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고은아,우민석,강다원 사단법인 한국동물생명공학회 2022 한국동물생명공학회지 Vol.37 No.2
Receptor tyrosine kinase c-Kit, a marker found on interstitial cells of Cajal (ICCs), is expressed in Leydig cells, which are testicular interstitial cells. The expression of other ICC markers has not yet been reported. In this study, we investigated the expression of c-Kit and anoctamin 1 (ANO1), another ICC marker, in mouse testes. In addition, the relationship between c-Kit and ANO1 expression and Leydig cell function was investigated. We observed that c-Kit and ANO1 were predominantly expressed in mouse Leydig cells. The mRNA and protein of c-Kit and ANO1 were expressed in TM3, a mouse Leydig cell line. LH induced an increase in intracellular Ca2+ concentration, membrane depolarization, and testosterone secretion, whereas these signals were inhibited in the presence of c-Kit and ANO1 inhibitors. These results show that c-Kit and ANO1 are expressed in Leydig cells and are involved in testosterone secretion. Our findings suggest that Leydig cells may act as ICCs in testosterone secretion
고은아 인문사회 21 2023 인문사회 21 Vol.14 No.3
This study examines the effect of housing poverty on depression in middle-aged single-person households, focusing on the rise of this demographic and poor housing conditions. Using data from the Korean Welfare Panel Study’s 17th year (2022), a regression analysis was conducted on 391 single-person households aged 40 to 64. The study confirmed the housing poverty and depression status of middle-aged single-person households, and verified the impact of housing poverty on depression. As the proportion of housing expenses in monthly consumption increases, depression is more likely to occur when residing in unstable housing types such as rental or lease. The final results indicate the need to address the blind spots in housing welfare for middle-aged single-person households and the necessity of improving institutional support for stable entry into the elderly generation.
통합과학, 화학 I, 화학 II의 성취기준과 교과서 활동 및 평가 문항의 과학과 핵심역량 분석: '산·염기·중화반응'과 '산화·환원'을 중심으로
고은아,최애란,Ko, EunAh,Choi, Aeran 대한화학회 2019 대한화학회지 Vol.63 No.6
This study analyzed achievement standards in the 2015 Science Education Standards as well as activities and assessment items in the Integrated Science, Chemistry I, and Chemistry II textbooks using science core competencies and subcomponents. All five scientific core competencies, in order of scientific thinking capacity, scientific inquiry capacity, scientific communication capacity, scientific problem solving capacity, and scientific participation and lifelong learning capacity, were included in the achievement standards of Integrated Science. Scientific thinking capacity, scientific inquiry capacity, and scientific communication capacity were included in the achievement standards of Chemistry I. The achievement standards of Chemistry II only included scientific thinking capacity. All five scientific core competencies were involved in activities of Integrated Science, Chemistry I, and Chemistry II textbooks and the highest propotion was scientific thinking capacity and scientific inquiry capacity. All five scientific core competencies were involved in assessment items of Integrated Science, Chemistry I, and Chemistry II textbooks and the highest proportion was scientific thinking capacity. 본 연구에서는 2015 과학과 교육과정에 따른 통합과학, 화학 I, 화학 II의 '산·염기·중화반응', '산화·환원' 관련 성취기준과 교과서 활동 및 평가 문항을 과학과 핵심역량과 과학과 핵심역량별 하위요소를 기준으로 분석하였다. 통합과학의 성취기준에는 과학적 사고력이 가장 많이 포함되어 있었고, 과학적 탐구 능력, 과학적 의사소통 능력, 과학적 문제 해결력, 과학적 참여와 평생 학습 능력 순으로 5가지 과학과 핵심역량이 모두 포함되어 있었으나, 화학 I의 성취기준에는 과학적 사고력, 과학적 탐구 능력, 과학적 의사소통 능력이 포함되어 있었고, 화학 II의 성취기준에는 과학적 사고력만 포함되어 있었다. 통합과학, 화학 I, 화학II 교과서의 '산·염기·중화반응', '산화·환원' 활동에는 5가지 과학과 핵심역량이 모두 포함되어 있었고, 각 교과에서 과학적 탐구 능력과 과학적 사고력이 높은 비율로 포함되어 있었다. 통합과학, 화학 I, 화학 II 교과서의 '산·염기·중화반응', '산화·환원' 평가 문항에도 5가지 과학과 핵심역량이 모두 포함되어 있었으며, 각 교과에서 모두 과학적 사고력이 포함된 비율이 매우 높게 나타났다.
노인의 주거환경이 지역사회 계속거주에 미치는 영향: 지역별 비교를 중심으로
고은아 한국노년학회 2023 한국노년학 Vol.43 No.5
This study aims to investigate the influence of the residential environment on Aging in Place for the elderly. It also acknowledges that the effects of residential environment factors on Aging in Place might vary due to regional differences between urban and rural areas. Consequently, the study seeks to establish an empirical approach considering regional characteristics, assessing whether the residential environment in each area supports elderly individuals in maintaining their community living. The analysis utilized data from the 2020 Elderly Survey, encompassing 8,878 participants, including 6,541 elderly residents from urban settings and 2,337 from rural areas. Results indicated that rural seniors exhibited a stronger preference for Aging in Place, with 65.3% compared to 61.7% among urban counterparts, highlighting their inclination towards remaining within their local community. Urban areas indicated higher satisfaction with the physical environment, while rural areas showed greater contentment with the social environment, particularly community relationships. Binary logistic regression analysis demonstrated that urban elderly individuals were more likely to opt for Aging in Place when they reported higher housing satisfaction, better accessibility to the external environment, and limited opportunities for social interaction with neighbors. In rural areas, a higher likelihood of choosing community-based living was observed when housing satisfaction, active participation in social activities, and community relationship satisfaction were greater. In light of these findings, it is advisable to develop policies aligned with the unique characteristics of urban and rural contexts, aiming to facilitate Aging in Place among the elderly population.