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고지방 식이와 일반사료를 섭취한 랫드에서 미생탕의 항비만 효과
류재면(Jae Myun Ryu),이태희(Tae Hee Lee),서임권(Im Kwon Seo),이승호(Seung Ho Lee),장용훈(Young Hun Chang),김윤배(Yun-Bae Kim),황석연(Seock-Yeon Hwang) 한국독성학회 2006 Toxicological Research Vol.22 No.4
Misaengtang (MST), a formula of Korean herbal medicines, has been used as a weight-controlling recipe. We have investigated two experiment of body weight regulation by MST in rats. i) The anti-obesity effect of MTS on a high fat diet-induced obesity, male Sprague-Dawley rats were fed with a high-fat diet containing 30% in the absence or presence of MST (0.3, 1 or 3%) or a reference orlistat (0.05%) for 6 weeks. ii) weight-decrease effect of MST on normal diet, same animal were fed with a normal diet in the absence or presence of MST (3%) for 6 weeks. And the body weights, daily feed and water consumptions, organ weights, fat weights serum biochemistry were measured. In both experiments, MST and orlistat did not affect the body weight gain. But orlistat significantly increased the feed and water consumptions, leading to low-feed efficiency, and orlistat markedly reduced abdominal, paratesticular and perirenal fat weights, although increased the kidney weights. In MST, low dose (0.3%) of MST decreased the perirenal fat and increased the kidney weights in rats fed HFD, and MST 3% decreased the abdominal fat weights in rats fed normal diet. In addition, Orlistat caused changes in parameters of hepatotoxicity (AST and glucose), nephrotoxicity (BUN and B/C ratio) and lipid metabolism (HDL and triglycerides). In comparison, MST decreased AST, ALP and ALT, the hepatotoxicity markers, and somewhat improved the hepatic fatty degeneration. Taken together, it is suggested that MST does not exert anti-obesity activity as well as remarkably direct effects, but MST may be potentially benefit for dietary cure and exercise-cure of obesity.
1,2-Dimethylhydrazine에 의해 유발된 Colonic Aberrant Crypt Foci에 대한 마늘추출물의 암예방효과
김태명(Tae Myoung Kim),류재면(Jae Myun Ryu),권현정(Hyun Jung Kwon),황인국(In Guk Hwang),반정옥(Jung Ok Ban),정헌상(Heon Sang Jeong),홍진태(Jin Tae Hong),김대중(Dae Joong Kim) 한국독성학회 2007 Toxicological Research Vol.23 No.2
Garlic (Allium sativum L.) with the food supplement material and medicine was used traditionally in Asia and Europe. Epidemiological studies revealed that the intake of garlic reduced incidences of various cancer including digestive system. The present study was designed to investigate the effect of garlic ethanol extract on the development of colonic aberrant crypt foci (ACF) induced by 1,2-dimethylhydrazine (DMH) in male F344 rats. Five-week-old rats were given four times for two weeks to subcutaneous injections by DMH (30 ㎎/㎏ body weight) to induce ACF. The animals were divided into groups that fed diet containing garlic ethanol extract at five different doses (0.1, 0.2, 0.5, 2, 5%), respectively, animals were evaluated for the total number of ACF and total aberrant crypts (AC) per colon detected from methylene blue-stained rat colon. ACF were formed in animals in DMH-treated group. The feeding suppressed potently the appearance ACF in the colon of rats. Especially, fed diet containing garlic ethanol extract at intermediate dose (0.5%) significantly reduced the number of ACF and AC per colon (p < 0.05). Garlic ethanol extract inhibited DMH-induced overexpression of Activator Protein-1 (AP-1) and β-catenin genes related to cell proliferation that also upregulated the expression of p21Waf1/Cip1 mRNA, a cell cycle-regulating gene. These results suggested that garlic ethanol extract may inhibit ACF formation, β-catenin gene as the early preneoplastic marker of malignant potential in the process of colon carcinogenesis.
사람 대장암 세포주에서 Diallyl Disulfide의 세포증식억제 및 Apoptosis 유도 효과
김태명(Tae Myoung Kim),류재면(Jae Myun Ryu),권현정(Hyun Jung Kwon),우관식(Koan Sik Woo),정헌상(Heon Sang Jeong),홍진태(Jin Tae Hong),김대중(Dae Joong Kim) 한국독성학회 2005 Toxicological Research Vol.21 No.4
Epidemiological and laboratory studies provide insight into the anti-carcinogenic potential of garlic and its constituent compounds. Garlic is appealing as an anti-carcinogenic agent due to its ability to induce apoptosis in vitro. Diallyl disulfide (DADS) is one of the major components of garlic that used to determine inhibition of cell proliferation and induced apoptosis in human colon cell lines. In this study, human colorectal cancer cell lines (LOVO, HCT-116, SW-480) were exposed to DADS. The inhibitory effects of DADS dose level more than 50 μM in the cell viability of all cell lines. Cell growth activity inhibits of human colon cancer cell lines. The inhibitory effects of DADS dose level more than AFG₁5~50 μM in the cell growth using MTT assay. We found that DADS may have the apoptosis action (chromatin condensation, DNA fragmentation) using DAPI staining and increased the expression of caspase-3 at the dose level more than 100 μM, decreased the expression level of β- catenin at dose dependent in the western blotting. We suggest that DADS may have a potential candidate as cancer chemopreventive agents.
황석연(Seock-Yeon Hwang),권운(Woon Kwon),채희열(Hee-Youl Chai),조영민(Young-Min Cho),이남진(Nam Jin Lee),류재면(Jae Myun Ryu),신지순(Ji Soon Sin),김태명(Tae Myung Kim),조정희(Jung-Hee Cho),장자영(Ja Young Jang),박정휘(Jung-Hui Park) 한국실험동물학회 2004 Laboratory Animal Research Vol.20 No.3
The purpose of this study was to confirm the safety of the water extract of Mori folium single (MFS) or mixed (MFM) compound. Male Sprague-Dawley rats were orally administered with MFS or MFM at dose levels of 0.5, 1.0 or 2.0 g/㎏/day for 4 weeks. As results, there were no significant differences in the body weight gain between vehicle control and MFS or MFM-treated rats. Also, significant changes in daily feed intake and water consumption were not observed during the experimental period. In hematological analysis, there was a trend of decrease in prothrombin time, in contrast to a slight delay in activated partial thromboplastin time following MFS or MFM treatment. And white blood cells (WBC), especially lymphocytes, somewhat increased. In serum biochemical analysis, aspartate transaminase, alanine transaminase and alkaline phosphatase, related to hepatic injuries, decreased. Also, renal and pancreatic toxicity parameters such as blood urea nitrogen, creatinine and amylase decreased by MFS or MFM treatment. Interestingly, serum globulin fraction in total proteins increased, suggestive of an immunopotentiation effect, in accordance with the increase in WBC. There were no significant changes in organ weights, and no gross and histopathological lesions were observed. Taken all together, it is proposed that repeated treatment with the extract of Mori folium or its mixture, available in oriental clinics, may not exert considerable adverse effects, and that rather protect against tissue injuries and enhance immune functions.
황석연(Seock-Yeon Hwang),권운(Woon Kwon),채희열(Hee-Youl Chai),조영민(Young-Min Cho),이남진(Nam Jin Lee),류재면(Jae Myun Ryu),신지순(Ji Soon Sin),김태명(Tae Myung Kim),조정희(Jung-Hee Cho),김은주(Eun Ju Kim),박정휘(Jung-Hui Park),강종 한국실험동물학회 2004 Laboratory Animal Research Vol.20 No.3
Four-week repeated-dose toxicity study was performed to confirm the safety of the water extract of Mori radicis cortex single (MRCS) or mixed (MRCM) compound. Male Sprague-Dawley rats were orally administered with MRCS or MRCM at doses of 0.5, 1.0 or 2.0 g/㎏/day for 28 days. In the results, there were no significant differences in the body weight gain between vehicle control and MRCS or MRCM treatment groups. Also, no significant changes in daily feed intake and water consumption were observed throughout the experimental period. In hematological analysis, there was a trend of increases in red blood cells at 0.5 and 1.0 g/㎏ of MRCM and in hemoglobin at 0.5 g/㎏ of MRCM, although such changes were in normal ranges. In addition, white blood cells, especially neutrophils, slightly increased, without statistical significance, following treatment with MRCS or MRCM. Interestingly, serum biochemical parameters including aspartate transaminase and alanine transaminase, related to hepatic injuries, decreased at all doses after 28-day treatment with MRCS or MRCM, suggestive of protective effects against tissue damage. No significant changes in organ weights were observed, in accordance with normal features in gross and microscopic findings. Taken together, it is suggested that repeated treatment with the extract of Mori radicis cortex or its mixed compound, available in oriental clinics, may not exert considerable side effects.
황석연(Seock-Yeon Hwang),권운(Woon Kwon),채희열(Hee-Youl Chai),조영민(Young-Min Cho),류재면(Jae Myun Ryu),김동규(Dong Kyu Kim),신지순(Ji Soon Sin),김태명(Tae Kyung Kim),조정희(Jung-Hee Cho),신선희(Sunhee Shin),박정휘(Jung-Hui Park) 한국실험동물학회 2004 Laboratory Animal Research Vol.20 No.3
Four-week repeated-dose toxicity of Kamiguibitang was investigated in rats. Male Sprague-Dawley rats were orally administered with Kamiguibitang at doses of 200, 800, 1,600 or 3,200 ㎎/㎏/day or its vehicle for 28 days. There were no significant differences in the body weight gain between vehicle control and Kamiguibitang-treated groups. Significant changes in daily feed intake and water consumption were not observed throughout the experimental period. There were trends of increase in platelets and white blood cells, in parallel with increases in serum globulin level and spleen weight, suggestive of inflammatory response and/or immune enhancement. Serum parameters of hepatic and renal injuries, such as aspartate transaminase, alanine transaminase, alkaline phosphatase, cholesterol, triglyceride, creatinine, phosphorus, calcium, sodium and potassium, also increased at low doses (200-800 ㎎/㎏) of Kamiguibitang, although the levels were suppressed at high doses (1,600-3,200 ㎎/㎏). However, no gross and histopathological lesions were seen at all doses. Based on the results, no observed adverse effect level (NOAEL) of Kamiguibitang was found to be lower than 200 ㎎/㎏, which is comparable with clinical dose (100 ㎎/㎏) in human. In spite of the relatively-low NOAEL, it is suggested that repeated treatment with Kamiguibitang may not exert considerable adverse effects, as inferred from that major hematological and blood biochemical changes were results of pharmacological effectiveness on immunomodulation, and that no histopathological lesions were exerted up to 32 folds of clinical dose (3,200 ㎎/㎏),