조현병 스펙트럼 장애의 1년 유지 치료에서 클로자핀과 병용 치료제의 처방 양상 분석

김재원,김세현,장진혁,문선영,강태욱,김민아,권준수,Kim, Jaewon,Kim, Se Hyun,Jang, Jin-Hyeok,Moon, Sun-Young,Kang, Tae Uk,Kim, Minah,Kwon, Jun Soo 대한생물정신의학회 2021 생물정신의학 Vol.28 No.2

Objectives Clozapine is the most effective atypical antipsychotic agent for the treatment-resistant schizophrenia (TRS), however, only 40%-70% of TRS patients respond to clozapine. Moreover, TRS encompasses various symptom dimensions. Therefore, augmentation with other medications for clozapine is frequently applied. However, the prescription pattern of clozapine and combined medications in Korea is yet to be examined. This study aims to investigate the maintenance treatment pattern of clozapine and augmentation agents in one Korean tertiary hospital. Methods The patients with schizophrenia spectrum disorders under clozapine maintenance, defined as one-year clozapine continuation, were subjected for analysis. Medication data at one-year time-point after clozapine initiation was extracted and analyzed. Results Among total 2897 patients having clozapine prescription experience from January 2000 to December 2018, 1011 patients were on clozapine maintenance. The mean age of clozapine initiation was 30.2 ± 11.3 years, and the maintenance dose of clozapine was 217.8 ± 124.3 mg/day. Combination rate of antipsychotics, mood stabilizers, and antidepressants were 43.5%, 25.3%, 38.6%, respectively. Most frequently prescribed drugs in each category were aripiprazole, valproate, and sertraline. Olanzapine equivalent dose of combined antipsychotics was 10.4 ± 7.7 mg/day. Male patients were prescribed higher dose of combined antipsychotics and higher rate of antidepressants. Female patients had later onset of clozapine prescription. Patients with two or more combined antipsychotics were prescribed higher dose of clozapine and higher rate of antidepressants compared to patients with one combined antipsychotic. Conclusions Taken together, among the patients taking clozapine, a substantial rate of patients were under polypharmacy. The present findings based on the real-world prescription pattern could provide the valuable clinical information on the treatment of TRS-related conditions.

영어 접두사 out-과 e(x)-의 의미 확산에 대한 통시적 연구

김재원(Kim, Jaewon) 미래영어영문학회 2021 영어영문학 Vol.26 No.3

The purpose of this study is to examine the Germanic prefix out- and the Latin prefix e(x)- from the diachronic point of view. The two prefixes are heterogeneous, but are members of the parent language called the primitive Indo-European. From the Middle English period when the two prefixes coexisted, they became morphosemantic variations. To carry out the research in detail, the prefixes out- and e(x)- are divided into three forms: out-¹, out-², out-³ and e(x)-¹, e(x)-², e(x)-³. This study provides a comparative analysis of the prefixes out- and e(x)- and describes systematically their semantic diffusion process.

영상번역에서의 가독성 제고를 위한 전환번역 사례분석 연구

김재원(Kim Jaewon) 미래영어영문학회 2016 미래영어영문학회 학술대회 자료집 Vol.2016 No.12

Screen translation is carried out by the conveying meaning system through multiplex channels. Therefore it needs some translating methods to overcome the spatio-temporal restrictions and to lighten the cognitive load of the audience. The purpose of this research is to explore the effective switching strategies for translating movies and TV dramas from English into Korean. To begin with, we briefly review the main notions - readability, reduced translation, dynamic equivalence, shift - which provide a conceptual background for the systematic study of switching translation. Then, we study switching translation cases dividing into structural switching and conceptual switching. And in the latter case, various translations tactics such as generalization, specialization, substitution are introduced. Lastly, content relevant substitution, situational substitution and functional substitution are shown separately as substitution examples.

현장 응력조건에 따른 암석 투과도 특성 분석

김재원(Jaewon Kim),최준형(Junhyung Choi),최금봉(Keumbong Choe),심수민(Sumin Sim),이대성(Dae Sung Lee) 한국암반공학회 2017 터널과지하공간 Vol.27 No.1

본 연구는 유·가스 저류층의 암석 투과도 분석을 위해 다양한 층리를 가진 암석과 치밀사암(tight sandstone)을 이용하여 실제 현장의 응력조건을 고려한 암석 투과도를 연구하였다. 다양한 층리를 고려하기 위하여 수평/수직 층리(horizontal & vertical bedding) 및 층리가 존재하지 않는(non-bedding) 암석 시료를 사용하였으며, 균열이 존재하는 저류층의 암석 투과도를 연구하고자 인공균열을 생성시킨 치밀사암을 사용하였다. 실제 심도에서 암석이 받는 유효응력(effective stress)을 암석 투과도 실험에 구현하기 위해 삼축 압력셀을 이용하여 심도별 암석투과도 실험을 수행하였다. 암석 시료에 가해지는 유효응력 및 공극압으로 구분하여 응력조건을 고려하였다. 실험은 두 가지 형태의 응력 해방조건을 고려하여 실시하였다. 또한 암석 투과도 개선을 위한 균열 지지제(proppant)를 주입해 응력조건별 균열 암석 투과도 변화 양상을 분석하였다. 실험결과, 층리 암석투과도에서는 층리가 존재하지 않는 암석 시료가 응력에 가장 민감하게 반응하였으며, 균열 암석 투과도에서는 균열 지지제주입 유무에 따라 암석 투과도 값이 크게 달라지는 것을 확인 할 수 있었다. In this study, bedding rock permeability was measured using Berea sandstones with three different beddings. The fracture permeability was also measured using tight sandstone with two different fracture regimes considering in-situ stress conditions. The Berea sandstone with vertical, horizontal and non-bedding was used to analyze evolution of permeability upon in-situ stress conditions. In order to describe applied effective stress around rock in underground, the triaxial pressure cell & hydrostatic pressure cell was designed and permeability experiments were performed with controlled axial and confining pressures. The measurement of permeability was conducted by increasing and decreasing effective stress. The permeability of non-bedding rock sample is the most sensitive to applied stress conditions and fracture permeability of tight sandstone increases with fracture treatment with proppant.

금 코팅 구리나노와이어 기반 바이오 센서

김재원(Jaewon Kim),김동관(Dongkwan Kim),방준혁(Junhyuk Bang),고승환(Seung Hwan Ko) 대한기계학회 2021 대한기계학회 춘추학술대회 Vol.2021 No.11

Copper nanowire has mortal disadvantages in the oxidation and inadequacy of biological compatibility, which sometimes exceed its advantages like low-cost characteristics, excellent mechanical and electrical properties. In this paper, we introduce an innovative biocompatible and oxidation-resistant Cu–Au core–shell nanowire. The Cu–Au core–shell nanowire reveals stable electrical property against oxidation under the severe environment of 80% relative humidity and 80 °C temperature. Moreover, to verify appropriateness for the biomedical application, the improved biocompatibility and chemical stability are examined. Even after the harsh environment test, Cu-Au core-shell nanowire electrode utilized as electrocardiogram (ECG) and electro-myogram (EMG) sensors indicates remarkable biocompatibility and oxidation-resistance. The Cu–Au core–shell nanowire can contribute to cost-effective and stable diverse wearable electronics applications.

한국사회에서 누가 윤리적 소비를 하는가?

김재원(Jaewon Kim),김민지(Minzee Kim),최샛별(SetByol Choi) 한국문화사회학회 2023 문화와 사회 Vol.31 No.3

Ethical consumerism has been regarded as an alternative consumption to overcome environmental and social problems plaguing our planet today. Therefore many researchers have paid lots of attention on ethical consumerism to find the way to facilitate it. However research that tried to identify the characteristics of ethical consumers or the factors influencing ethical consumption behavior have been reporting conflicting results, causing a lot of confusion in exploring the ethical consumption landscape. This study aims to provide more comprehensive understanding of ethical consumerism in Korea examining various aspects of age groups. To this end this study used 2018 Korea General Social Survey Data, which the sample size is 645. Empirical results indicate that ethical consumers in Korea is mainly 2·3·40s. However women in their 20s showed an active interest in ethical consumption while men in their 20s showed relatively low interest in it. Furthermore this study reaffirms that respondent socioeconomic factors have a great influence on intention to practice ethical consumption, confirming the emergence of ‘eco-habitus’ in Korea society. Moreover the political characteristics of ethical consumers showed complex patterns. This study closely reconsiders the characteristics of ethical consumers that have been reported very inconsistently and examines various aspects of each group within the field of ethical consumerism.

시스템에어컨 미세먼지센서 적용을통한 공기질개선

김재원(JaeWon Kim),김희식(Hie Sik Kim) 대한기계학회 2018 대한기계학회 춘추학술대회 Vol.2018 No.5

시스템에어컨은 집에서나 혹은 큰 오피스빌딩에서 많이 설치된 공조설비이다. 이들은 상업용으로 냉난방을 하기위한 시스템으로 많은 보급을 해오고 있다. 하지만 공기질을 제어하기 위해서 자체적으로만 순환 하는데에 많은 제약조건이 있다. 이러한 날라 다니는 먼지가 사무공간과 같은 곳에서 떠다니는 것은 업무하는데 근로자들에게는 좋지않은 영향을 줄 수 있다. 그래서 이러한 공기에 떠다니는 미세입자들은 제어를 통해서 관리가 되어야 한다. 기존설비와는 다르게, 본 논문에서는 시스템에어컨에 미세먼지센서를 적용하여 공기질을 개선 할 수 있는 연구를 진행했다. 미립자를 인지하는 LED, Photo 소자를 이용하여 이들의 데이터를 시스템에어컨에 적용시키고 관리할 수 있는 알고리즘을 적용하였으며, 이를 통해 실제 얼만큼 개선되었는지 현장에 설치하여 그 효과를 확인할 수 있는 연구를 진행하였다. System air condition is widely spread for general household or large office buildings. It is shuttled down as commercial products for heating and cooling air conditioning system for many buildings. However, it has limitation of air dust quality control in the self indoor circulated air from air condition. Airborne dust is very harmful for the workers in the office. So, this airborne micro dust should be controlled. Unlike a stereo type air cleaner, I applied sensor for research to air cleaning system which had included five-steps equipment improve the air quality by using LED device and photo element. The largest dust particles in PM10, PM2.5 or higher is to remove harmful indoor dust. In this proceed, I apply to particle dust sensor to the system air condition. I have come up with algorithms that improve the quality of particle dust air. And installed equipment system is how much improve to get air purification condition and effect on indoor comfort air.

묵비권과 변호인의 도움을 받을 권리 - 미란다 판결의 법사회학적 분석 : 묵비권과 변호인의 도움을 받을 권리

김재원(Kim JaeWon) 성균관대학교 비교법연구소 2007 성균관법학 Vol.19 No.2

The U.S. Supreme Court"s landmark decision in Miranda v. Arizona (1966) established the principles and practices of procedural justice for suspects in custodial interrogation. Miranda warnings enshrine the consitutional rights of custodial suspects against self-incrimination. These rights are consisting of five basic components: (1) right to silence, (2) use of any statements against the suspect, (3) right to counsel, (4) access to counsel for indigent suspects, and (5) assertion of rights at any time. Thanks to popular TV dramas like "Law and Order", most people are quite familiar with a scene in which a police officer reads the suspect the standard Miranda warnings off of a card. It seems, therefore, that the principle and practice of Miranda warnings became an integral part of our legal culture. Part Ⅱ describes in detail the background of the Miranda trial in order to lay a foundation for further analysis of the case. Part Ⅲ deals with the exclusionary rule, one of the most distinctive and controversial legal doctrine stemmed from the U.S. Supreme Court. The part discusses the major positions taken by U.S. and State courts before and after the Miranda decision. Part Ⅳ summarizes the contributions and shortcomings of the landmark decision, and proposes a much realistic approach to the problem. The paper suggests that the right to remain silent should be considered as a pair with the right to counsel. Without the latter, the former can hardly be used for the benefit of any suspects.

미래우주산업의 프로젝트매니지먼트와 시스템엔지니어링 역량 확보 방안 - 국내 인적자원개발을 중심으로

김재원(Kim Jaewon),사르파라즈(Md Sharfaraz Ibne Syeed),박진영(Jeenyoung Park),박창우(Changwoo Park) 한국항공우주학회 2022 한국항공우주학회 학술발표회 논문집 Vol.2022 No.4

스캐닝 라이다 관측을 통한 부산 감만항 주변 PM<SUB>2.5</SUB> 발생원 연구

김재원(Jaewon Kim),노영민(Youngmin Noh) 한국대기환경학회 2023 한국대기환경학회지 Vol.39 No.4