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First detection of West Nile virus in domestic pigeon in Korea
김경설,Hanseul Oh,송주하,Moonsuk Hur,Jae-Hwa Suh,정원화,Jong-Taek Kim,Hong-Shik Oh,Jae-Hak Park 대한수의학회 2016 Journal of Veterinary Science Vol.17 No.4
West Nile virus (WNV) is a mosquito-borne zoonotic pathogen that has spread throughout Europe and the United States. Recently, WNV spreadto East and Southeast Asia, and great efforts have been made in South Korea to prevent the spread of WNV from neighboring countries. Inthis study, we diagnosed the first case of WNV in pigeons (Columba livia domestica) residing in cities using a competitive enzyme-linkedimmunosorbent assay and confirmed it with nested reverse transcription polymerase chain reaction analysis and sequencing. This is the firstreport to provide convincing evidence that WNV is present within South Korea.
Improved human hematopoietic reconstitution in HepaRG co-transplanted humanized NSG mice
Jin Kim,유보경,Ukjin Kim,Chang-Hwan Kim,Gyeung-Haeng Hur,김경설,Jae-Hak Park 생화학분자생물학회 2020 BMB Reports Vol.53 No.9
Several humanized mouse models are being used to study humanspecific immune responses and diseases. However, the pivotal needs of fetal tissues for the humanized mice model have been huddled because of the demand for ethical and medical approval. Thus, we have verified the hematopoietic and immunomodulatory function of HepaRG and developed a new and easy humanized mouse model to replace the use of fetal liver tissue. HepaRG co-transplanted Hu-NSG mice significantly increased CD45+ lymphocytes and CD19+ B cells and CD3+ T cells than normal Hu-NSG, suggesting enhanced reconstitution of the human immune system. These results have improved the applicability of humanized mice by developing new models easily accessible.
Tae-Hyoun Kim,Dong-Su Kim,Ju-Hee Han,장서나,김경설,석승혁,Dong-Jae Kim,Jong-Hwan Park,박재학 대한수의학회 2014 Journal of Veterinary Science Vol.15 No.4
Corynebacterium (C.) bovis infection in nude mice causeshyperkeratosis and weight loss and has been reportedworldwide but not in Korea. In 2011, nude mice from ananimal facility in Korea were found to have white flakes ontheir dorsal skin. Histopathological testing revealed that themice had hyperkeratosis and Gram-positive bacteria werefound in the skin. We identified isolated bacteria from theskin lesions as C. bovis using PCR and 16S rRNA sequencing. To the best of our knowledge, this is the firstreport of C. bovis infection in nude mice from Korea.
유보경,Seong Woo Choi,Seul-Gi Lee,정영훈,Ukjin Kim,Jin Kim,정초록,Hyung-Min Chung,Jae-Hak Park,김경설 생화학분자생물학회 2020 BMB Reports Vol.53 No.8
In accordance with requirements of the ICH S7B safety pharmacology guidelines, numerous next-generation cardiotoxicity studies using human stem cell-derived cardiomyocytes (CMs) are being conducted globally. Although several stem cell-derived CMs are being developed for commercialization, there is insufficient research to verify if these CMs can replace animal experiments. In this study, in vitro high-efficiency CMs derived from human embryonic stem cells (hESC-CMs) were compared with Sprague-Dawley rats as in vivo experimental animals, and primary cultured in vitro rat-CMs for cardiotoxicity tests. In vivo rats were administrated with two consecutive injections of 100 mg/kg isoproterenol, 15 mg/kg doxorubicin, or 100 mg/kg nifedipine, while in vitro rat-CMs and hESC-CMs were treated with 5 μM isoproterenol, 5 μM doxorubicin, and 50 μM nifedipine. We have verified the equivalence of hESC-CMs assessments over various molecular biological markers, morphological analysis. Also, we have identified the advantages of hESC-CMs, which can distinguish between species variability, over electrophysiological analysis of ion channels against cardiac damage. Our findings demonstrate the possibility and advantage of high-efficiency hESC-CMs as next-generation cardiotoxicity assessment.