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Scopolamine Hydrobromide 및 $\ell$-Hyoscyamine의 생체이용성에 미치는 위산도의 영향
김창영,함성호,한상수,손동환,고건일,김재백,Kim, C. Y.,Ham, S. H.,Han, S. S.,Sohn, D. H.,Ko, G. I.,Kim, J. B. 한국임상약학회 1993 한국임상약학회지 Vol.3 No.2
The effects of gastric acidity on the bioavailability of scopolamine hydrobromide and ${\ell}$-hyoscya-mine were studied in rabbits. Each drug was administered orally at dose of 0.2mg/kg to gastric acidity controlled rabbits. The plasma concentration of scopolamine and ${\ell}$-hyoscyamine were determined by selected ion monitoring in GC/MSCScopolamine; m/Z= 138, ${\ell}$-Hyoscyamine; m/z= 124). Rabbits with hypoacidity showed significantly higher Cp and AVC than rabbits with hyperacidity after oral administration of each drug. From the results of this experiment, it is desirable that dosage regimen of dose of scopolamine and hyoscyamine should be adjusted when the drugs should be administered with antacids in clinical practice.
식물을 흡착제로 이용한 각종 금속이온의 포집제거에 관한 연구 (Ⅱ) , Cucurbita moschata 잎을 흡착제로 이용한 수종 금속이온의 포집 제거 및 그 이론에 관한 연구
한상수(S . S . Han),김주신(J . S . Kim),김재백(J . B . Kim),고건일(G . I . Ko) 한국약제학회 1987 Journal of Pharmaceutical Investigation Vol.17 No.4
Adsorption of metal ions(Ag^+, Co^(2+), Zn^(2+)) from water by the formalin treated leaves of Cucurbita moschata was surveyed by atomic absorption spectroscopy. The rate of adsorption by the formalin treated leaves of Cucurbita moschata was evaluated under the condition of variation in temperature, stirring time and metal ion concentration. The result was as follows; Formalin treated sample had greater adsorbability than nontreated sample and active carbon, which were not denaturated at 110℃ and room temperature for the long period. The adsorption of metal ions by the formalin treated leaves of Cucurbita moschata was evaluated to discover useful scavenger. Adsorption of silver, cobalt and zinc by the formalin treated leaves of Cucurbita moschata roughly follows Freundlich isotherms in the concentration range of each 5-200 ㎍ of Ag, Co and Zn per milliliter. Namely, in the case of silver; logX/m=0.55 logC+2.65, in the case of cobalt; log X/m=0.77 logC+2.63, in the case of zinc; logX/m=0.70 logC+2.56
Chestnut내과피를 이용한 수용액중 중금속의 흡착제거에 관한 연구
박성은,고건일,김재백 圓光大學校 藥品硏究所 1990 藥品硏究所報 Vol.5 No.1
Adsorption of metal ions(Cd^2+, Pb^2+) in water by atomic absorption spectrophotometer. Rate of adsorption by the endocarp of chestnut was evaluated under the condition of variation in temperature, shaking time, solution pH, adsorbent amount, and metal ion concentration. The results are as follows: 1. Adsorption rate of Cd^2+, Pb^2+ in water by the endocarp coarse powder of chestnut was each 55∼90%, 22∼99% in the concentration of each Cd^2+ 2.5∼20μg/ml, Pb^2+ 2.5∼200μg/ml. 2. Endocarp coarse powder of chestnut has greater adsorbability than water extracted sample, i.e., 2.2 times in Cd^2+, 2.5 times in Pb^2+. 3. Adsorption of Cd^2+, Pb^2+ by the endocarp coarse powder of chestnut roughly following Freundlich isotherms in the concentration range of each Cd^2+∼20μg/ml, Pb^2+ 2.5∼200μg/ml.
Glycyrrhizae Radix 함유 다당류제제의 Biological Response Modification 효과에 관한 연구
강기홍,한상수,김형민,고건일,김재백 圓光大學校 藥品硏究所 1989 藥品硏究所報 Vol.4 No.1
This study was done to know the effect of the polysaccharide as BRM(Biological Response Modifiers) in mice. The author obtained the following results: 1. The amount of glycyrrhizin in GAMBIMAM was about 0.06 w/w %. 2. There was depressive effect of GAMBIMAM on the contact hypersensitivity (CHS) reactions against 2,4-dinitro-1-fluoro-benzene(DNFB) Especially, GAMBIMAM inhibited the elicitation but not the induction of contact sensitivity. 3. GAMBIMAM suppressed the delayed type hypersensitivity(DTH) reactions against sheep red blood cells (SRBC) 4. There was no effects of the GAMBIMAM on the humoral immune responses against SRBC. 5. GAMBIMAM suppressed markedly the depression of CHS reaction induced by the ultraviolet radiation 6. There was no effects of GAMBIMAM on the depression of DTH reaction induced by the ultraviolet radiation 7. GAMBIMAM induced dose-dependent suppression of CHS reaction.
어린이와 Scopolamine Patch(KIMITE)
신창범,고건일 圓光大學校 藥品硏究所 1987 藥品硏究所報 Vol.2 No.1
Efficacy and safety of Scopolamine Patch Preparaton are investigated in 60 case of childrens. In this result, we suggested that it may be useful and safe in dose of children for prevention of motion sicknness.
HPLC 를 이용한 제제중 프레드니솔론의 함량균일성시험에 관한 연구
김형국,고건일,김재백 한국약제학회 1983 Journal of Pharmaceutical Investigation Vol.13 No.1
A convenient high-performance liquid chromatographic method for the quantitative determination and content uniformity of prednisolone in tablets is described. The prednisolone was chromatographed using a μ-Bondapak C_(18) column and the eluent 70% MeOH at a flow rate 1.0㎖/min. Diethystilbestrol was used as an internal standard. The UV detector responce at 254nm was linear for prednisolone in the 10-60㎍/㎖ range under conditions of the analysis.
Microcapsule의 可笑化 時間과 藥物의 溶出에 關한 硏究
김창영,고건일,김재백 圓光大學校 藥品硏究所 1986 藥品硏究所報 Vol.1 No.1
Microencapsulated phenacetin were prepared by coacervation of aqueous Cellulose Acetate Phthalate(C.A.P) solutions. Appropriate solutions were made by dissolving C.A.P. in an equivalent concentration of Disodium hydrogen phosphate. The C.A.P. shells are plasticized by imbibition with 5% Glycerol solution and that dissolution rate determined in 0.1N Hydrochloric acid solution containing 0.4% sodium lauryl sulfate. As a result, plasticized microencapsulated phenacetin during 2 minutes, 5 minutes and 8 minutes correlated between dissolution rate and plasticizing time in microcapsules. Plasticized microencapsulated phenacetin during 12 minutes and 15 minutes was not correlated between dissolution rate and plasticizing time in microcapsules. And the other, microcapsuies were dyed with Methylene blue solution. As a result, nonmicroencapsulated phenacetin was not dyed. but microencapsulated phenacetin was dyed with Methylene blue solution.
김재백,고건일,최진영,한상수,함성호 圓光大學校 藥品硏究所 1986 藥品硏究所報 Vol.1 No.1
The mass and infrared spectra of the methyl esters of 5 chlorophenoxy acid herbicides are presented. Ultraviolet analysis data are discussed and proton magnetic resononce spectra are tabulated. Because of the sensitivity of the technique, the mass spectra are most useful for the identification of those compounds in residues, especially by combined gas chromatography mass spectrometry. The pure herbicides used for the recording of the spectra were obtained by synthesis and recrystallization. For the determination of chlorophenoxy carboxylic acid herbicides by gas chromatography, efficiency of methylation agents, Diazomethane, Dimethyl sulfate and Percholric acid in Methanol, was evaluated. A mixture of Dimethy sulfate in Methanol is an efficient methylating agent for the chlorophenoxy acetic acid herbicdes. Its efficiency was compared with Diazomethane and acid catalyzedreactions. In urine, blood and other tissues, determination of 2, 4-D and Dicamba was evaluated through methylation of the sample extract by gas chromatography.