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감은영,강은정,류지연,박수연,정민영,김종한,최정화 대한한방안이비인후피부과학회 2020 한방안이비인후피부과학회지 Vol.33 No.2
Objectives : Recently the aesthetic, especially skin whitening, is focused on. This study was designed to investigate the effects of Gypsum Extract(GE) on skin whitening using B16F10 cell lines. Methods : In this study, we investigated effect of GE on cell viability, melanin synthesis, Superoxide dismutase(SOD)-like activity and tyrosinase activity in vitro and in vivo. Results : In results, The proliferation of B16F10 cell lines was increased by GE concentration. But there was no statistical signification. Melanin synthesis was decreased except GE 125㎍/㎖ of treated group. And the melanin synthesis ratio was increased in group being treated α-MSH. But After treating GE, it was decreased compared to Non-GE treated group. In addition, the SOD-like activity was enhanced in more than GE 125㎍/㎖ of treated group. And the activity of tyrosinase in vitro was inhibited in GE 500㎍/㎖ and 1,000㎍/㎖ of treated groups. The activity of tyrosinase in vivo was reduced in both Arbutin 500㎍/㎖ of treated group and Gypsum 500㎍/㎖ of treated group compared to controled group. After being treated α-MSH, the activity of tyrosinase was enhanced. But after treating Arbutin 500㎍/㎖ or Gypsum 500㎍/㎖, it was inhibited being compared to the group of Non-medicament treated. Conclusion : The results of this study showed the effects of GE that can inhibit melanin synthesis and the activity of tyrosinase and enhance the SOD-like activity. It means that gypsum has the skin whitening effect.
가감통청산 및 한방 치료를 통한 화폐상 습진 치험 1례
감은영,강은정,윤석영,김민욱,최정화 대한한방안이비인후피부과학회 2020 한방안이비인후피부과학회지 Vol.33 No.4
Objectives : The aim of this study is to report the effect of Gagamtongchung-san and Korean medicine on the treatment of nummular eczema. Methods : A 52-year-old male had suffered from nummular eczema in forearm, dorsum manus and fossa cubitalis. We treated him with herbal medicine, acupuncture and herbal external medicine. In order to evaluate the results of these treatments, we observed pruritus and heat sensation of the patients and took photographs of the lesions. Results : After treatment, the nummular eczema lesions of patient was remarkably disappeared, NRS of pruritus and heat sensation decreased from 10 to under 2 and DLQI score changed from 28 to 9. Conclusions : According to the result, Gagamtongchung-san and Korean medicine can be effective for the treatment of nummular eczema and the improvement of quality-of-life.
麻杏薏甘湯과 Trichloroacetic acid (TCA) 병행치료를 이용한 심상성 사마귀의 한방 치험 1례
강은정,감은영,최정화,김종한,박수연,정민영 대한한방안이비인후피부과학회 2020 한방안이비인후피부과학회지 Vol.33 No.2
Objectives : The purpose of this study is to report the effects of Mahaengeuigam-tang and Trichloroacetic acid(TCA) on hand warts. Exfoliation, such as TCA is a method developed from traditional medicine and used to treat hyperkeratosis skin in this patient. Methods : A patient with Verruca Vulgaris was treated with herbal medicine, including Mahaengeuigam-tang and application of TCA on wart lesions. Changes in lesions were evaluated by photographs. Results : After 3 months of treatment, The patient’s lesions showed complete clearance. There are no adverse effects and no relapse of Verruca Vulgaris after 57 days of last treatment. Conclusions : According to the result, Mahaengeuigam-tang and External treatment such as TCA developed from traditional medicine can be effective for Verruca Vulgaris.
주사(Rosacea)의 한약 치료에 대한 체계적 문헌고찰 및 메타분석
강은정,감은영,김서희,윤석영,전석희,최정화,김종한,박수연,정민영,Kang, Eun-Jeong,Kam, Eun-Young,Kim, Seo-Hee,Yoon, Seok-Yeong,Jeon, Seok-Hee,Choi, Jung-Wha,Kim, Jong-Han,Park, Soo-Yeon,Jung, Min-Yeong 대한한방안이비인후피부과학회 2021 한방안이비인후피부과학회지 Vol.34 No.3
Objectives : This review was conducted to validate the effectiveness and safety of herbal medicine combined with conventional therapy for rosacea. Methods : Randomized controlled trials(RCTs) reporting the effects of herbal medicine treatment on rosacea were searched through eight electronic databases from 2016 to March 17, 2020. This study collection and data extraction were performed by two independent reviews. The Cochrane risk-of-bias tool was used for the evaluation of the risk of bias in all included RCTs. Mean differences(MD) and Risk ratio(RR) of 95% Confidence intervals(Cls) were calculated and data synthesis was conducted using Review Manager(RevMan, ver.5.4) Results : Eighteen RCTs were included and all trials compared the combined therapy of herbal medicine with conventional western therapy to conventional therapy alone. The effective rate of the combination of herbal medicine with western medicine(RR 1.20, 95% CI : 1.13-1.28, p<0.00001, I<sup>2</sup>=0%), the effective rate of the combination of herbal medicine with laser-based therapy(RR 1.12, 95% CI : 1.04-1.21, p=0.004, I<sup>2</sup>=18%) and the effective rate of the combination treatment group using herbal medicine, western medicine and external drugs were all statistically higher that of the control group(RR 1.19, 95% CI : 1.11-1.28, p<0.00001, I<sup>2</sup>=0%). The score of non transient erythema(MD -0.36, 95% CI : -1.01 0.29, p=0.27, I<sup>2</sup>=93%), flushing(MD -0.69, 95% CI : -0.97, 0.41, p<0.00001, I<sup>2</sup>=32%), papules or pustules(MD 0.10, 95% CI : -0.15, 0.35 p=0.44, I<sup>2</sup>=0%) were also seen in the herbal medicine and western medicine combination group. The overall risk of bias of the included studies was some concerns. No serious adverse effects were observed. Conclusions : This review found the safety and effectiveness of the combined therapy of herbal medicine with conventional western therapy for rosacea.
감맥대조탕이 DNCB로 유발된 생쥐의 아토피피부염에 미치는 영향
류지연,감은영,강은정,최정화,김종한,박수연,정민영 대한한방안이비인후피부과학회 2020 한방안이비인후피부과학회지 Vol.33 No.2
Objectives : Atopic dermatitis is a chronic inflammatory skin disease with frequent relapses. This study was to investigate the effects of Gammakdaejo-tang(GMD) in DNCB induced atopic dermatitis mice. Methods : The study was divided into five comparion groups. 2,4-dinitrochlorobenzene(DNCB) solution was applied to Nc/Nga mice to induce atopic dermatitis, followed by normal group, negative control group with distilled water, positive control group with Dexamethasione and GMD 200㎎/㎏ or 400㎎/㎏. The control group was orally administered 200㎕ once daily for 4 weeks. Visual skin condition, Immunoglobulin E, Histamine, Cytokine, Immune cells, Tissue biomarkers were observed. Results : As a result of the dermatitis score evaluation, it was confirmed that the GMD-administered group improved symptoms compared to the negative control group. As a result of measuring IgE, the GMD-administered group significantly decreased compared to the negative control group. As a result of measuring Histamine, GMD group except 200㎎/㎏ of GMD significantly decreased compared to negative control group. As a result of measuring cytokine, GMD 200㎎/㎏ significantly reduced IL-1β, IL-6 and TNF-α compared to the negative control. 400㎎/㎏ significantly reduced IL-1β, IL-4, IL-5, IL-6, IL-10, TNF-α and significantly increased IL-2, IFN-γ. As a result of confirming the immune cells, all experimental groups showed no difference in basophil, GMD group significantly reduced monocyte and eosinophil compared to negative control group, and GMD 400㎎/㎏ group significantly reduced white blood cell and neutrophil. And significantly increased lymphocytes. As a result of measuring the gene expression level, all GMD group significantly increased TGF-β1 compared with the negative control group, and filaggrin, VEGF and EGF were significantly increased in GMD 400㎎/㎏ group. Epidermis, dermis thickness, and eosinophil infiltration were found to be decreased in all GMD groups compared with the negative control group. Conclusions : GMD is effective in atopic dermatitis by reducing imbalance of immune response of T cells (Th1 / Th2) and reducing skin tissue damage and inflammatory response.
陽毒白虎湯 처방과 黃連解毒湯 濕布를 병행한 주사의 한방 치험 1례
강은정,이호찬,감은영,최정화,김종한,박수연,정민영 대한한방안이비인후피부과학회 2019 한방안이비인후피부과학회지 Vol.32 No.3
Objectives : The aim of this study is to report the effects of Yangdokbaekho-tang and Hwangryunhaedok-Tang wet dressing on the treatment of erythrotelangiectatic rosacea patient. Methods : A patient with Erythrotelangiectatic Rosacea treated with Yangdokbaekho-tang, Hwangryunhaedok-Tang wet dressing and acupuncture. We evaluated the score(frequency × intensity) of the hot flush, the main symptom of rosacea and NRS(numeral rating scale) for the subjective symptom. Results : After treatment, the score of the hot flush decrease from 20 to 6. the NRS changed and NRS score improved from 7 to 1. There are no adverse effects and no relapse of erythrotelangiectatic rosacea after 18 days of discharge. Conclusions : According to the result, Korean Medicine such as Yangdokbaekho-tang and Hwangryunhaedoktang wet dressing can be effective for the treatment of erythrotelangiectatic rosacea.
윤석영,노민영,감은영,강은정,김종한,최정화,박수연,정민영,이지현 대한한방안이비인후피부과학회 2020 한방안이비인후피부과학회지 Vol.33 No.4
Objectives : The purpose of this study is to report the effect of Korean medicine treatment on limitation of eye movement in Miller-Fisher Syndrome. Methods:A patient was treated with herbal medicines, acupuncture(including electropuncture, phamacopuncture), Moxibustion and cupping therapy. To evaluate the result of this treatment, we used photographs of eye movement, Scott and Kraft score of both eye, length of eyeball movement and visual analogue scale(VAS) for subjective symptoms. Results : After treatment, the limitation of eye movement and diplopia were remarkably improved. Also, other symptoms such as dizziness, gait disturbance, facial nerve disorder were disappeared. Conclusions : This study suggests that Korean medicine treatments are effective for patient with limitation of eye movement in Miller-Fisher Syndrome.
조경종옥탕가미방으로 호전된 다낭성난소증후군에 의한 희발월경 환자 증례 보고
김민욱,김보리,감은영,양승정,조성희 대한한방부인과학회 2020 大韓韓方婦人科學會誌 Vol.33 No.3
Objectives: The purpose of this study is to report the effect of Jokyeongjongok -tang-gami in case of oligomenorrhea patients classified with gan-ulgiche and eumheo due to polycystic ovary syndrome. Methods: Three patients suffering from oligomenorrhea due to polycystic ovary syndrome were treated with korean medical treatment (herbal medicine, moxibustion, acupuncture) more than 3 months. The patients classified with gan-ulgiche and eumheo were treated with Jokyeongjongok-tang-gami. Results: Three oligomenorrhea patients recovered normal menstrual cycle more than 3 times after taking Korean medical treatment for 3~6 months. Conclusions: This 3 cases classified with gan-ulgiche and eumheo show Jokyeongjongok -tang-gami is effective on patients with rare menstruation due to polycystic ovary syndrome.