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실크/PLGA 하이브리드 필름에서 실크가 인간 대동맥 내피세포의 부착과 증식에 미치는 효과
이지혜(Ji Hye Lee),이소진(So Jin Lee),김슬지(Seul Ji Kim),김경희(Kyoung Hee Kim),김영래(Young Lae Kim),송정은(Jeong Eun Song),이동원(Dong Won Lee),강길선(Gil Son Khang) 한국고분자학회 2013 폴리머 Vol.37 No.2
혈관내피세포는 혈관 안쪽을 덮고 있는 편평한 세포층으로, 혈관의 기능과 혈관평활근세포의 증식을 조절한다. 폴리락타이드글리콜라이드 공중합체(PLGA)는 물성이 좋고 분해속도를 조절하기 좋은 생분해성 합성고분자이며, 여러 형태로 제조하기 쉽다. 누에에서 얻은 실크 피브로인은 18가지 아미노산으로 구성되어 있고 세포의 부착과 세포 기능 유지에 중요하며 화장품, 의료분야 등 다양한 분야에서 응용되고 있다. 본 연구에서는 용매 증발법을 이용하여 0, 10, 20, 40 및 80 wt%의 실크를 이용하여 실크/PLGA 하이브리드 필름을 만들었으며, MTT, SEM, ELISA, 면역세포화학염색법을 실시하였다. 실크/PLGA 하이브리드 필름에서 실크 함량에 따른 인간 대동맥 내피세포의 부착과 증식을 측정한 결과, 40 wt%의 실크/PLGA 하이브리드 필름에서 세포의 부착과 증식이 가장 높았으며, 이런 결과들은 실크가 세포의 증식에 좋은 영향을 미치고 실크/PLGA 하이브리드 필름의 표면이 인간 대동맥 내피세포의 성장에 알맞은 환경이라는 것을 확인할 수 있었다. The vascular endothelial cells are the inner layers of blood vessels. It regulates the function of blood vessels and proliferation of vascular smooth muscle cells. Poly(lactide-co-glycolic acid) (PLGA) is a biodegradable synthetic polymer with a well-controlled degradation rate and an acceptable mechanical strength. It can be easily fabricated into many shapes. Silk consists of 18 amino acids. It found important for attaching cells cultured in vitro, and maintaining cell functions. In this study, we fabricated silk/PLGA biomaterial hybrid films of 0, 10, 20, 40 and 80 wt% silk. We performed MTT, SEM, ELISA, and immunocytochemistry analyses. We confirmed the adhesion and the proliferation of HAECs on silk/PLGA according to the content of silk, and 40 wt% silk/PLGA hybrid films have superior adhesion and proliferation properties. These results demonstrate that silk/PLGA hybrid films provide suitable surfaces for HAECs, and there is the effect of silk on cell growth and proliferation.
청폐사간탕(淸肺瀉肝湯)의 혈소판 응집억제 작용에 대한 in vitro 연구
박영주,김슬지,양가은,이미정,이지숙,강덕희,김영찬,이우경,류재환,Park, Young-Ju,Kim, Seul-Ji,Yang, Ga-Eun,Lee, Mi-Jung,Lee, Ji-Sook,Kang, Deok-Hui,Kim, Young-Chan,Lee, Woo-Kyung,Ryu, Jae-Hwan 대한한방내과학회 2010 大韓韓方內科學會誌 Vol.31 No.4
Objective : The study was designed to test the anti-platelet effect of the extract Cheongpyesagan-tang and compare it with aspirin in vitro. Methods : The extract from Cheongpyesagan-tang was made by the pharmacy department of Kyung Hee Oriental Medical Hospital. The extract was investigated for inhibition against the collagen induced aggregation of human platelet suspensions on aggregometry. Aspirin and aspirin-Cheongpyesagan-tang were investigated together. Results : 1. In collagen induced human platelet aggregation test, the extract from Cheongpyesagan-tang significantly inhibited in concentration 30mg/ml (p<0.05), 40mg/ml, 50mg/ml (p<0.001) and the effect depended on concentration over 20mg/ml. 2. Aspirin and aspirin-Cheongpyesagan-tang inhibited collagen induced human platelet aggregation significantly (p<0.001). Aspirin-extract of Cheongpyesagan-tang inhibition rate was higher than aspirin only (p<0.05). Conclusions : The extract of Cheongpyesagan-tang has anti-platelet aggregation and synergic effect with aspirin on human platelet in vitro.
한방병원 중증치료실 입원 중 항생제 연관성 설사를 진단받은 환자에 대한 임상적 고찰
양가은,김슬지,박영주,이미정,이지숙,류재환,Yang, Ga-Eun,Kim, Seul-Ji,Park, Young-Ju,Lee, Mi-Jung,Lee, Jee-Sook,Ryu, Jae-Hwan 대한한방내과학회 2010 大韓韓方內科學會誌 Vol.31 No.2
Objectives : This study was designed to investigate the effectiveness of adjunctive herbal therapy combined with conventional therapy on antibiotic-associated diarrhea (AAD) treatment. Methods : The medical records of 25 patients admitted to the Intensive Care Unit at Kyunghee Oriental Medical Center between January 1, 2009 and January 30, 2010 were reviewed. The charts were analyzed for the general characteristics, site of infection, predominant bacteria, antibiotic treatment, herbal medicine treatment, effect on liver and kidney functions, and the effect of therapy on diarrheal duration. Results : 48% of the 25 patients were male while 52% were female. The average age was 67.2 years old. The most commonly used antibiotic was fluoroquinolone (40.0%) and the most commonly used herbal medicine was Samchulkunbi-tang (24.0%). The average diarrheal duration was 8.9 days. No significant change in hepatic and renal function was discovered before and after treatment with herbal medicine. Conclusions : The results suggest that herbal therapy would be a safe and effective treatment for AAD. Further study investigating the usage of herbal medicine in AAD treatment is anticipated.
원산지별 홍삼투여에 따른 백서의 자연살해세포 활성도 변화에 대한 연구
임주혁,조인영,민경윤,이혜영,김슬지,박영주,류재환,이범준,김성욱,주일우,Im, Ju-Hyuk,Cho, In-Young,Min, Kyoung-Yoon,Lee, Hae-Yong,Kim, Seul-Ji,Park, Young-Ju,Lew, Jae-Hwan,Lee, Beom-Joon,Kim, Sung-Wook,Joo, Il-Woo 대한한방내과학회 2008 大韓韓方內科學會誌 Vol.29 No.4
Objectives : The purpose of this experiment is comparing the difference on natural killer cell activity through Korean red ginseng and Chinese red ginseng by $^{51}Cr$ release assay. Methods : Thirty rats were equally divided into a Korean red ginseng group, a Chinese red ginseng group and a control group. Korean and Chinese red ginseng were administrated to the rats at 200mg daily for a weak, while 0.9% normal saline was given to the control. Percent specific lysis (PSL) and lytic units (LU) were calculated from spleen cells by $^{51}Cr$ release assay. Results : Percent specific lysis of the Korean red ginseng group was significantly higher than that of the control in the ratio of 100:1, effector cell:target cell (p<0.05). Percent specific lysis of Korean red ginseng group was also significantly higher than that of the Chinese red ginseng group in the ratio of 25:1, effector cell:target cell (p<0.05). Chinese red ginseng showed no effect on NK cell activity. Conclusions : These findings suggest that Korean red ginseng improves immunologic function and shows superior effects than Chinese red ginseng.
이소진(So Jin Lee),김혜윤(Hye Yun Kim),김슬지(Seul Ji Kim),양재원(Jae Won Yang),이선의(Seon Ui Lee),박찬흠(Chan Hum Park),주천기(Choun Ki Joo),강길선(Gilson Khang) 한국고분자학회 2014 폴리머 Vol.38 No.3
망막색소상피(RPE)는 건강한 망막을 유지하는데 중요한 역할을 하고 RPE의 퇴화는 많은 망막질병을 유발한다. RPE 이식은 최근 망막 퇴화에 대한 가능성 있는 치료법으로 제시되고 있다. RPE 세포를 안전하게 이식하기 위해서는 지지체가 필요하므로 독특한 기계적 성질과 생체적합성을 갖는 실크를 사용하여 필름을 제조하였다. 실크필름의 FTIR, 접촉각 및 생분해성을 측정한 후, RPE 세포를 실크필름에 파종하여 그 영향을 확인하였다. MTT 분석,SEM, 면역형광염색, RT-PCR을 통해 세포의 부착, 생존도, 형태유지, 특이적 mRNA의 발현을 분석하였다. 본 연구에서는, 실크필름에 배양한 RPE 세포의 부착, 증식 및 표현형 유지가 뛰어남을 확인함으로써 실크필름의 망막 재생을 위한 조직 공학적 지지체로의 응용 가능성을 제시했다. The retinal pigment epithelium (RPE) plays an important role in maintaining a healthy retina and the degenerationof RPE caused a number of retinal diseases. The transplantation of RPE has recently become a possible therapeuticmodality for retinal degeneration. To transplant RPE cells securely, substrates are essential, and then as a substrate,we fabricated films using silk that has unique mechanical properties and biocompatibility. After the FTIR spectra, contactangle and biodegradation of silk films were confirmed, RPE cells were seeded and the influence of RPE cells on silk filmswas examined. We measured the cell adhesion, cell viability, morphology and specific mRNA expression by MTT assay,SEM, immunofluorescence and RT-PCR. In this study, we confirmed that attachment, proliferation and phenotype maintenanceof RPE cells cultured on silk films were great, and thereby we were able to confirm the potential applicationsof silk films as tissue engineering carrier for regeneration of retina.