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진행성 대장암 환자에서 FOLFOX4 복합화학약물 치료의 실패 후 2차 요법으로 FOLFIRI 복합화학약물 치료의 효과와 안전성
김재현 ( Jae Hyun Kim ),박선자 ( Seun Ja Park ),박무인 ( Moo In Park ),문원 ( Won Moon ),김성은 ( Sung Eun Kim ),구기환 ( Ki Hwan Ku ),송성은 ( Sung Eun Song ),김제훈 ( Je Hun Kim ) 대한소화기학회 2014 대한소화기학회지 Vol.63 No.1
Background/Aims: The incidence of colorectal cancer has been increasing every year in Korea. Irinotecan- or oxaliplatin-based regimens including biologic agents are known to be effective in patients with advanced colorectal cancer. But in practice, FOLFOX (combination of oxaliplatin, 5-fluorouracil, and leucovorin) or FOLFIRI (combination of irinotecan, 5-fluorouracil, and leucovorin) regimens without biologic agents are more commonly used in Korea due to of the high costs of biologic agents. The aim of this study was to evaluate the efficacy and toxicity of FOLFIRI following FOLFOX4 in patients with advanced colorectal cancer. Methods: A total of 54 patients with advanced colorectal cancer who were treated between May 2005 and May 2013 with FOLFOX4 as first-line chemotherapy and with FOLFIRI as second-line chemotherapy at Kosin University Gospel Hospital (Busan, Korea) were reviewed retrospectively. Results: A total of 54 patients received second-line FOLFIRI chemotherapy. Five patients (9.3%) had a partial response, 29 patients (53.7%) had a stable disease. The median overall survival was 8.90 months and the median time to progression was 4.33 months. Toxicities were tolerable. Conclusions: In a Korean population, FOLFIRI as second-line chemotherapy is effective and well tolerated in patients with advanced colorectal cancer after failure of FOLFOX4. Although the efficacy of FOLFIRI in this study was lower than that of second-line FOLFIRI with biologic agents, these results can help in the formulation of a treatment strategy for financially troubled patients. (Korean J Gastroenterol 2014;63:18-24)
넙치(Paralichthys olivaceus)육의 사후 조기 변화 3. 치사 방법이 ATP 관련 물질과 유산 함량의 변화에 미치는 영향
김재현(Jae-Hyun KIM),이남걸(Nam-Geoul LEE),김육용(Yuck-Yong KIM),이근우(Keun-Woo LEE),조영제(Young-Je CHO) 군산대학교 수산과학연구소 1994 군산대학교 수산과학연구소 연구논문집 Vol.2 No.-
To clarify the effects of killing methods on biochemical changes of plaice, Paralichthys olivaceus muscle at early period after death. cultured plaices were killed by the following four different methods: 1. spiking at the brain instantly. 2. letting them to die in the air 3. dipping in sea water including anesthetic. 4. electrifying in sea water. Immediately after death. the changes in ATP and its related compounds. ATP breakdown. and IMP or lactate accumulation rates of muscle during storage at 5℃ were studied. ATP in samples killed by letting and electrifying were decomposed more rapidly than spiking and dipping samples. The rate constant of ATP breakdown were O.429h 1 for samples killed by electrifying. 0.224h-¹ for letting samples, 0-195h-¹ for spiking samples, and O.167h-¹ for dipping samples. The maximum speed and content of IMP or lactate accumulation were showed in samples killed by electrifying among the all killing methods. The rate constant of lactate accumulation were 2.256h I for samples killed by electrifying. 1.123h ¹ for letting samples. O.534h ¹ for spiking samples, and 0.526h-¹ for dipping samples. From the results above, it was revealed that electrifying in sea water could accelerate ATP breakdown and accumulation of IMP or lactate among the all killing methods. The other hand, dipping in sea water including anesthetic delayed those changes.
자가면역 갑상선염을 동반한 비장의 염증성 가성 종양 1예
류제헌 ( Je Hyun Ryu ),이경해 ( Kyung Hae Lee ),김재현 ( Jae Hyun Kim ),박선만 ( Sun Man Park ),김영진 ( Young Jin Kim ),계세협 ( Sea Hyub Kae ),이진 ( Jin Lee ) 대한내과학회 2017 대한내과학회지 Vol.92 No.4
염증성 가성 종양은 다양한 염증세포의 침윤과 섬유성 간질로 구성된 양성 질환으로 폐에 가장 많이 발생하며, 간, 뇌, 신경계, 위장관, 비뇨기계, 결합조직 등 다양한 장기에서 발생할 수 있지만, 비장에 발생하는 염증성 가성 종양은 매우 드물다. 감염, 실질내 출혈 또는 자가면역 질환 등이 병인으로 추정되지만 아직 확실하게 밝혀진 바는 없으며, 림프종, 전이성 병변 등 악성 종양과 감별이 어려워서 수술 전 진단이 어렵다. 간헐적인 복통을 보여 내원한 54세 여자에서 시행한 복부 초음파 검사에서 3년 전에 없었던 3 cm 크기의 비장 종괴를 발견하였다. 같이 시행한 혈액 검사에서 갑상선기능 검사에서 갑상선 기능저하증의 소견을 보였고, 항갑상선글로불린 항체와 항미크로솜 항체는 모두 양성이었으며, 갑상선 초음파 검사에서 갑상선은 미만성으로 크기가 증가되어 있었다. 수술을 시행하였고, 조직검사에서 방추형세포가 주로 관찰되며, 림프구, 형질세포, 조직구 등 만성 염증세포의 침윤이 관찰되어 염증성 가성 종양으로 확진하였다. 자가면역 갑상선염과 동반한 비장의 염증성 가성 종양을 경험하여 문헌고찰과 함께 보고하는 바이다. Inflammatory pseudotumor is a benign disease entity, which is histologically composed of inflammatory cells and fibrotic stroma. It is mainly found in the respiratory tract, but it has also been reported in the liver, central nervous system, soft tissues, urological system, and gastrointestinal tract. It is extremely rare in the spleen and there have been no cases of splenic inflammatory pseudotu-mor associated with autoimmune thyroiditis in Korea. The pathogenesis or etiology is unknown, but hypotheses include infection, autoimmunity, and parenchymal necrosis with hemorrhage. Because inflammatory pseudotumor may mimic malignant tumors on radiologic findings, pathologic confirmation is necessary to distinguish it from lymphoproliferative disorders of the spleen and oth-er malignant tumors. We report a case of inflammatory pseudotumor of the spleen associated with autoimmune thyroiditis in a pa-tient who complained of periumbilical pain. (Korean J Med 2017;92:406-410)
평면부 유리체절제술과 실리콘기름충전술을 시행한 눈에서 망막층 두께의 변화 분석
김재현(Jae Hyun Kim),윤요셉(Yo Sep Yoon),우제문(Je Moon Woo),민정기(Jung Kee Min) 대한안과학회 2021 대한안과학회지 Vol.62 No.7
목적: 열공망막박리 및 안내이물 환자에서 유리체절제술과 실리콘기름충전술을 시행한 후 성공적으로 망막 재유착을 보인 환자에서 망막층 두께의 변화를 알아보고자 하였다. 대상과 방법: 유리체절제술과 실리콘기름 충전을 시행한 환자 28명 28안(열공망막박리 24안, 안내이물 4안)을 대상으로 후향적 연구를 진행하였다. 파장가변 빛간섭단층촬영기의 삼차원 광각모드를 사용하여 실리콘기름 충전 도중 및 제거 후 시점에서 망막전층, 망막신경섬유층 및 신경절세포-내망상층의 두께를 황반부 Early Treatment Diabetic Retinopathy Study subfield에서 측정했고, 정상 반대안과 차이를 비교 분석하였다. 결과: 실리콘기름 충전 기간 동안 망막전층 두께 감소에 비하여 망막신경섬유층과 신경절세포-내망상층의 경우 실리콘기름 유지 기간이 길어질수록 평균 두께 감소가 두드러졌다. 망막전층, 망막신경섬유층 및 신경절세포-내망상층의 두께는 실리콘기름 충전 중에 측정한 값보다 제거 후 및 정상 반대안을 측정한 값이 유의하게 크게 측정되었다. 결론: 실리콘기름 안구 내 충전술은 망막층 두께 변화를 유발할 수 있다. 실리콘기름의 안구 내 충전 기간이 길어질수록 내망막층의두께 감소를 더 유발할 수 있다. Purpose: To investigate changes in the retinal layer thickness in rhegmatogenous retinal detachment (RRD) and intraocular foreign body (IOFB) patients undergoing successful pars plana vitrectomy (PPV) with silicone oil tamponade. Methods: This retrospective study included 28 eyes of 28 patients (RRD: 24 patients; IOFB: 4 patients) that were successfully repaired with PPV with silicone oil tamponade. The thickness measurements of the total retina, retinal nerve fiber layer (RNFL), and ganglion cell-inner plexiform layer (GC-IPL) were performed with swept-source optical coherence tomography in nine Early Treatment Diabetic Retinopathy Study subfields, using the wide three-dimensional mode before and after silicone oil tamponade removal. The measurements were compared and differences were analyzed with respect to normal fellow eyes. Results: The RNFL and GC-IPL thickness measurements decreased remarkably as the silicone oil tamponade period progressed, compared with the thickness of the total retinal layer. The average thicknesses of the total retina, RNFL, and GC-IPL were significantly greater in eyes in which the silicone oil had been removed than in those in which the silicone oil remained. Conclusions: Silicone oil tamponade can change the thickness of the retina layer. The longer the silicone oil is tamponaded, the more significant the reduction in thickness of the inner retinal layer.
IoT 센서를 이용한 음압격리병동 및 일반병동 환경성능 비교 평가
김지희(Kim, Ji-Hi),김재현(Kim, Je-Hyun),성민기(Sung, Min-Kim) 한국건축친환경설비학회 2024 한국건축친환경설비학회 논문집 Vol.18 No.1
In this study, an Internet of Things (IoT) environmental sensor was developed to effectively manage indoor air quality in Negative Pressure Isolation Wards (NPIWs). Using this sensor, environmental performance data of both NPIWs and general patient rooms were analyzed. During the summer, humidity levels were consistently high in all rooms, while in the fall, humidity levels decreased by approximately 30% in Hospital A and 20% in Hospital B. Among the general patient rooms, multi-patient rooms exhibited elevated concentrations of CO₂. PM<SUB>2.5</SUB> concentrations were largely influenced by outdoor air, registering low values in most rooms. However, medical procedures or disinfection processes led to PM<SUB>2.5</SUB> concentrations within hospital rooms spiking to over 50 times the initial levels, taking about 4 hours to recover. The data acquired in this study is expected to serve as foundational information for the effective management of indoor air quality in NPIWs in the future.
압입하중-변위곡선 분석을 통한 폴리머 소재의 절삭표면상태 예측에 관한 연구
전은채(Eun-Chae Jeon),김재현(Jae-Hyun Kim),제태진(Tae-Jin Je) 한국기계가공학회 2011 한국기계가공학회지 Vol.10 No.4
UV imprinting process can manufacture high-functional optical components with low cost. If hard polymers can be used as transparent molds at this process, the cost will be much lower. However, there are limited researches to predict the machinability and the burr of hard polymers. Therefore, a new method to predict them by analyzing load-depth curves which can be obtained by the instrumented indentation test was developed in this study. The load-depth curve contains elastic deformation and plastic deformation simultaneously. The ratio of the plastic deformation over the sum of the two deformation is proportional to the ductility of materials which is one of the parameters of the machinability and the burr. The instrumented indentation tests were performed on the transparent molds of the hard polymers and the values of ratio were calculated. The machinability and the burr of three kinds of hard polymers were predicted by the ratio, and the prediction was in agreement with the experimental results from the machined surfaces of the three kinds of hard polymers.