the leading cause of DIA. Although epinephrine is the drug of choice in the treatment of acute anaphylaxis, fewer than 50% of the study patients received epinephrine to treat DIA. (Korean J Med 2015;88: 281-287)
한국산 검정콩 및 쌀보리 α - Amylase 저해물질의 이화학적 특성
문주석(Ju-Seok Moon),배영일(Young-Il Bae),심기환(Ki-Hwan Shim) 한국식품영양과학회 1998 한국식품영양과학회지 Vol.27 No.3
한국산 검정콩과 쌀보리로부터 분리ㆍ정제한 α-amylase 저해물질의 이화학적 특성을 조사한 결과는 다음과 같다. 즉 검정콩과 쌀보리 α-amylase 저해물질의 전처리 시간은 30분에 저해활성도가 가장 높았으며, 그 이상의 시간에서는 변화가 없었다. 최적 pH는 phosphate 및 Tris-HCl 완충액에서 7.0이였으며, pH 6~8에서 안정하였다. 검정콩과 쌀보리 α-amylase 저해물질의 열 안정성은 70℃에서 17분 동안 50%의 저해활성도를 유지하였다. 검정콩과 쌀보리 α-amylase 저해물질은 모두 porcine pancreatic과 human saliva의 α-amylase에 대해서 높은 저해활성도를 나타내었고, 모두 농도가 높을수록 저해활성도가 높았으며, 기질에 대해 비경쟁적으로 작용하였다, Pepsin 처리시 검정콩 쌀보리 α-amylase 저해물질은 각각 40, 30분, trypsin 처리시 각각 30, 50분 동안 50% 저해활성도를 유지하였다. 검정콩과 쌀보리 α-amylase 저해물질은 이온강도가 높을수록 저해활성도가 높았고, maltose의 영향은 70mM에서 최대 저해활성도를 보였으며, 그 이상의 농도에서는 변화가 없었다. 효소-저해물질 복합체가 형성된 후 maltose 첨가는 저해활성도에 영향을 미치지 않았으며, 무기염에 대한 영향은 칼륨 및 마그네슘에서 저해 활성도가 높았다. The physicochemical properties of the α-amylase inhibitors from black bean and naked barley in Korea were investigated. Preincubation time for maximum inhibition was 30 min and no activity change was seen after that time. Optimum pH of the α-amylase inhibitors from the black bean and naked barley was pH 7.0 and the inhibitory activities were stable in the range of pH 6.0-8.0 in both phosphate and Tris-HCl buffer solutions. Both inhibitors maintained more than 50% of activity after incubation for 17 min at 70℃. The inhibitors from the black bean and naked barley maintained more than 50% of activities after treatment for 40 min and 30 min with pepsin, and 30 min and 50 min with trypsin, respectively. Both inhibitors functioned via a noncompetitive mechanism and were active against porcine pancreatic and human salivary α-amylases. The activities of both inhibitors were linear for the ionic strength ranging from 0 to 0.9. The addition of 70 mM maltose to the reaction mixture caused a maximum increase in the relative activities of both inhibitors, but it did not affect the dissociation of the EI complex. The activities of both inhibitors were significantly enhanced by adding 1mM of K^+ or Mg^(2+).
Cellulase를 생산하는 Aspergillus niger MAN - 831과 Aspergillus wentii MAW - 538의 원형질체 형성 및 융합
박석규(Seok-Kyu Park),이상원(Sang-Won Lee),문일식(Il-Shik Moon),손봉수(Bong-Soo Shon),강성구(Seong-Koo Kang) 한국식품영양과학회 1995 한국식품영양과학회지 Vol.24 No.6
섬유성 biomass의 효율적 이용을 위하여 CMCase, avicelase 분비력이 높은 균주(A. wentii MAW-598)와 β-glucosidase(A. niger MAN-831) 분비력이 우수한 균주의 포자를 이용한 원형질체 형성ㆍ재생조건 및 융합을 실시하였다. 원형질체 형성 및 재생의 최적조건은 5일 성숙한 포자를 30㎍/㎖ 농도의 2-DG로 4시간 전배양하여 0.7M KCl 삼투압 안정제, novozyme(7.5㎎/㎖)+driselase(2.5㎎/㎖) 혼합효소로 5시간 반응시키는 것이 효과적이었다. 원형질체 융합 조건은 CaCl₂ 15mM, 25% PEG 4000, pH 6~7, 36℃에서 25~30분간 처리하였을 때 효과적이었으며, 융합빈도는 7.94×10(^-4)로 나타났다. FA-208 융합주는 친주에 비하여 각각 1.5, 1.3, 1.2배 효소활성의 증가를 나타내었다. For the effective utilization of cellulosic biomass, conidial protoplast fusion between Aspergillus niger MAN-831(β-glucosidase) and A. wentii MAW-538(CMCase and avicelase), which produced potently cellulolytic enzymes was carried out. Optimal conditions for formation and regeneration of protoplast were conidiospore age-5 days, 2-DG-30㎍/㎖, preincubation time-4 hours, osmotic stabilizer-0.7M KCl, novozyme(7.5㎎/㎖)+driselase(2.5㎎/㎖) and reaction time of enzyme-5 hours. Optimal conditions for protoplast fusion were obtained by treatment of protoplasts with 15mM CaCl₂ and 25% polyethylene glycol 4000(pH 6~7) as fusogenic agent at 36℃ for 25~30 minutes. The frequency was then 7.94×10^(-4). CMCase, avicelase and β-glucosidase activity of fusant F-208 strain was 1.5, 1.3, 1.2 times higher than those of parental strains, respectively.
박석규(Seok-Kyu Park),서권일(Kwon-Il Seo),최성희(Seong-Hee Choi),문주석(Ju-Seok Moon),이영환(Young-Hwan Lee) 한국식품영양과학회 2000 한국식품영양과학회지 Vol.29 No.2
시판되는 전통 한식된장의 품질을 규격화하기 위하여 일반성분, 아미노산, 유기산 및 지방산 조성을 조사하였다. 시판 된장의 수분, 조단백질, 조지방, 적정산도(0.1 N NaOH 소비 mL수), 산가 및 염도는 각각 평균 54.7%, 13.8%, 8.0%, 14.4 mL, 45.7 mg/g 및 11.8%였다. 아미노산성 질소의 함량은 평균 345.3 mg%로서 207.6~451.8mg%의 범위로 시료간에 1.1~2.2배 이상 차이를 나타내는 경우도 있었다. Hunter 색차계의 L(명도), a(적색도), b(황색도)값은 각각 평균 37.4, +9.7, +21.3이었으며, 수용성 및 지용성 물질은 흡광도로 각각 평균 2.58, 0.38로서 전자가 후자보다 평균 7.1배 이상 높았다. 유리 및 구성아미노산의 총 함량은 각각 평균 3.81, 9.72%였으며, 시료간에 1.1~3.7배와 1.1~2.0배의 차이가 나타났다. 가장 많은 아미노산은 glutamic acid로서 각각 0.57, 1.24%였으며, 가장 적은 아미노산은 각각 arginine(0.03%)과 cystine(0.21%)였다. 유기산은 lactic acid(평균 0.34%)가 가장 많았는데 시료간에 0.15~0.86%의 범위로 큰 차이를 나타내었으며, 다음으로는 malic 및 citric acid의 순으로 많았다. 총 지방산 중에 linoleic acid의 비율(평균 52.17%)이 가장 높았으며, 불포화 지방산은 평균 83.89%를 차지하였고, 다가불포지방산의 비율은 평균 61.18%를 차지하였으며 시료간에 51.52~64.91%의 범위로 차이를 많이 나타내었다. To standardize quality characteristics of commercial doenjang prepared by traditional method, general components, organic acids, amino acids and fatty acid composition were investigated. Moisture, crude protein, crude lipid, titratable acidity (expressed as milliliter of 0.1 N NaOH), acid value and salinity were 54.7%, 13.8%, 8.0%, 14.4 mL, 45.7 mg/g and 11.8%, respectively. The content of amino type nitrogen was 345.3 mg% (w/w) in the range of 207.6 to 443.5 mg% being 1.1~2.2-fold for all samples. Average value of Hunter color for L (lightness), a (redness) and b (yellowness) were 37.4, +9.7 and +21.3, respectively. Browning index value (expressed as optical density at 425 nm) of water-soluble compound (2.58) was above 7.1 times higher than that of the water-insoluble compound (0.38). Total contents of free and total amino acid were 3.81 and 9.72%, respectively, and then the former (1.1~3.7 times) was more different in all samples tested than that of the latter (1.1~2.0 times). Among amino acids, glutamic acid was abundant and its content of free and total amino acids was 0.57 and 1.24%, respectively. Of organic acids, lactic acid was the most abundant being 0.34% (average) and ranged from 0.15 to 0.86%. Linoleic acid (52.17%, as area%) was the highest content of the total fatty acids. Unsaturated and polyunsaturated fatty acids were 83.89 and 61.18%, respectively. Polyunsaturated fatty acid was markedly different among all samples and ranged from 51.52 to 64.91%.
꾸지뽕(Cudrania tricuspidata) 민간요법에 의한 약물유해반응 2예: 전격성 간염 및 급성 전신성 발진성 농포증
고범석 ( Beom Seok Koh ),박혜정 ( Hye Jung Park ),김성렬 ( Sung Ryeol Kim ),문일주 ( Il Joo Moon ),임동우 ( Dong Woo Leem ),박경희 ( Kyung Hee Park ),이재현 ( Jae Hyun Lee ),박중원 ( Jung Won Park ) 대한천식알레르기학회 2014 Allergy Asthma & Respiratory Disease Vol.2 No.5
Cudrania tricuspidata is a deciduous tree belonging to the Moraceae plant, which has been widely used as a folk remedy or health supplements in the Asian countries including Korea. As far as we know, side effects from taking the extract of C. tricuspidata has not yet been reported. We reviewed the electronic medical records of 2 patients who had adverse drug reactions to C. tricuspidata. The first case was a 30-year-old woman without a specific medical history. She was admitted with a 2-week history of jaundice and dyspepsia after taking extract of C. tricuspidata for 3 days. Initial laboratory findings were as follows: aspartate aminotransferase, 364 IU/L; alanine aminotransferase, 574 IU/L; total bilirubin, 36.3 mg/dL; and direct bilirubin, 18.3 mg/dL. She was conservatively treated for liver and renal failure while awaiting liver transplantation. However, she was expired due to combined pneumonia and progressed hepatic and renal failure. The second case was a 42-year-old woman who has chronic urticaria without other medical history. She was admitted with a 3-month history of whole body rash with small pustular vesicle after taking extract of C. tricuspidata. She was treated with intravenous steroids and antihistamines. Skin lesions were improved after 1 week. Here, we report 2 cases of adverse drug reaction to C. tricuspidata. It should be considered that C. tricuspidata ingestion could cause severe adverse drug reactions such as liver failure and acute generalized exanthematous pustulosis.(Allergy Asthma Respir Dis 2014;2:387-390)