토끼에서 EPO(Erythropoietin)의 안점막자극성 및 피부자극성시험

강병철,남정석,제정환,이석만,양재만,이학모,박재학,송동호,유선희 한국독성학회 1997 Toxicological Research Vol.13 No.1

This test was performed to evaluate the ocular and skin irritation of EPO (Erythropoietin). The results as follows: 1. Ocular irritation test There were no observed clinical signs, body weght changes by EPO during experimental period. The acute ocular irritation index(A.O.I.), mean ocular irritation index(M.O.I.) and Day-7 individual ocular irritation index(I.O.I.) of EPO at dose of 1000U and 10, 000U were 0, respectively. Therefore we evaluated that EPO was non-toxic to eyes. 2. Skin irritation test There were no observed clinical signs, body weght changes and gross pathologic findings by EPO during experimental period. There were no observed erythema, eschar formation and edema formation on intact and abraded skin treated by EPO. The primary irritation index(P.I.I.) of EPO at dose of 1000U and 10, 000U were 0, respectively and were evaluated none irritating product about skin irritation.

기관지 결핵환자의 내과적 치료중 또는 치료후의 기관지 변화에 대한 전산화 단층촬영 소견

강병철 대한영상의학회 1995 대한영상의학회지 Vol.32 No.1

Purpose : The purpose of this study wass to evaluate the bronchial change of the endobronchial tuberculosis onCT scan during and after medical treatment to guide. Materials and Methods : We prospectively analyzed thebronchial changes on CT scans of 14 endobronchial tuberculous lesions in 11 patients. The diagnosis of theendobronchial tuberculosis was obtained by bronchoscopic biopy, washing cytology. The mean period of treatmentbefore follow-up CT scan is 5.2 months (2-12 months). Results : Improving process of the endobronchial lesionswere observed in 1 smooth tapered obstruction and 1 irregular narrowing. Normaization of the CT findings after orduring the medical treatment were seen in 4 smooth narrowing. 1 irregular narrowing, 1 tapered obstrction, 1V-shaped obstruction, 1 abrupt amputation, and 3 focal nodular narrowings. Little interval changes was observed inonly 1 case of the V-shaped obstruction. Conclusion : The patency of most of the narrowed or obstruted bronchuswere improved during or after medical treatment, except in one case of V-shaped obstruction.

갑상선자극호르몬 분비뇌하수체선종의 자기공명소견

강병철 대한영상의학회 1995 대한영상의학회지 Vol.32 No.1

Purpose : To demonstate and evaluate the value of MRI findings of the TSH(Thyroid-Stimulating Hormone, TSH,Throtropin)-secreting pituitary adenoma. Materials and Methods : The authors reviewed retrospectively the MRimages of 4 patients with TSH-secreting pituiatary adenoma. Evaluation of the anatomical location, signalcharacteristics, enhancement patterns, size, shape and circunferential changes were made. Results : Nocharacteristic common MR findings in size, shape, signal intensity, and circumferential changes of TSH-secretingpituiatary adenoma waere observed among 4 cases (size; 5X7mm to 10X11mm, shape;ovoid to round, signalintensity;high in 1 case on T1 and T2W1, isosignal intensity in the other 3 cases, circumferential change;stalkdeviation in 1 case, no stalk deviation in cases). But, the tumors were centrally located at the anteriorpituitary gland and showed relatively homogeneous signal intensity on MR images of all 4 patients. Conclusion : Weconclude that centrally-located mass at the anterior pituitary gland with homogeneous signal intensity on MR imagemay be suggestive of the TSH-secreting pituitary adenoma, although the MR findings are not specific for thedisease.

파열형 요추추간판 탈출증에서 자기공명 영상의 진단적 의미

강병철 대한영상의학회 1994 대한영상의학회지 Vol.30 No.3

목 적: 요추추간판 탈출증 중, 파열형 추간판탈출중애서 자기공명영상 소견을 분석하여 수술전 진단에 유용한 소견을 얻고자 하였다. 대상 및 방법: 1992년1월1일부터1992년 8월20일까지 약 8개월동안 연세대학교 영동세브란스병원에 내원하여 자기공명영상을 얻고 수술로 확인된 17명의 20병소에서의 파열형 요추추간판 탈출증을 대상으로 자기공명영상과 병리 및 수술 소견을 서로 비교 분석하였다. 결과: 1) 후종인대의 신호간도선인 Black Line의 단락을 시상면 SE영상에서 19예, 횡단면 GE영상에서 17예를 각각 관찰할 수 있었고, 2) 주변 경막외 지방공간의 확장을 16예에서 관찰할 수 있었다. 3) 추간판 공간내에 존재하는 추간판과 비교한 돌출된 추간판의 신호강도의 변화는 증가, 비슷, 감소 정도가 각각, T1강조영상에서는 10,0,1예 T2강조영상에서는 10,7,3예, GE영상에서는 10,9,1예이었다. 결 론: 파열형 요추추간판 탈출증의 가장 중요한 자기공명영상의 소견은 후종인대의 신호강도선인 Black Line의 단락이며, 부수적으로 돌출된 추간판의 신호강도의 변화와 주변 경막외 지방공간의 확장도 함께 관찰될 수 있는 소견이다. Purpose : The purpose of this study is to describe the findings of the transligamnetous type of the herniated lumbar disc (HLD) with magnetic resonance MR imaging.Materials and Methods : We retrospectively analyzed the MR images of surgically proven 20 cases of transligamentous type of HLD from January 1, 1992 to August 20, 1992. The MR imaging was performed with 1.07 MR unit, using sagittal spin echo (SE) and axial gradient echo (GE) techniques.Results: The results were as follows; 1) the interruption of black line of the posterior longitudinal ligament(PLL) was identified in 19 levels and 17 levels in sagittal SE and axial GE images, retrospectively ,2) the widening of adjacent epidural fat space was demonstrated in 16 cases of central or posterolateral HLD. The herniated disc material, as compared with the parent intervertebral disc, showed intermediate signal intensity (Sl) in 19 and low Sl in 1 level on TIWI, high 51 in 10, intermediate 51 in 7, low 51 in levels on T2Wl, and high Sl in 10, intermediate 51 in 9, low 51 in 1 level on GE imagesConclusion : The most important sign of the transligamentous type HLD on MRI was the interruption of the black line with additional finding of the widening of adjacent epidural fat space. The MR signal intensity of the herniated disc was variable. Axial GE image was valuable for the evaluation of the direction of HLD and it relationship with neural structure, but had no addiational information for the degree and biochemical change of HLD over SE image.

유방암환자의 호르몬수용체와 유방촬영술 소견과의 관계

강병철 대한영상의학회 1994 대한영상의학회지 Vol.31 No.5

A Newly Designed Y-shaped Covered Stent in the Palliative Treatment of Hepatic Hilar Malignant Obstruction: Case Report

강병철,이소원,정환훈 대한영상의학회 2013 Korean Journal of Radiology Vol.14 No.1

We report a case in an inoperable patient with the hilar malignant biliary obstruction treated palliatively by the use of a newly designed Y-shaped covered stent without interfering contra-lateral bile duct. We percutaneously inserted a newly designed Y-shaped covered stent into a biliary tree in an inoperable patient with Bismuth Type II cholangiocarcinoma. We checked tubograms, enhanced CT studies, and blood bilirubin levels before, one week after, and at every three month after the stenting, by observing closely the signs of clinical infection as well. The follow-up period was about 12 months. The placement of the Y-shaped covered stent was successful and resulted in adequate biliary drainage in the immediate post-procedural tubogram and in the follow-up abdominal CT. The serum bilirubin levels did not show elevation after the insertion of the Y-shaped covered stent.

당뇨관리수첩 외 1편

강병철 천년의시작 2015 (계간)시작 Vol.14 No.2

신규 개인제독키트, SDK시제품(가칭)의 면역독성평가에 관한 고찰

강병철,이학모,제정환,남정석,이석만,양재만,박재학,이영순 한국독성학회 1998 Toxicological Research Vol.14 No.2

To evaluate immunotoxicity of skin decontamination kit(SDK) newly-developed in Agency for Defense Development(ADD), delayed contact hypersensitivity (maximization) test and passive cutaneous anaphylaxis(PCA) test of SDK were performed and the results were compared with those of M 291. In maximization test, sensitization reaction was induced by id injection (2.5 mg / 0.1 $\textrm{m}{\ell}$/ guinea pig or 2.5 mg+CFA/0.1 $\textrm{m}{\ell}$/guinea pig) and topical application (2.5 mg/$\textrm{m}{\ell}$/guinea pig) with SDK or M291 at an interval of 1 week, and 2 weeks later, challenged by topical application with 25 mg/$\textrm{m}{\ell}$/guinea pig. SDK and M291 did not induce any reactions, showing 0 point of sensitization score and 0% of sensitization rate. In conclusion, it is suggested that SDK and M291 do not induce delayed contact hypersensitivity. In PCA test, rats were administered id with mouse anti-SDK serum and challenged iv with a mixture of antigen SDK and Evan's blue. SDK did not induce blue spots at the injection sites of both high (2.5 mg/mouse) and low (1.25 mg/mouse) dose-induced antisera. In contrast, BSA, positive control produced spots larger than 5 mm in diameter at the injection sites of BSA-induced antiserum up to $2^2$ ~ $2^4$dilution. In conclusion, it is suggested that SDK do not induce IgE production and is not a PCA-reaction inducer.

서울대학교 채소육종연구센터

강병철 한국원예학회 2014 한국원예학회 학술발표요지 Vol.2014 No.5

실험동물시설에서 Sendai virus 감염사고 대처의 예

강병철 한국실험동물학회 2006 한국실험동물학회 학술발표대회 논문집 Vol.2006 No.-