Curcuma longae Radix, Phellinus linteus 및 Scutellariae Radix 혼합추출물의 $A{\beta}$ (25-35) 유도 배양신경세포독성 및 마우스기억손상 억제효과

김주연,정하연,반주연,유재국,배기환,성연희,Kim, Joo-Youn,Jeong, Ha-Yeon,Ban, Ju-Yeon,Yoo, Jae-Kuk,Bae, Ki-Hwan,Seong, Yeon-Hee 한국약용작물학회 2009 한국약용작물학회지 Vol.17 No.6

The present study investigated an ethanol extract (HS0608) of a mixture of three medicinal plants of Curcuma longae radix, Phellinus linteus, and Scutellariae radix for possible neuroprotective effects on neurotoxicity induced by amyloid $\beta$ protein ($A{\beta}$) (25-35) in cultured rat cortical neurons and antidementia activity in mice. Exposure of cultured cortical neurons to $10\;{\mu}M$ $A{\beta}$ (25-35) for 36 h induced neuronal apoptotic death. At $1-50\;{\mu}g/m{\ell}$, HS0608 inhibited neuronal death, elevation of intracellular calcium concentration ($[Ca^{2+}]_i$), and generation of reactive oxygen species (ROS) induced by $A{\beta}$ (25-35) in primary cultures of rat cortical neurons. Memory loss induced by intracerebroventricular injection of ICR mice with 15 nmol $A{\beta}$ (25-35) was inhibited by chronic treatment with HS0608 (25, 50 and 100 mg/kg, p.o. for 7 days) as measured by a passive avoidance test. From these results, we suggest that the antidementia effect of HS0608 is due to its neuroprotective effect against $A{\beta}$ (25-35)-induced neurotoxicity and that HS0608 may have a therapeutic role in preventing the progression of Alzheimer's disease.

기체주입노즐의 내부유동양식의 구분

김주연,이상용,Kim, Joo-Youn,Lee, Sang-Yong 대한기계학회 2000 大韓機械學會論文集B Vol.24 No.2

An experimental study was conducted to examine the internal flow patterns inside the mixing chamber of effervescent atomizers. The mixing chamber has the rectangular cross section ($8mm{\times}2mm$) and made of transparent acrylic plate for flow visualization. The parameters tested were the air/liquid ratio (ALR), injection. pressure, and the nozzle orifice diameter. Three different flow regimes were observed; bubbly, annular, and intermittent flows. In the bubbly flow regime, the discharged mixture was disintegrated into drops through the bubble expansion and the ligament breakup. On the other hand, in the annular flow regime, the liquid annulus was disintegrated into small drops by the aerodynamic interaction between the phases due to the high relative velocities between the gas and the liquid. In the intermittent flow regime, the bubble-expansion/ligament-disintegration mode and the annulus-disintegration mode appeared alternatively. The correlations representing the transition criteria between the two-phase flow patterns within the mixing chamber were proposed based on the drift-flux models.

Moutan Cortex Extract Inhibits Amyloid ${\beta}$ Protein (25-35)-induced Neurotoxicity in Cultured Rat Cortical Neurons

김주연,주현수,반주연,송경식,성연희,Kim, Joo-Youn,Ju, Hyun-Soo,Ban, Ju-Yeon,Song, Kyung-Sik,Seong, Yeon-Hee The Korean Society of Medicinal Crop Science 2008 한국약용작물학회지 Vol.16 No.6

Moutan cortex, the root bark of Paeonia suffruticosa Andrews (Paeoniaceae), has pharmacological effects such as anti-inflammatory, antiallergic, analgesic and antioxidant activities. We investigated a methanol extract of Moutan cortex for neuroprotective effects on neurotoxicity induced by amyloid ${\beta}$ protein ($A{\beta}$) (25-35) in cultured rat cortical neurons. Exposure of cultured cortical neurons to $10\;{\mu}M\;A{\beta}$ (25-35) for 24 h induced neuronal apoptotic death. Moutan cortex inhibited $10\;{\mu}M\;A{\beta}$ (25-35)-induced neuronal cell death at 30 and $50\;{\mu}g/m{\ell}$, which was measured by a 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl-tetrazolium bromide (MTT) assay and Hoechst 33342 staining. Moutan cortex inhibited $10\;{\mu}M\;A{\beta}$ (25-35)-induced elevation of intracellular calcium concentration ($[Ca^{2+}]_i$), and generation of reactive oxygen species (ROS) which were measured by fluorescent dyes. Moutan cortex also inhibited glutamate release into medium induced by $10\;{\mu}M\;A{\beta}$ (25-35), which was measured by HPLC. These results suggest that Moutan cortex prevents $A{\beta}$ (25-35)-induced neuronal cell damage by interfering with the increase of $[Ca^{2+}]_i$, and then inhibiting glutamate release and ROS generation. Moutan cortex may have a therapeutic role in preventing the progression of Alzheimer's disease.

입경 측정을 위한 영상 처리 기법의 개선

김주연,추정호,이상용,Kim, Joo Youn,Chu, Jeong Ho,Lee, Sang Yong 대한기계학회 1998 大韓機械學會論文集B Vol.22 No.8

In the present work, the image processing technique for measurement of drop sizes has been improved. Firstly, the local processing concept was adopted in addition to the global processing technique to take account of non-uniformity of the illumination intensity ; thereby, basically, the measurement error can be reduced. Also, the unfocussed image of drops can be eliminated more precisely since the elimination process is based on the local normalized contrast. Secondly the algorithms to process the partially detected or overlapped drop images and the non-spherical drop images were developed. Finally, the improved algorithm was tested by using an artificially prepared image-frame, where the partial or overlapped particles and the non-spherical particles are mixed with the normal spherical ones (with their true size-distributions known a priori). The results showed that both the recognition rate of the number of particles and the measurement accuracy were improved prominently.

김종하의 행보를 통해 본 서울올림픽 개최

김주연 ( Kim Joo-youn ) 한국체육사학회 2021 체육사학회지 Vol.26 No.2

1988년 서울올림픽은 한국 스포츠의 성장 동력으로서 상징적인 의미를 지니고 있다. 본 연구는 서울올림픽 개최 당시에 대한체육회장이었던 김종하(金宗河)의 행보를 살펴보는데 목적을 두었으며, 이를 위해서 구술 자료 및 회고록과 월간 『체육』 등을 참고하였다. 김종하는 고등학교 때부터 송구(핸드볼) 선수로 활동하였고, 육군사관학교 재학 중에 전국체육대회 우승 등의 체육 활동을 하면서 선배인 전두환과 인연을 맺었다. 그는 제29대 대한체육회장으로 취임한 이후에 경기인 출신 최초의 대한체육회장으로서 상근직 업무를 실행하였고, 서울아시아경기대회와 서울올림픽 개최에 기여하였다. 그러나 정권 교체와 대회 중의 불상사로 인해서 서울올림픽 이후의 활동은 한정되었다. 이러한 김종하의 행보를 통하여 제5공화국 체육 정책의 지향점과 그로 인한 명암을 짚어 볼 수 있었다. 이제까지는 주로 서울올림픽의 대외적인 성과에 이목을 집중하였지만, 앞으로는 대내적인 과정의 의미를 되새길 수 있는 다양한 인물들에 관한 연구가 진행되어야 하겠다. The 1988 Seoul Olympic Games have a symbolic meaning in the development of Korean sports. Therefore, it is necessary to look at the activities of Kim Jong-Ha (1934-2019), the 29th president of the KSOC at the time of the Seoul Olympics. Kim Jong-Ha's background was a handball player. Kim Jong-Ha, who served as the 29th president of the KSOC. For this purpose, this study referred to Kim Jong-Ha's oral materials, memoirs, and monthly magazine sports. Kim Jong-ha played as a handball player in high school, and went to the Korea Military Academy. As the 29th president of the Korea Sports Association, he remained faithful to his duties as a full-time sports chairman. Kim Jong-Ha's activities take a look at the direction of the 5th Republic's sports policy. Although attention has been focused on the achievements of the Seoul Olympics, research on various people is needed to find the meaning of hosting the Seoul Olympics in the future.

대학 수학 북한이탈주민을 위한 경제 분야 외래어 학술 전문어휘 선정에 관한 연구

김주연 ( Kim Joo-youn ) 한민족어문학회 2018 韓民族語文學 Vol.0 No.80

본고는 북한이탈주민을 대상으로 남한 대학에서 수학할 때 필수적으로 익혀야할 경제분야의 학술 전문어휘 가운데 외래어를 중심으로 살펴보았다. 학문 목적 북한이탈주민이 대학 수학 중 가장 어려워하는 영역 중의 하나인 전공 관련 학술 전문어휘 가운데 외래어에 초점을 두고 살펴보았다. 우선은 설문조사를 실시하여 학문 목적 북한이탈주민을 대상으로 전공 분야의 학술전문어휘 학습 현황을 살펴보고자 하였다. 그리고 경제 분야의 학술 전문어휘 가운데 주요 외래어 목록을 선정하여 선정된 어휘목록에 대한 북한 대응어와 뜻풀이를 살펴봄으로써 효율적인 어휘 교육에 활용할 수 있는 기초 자료를 마련하고자 하였다. 이를 위하여 경제 분야의 학술 전문어휘 가운데 외래어 목록을 구성하고 고빈도 어휘목록을 선정하여 이에 대응하는 북한 대응어를 살펴보았다. 북한이탈주민의 대학 수학에 필요한 경제 분야 학술 전문어휘 가운데 외래어 목록과 북한 대응어 제공이 대학 수학 능력 향상에 일조하기를 기대한다. This article is intended to study loanwords used in the academic vocabulary of North Korean defectors who major in economic fields in South Korean universities. This study focuses on the academic loan words which North Korean defectors feel are the most difficult to understand in their fields of study. Through questionnaires, we considered the status of learning loan words that are used for academic purposes by North Korean defectors. This study defines words that are part of academic vocabularies and also constructs vocabulary lists that are relevant to the economic and academic fields in order to determine which words are used most frequently. We provide basic data that can be used for effective vocabulary education by examining both the North Korean vocabulary and the meaning of the words on the selected vocabulary list. The list includes important loan words used in academics, focusing on words used within academics, and particularly within the economic fields. The purpose of this study will help North Korean defectors settle in the Republic of Korea through providing a list of essential academic loan words.

韓國人日本語學習者의 文末助詞 'よ'의 인토네이션 學習에 관한 考察

김주연(Kim Joo Youn,金?衍) 일본어문학회 2015 일본어문학 Vol.71 No.-

The report has it that we are going to study a effective learning of intonation on the basis of sentence-final particles 'YO' which changes according to a various expressive will if speaker. The dialogue of using phonetic learning is an important learning sector which is obstructed by emotional misunderstanding caused by a delicate change of intonation, so we can't communicate well. It is useful to study a effective learning strategy of intonation learning, which is going to establish a specific learning method on the basis it. According to the study, we get the next result on the research of which learning strategy is effective about sentence-final particles YO's intonation learning. It is influenced by 'accent learning strategy' and 'pronunciation learning strategy' among two methods the former is more powerful than the latter. But it is a next task to find out which method is efficient to intonation learning in detail among these strategies. We think it is going to establish foundations to develop a specific way of education throughout on study of meaningful learning strategy, even we don't predict a exact relation between intonation learning and learning strategy just only this analysis.

동아시아 무도의 체육 및 스포츠 변용: 유도에 내재된 서구의 영향을 중심으로

김주연 ( Joo Youn Kim ),김은정 ( Eun Jung Kim ) 한국체육사학회 2016 체육사학회지 Vol.21 No.2

동아시아 무도는 전쟁기술에서 체육 및 스포츠를 거쳐 올림픽 종목으로 자리 잡았고, 세계화라는 명목 하에 변화를 거듭하고 있다. 특히 서구의 영향을 받아서 동아시아 무도가 체육 및 스포츠로 변용되었는데, 그 역사적인 과정을 조명하기 위해서 유도에 있어 영국과 미국의 영향을 사례로 살펴보았다. 유도는 메이지 유신을 통해 전쟁기술인 유술(柔術)에서 신체교육 차원의 유도(柔道)로 변화되었고, 제2차 세계대전을 기점으로 하여 스포츠 유도(Judo)로 탈바꿈되었다. 기존에 유도의 변화와 관련된 연구들은 대부분 가노지고로와 일본 유도계의 활동에 초점을 맞춰왔지만, 실제로 그 변화에는 영국과 미국을 중심으로 한 서구의 영향이 적지 않았다. 오늘날 동아시아 무도는 ‘무도스포츠’ 또는 ‘스포츠무도’라고 불리고 있는데, 이제 그 속에 포함된 무도와 스포츠 간의 정체성 혼란에 대해서 심도 있는 논의가 필요한 시점이다. East Asian martial arts has changed continuously from military tactics to physical education and sports, even olympic sports. Under the name of globalization, East Asian martial arts proceed without stopping change to be global sport. This research was influenced by Western influence of the East Asian history to illuminate a process, guided by making case with the impact of the British and the United States on to examine. Judo transformed from originally jujitsu(柔術) as military tactics, and changed the Meiji Restoration induction of judo(柔道) as physical education level, after then the second world war as sport judo(Judo). Most studies been focused on these changes by Gigoro Kano and the other Japanese’effort. But actually these changes contributed largely by England and the United States. A historical example by Western Influence may require to anguish a identity of East Asian martial arts as current named ‘martial art sport’or‘sport martial art’.

SCR 시스템의 요소용액 미립화 및 분해반응 예측

김주연(Joo Youn Kim),두병만(Byung Man Doo) 한국자동차공학회 2004 한국자동차공학회 춘 추계 학술대회 논문집 Vol.- No.-

The spray-induced mixing characteristics and thermal decomposition of aqueous urea solution into ammonia have been studied to design optimum sizes and geometries of the mixing chamber in SCR (Selective Catalytic Reduction) system. The cold flow tests about the urea-injection nozzle were performed to clarify the parameters f spray mixing characteristics such as mean diameter and velocity of drops and spray width determined from the interactions between incoming air and injected drops.<br/> Discrete particle model in Fluent code was adopted to simulate spray-induced mixing process and the experimental results on the spray characteristics were used as input data of numerical calculations. The simulation results on the spray-induced mixing were verified by comparing the spray width extracted from the digital images with the simulated tracks of injected drops. The single kinetic model was adopted to predict thermal decomposition of urea solution into ammonia and solved simultaneously along with the verified spray model. The hot air generator was designed to match the flow rate ad temperature of the exhaust gas of the real engines. The measured ammonia productions in the hot air generator were compared with the numerical predictions and the comparison results showed good agreements. Finally, we concluded that the design capabilities for sizing optimum mixing chamber were established.

국내 학습장애 연구에 대한 최근 동향 및 중재특성 (학술지를 중심으로)

김주연 ( Kim Joo-youn ) 대구대학교 특수교육재활과학연구소 2020 특수교육재활과학연구 Vol.59 No.4

본 연구는 2014년부터 2020년까지의 학습장애 관련 연구를 실시한 학술지를 중심으로 분석하여 학습장애의 연구동향을 분석하는데 목적이 있다. 총 165편의 학습장애 연구 논문을 대상으로 연구방법, 연구대상, 연구주제, 선별방법, 중재, 진단평가에 대해 분석하였다. 연구결과 첫째, 연구방법으로는 문헌연구, 실험연구, 조사연구, 인식 및 기타, 검사 도구 개발 연구 순으로 나타났다. 연구대상을 분석한 결과 초등학생을 대상으로 한 연구가 많았다. 연구 대상의 하위영역별로 살펴보면 대부분의 연구 제목이 학습장애로 명시된 연구들이 많았다. 연구주제를 살펴보면 인식 및 동향에 관련된 연구들이 많았다. 둘째, 국내 학습장애 중재 연구의 특성을 살펴보면 지능검사, 기초학습기능검사, 학업성취도 결과, 한국학습장애학회의 진단기준을 가장 많이 사용한 것으로 알 수 있었다. 중재전략을 살펴보면 학습장애, 읽기장애, 수학 장애, 쓰기 장애를 대상으로 한 논문으로 많았으며 실험연구 중에서 중재전략을 살펴보면 읽기영역에 관련된 연구가 많이 이루어졌다. 진단평가를 살펴보면 대부분이 중재전략에 맞춰서 효과성을 보기위한 도구를 직접 제작하는 경우가 많이 나타났다. 그 결과 학습 장애에 대한 연구는 꾸준히 이루어지고 있지만 도구개발, 사회성 연구가 부족함을 보이고 있으며 초등학생 대상연구로 편중되어 있음을 알 수 있다. 기존의 연구들은 중재전략에서 단일성 목표만을 달성하기 위한 연구가 많았으며 학습장애의 하위특성별로 나누어진 연구가 아니라 융합적인 연구가 필요함을 알 수 있다. 특히나 과학적이면서 자세하게 다룰 수 있는 질적인 지표에 이루어진 연구가 이루어져야하는 필요성에 대해 언급하였다. The purpose of this study is to analyze the research trends of learning disabilities by focusing on the journals that conducted research on learning disabilities from 2014 to 2020. A total of 165 research papers on learning disability were analyzed on research methods, subjects, research subjects, screening methods, arbitration and diagnostic evaluation. The results of the research showed that first, the methods of research were written in the order of literature research, experimental research, investigation research, recognition and other research, and inspection tool development research. According to an analysis of research targets, there were many studies on primary school subjects. If you look at the sub-area of the study, there were many studies whose titles were mostly specified as learning disabilities. Looking at the research topics, there were many studies related to perception and trends. Second, if you look at the characteristics of the domestic study disorder arbitration research, you can see that the intelligence test, basic learning function test, academic achievement result, and the diagnosis criteria of the Korean Association of Learning Scholarship were used the most. If you look at the arbitration strategy, there were many papers for learning disabilities, reading disorders, math problems, and writing disorders, and if you look at the arbitration strategy during experimental research, many studies related to reading areas have been conducted. If you look at the diagnostic evaluation, most of them often produce their own tools to see their effectiveness in line with the arbitration strategy. As a result, research on learning disabilities has been carried out steadily, but there is a lack of tool development and social studies, and it is biased toward research on elementary school students. Existing studies have shown that there have been many studies in the arbitration strategy to achieve only one goal, and convergence studies are needed, not those divided by the sub-characteristics of learning disabilities. In particular, he mentioned the need for research to be done on qualitative indicators that are scientific and detailed.