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강원도 춘천 인근지역 주민에서의 Rickettsia 에 대한 항체보유 현황과 과거 감염 환자에서의 항체 역가의 변동
김계영(Kae Young Kim),이상조(Sang Jo Lee),백혜진(Hye Jin Baeg),길현교(Hyun Gyo Kil),이영천(Young Chun Lee),최문기,유지소(Ji So Ryu),이종호(Jong Ho Lee),조민기(Min Kee Cho) 대한내과학회 1991 대한내과학회지 Vol.40 No.1
Rickettisal infection is one of the common causes of acute febrile illness occurring every autumn in the rural areas of Korea. The diagnosis of Rickettsiosis is usually made by serologic tests. Diagnostic criteria is based on the seropositive rates and antibody titer of the normal population. In order to determine the serologic criteria of the present infection in the chuncheon area of Kangwondo, we examined the antibody titer of normal residents sera which was collected during July of 1989, just before the epidemic season. We also examined the changing pattern of antibody titer in the patients who had suffered from rickettsial infections one year before. 1) The seropositive rates of R. typhi, R. prowazekii, ad R. tsutsugamushi were 17.6%, 32.3% and 9.2%, respectively. 2) The seropositive rates of R. typhi and R. prowazekii were higher in male, but those of R. tsutsugamushi were higher in females. 3) Rural residents showed higher seropositive rates to all three strains of rickettsia than those of urban residents. 4) Antibody titer of R. typhi and R. prowazekii were less than 1:640 in all positive sera except one which 1:1280 to R. prowazekii. In case of R. tsutsugamushi, antibody titers of all positive sera were less than 1:80. 5) All the five patients who had suffered from murine typhus one year before showed marked decreases in total antibody response to R. typhi (less than or equal to 1:80), but in the case of tsutsugamushi disease four of eight patients with past infections showed lasting total antibody titers of more than 1:640 even though IgM responses were negative in all patients. In conclusion, the serologic diagnosis of present rickettsial infection could be possible with first single serum when total and IgM antibody titers are 1:640 and 1:40 or more, respectively, in murine typhus, and 1:80 and 1:10 or more, respectively, in tsutsugamushi disease.
허파혈관주위세포에서 저산소증에 의한 생존능의 억제와 유전자 발현의 변화
신종욱 ( Jong Wook Shin ),김계영 ( Kae Young Kim ),이영우 ( Young Woo Lee ),정재우 ( Jae Woo Jung ),이병준 ( Byoung Jun Lee ),김재열 ( Jae Yeol Kim ),조인호 ( In Ho Jo ),박인원 ( In Won Park ),최병휘 ( Byoung Whui Choi ) 대한결핵 및 호흡기학회 2004 Tuberculosis and Respiratory Diseases Vol.57 No.1
백혜진(Hye Jin Baeg),김계영(Kae Young Kim),채동완(Dong Ywan Chae),이영천(Young Chun Lee),최문기(Moon Gi Choi),장연복(Yeon Bog Jang),오하영(Ha Young Oh),박정식(Jung Sik Park) 대한내과학회 1991 대한내과학회지 Vol.40 No.3
Tuberculosis is one of the major infectious disease in Korea, despite its prevalence has been falling. In renal Tuberculosis, there are considerable complications at the time of diagnosis, because of the long duration from exposure to onset of symptoms, which are usually non- specific. In spite of antituberculous chemotherapy, complications may progress and cause obstructive uropathy. In order to evaluate the clinical characteristics of the renal tuberculosis, we reviewed 70 cases of renal tuber- culosis who were admitted to the Hallym University haspital between January 1984 and December 1988, and follwing results were obtained. 1) Renal tuberculosis was predominent in 4th and 5th decades, average age was 39.8 years and males predominated in 1.8:l. 2) The most common presenting symptom was gross hematuria (45.7%), the flank pain, dysuria, nocturia, frequency and fever as a constitutional symptoms in that order. 3) Abnormal findings of urinanalysis were observed in 82.9% of cases and azotemia was found in 25.7%. Asymptomatic urinary abnormality was noted in 25.7%. 4) The positive findings of urine AFB staining in 27.1%,, positive urine AFB culture 5.7%, and 34.3% of cases showed characteristic histopathologic findings. Abnormal urographic findings were seen in 98.5%, and the left kidney was affected predominently (41.5%). 5) Previous extrarenal tuberculosis was noted in 42. 3% and its average duration was 9.3 years. Active extrarenal tuberculosis was associated in 14.3% of cases. 6) The most common complication was hydronephrosis and hydroureter (44.3%), then stone, and secondary infection in that order. 7) Among 6 azotemic patients who were followed more than 3 months after treatment, serum creatinine clearence level was decreased in 5 patients.
Insertion Sequence 6110의 Mixed-Linker 중합효소 연쇄반응을 이용한 Mycobacterium tuberculosis의 Molecular Typing
김재삼,김계영,허완재,임채호,정희진,박승철,성낙현,김우주,김민자 대한감염학회 1996 감염 Vol.28 No.1
목적 : M. tuberculosis에서 mixed-linker를 이용한 IS6110의 PCR을 시행하여 그 RFLP를 분석하고, 이를 기존의 RFLP법에 의한 결과와 비교 분석하여 신속하고 효과적인 molecular typing법으로서의 유용성을 검토하였다. 방법 : Mixed-linker PCR법을 이용하여 다양한 약제 감수성을 보이는 13명의 환자에서 분리된 14결핵 균주들의 임상 분리균을 대상으로 IS6110과 이에 인접된 염기서열을 포함하는 다양한 절편들을 증폭시켜 얻어진 mixed-linker RFLP를 conventional RFLP와 비교하였다. 결과 : 13명의 환자에서 분리된 13균주들의 mixed-linker RFLP 결과 모든 다른 RFLP양상을 보였으며, 이는 conventional RFLP의 결과와 일치하였다. Mixed-linker PCR법으로 증폭된 절편들은 기본적으로 150-600 bp 사이에 존재하였으며, IS6110의 한절편인 소식자로 Southern hybridization하여 IS6110에 특이함을 증명하였다. Mixed-linker RFLP는 conventional RFLP보다 더 많은 수의 절편들을 보여 주었다. Mixed-linker와 conventional RFLP 양상들은 약제 내성과 무관하였다. 결론 : Mixed-linker PCR법은 기존의 conventional RFLP법보다 더욱 간편한 방법으로 결핵균의 신속한 동정 및 molecular typing을 가능하게 하여 결핵의 역학조사에 효과적인 방법임을 알 수 있다. Background : Various classic typing methods including phage typing, antibiotic resistance typing and multilocus enzyme electrophoresis have been proven inefficient because of the phenotypic and genotypic homogeneities of the Mycobacterium tuberculosis(M.tuberculosis) species. Thus, DNA restriction fragment length polymorphism(RFLP) analysis using the repetitive element insertion sequence 6110(IS6110) of the M. tuberculosis genome has been proposed to be a powerful epidemiologic tool. However, this method requires large amount of genomic DNA and Southern hybridization procedures. The aim of this study was to evaluate DNA RFLP analysis by mixed-linker polymerase chain reaction(mixed-linker PCR) for a rapid, simple typing method, which specifically amplified genomic RFLP fragments containing IS6110 with using one primer specific for IS6110 and a second primer complementary to a linker ligated to the restricted genomic DNA. Methods : Fourteen clinical isolates of M. tuberculosis with various drug susceptibilities including 2 strains isolated from a patient were used for the study. Their RFLP patterns by mixed linker-PCR(mixed liker RFLP) were analyzed and compard with those by the conventional RFLP method. Results : Mixed-linker RFLP obtained from 13 isolates of 13 patients showed all different reproducible patterns and 2 isolates from the same patient showed almost the same RFLP patterns which had different drug susceptibility. mixed-linker RFLP patterns were correlated to the results by the conventional RFLP. And mixed-linker RFLP showed a higher number of fragments containing IS6110 than those by the conventional RFLP. However, both mixed-linker and conventional RFLP were independent of drug resistance patterns. Conclusion : Mixed linker-RFLP is a rapid, simple typing method with high discrimination and reproducibility, and seems to be useful for epidemiologic study of M. tuberculosis.