가토(家兎)의 간장(肝臟) 및 신장(腎臟)에서의 색소분필(色素分泌) 과정(過程)에 관(關)하여

남숙현,Nahm, Sook-Hyun 대한생리학회 1971 대한생리학회지 Vol.5 No.2

That different mechanisms are involved in the secretory processes by the liver and the kidney of various dyes has been indicated by Sporter (1959), Kim and Hong (1963). Andrews (1958). suggested that a striking difference in the dye-secretory mechanism existed even in the same organ from species to species. Hence, the attempt has been made to study in the rabbit the secretory processes by the live. and the kidney of either phenol red (PSP), bromsulfalein (BSP) or green in the presence of Na-acetate, Na-taurocholate, P-Aminohippurate (PAH) or Benemid. In 37 rabbits, weighing about 2kg., anesthetized with ether, a dye was administered in such 8 manner that the plasma concentration was kept at a relatively constant level throughout the whole experimental period. Hepatic bile sad urine samples were quantitatively collected through the canulae which were previously inserted into the common bile duct (with the cystic duct ligated) and the urinary bladder, respectively, while arterial samples were taken from a femoral artery. After 50 min from the onset of dye administration, these samples were obtained every 10 mit for a period of 40 min. This was followed by the administration of either Na-acetate, Na-tauro-cholate, PAH or Benemid with a repetition of the same sample collecting procedures just stated. The results may be summarized as follows: 1) Na·acetate augmented urinary clearance of PSP by nearly 300 per cent, but lowered urinary BSP clearance by about 50 per cent. It enhanced biliary BSP clearance by 40% and had no effect on biliary psp clearance. 2) Na-taurocholate lowered biliary and urinary clearance of PSP by 10 per cent and 30 per cent respectively, and had no effect on both biliary and urinary clearance of BSP. 3) PAH lowered both biliary and urinary excretion of BSP and PSP, while it lowered the biliary excretion of indocyanine green which was excreted only in the bile. 4) Benemid suppressed BSP excretion by the liver and the kidney. 5) raper chromatographic analysis of PSP and of BSP in the bile and urine samples gave the following results: a) PSP Ivas excreted in the urine and bile only in free forms, and no modification in the excretory pattern was brought about by Na-taurocholate. b) BSP was excreted in the urine in 4 different conjugated froms and in the bile in both 3 different conjugated forms and in a free form. Na-taurocholate modified the excretory pattern of the urinary BSP.

원저 : 슬관절 자극이 횡격신경 및 흡식중추신경에 미치는 영향

조동일 ( Dong Ill Cho ),한희철 ( Hee Chul Han ),남숙현 ( Sook Hyun Nahm ) 대한결핵 및 호흡기학회 1993 Tuberculosis and Respiratory Diseases Vol.40 No.6

GABA가 동통자극에 대한 흑질 뉴론의 반응에 미치는 영향

남숙현,이배환 고려대학교 의과대학 1990 고려대 의대 잡지 Vol.27 No.2

The present study was conducted to determine what GABAergic receptor IS involved in substantia nigra(SN) pain modulation mechanism. After the spontaneous activity of SN neurons was recorded, the responses of neurons to noxious peripheral stimulation and to iontophoretically applied GABA, SR95531, baclofen, and naloxone were observed. Results are as follows : 1. GABA inhibited the activities of S N neurons responding to noxious stimulation. 2. SR95531 increased the spontaneous activities of SN neurons and disinhibited the effect of GABA. 3. Baclofen had little effect on the activities SN neurons. 4. Naloxone tended to inhibit neuronal activities but did not correspond to effects of GABAergic drugs. These results suggest that GABAA receptor is involved in SN pain modulation mechanism mediated by GABA and this mechanism is not identical to opiate system.

인체 생리기능의 계절적 변동에 관한 연구

남숙현 고려대학교 의과대학 1973 고려대 의대 잡지 Vol.10 No.2

This experimental was carried out to investigate the existence or absence of adaptation to seasonal changes exhibited by men living in temperate climates for period of one year. The percentage of total body fat were calculated from skinfold thickness and urinary 17-ketosteroid excretion were measured by Rapaport's method every season for the same subject in 60 healthy Koreans, Skinfold thichness at five sites, namely, back waist arm, abdomen and knee were measured by means of a Lange caliper. The findings obtained were as follows; 1. The course of increase in total body fat was identical to that of body growth from spring to winter season in a teen-agers of between 10 and 14 years. The mean total fat for one year were 17.4% of body weight in boys and 23.8% in girls. 2. Total body fat showed a decrease in a twenties, namely, 13.3% in male and 23.0% in female. subject. 3. In a thirties, the total body fat was predominantly increased to 26% of body weight, while negligible in male. 4. The skinfold thickness on all sites were greater in females than males at the same age. Although they showed different pattern. 5. Seasonal fluctuation has been observed in total body fat and subcutaneous fat thickness after twenties, rising during winter and early spring falling in the summer. 6. The regional differences of the subcutaneous fat thickness was greater in male than that of female. neater in male 7. Urinary 17-ketosteroid excreation showed a continuous increase in absolute value as age increased, and falling in the summer in male. while any demonstrable changes in female. Theories concerning the mechanism of the adaptation to seasonal changes were reviewed for the purpose of explanation of the results obtained. From the above findings, it may be speculated that seasonal fluctuation of fat and cortical hormone is an adaptation to cold, the increased fat providing extra thermal insulation. but it might also be related to the pattern of activity and food intake in excess of energy expenditure.

이개신경-미주신경 반사에 대한 전기생리학적 고찰

남숙현 최신의학사 1986 最新醫學 Vol.29 No.7

각종 Benzene 및 Phenol계 물질이 담즙 배설에 미치는 영향

남숙현 우석대학교 의과대학 1970 우석의대잡지 Vol.7 No.2

The effect of 2,4-dinitrophenol and its chemically related compounds on biliary secretion were investigated in the anesthetized dogs. The results are summarized as follows; 1. All compounds possessing Phenol-rings tested in this experiment with exception of amino Phenol produced a marked increase in bile flow with concomitant decrease in concentration of chelate. Of these compounds, 2,4-dinitrophenol was the most potent in increasing the bile flow, picric acid in contrast, was the least potent. 2. The compounds possessing benzene-ring also produced the increase in bile flow. However their potency was somewhat lower than that of compounds possessing phenol-ring, among these compounds, chlorbenzene was the most potent agent in increasing bile flow. From the above findings, it is suggested that to produce the increase in bile flow by these compounds it is necessary to have two nitro groups on the same molecule and they have to be in positions 2 and 4 on the benzene-ring.

Noradrenaline이 근방추의 흥분성에 미치는 영향

현정,남숙현,홍승길 고려대학교 의과대학 1984 고려대 의대 잡지 Vol.21 No.1

The present experiment was done to determine the effects of noradrenaline on the muscle spindle in cats. The reaction site was determined by recording the changes of impulses from group Ia and group Ⅱ muscular afferents of peripheral sensory nerves and dorsal roots. The results are as follows: 1. 36 group Ia muscular afferents were recorded according to extracellular recording and 5 out of 36 showed enhancement of impulse discharge after 1-2 ㎍ noradrenaline injection, 8 showed decrease and 20 showed initial enhancement followed by decrement, but 3 gave no response at all. 2. The administration of KCI solution did not give nay influences to impulse changes of group Ia muscular afferents activated by noradrenaline, however,the injection of bradykinin diminished the decreasing effect of noradrenaline. 3. A small amount of noradrenaline slightly increased the systemic blood pressure but this kind of blood pressure changes was indifferent to the change of the excitability of group Ia muscular afferents from muscle spindle. However, a large amount of noradrenaline increased the blood pressure about 50 ㎜Hg above normal level which influenced the excitatory effect of the muscle spindle. 4. 22 out of 25 group Ⅱ muscular afferents did not show any responses to noradrenaline. Summerizing above results, it could be assumed that the initial excitatory response of group Ia muscular afferents following the injection of noradrenaline was not attributed to vasoconstriction but to direct effects on muscle stretch receptor, and its depressive response were due to the asphyxia resulted from vasoconstriction. And also, it could be suggested that noradrenaline acts on equator region of the muscle spindle, that is, the distribution area of group Ia muscular afferents.

체성-심장반사에 의한 혈압변화가 심장 미주신경의 임펄스발사에 미치는 영향

정시전,홍승길,남숙현 고려대학교 의과대학 1985 고려대 의대 잡지 Vol.22 No.1

Somato-cardiac and somato-vagal reflex responses were studied by recording simultaneously the change of the arterial blood pressure and impulse discharge of the cardiac vagal afferents following electrical excitation of radial nerve in nembutal and alpha-chloralose anesthetized cats. The stimulation of the radial nerve has been done in group Ⅱ, Ⅲ, and Ⅳ fibers and the results are summarized as follows; 1. The stimulation of group Ⅱ radial afferents lowered arterial blood pressure and diminished the impulse discharge of the cardiac vagal afferents. 2. Simultaneous activation of group Ⅱ and Ⅲ of radial nerve resulted lowering blood piessure and diminishing impulse discharge of cardiac vagal afferents followed by immediate increase. 3. The electrical stimulation of group Ⅳ radial afferents increased arterial blood pressure and the impulse discharge of cardiac vagal afferents. To summarize above results, it was presumed that radial nerve, same as the other somatic nerve, has the effects on the cardiac function and especially group Ⅱ muscle afferents are related to lowering the arterial blood pressure. Also, ir was noticed that the change of impulse discharge of cardiac vagal afferents after electrical stimulation of radial nerve was the secondary effects of reflex reaction between the radial nerve and the heart.

화학적으로 활성화된 GroupⅢ와 GroupⅣ구심성 근신경의 Gamma Motoneuron에 대한 반사효과

방대홍,홍승길,남숙현 고려대학교 의과대학 1983 고려대 의대 잡지 Vol.20 No.3

In decerebrated cats the effects of fine muscle afferents (groups Ⅲ and Ⅳ) upon gamma motoneurons were studied. The efferent activity was exracellularly recorded from small filaments of ventral roots or from filaments of musole nerves. Fine muscle afferents were selectively activated by bradykinin, potassium and serotonin. For comparison, succinylcholine was administrated to activated muscle spindle afferents. Forty gastrocnemius-soleus gamma motoneurons were recorded. Thirty-six (90%) of them had a tonic background discharge in the absence of intentional stimulation. A high susceptibility to an increased activity in fine muscle efferents was found for the gamma motoneurons. Practically all neurons both to homonymous extensor and antagonistic flexor muscles responded with an excitation to at least one of the algesic substances applied. Only two out of fifteen gamma motoneurons responded to succinylcholine. Thus indicationg a weak convergence from muscle spindle afferents. Control experiments demonstrated that the responses to bradykinin and potassium are entirely due to the nervorus outflow from the gastrocnemius-soleus muscle. In contrast, serotonin influencing the gamma motoneurons has unknown additional sites of action. The results indicate that muscular group Ⅲ and/or group Ⅳ units activated by algesic substances evoke excitatory effects upon gamma motoneurons.

Radioimmuno assay of Carcinoembrionic Antigen

Nahm, Sook Hyun 고려대학교 의과대학 1978 고려대 의대 잡지 Vol.15 No.2

This report, in general, discussed the carcinoembrionic antigen (CEA) which plays the most useful role for monitoring cancer patients during the post therapeutic followup period. The CEA levels using radioimmunoassay (RIA) technique in 42 patients with various type of cancer were determined. It was found that 17 samples from the patients who had been under immunotherapy program with B.C.G. and/or levamisole along with other therapeutic modalities revealed no higher than normal range of CEA levels (1 to 5 ng/ml), while out of 25 non-immunotherapeutic patients 7 samples showed over 5ng/ml CEA levels.