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인간의 건강 향상을 위한 기능성 천연소재 연구 : 운향과 과실류 발효추출물의 항산화 및 항균 비교 분석
김미경(Kim, Mee kyoung) K교육연구학회 2021 사회과학리뷰 Vol.6 No.3
본 연구에서는 운향과 과실류(유자, 자몽, 레몬, 밀감, 오렌지, 탱자)의 식품 및 화장품 기능성 소재로서의 적용 가능성을 확인하고자 6종을 혼합하여 발효한 후 에탄올로 추출한 추출물의 naringin, hesperidin의 함량, 항산화능 및 항균력을 비교 분석하였다. 그 결과 버섯발효 에탄올 추출물(FME)이 naringin 220.36 μg/mL, hesperidin 1254.67 μg/mL로 가장 높은 함량을 나타내었다. 항산화 효과는 DPPH 라디컬 소거능과 ABTS 라디컬 소거능에서 에탄올 추출물(MRE)와 버섯발효 에탄올 추출물(FME)이 자연발효 및 젖산발효 에탄올 추출물(FSE, FME)에 비해 다소 높은 소거능을 나타내었고 antioxidant protection factor에서는 버섯발효 에탄올 추출물(FME)가 다른 추출물에 비해 소거능이 높게 나타났다. 피부 상재균에 대한 항균활성은 젖산발효 에탄올 추출물(FLE)이 S. epidermidis(16.9~22.3 mm)와 P. acnes(8.5~10.4 mm) 균에서 항균력을 나타내었고 버섯발효 에탄올 추출물(FME)은 S. epidermidis(12.0~16.1 mm), E. coli(9.5~13.3 mm) 및 P. acnes(9.0~13.1 mm) 균에서 항균활성을 나타내었다. 이상의 결과로 보아 버섯발효 에탄올 추출물(FME)은 피부 미용 식품 및 기능성 화장품의 소재로서의 활용이 가능할 것으로 사료된다. This study evaluated hesperidine and naringin contents, antioxidant and antimicrobial activities of the extracts of fermented Rutaceae fruits(citron, grapefruit, lemon, mandarin orange, orange, trifoliate) in order to confirm the applicability as food and cosmetic functional materials. The samples used in th experiment were ethanol extract from mixed Rutaceae fruits (MRE), ethanol extract of mixed Rutaceae fruits fermented with sugar (FSE), ethanol extract of mixed Rutaceae fruits fermented with lactic acid bacteria (FLE) and ethanol extract of mixed Rutaceae fruits fermented with mushroom mycelium (FME). The content of narigin and hesperidin was highest in FME. In DPPH radical scavenging activity and ABTS radical scavenging activity, MRE and FME showed higher scavenging activity than FSE and FME. In the antioxidant protection factor, FME was higher than that of other extracts. In antibacterial activity against skin flora, FLE showed antibacterial activity against S. epidermidis and P. acnes, and FME showed antibacterial activity against S. epidermidis, E. coli and P. acnes. Therefore, it is considered that the ethanol extract of mixed Rutaceae fruits fermented with mushroom mycelium can be used as a natural material for cosmetic and food.
청소년기에 발생하여 하부 생식기 폐색과 양측 난관 농양을 초래한 심한 소음순 유착
김미경 ( Mi Kyoung Kim ),김수현 ( Soo Hyun Kim ),차선희 ( Sun Hee Cha ),이미화 ( Mee Hwa Lee ) 대한산부인과학회 2009 Obstetrics & Gynecology Science Vol.52 No.10
Labial adhesions are extremely rare in adolescent and adult populations, because the etiology of this entity commonly relates to chronic vulvar inflammation or irritation, and is basically associated with low estrogen status. Although a few cases reported urinary retention resulting from severe labial adhesions, there is no report of labial adhesion that precipitates upper genital tract infection in prepubertal and postpubertal females. We present a rare case of severe labial adhesion and consequential lower genital tract obstruction that allegedly causing bilateral pyosalpinx in a 14-year-old adolescent girl who decisively denied sexual experience. The patient was successfully treated with surgical lysis of adhesion and administration of antibiotics.
김미경 ( Mee Kyoung Kim ) 대한내과학회 2013 대한내과학회지 Vol.84 No.5
Obesity is associated with a reduction in life expectancy and an increase in mortality from cardiovascular diseases, cancer, and other causes. The U.S. Preventive Service Task Force (USPSTF) recommends screening all adults for obesity. Clinicians should offer or refer patients with a body mass index of 30 kg/m2 or higher to intensive, multicomponent behavioral interventions. Behavioral interventions can lead to a moderate weight loss and improvement in blood sugar and other risk factors for cardiovascular disease. Behavioral interventions decreased the incidence of diabetes diagnosis by about 50% over 2 to 3 years. Orlistat, phentermine, diethylpropion, phendimetrazine, mazindol have been approved as anti-obesity drugs by Korea Food and Drug Administration. The U.S. Food and Drug Administration approved lorcaserin and phentermine plus topiramate combination for treatment of obesity in 2012. (Korean J Med 2013; 84:624-628)
김미경 ( Mee Kyoung Kim ),임동준 ( Dong Jun Lim ),백기현 ( Ki Hyun Baek ),송기호 ( Ki Ho Song ),강무일 ( Moo Il Kang ),이광우 ( Kwang Woo Lee ),이종욱 ( Jong Wook Lee ) 대한내과학회 2008 대한내과학회지 Vol.75 No.6
불가피하게 반복적인 수혈을 받는 환자에서 수혈과 관련하여 이차성 혈색소 침착증이 발생할 수 있는데, 본 저자들은 재생불량성 빈혈로 10년간 약 400pints의 수혈을 받은 환자에서 피부 색소 침착, 저성선자극호르몬에 의한 성선기능저하, 당뇨병, 간기능 장애, 확장성 심근병증에 의한 울혈성심부전 등 여러 가지 심각한 합병증을 동반한 이차성 혈색소 침착증 증례를 경험하였기에 문헌고찰과 함께 보고하는 바이다. We report a case of transfusion-associated hemochromatosis in a 38-year-old female who had severe aplastic anemia. She had undergone conservative treatment consisting of multiple transfusions because she had no suitable HLA-matched bone marrow donor. She had received 400 units of red blood cells (RBCs) over 10 years. The transferrin saturation and serum ferritin were increased to 88.4% and 29,905 ng/mL, respectively. Abdominal computed tomography (CT) showed increased densities in the liver and myocardium, suggesting iron deposits in those organs. In general, transfusional iron overload results in primarily reticuloendothelial iron accumulation, which is considered to be less harmful than parenchymal iron accumulation. Nevertheless, our patient had many striking complications associated with hemochromatosis, such as skin pigmentation, hypogonadotropin hypogonadism, insulin-requiring diabetes mellitus, impaired liver function, and left ventricular dysfunction. (Korean J Med 75:709-713, 2008)
연구논문 : 돼지감자분말 첨가가 쌀 스펀지케이크의 품질 특성과 항산화능에 미치는 효과
김미경 ( Mee Kyoung Kim ),이은주 ( Eun Ju Lee ),김경희 ( Kyung Hee Kim ) 한국식생활문화학회 2014 韓國食生活文化學會誌 Vol.29 No.2
This study was conducted to evaluate the quality characteristics and antioxidant activities of rice flour sponge cakes containing 0, 20, 30, 40, and 50% Helianthus tuberosus powder (HTP). As HTP content of sponge cake increased, the pH of sponge cake batter significantly decreased, whereas specific gravity significantly increased (p<0.05). Meanwhile, volume and symmetry indices of sponge cake were inversely proportional to HTP amount. Further, with higher HTP content in sponge cake, L and b values of crumbs significantly decreased (p<0.05), whereas a value significantly increased (p<0.05). L, a, and b values of crust significantly increased with higher HTP content. For texture characteristics, hardness, cohesiveness, gumminess, and chewiness of sponge cake significantly increased (p<0.05),whereas cohesiveness did not significantly change. In the sensory evaluation test, rice sponge cake prepared with 10% HTP showed the highest sensory scores in terms of color, flavor, taste, softness properties, and overall preference. The levels of total polyphenol compounds and DPPH radical scavenging activities of rice sponge cakes significantly increased with higher HTP contents (p<0.05). The results of this study suggest that rice sponge cake containing 10% HTP is the most appropriate for quality characteristics and sensory evaluation. This study also provides a way to increase the quality, texture characteristics, and organoleptic properties of sponge cake while reducing HTP content to less than 10% in order to satisfy consumer tastes.
발열과 요통을 동반한 혈액투석 환자에서 발견된 경막의 농양
송준창 ( Joon Chang Song ),김미경 ( Mee Kyoung Kim ),김윤정 ( Youn Jeong Kim ),김성용 ( Sung Yong Kim ),김영수 ( Young Soo Kim ),유혜영 ( Hye Young You ),양철우 ( Chul Woo Yang ),김용수 ( Yong Soo Kim ),방병기 ( Byung Kee Bang 대한신장학회 2003 Kidney Research and Clinical Practice Vol.22 No.2
Epidural abscess in hemodialysis patient is uncommon diseases, but it causes severe neruological complication if diagnois is delayed. In the clinical practice, because it is difficult to differentiate epidural abscess with simple back pain. Therefore, it is important to make early diagnosis and treatment of epidural abscess to prevent nuurological sequellae. We here report a case of epidural abscess with early diagnosis and successful treatment. A 54-year-old male patient was admitted to back pain and fever. Under the presumptive diagnosis of epidural abscess, MRI was perofrmed, and it revealed epidural abscess. Intravenous antibiotic treatment was started and drain of abscess was subsequently performed since back pain was persisted. He discharged without neurologic sequellae. Our case strongly suggests that epidural abscess should be considered in patients and early radiologic evaluation and treatment are mandatory to prevent neurological complication.
부신우연종의 진료지침: 대한내분비학회 진료지침제정위원회
이정민 ( Jung-min Lee ),김미경 ( Mee Kyoung Kim ),고승현 ( Seung-hyun Ko ),고정민 ( Jung-min Koh ),김보연 ( Bo-yeon Kim ),김상완 ( Sang-wan Kim ),김수경 ( Soo-kyung Kim ),김혜진 ( Hae-jin Kim ),류옥현 ( Ohk-hyun Ryu ),박주리 ( Jur 대한내과학회 2017 대한내과학회지 Vol.92 No.1
An adrenal incidentaloma is an adrenal mass found in an imaging examination performed for reasons unrelated to suspected adrenal disease. The prevalence of adrenal incidentaloma increases with age; there is no gender difference, but it is often accompanied by obesity, diabetes mellitus, or hypertension. The detection of adrenal incidentaloma is expected to rise with the rapid development of imaging technology and increasing frequency of imaging studies. The Korean Endocrine Society is promoting appropriate practice guidelines to meet the rising incidence of adrenal incidentaloma, in cooperation with the Korean Adrenal Gland and Endocrine Hypertension Study Group. In this paper, we discuss important core issues for treating adrenal incidentaloma, along with the most important factors for healthcare providers who treat and manage affected patients. Initially, we identified 47 recommendations using the Delphi technique, after evaluating core propositions. We reduced these to the 20 most critical recommendations. (Korean J Med 2017;92:4-16)