http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Oligonucleotide Microarray와 cDNA Microarray를 이용한 위암조직의 대단위 유전자 발현 비교
정광화,김정규,노지헌,은정우,배현진,이석형,박원상,유남진,이정용,남석우 대한약학회 2007 약학회지 Vol.51 No.3
Gastric cancer is one of the most comon malignancies in Korea, but the predominant molecular event under-lying gastric carcinogenesis remain unknown. Recently, DNA microaray technology has enabled the comprehensive anal-ysis of gene expression level, and as such has yielded great insight into the molecular nature of cancer. However, despitethe powerful approach of this techniques, the technical artifacts and/or bias in applied array platform limited the liability ofsuch as olignucleotide microaray and cDNA microaray, to identify gastric cancer related large-scale molecular signatureof the same human specimens. When thirty sets of matched human gastric cancer and normal tissues subjected to oli-gonucleotide microaray, total 623 genes were resulted as differently expresed genes in gastric cancer compared to normaltissues, and 252 genes for cDNA microaray analysis. In addition, forty three outlier genes which reflect the characteristicexpression signature of gastric cancer beyond array platform and analytical protocol was recapitulated from two differentexpression profile. In conclusion, we were able to identify robust large-scale molecular changes in gastric cancer by applyingKeywords . cDNA microaray, oligonucleotide microaray, gastric cancer
진재호,조우연,노지헌,이상기 한국운동생리학회 2020 운동과학 Vol.29 No.4
PURPOSE: Proprotein Convertase Subtilisin/Kexin type 9 (PCSK9) is a pivotal regulator of low lipoprotein-cholesterol (LDL-C) and LDL receptor (LDLR) metabolism, and the interest in PCSK9 has increased in cardiovascular diseases. Exercise reduces blood LDL-C via PCSK9-LDLR pathway in the liver and the vasculature. However, the mechanism of exercise-induced inhibition of PCSK is unclear. The aim of this review is to describe the role of exercise on PCSK9-LDLR axis in cardiovascular diseases. METHODS: This study review 34 previous studies focusing on the effect of exercise on PCSK9 in the human and animal. RESULTS: The effects of exercise and lifestyle intervention on hepatic and circulating PCSK9 are controversial. However, exercise consistently increases hepatic LDLR, and inhibits atherosclerosis via suppression of PCSK9 and LOX-1 in atherosclerotic region. CONCLUSIONS: Even though experimental data are still very limited, exercise training can improves blood LDL-C via inhibition of PCSK9 and enhancement of LDLR in liver and vasculature. The study of exercise on PCSK9 are urgently needed.
대단위 발현유전체학 분석을 통한 휘발성 유기화합물에 노출된 랫트 간조직에서의 특징적 분자 신호 해독
김정규(Jeong Kyu Kim),노지헌(Ji Heon Noh),정광화(Kwang Hwa Jung),은정우(Jung Woo Eun),배현진(Hyun Jin Bae),사홍건(Hong Jian Xie),김민규(Min Gyu Kim),장영균(Young Gyoon Chang),박원상(Won Sang Park),이정용(Jung Young Lee),남석우(Suk Wo 한국환경독성학회 2011 한국독성학회 심포지움 및 학술발표회 Vol.2011 No.10
유전체발현 변화 분석을 통한 랫트 간조직에서 다환방향족탄화수소의 위해성을 예측할 수 있는 특이생체지표군의 확립
정광화(Kwang Hwa Jung),노지헌(Ji Heon Noh),은정우(Jung Woo Eun),김정규(Jeong Kyu Kim),배현진(Hyun Jin Bae),사홍건(Hong jian Xie),장영균(Young Gyoon Chang),김민규(Min Gyu Kim),박원상(Won Sang Park),이정용(Jung Young Lee),남석우(Suk Wo 한국환경독성학회 2011 한국독성학회 심포지움 및 학술발표회 Vol.2011 No.10
진재호 ( Jaeho Jin ),조우연 ( Wooyeon Jo ),노지헌 ( Ji Heon Noh ),이상기 ( Sang Ki Lee ) 대한운동사협회 2022 대한운동사협회 운동사대회자료집 Vol.2022 No.-
Proprotein Convertase Subtilisin/Kexin type 9 (PCSK9) is a pivotal regulator of low lipoprotein-cholesterol (LDL-C) metabolism, and the interest in PCSK9 has increased in cardiovascular diseases. PURPOSE: Exercise reduces blood LDL-C via PCSK9-LDLR pathway in liver. However, the mechanism of exercise-induced inhibition of PCSK is not unclear. The aim of this review is to describe the role of exercise on PCSK9-LDLR axis in cardiovascular diseases. METHODS: This study reviews 34 previous studies focusing on the effect on exercise on PCSK9 in the human and animal. RESULTS: The effects of exercise and lifestyle intervention on hepatic and circulating PCSK9 are controversial. However, exercise consistently increases hepatic LDLR, and inhibits atherosclerosis via suppression of PCSK9 and LOX-1 in atherosclerotic region. CONCLUSIONS: Even though experimental data are still very limited, exercise training can improves blood LDL-C via inhibition of PCSK9 and enhancement of LDLR in liver and vasculature. The study of exercise on PCSK9 are urgently needed.