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하상원,정선주,김재승,임주혁,이명종 대한신경과학회 2004 대한신경과학회지 Vol.22 No.3
Chorea is an uncommon clinical manifestation of Sytemic lupus erythematosus (SLE). Its pathogenic mechanism has not been clearly clarified. We report a 54-year-old woman with SLE who presented with generalized chorea as an initial manifestation. Fluorine-18-fluorodeoxyglucose (FDG) PET revealed increased metabolism in the bilateral putamen. Intravenous and oral administration of steroid markedly improved chorea. Hypermetabolism of the bilateral putamen diminished on follow-up FDG-PET after the disappearance of chorea. This study suggests that chorea in SLE is associated with striatal hypermetabolism.
Differential Diagnosis of Parkinsonism Using Dual-Phase F-18 FP-CIT PET Imaging
진소영,이종식,오승준,정선주,김재승,오정수,이상주,오민영 대한핵의학회 2013 핵의학 분자영상 Vol.47 No.1
Purpose Dopamine transporter (DAT) imaging can demonstrate presynaptic dopaminergic neuronal loss in Parkinson’s disease (PD). However, differentiating atypical parkinsonism (APD) from PD is often difficult. We investigated the usefulness of dual-phase F-18 FP-CIT positron emission tomography (PET) imaging in the differential diagnosis of parkinsonism. Methods Ninety-eight subjects [five normal, seven druginduced parkinsonism (DIP), five essential tremor (ET), 24PD, 20 multiple system atrophy-parkinson type (MSA-P), 13multiple system atrophy-cerebellar type (MSA-C), 13 progressive supranuclear palsy (PSP), and 11 dementia with Lewy bodies (DLB)] underwent F-18 FP-CIT PET. PET images were acquired at 5 min (early phase) and 3 h (late phase) after F-18FP-CIT administration (185 MBq). Regional uptake pattern of cerebral and cerebellar hemispheres was assessed on early phase images and striatal DAT binding pattern was assessed on late phase images, using visual, quantitative, and statistical parametric mapping (SPM) analyses. Results Striatal DAT binding was normal in normal, ET,DIP, and MSA-C groups, but abnormal in PD, MSA-P,PSP, and DLB groups. No difference was found in regional uptake on early phase images among normal DAT binding groups, except in the MSA-C group. Abnormal DAT binding groups showed different regional uptake pattern on early phase images compared with PD in SPM analysis (FDR<0.05). When discriminating APD from PD, visual interpretation of the early phase image showed high diagnostic sensitivity and specificity (75.4 % and 100 %, respectively). Regarding the ability to distinguish specific APD, sensitivities were 81 % for MSA-P, 77 % for MSA-C, 23 % for PSP,and 54.5 % for DLB. Conclusions Dual-phase F-18 FP-CIT PET imaging is useful in demonstrating striatal DAT loss in neurodegenerative parkinsonism, and also in differentiating APD, particularly MSA, from PD.
서민정,오민영,조민정,정선주,이종식,김재승 대한핵의학회 2014 핵의학 분자영상 Vol.48 No.4
Purpose 18F-FP-CIT [18F-fluorinated N-3-fluoropropyl-2-beta-carboxymethoxy-3-beta-(4-iodophenyl) nortropane] is usefulfor detecting striatal dopamine transporter (DAT). SinceFP-CIT shows relatively high affinities for DAT and serotonintransporter (SERT), its binding can be influenced by selectiveserotonin reuptake inhibitors (SSRIs). We aimed to evaluatethe effect of SSRIs on the binding of 18F-FP-CIT. Methods In our 18F-FP-CIT positron emission tomography(PET) data pool, images of 24 drug-naive Parkinson’s disease(PD) patients (62.6±10.6 years), 111 PD patients takingSSRIs [escitalopram (n=19) and fluvoxamine (n=20)] orclonazepam (n=72), and 10 normal people were reviewed. PET images acquired 3 h after 18F-FP-CIT injection wereanalyzed by an automated method using a predefined volumeof interest (VOI) set of the striatum (ST), occipital cortex(OC), raphe nuclei (RN), and cerebellar cortex (CB). Theuptake ratios (URs) of each VOI to the CB were comparedamong the groups. Results The ST/CB URs of all PD groups were significantlylower than that of normal group. When adjusted for drugseverity, ST/CB URs were higher in drug-naive group buthad no difference among antidepressant groups. WhereasOC/CB URs were not different among groups (p>0.05),RN/CB URs were significantly lower in SSRI groups thanin non-SSRI groups (p<0.001) and showed similar resultswhen adjusted for disease severity. Conclusions PD patients taking SSRIs showed significantlydecreased URs in the RN but not the OC. When adjusted forHoehn and Yar (HY) score, ST URs were not different amongantidepressant groups. This result suggests that the OC may beused as a reference region for the quantification of DATbinding in 18F-FP-CIT PET images of PD patients takingSSRIs.
Longitudinal Decline of Striatal Subregional [18F]FP-CIT Uptake in Parkinson’s Disease
성창환,이재현,오정수,오민영,이상주,오승준,정선주,이종식,김재승 대한핵의학회 2017 핵의학 분자영상 Vol.51 No.4
Purpose Dopamine transporter imaging is suggested to be a useful imaging biomarker for Parkinson’s disease (PD) progression and monitoring drug effects.We investigated the longitudinal decline characteristics of striatal [18F]FP-CIT uptake in PD. Methods We retrospectively reviewed 35 PD patients and 9 non-PD patients. All patients underwent [18F]FP-CIT PET at the initial diagnosis and follow-up. PET images were spatially normalized and analyzed with eight striatal and one occipital VOI templates. We measured the specific to non-specific binding ratio (SNBR) of the striatal subregions and calculated the absolute annual reduction (AAR) and relative annual reduction (%RAR) of the SNBRs. Results Total striatal SNBRs in PD patients were significantly lower than those in non-PD patients, with the most significant difference in the posterior putamen. Both AAR (0.26 ± 0.14 vs. 0.09 ± 0.19, p < 0.05) and %RAR (6.9 ± 3.5 vs. 1.2 ± 2.7, p < 0.001) of total striatal SNBRs were significantly greater in PD than non-PD patients. There were no significant differences in the AAR and %RAR of total striatal SNBRs between elderly and young onset PD. The AARs of the posterior putamen were higher in early PD than in advanced PD. Conversely, the %RARs were not significantly different between early and more advanced PD. The disease duration was significantly negatively correlated with the AAR but not with the %RAR of the posterior putamen. Conclusions The longitudinal decline of striatal [18F]FP-CIT uptake in PD was nonlinear and significantly faster than that in non-PD, with a different rate of decline among the striatal subregions.
자발생 두개내 저압 환자의 방사성 동위원소 뇌조조영술 소견
문대혁(Dae Hyuk Moon),이희경(Hee Kyung Lee),류진숙(Jin Sook Ryu),신중우(Jung Woo Shin),정동진(Dong Jin Jung),김재승(Jae Seung Kim),임주혁(Joo Hyuk Im),이명종(Myoung Chong Lee),정선주(Sun Joo Jung) 대한핵의학회 1998 핵의학 분자영상 Vol.32 No.6
N/A Purpose: Radionuclide cisternography may be helpful in understanding pathophysiology of postural headache and low CSF pressure in patients with spontaneous intracranial hypotension. The purpose of this study was to characterize radionuclide cisternographic findings of spontaneous intracranial hypotension. Materials and Methods: The study population consists of 15 patients with spontaneous intracranial hypotension. Diagnosis was based on their clinical symptoms and results of lumbar puncture. All patients underwent radionuclide cisternography following injection of 111 to 222 MBq of Tc-99m DTPA into the lumbar subarachnoid space. Sequential images were obtained between 1/2 hour and 24 hour after the injection of Tc-99m DTPA. Radioactivity of the bladder, soft tissue uptake, migration of radionuclide in the subarachnoid space, and extradural leakage of radionuclide were evaluated according to the scan time. Results: Radionuclide cisternogram showed delayed migration of radionuclide into the cerebral convexity (14/15), increased soft tissue uptake (11/15), and early visualization of bladder activity at 30 min (6/10) and 2 hr (13/13). Cisternography also demonstrated leakage site of CSF in 4 cases and 2 of these were depicted at 30 min. Epidural blood patch was done in 11 patients and headache was improved in all cases. Conclusion: The characterstic findings of spontaneous intracranial hypotension were delayed migration of radionuclide and early visualization of the soft tissue and bladder activity. These scintigraphic findings suggest that CSF leakage rather than increased CSF absorption or decreased production may be the main pathophysiology of spontaneous intracranial hypotension. Early and multiple imaging including the bladder and soft tissue is required to observe the entire dynamics of radionuclide migration.