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다운 증후군과 임신 합병증에서 임신 제 2삼분기 양수내 Activin A, Inhibin A 와 B 의 농도와 이들 비율의 의의
류상우 ( Sang Woo Rhu ),이종건 ( Jong Gun Lee ),김용욱 ( Yong Wook Kim ),이영 ( Young Lee ),신종철 ( Jong Chul Shin ),류영옥 ( Young Oak Lew ),나종구 ( Jong Gu Rha ),김수평 ( Soo Pynug Kim ) 대한산부인과학회 2004 Obstetrics & Gynecology Science Vol.47 No.6
Objective : To evaluate the amniotic fluid levels and each ratio of activin A, inhin A and B in Down`s syndrome and other complicated pregnancies. Methods : This study was performed in 71 women who had undergone a midtrimester amniocentesis with the clinical indications and whose pregnancy outcome was retropsectively determined. Ten Down`s syndrome, 15 complicated pregnancies including, preeclamsia, gestational diabetesis mellitus, preterm labor, intrauterine growth restriction (IUGR), and 46 noncomplicated pregnancies with normal chromosome were included in this study. Amniotic fluid activin A, inhibin A and B were measure using enzyme linked immunosorbent assays (ELISA). Statistical analysis was performed with Mann-Whitney U test and regression analysis. Results : There were significant positive correlation (r=0.277, p=0.011) between the ratio activin A/inhibin B level and maternal age and significant positive correlation (r=0.261, p=0.015) between maternal age and the ratio inhibin A/inhibin B level. There were also significant positive correlation (r=0.202, p=0.045) between gestational weeks and inhibin A levels and significant positive correlation (r=0.474, p<0.001_ between gestational weeks and inhibin B levels. Amniotic fluid inhibin A and inhibin B levels were significantly (p<0.05) decreased in Down`s syndrome compared with the normal chromosomal groups but there was no difference in the ratio activin A/inhibin A and in the ratio activin A/inhibin B between these groups. The amniotic fluid levels of activin A, inhibins (A and B), each ratio of complicated pregnancies groups with normal chromosome was not significantly different from those of uncomplicated pregnancies with normal chromosome. Conclusion : This study revealed that amniotic inhibin levels were significantly decreased in Down`s sundrome. But, activin A and each ratio were unchanged. The results suggest that activin A may by relatively decreased in each case of Down`s syndrome.
이귀세라 ( Gui Se Ra Lee ),이종건 ( Jong Kun Lee ),한운섭 ( Woon Sup Han ),이영 ( Young Lee ),김사진 ( Sa Jin Kim ),나종구 ( Jong Gu Rha ),김수평 ( Soo Pyung Kim ),남궁성은 ( Seong Eun Namkoong ) 대한산부인과학회 2003 Obstetrics & Gynecology Science Vol.46 No.3
Objective : To determine the expression of vascular endothelial growth factor (VEGF), platelet-derived growth factor (PDGF) and intercellular adhesion molecule (ICAM-1) in placenta from pregnancies complicated by severe preeclampsia and normal pregnancies
김사진 ( Sa Jin Kim ),신종철 ( Jong Chul Shin ),윤철구 ( Chul Gu Yoon ),양용재 ( Yong Jae Yang ),이근호 ( Keun Hoo Lee ),박태철 ( Tae Chul Park ),나종구 ( Jong Gu Rha ),김수평 ( Soo Pyung Kim ),이희중 ( Hee Joong Lee ) 대한산부인과학회 2004 Obstetrics & Gynecology Science Vol.47 No.12
Objective : The purpose of this study was to compare the efficacy and the safety of two different dose regimens of intravaginal misoprostol for labor induction. Methods : Sixty-seven consenting women with maternal or fetal indication for labor and no prio
김연희 ( Yeun Hee Kim ),신종철 ( Jong Chul Shin ),이영 ( Young Lee ),박철훈 ( Cheol Hoon Park ),박인양 ( In Yang Park ),안현영 ( Hyun Young Ahn ),고현선 ( Hyun Sun Ko ),이연수 ( Youn Soo Lee ),나종구 ( Jong Gu Rha ) 대한주산의학회 2004 Perinatology Vol.15 No.4
Fetal vesicoallantoic cyst is extremely rare anomaly of umbilical cord. This disorder is thought to be a remnant of the extraembryonic portion of the allantois and incomplete obliteration of the vesico-allantoic lumen results in a wide spectrum of urachal anomalies. A 23-years-old primigravida was referred to our hospital at 18 weeks of gestation age because of fetal abdominal cystic mass in basal part of umbilicus. On the ultrasonographic examination, the cystic mass appeared to be in direct communication with the urinary bladder markedly distended. The cytogenetic study by amniocentesis showed normal 46, XY. The fetus was dead at 21 weeks of gestation age. The results of autopsy showed multiple anomalies. We report this rare case with review on similar anomalies of the allantois.
토끼 태아에서 표피성장인자 투여가 코티졸 , 티록신 , 프로락틴의 생성에 미치는 영향
김수평(Soo Pyung Kim),신종철(Jong Chul Shin),이종건(Jong Kun Lee),김용욱(Yong Wook Kim),변태섭(Tae Sup Byun),신재인(Jae In Shin),이종승(Chong Seong Yi),나종구(Jong Gu Rha) 대한산부인과학회 1998 Obstetrics & Gynecology Science Vol.41 No.12
Respiratory distress syndrome (RDS) is a major cause of death in premature neonates, and it is caused by the failure of morphological and biochemical lung maturation (synthesis and secretion of lung surfactant). It is known that cortisol, thyroxine, prolactin, epidermal growth factor (EGF), and estrogen accelerate the lung maturation. Cortisol and thyroxine are currently used in the antenatal treatment for the prevention of RDS in premature neonates. In order to evaluate the effect of EGF on the levels of cortsol, thyroxine, and prolactin, this study was undertaken. Phosphate buffered saline (PBS) with and without EGF was directly injected into the 25 days gestational fetus in uterus. Blood was collected for the measurement of cortisol, thyroxine, and prolactin one day or two days after the injection. Body weights and lung weights were also measured. The results were as follows: 1. There was no significant difference in body weights and lung weights between PBS-treated group(control group) and EGF-treated poup(experimental group), 24 hours and 48 hours after the injection. 2. 24 hours after the injection, the levels of cortisol were significantly inaeased in the EGF-treated group compared with those in the PBS-treated group. However 48 hours after the injection, there was no significant difference in the levels of cortisol between the two groups. The levels of thyroxine and prolactin in the EGF-treated group did not significantly differ from those in the PBS-treated group 24 hours and 48 hours after the injection. In conclusion, in vivo, the synthesis of cortisol may be affected by EGF treatment, which suggests that the action of EGF for lung maturation may be partially mediated by the increased endogenous levels of cortisol.
배양된 제대정맥내피세포에서 중증자간전증환자 혈청이 내피세포 생육 및 Endothelin-1합성에 미치는 영향
김용욱(Yong Yook Kim),나욱렬(Wook Yull Na),이종건(Jong Kun Lee),이영(Young Lee),백은정(Eun Jeong Baik),나종구(Jong Gu Rha),김사진(Sa Jin Kim),이형근(Hyung Gun Lee),신종철(Jong Chul Shin),김수평(Soo Pyung Kim) 대한산부인과학회 2000 Obstetrics & Gynecology Science Vol.43 No.7
Objectives: In order to assess the effects of sera from severe preeclamptic patients on endothelial cell viability in vitro and endothelin-1 synthesis in cultured human umbilical vein endothelial cells.Methods: The cultured human umbilical vein endothelial cells were incubated with media containing 10% sera from women with either preeclamptic patients or normal pregnancies for 24 hours or 48 hours. After then, their viability was measured by colorimetric MTT{3-(4,5-dimethylthiazol-2yl)2,5-diphenyl tetrazolium bromide} assay and their production of endothelin-1 was measured. We also measured the serum levels of endothelin-1 level in sera obtained from the normal and severe preeclamptic pregnancies. Results: The calorimetric MTT assay revealed that after 24 hours, the absorbances in the media treated with normal pregnancies and severe preeclampsia sera were 0.0718±0.0078 and 0.0837±0.0129, respectively and after 48 hours, they were 0.1133±0.0103 and 0.1268±0.0186, respectively. Serum obtained from severe preeclampsia did not affect endothelial cell viability. 2. The serum mean levels of endothelin-1 in normal and severe preeclamptic pregnancies were 22.66±8.6 fmol/ml and 48.98±25.27 fmol/ml. The mean level in preeclamptic sera was significantly higher than that of normal pregnant women. (P<0.05) 3. After 24 hours, the mean amount of endothelin-1 stimulated by normal pregnant and severe preeclamptic sera were 37.52±18.41 fmol/ml and 97.58±53.64 fmol/ml, respectively. The mean amount of endothelin-1 in preeclamptic sera-treated cells was significantly higher than that of normal pregnant sera-treated cells. (P<0.05). Conclusion: The sera from severe preeclamptic women do not affect cell viability but act selectively on specific activation of their function such as endothelin-1 production. And it is necessary that the identification and isolation of the putative serum factor(s) will be performed to resolve the pathogenesis in future.
OVCAR-3와 SKOV-3 난소암 세포주에서 Flow Cytometry를 이용한 Apoptosis와 p53 단백의 측정
윤주희 ( Yoon Joo Hee ),최운만 ( Choi Woon Min ),조윤성 ( Jo Yun Seong ),나종구 ( Rha Jong Gu ),한구택 ( Han Gu Taeg ) 대한산부인과학회 2003 Obstetrics & Gynecology Science Vol.46 No.7
Objective : Taxol (paclitaxel)-induced apoptosis was studied to understand their biological mechanism correlated with the expression of p53 in the SKOV-3 and OVCAR-3 ovarian cancer cell lines. Materials and Methods : The SKOV-3 and OVCAR-3 cell lines were cultured in RPMI 1640 medium without taxol (control group) and with taxol for 24 h and 48 h (experimental group). After harvest, the cells were stained with annexin V-FITC (fluorescein isothiocyanate) and anti-cytokeratin antibodies (clone CAM5.2 and clone MNF116). They were washed and stained with p53 antibody. After then the secondary antibodies, i.e., FITC- or phycoerythrin (PE)-conjugated goal anti-mouse (GAM) immunoglobulin G (GAM IgG-FITC or GAM IgG-PE) were added in the cells and they were incubated in the dark. DNA of these cells were stained sequentially with propidium iodide (PI). Standard FASCcan equipped with a 499 ㎚ single laser was used for the analysis of these cells. Results : Both of SKOV-3 and OVCAR-3 cell lines were arrested in the G_2M phase after treatment of taxol, suggesting that these cells would eventually enter into the stage of cell death. Fractions of negative cytokeratin and positive annexin V and amount of sub-G_0G_1 fraction indicative of apototic fractions were lower in the SKOV-3 cell line compared with that in OVCAR-3 cell line, probably as a result of lower sensitivity of SKOV-3 cell line to the taxol. p53 expression were not detected in SKOV-3 cell line. On the basis of observed findings in SKOV-3 cell line and findings of high expressions of p53 regardless of taxol treatment, no increase in their expressions according to culturing time, and gradual increases in sub-G_0G_1 fractions and in fractions of negative cytokeratin and positive annexin V indicative of apoptosis in OVCAR-3 cell line, we concluded that the expression of p53 would not be associated with cell cycle changes and the arrest in the G_2M pahse but associated with the appearance of apotosis. Conclusion : Our results suggest that flow cytometric detection of the apoptotic fractions would be an effective, fast, and accurate method for the chemosensitivity test in tumor cells before the administration of anti-cancer drugs in gynecologic cancer patients.