里程標

金亨默 韓國外國語大學 1975 槿花 Vol.1 No.1

Fructose-1,6-diphosphate가 첨가된 심근 보호액의 임상적용

김형묵,김광택,Kim, Hyeong-Muk,Kim, Gwang-Taek 대한흉부심장혈관외과학회 1991 Journal of Chest Surgery (J Chest Surg) Vol.24 No.7

Fructose-l, 6-diphosphate as an additive to cold crystalloid cardioplegia [St. Thomas sol.] was studied prospectively in 60 patients undergoing open heart surgery from January 1, 1991, to June 30, 1991. Thirty patients received cardioplegia with FDP[group I ] and 30 patients received cardioplegia without FDP [group II ]. There were no differences between two groups pre-operatively with regard to age, heart disease, cross-clamp time, cardiac enzymes, or hemodynamic measurements [p>0.05]. Cardiopulmonary bypass was established using ascending aorta and vena cava cannulation employing moderate systemic hypothermia [30oC nasopharyngeal temperature] and hemodilution All patients received cardioplegia through the aortic root at aortic root pressure of 80mm Hg. The composition of the cardioplegic solution and its delivery were identical in both groups except for the addition of FDP[1.5 mg/mL] in group I. The cardioplegic infusate consisted of St. Thomas Hospital solution. The initial dose was infused through the aortic root. Topical myocardial cooling with saline slush was employed in all patients. Recorded operative data were cardiopulmonary bypass and cross-clamp times, amount of cardioplegic infusate. Blood samples for assessment of lactate dehydrogenase [LDH], creatine kinase [CK] and transaminases [GOT, GPT] were obtained before and at 1,2,3,7th postoperative period. Better myocardial protection effect was noted in group I than group II with respect to the % change of cardiac enzymes, although the differences were not significant. We conclude that FDP is a safe additive to crystalloid cardioplegia and may be beneficial in open heart surgery patients.

PEO-$SO_3$를 이용한 항석회화 조직첨포의 개발(II) -동맥과 복막 이식 실험연구-

김형묵,백만종,김광택,이인성,김학제,이원규,박기동 대한흉부심장혈관외과학회 1998 Journal of Chest Surgery (J Chest Surg) Vol.31 No.11

연구배경 : 인체내 이식된 생체조직들은 석회화 변성으로 인해 그 내구성이 단축된다. 이러한 조직들을 이식하기전에 글루타르알데하이드(GA)로 고정후 sulphonated polyethyleneoxide(PEO-SO3)를 결합시키고 또한 조직내 의 잔유 알데히드기를 제거함으로써 석회화에 대한 내구성을 향상시킬 수 있다 재료 및 방법 : PEO-SO3 처리법과 잔유 알데히드기 제거의 석회화 방지 효과를 알아보기 위하여 GA 고정 후 PEO-SO3로 처리한 소 심낭 첨포를 잔유 알데히드기 제거를 위해 무균 생리식염수에 보존한 saline 군과 0.65% GA 용액 에 보존한 GA군, 그리고 이미 상품화되어 임상에서 사용되고 있는 product군을 8마리 개의 경동맥과 대퇴동 맥 및 복막에 이식하여 6주 후 적출하여 칼슘량 및 병리조직 소견에 대해 알아보았다. 결과 : 경동맥에서 채취한 조직첨포의 칼슘량은 saline군에서 GA군과 product군에 비해 유의하게 적었다 (saline; 2.89$\pm$0.31 vs. GA; 6.14$\pm$1.08 vs. product; 22.82$\pm$5.00 mg/g; p< .05). 대퇴동맥과 복막 이식 첨포에서의 칼슘량 또한 saline군에서 다른 두 군에 비해 가장 적었으나 통계적인 유의성은 없었다. 한편 병리조직 검사에서는 GA군에서 다른 두 군에 비해 조직의 석회화로 인한 변성 파괴가 심하였다. 결론 : 본 연구에서 소 심낭 조직 첨포와 결합한 PEO-SO3는 석회화를 감소시키고 또한 조직내 잔유 알데히드기 를 생리식염수로 세척하여 제거함으로써 항석회화 효과를 증가시킬 수 있었다. 결론적으로 PEO-SO3로 처리한 소 심낭 조직은 석회화 변성에 대한 강한 저항성을 보임으로써 심혈관 첨포나 인공 조직 판막 개발 에 도움를 줄 수 있을 것이다. Background: Calcific degeneration limits durabilities of the bioprosthetic tissues implanted in the human body. The direct coupling sulphonated polyethyleneoxide(PEO-SO3) to the bioprosthetic tissues after glutaraldehyde(GA) fixation and the removal of residual aldehyde groups from the tissues can augment the effect of calcification-resistance. Materials and methods: To study the anti-calcification effect by PEO-SO3 modification and the removal of the residual aldehyde groups of tissues, surface modified bovine pericardia(BP-PEO-SO3) were preserved in aseptic saline to wash out GA(saline group) and 0.65% GA solution(GA group). And then above two groups and PERIGUARD (Bio-vascular. Co.) (product group) were evaluated with respects to calcium contents and microscopic findings using in vivo implantation models at carotid and femoral artery and peritoneum of 8 adult dogs. Results: In the tissues retrieved from carotid artery, calcium content was significantly decreased in saline group than in other two groups(saline; 2.89±0.31 vs. GA; 6.14±1.08 vs. product; 22.82±5.00 mg/g of dried tissue; p<0.05). In the tissues retrieved from femoral artery and peritoneum, calcium amount was also decreased in saline group than in other two groups, but not reached the significant difference between groups. On the other hand, the pathologic findings of pericardial tissues showed marked destructuction in GA group compared to the other two groups. Conclusions: In this study, covalently PEO-SO3 bound to bovine pericardium decreased calcifications and the anti-calcification effect of BP-PEO-SO3 could be augmented by the washing out the residual aldehyde groups using saline after GA fixation. Conclusively, the PEO-SO3 modified bovine pericardium is highly resistant to calcification and can be useful for the development of calcification-resistant cardiovascular patches and valves.

체력관리의 습관화

김형묵 경희대학교부설 밝은사회문제연구소 1983 밝은 社會 Vol.3 No.1

食道穿孔 및 從隔洞炎

金炯默 최신의학사 1973 最新醫學 Vol.16 No.6

인공폐(산화기) 제작과 실험

김형묵 대한흉부심장혈관외과학회 1982 Journal of Chest Surgery (J Chest Surg) Vol.15 No.2

We have designed a new type of bubble oxygenator (KOREA-KIM VENOTHERM OXYGENATOR) made of PVC sheet and deforming mesh incorporated in the heat exchanger, and evaluated in experimental animal for the analysis of it`s efficiency. The Oxygenator has low priming volume with high flow rate up to 6 L/rain, and efficiency of heat exchanger was excellent as 1-$1.5^{\circ}C.$ using total cardiopulmonary bypass method under moderate to deep hypothermia. Average priming volume of 1317 ml with 30% hemodilution method was perfused with an average of 1.1-3.0 L/min.$M^2$of arterial blood and pure oxygen at a rate of 2-3.4 L/min for 49.6 minutes continuously in average. During total cardiopulmonary bypass, average $PaO_2$ was $159.8{\pm}60$mmHg, $PaCO_2$ $41.0{\pm}3$mmHg respectively under $SaO_2$ over 96% with systolic arterial pressure of 70 mmHg and CVP of 5-10 cm$H_2O$. Plasma free Hemoglobin was $7.0{\pm}4$ mg/dl with 25% drop of hemoglobin and hematocrit at the end of cardiopulmonary bypass. This KKV Oxygenator was observed to have excellent capabillty of oxygen and carbon dioxide gas transfer with small amount of blood trauma, and the efficiency of heat exchanger was satisfactory during cooling and rewarming of the bubbled blood. Disadvantages have included the somewhat poor deforming effect due to loose PVC fiber mesh, the extracompact character of Teflon filters, and the rough inner surface of the heat exchanger copper pipes.

기획특집-한국의 인공장기 연구개발현황

김형묵,Kim, Hyeong-Muk 한국과학기술단체총연합회 1994 과학과 기술 Vol.27 No.12

초인간 6백만불의 사나이가 하나의 과학소설(SF)에 등장하는 가공인물이 아니라 현실로 다가오고 있다. 현대의학의 눈부신 발전에 힘입어 병들거나 고장난 인체부위를 인공장기나 다른 사람의 장기로 갈아끼우는 본격적인 인간개조시대가 열리고 있기 때문이다. 6배만불의 사나이는 가능한 것일까? 인공장기 연구개발 현황과 문제점을 총점검해 본다.

단전호흡운동을 통한 氣의 止感에 관한 연구

金亨默 청주대학교 교육문제연구소 1996 교육과학연구 Vol.10 No.1

2004년 청주대학교 성폭력 실태조사

김형묵,이연희 청주대학교 학생생활연구소 2004 學生生活硏究 Vol.26 No.-

중년여성들의 숙련자와 비숙련자간 수영운동 후 신체조성 비교

김형묵,박관도 청주대학교 학술연구소 2004 淸大學術論集 Vol.4 No.-

The purpose of this study is to analyze 'how swimming' for twelve weeks affects the body development of middle-aged women. An investigation into the body development of thirteen women in a two-month period and a one-year period was performed. Each woman that participated in the swimming trials was asked to continually practice one hour in the morning three times a week before and after the investigation. The study arrived at the following conclusion. 1) The weight after swimming was found to have decreased significantly by 0.7kg in the case of the unskilled group and 0.6kg in the case of the expert group. 2) FAT(%) before and after investigation had similarly decreased by 2% in the case of the unskilled group and by 1.7% in the case of the expert group. FAT percentages(%) of the unskilled group were reduced by more than 0.3% when compared to the expert group. 3) FAT mass(kg) before and after the investigation had similarly decreased by 1.3kg in the case of the unskilled group and by 1.1kg in the case of the expert group. FAT mass(kg) of the unskilled group was reduced by more reduced by more than 0.2kg in comparison with the expert group. 4) The variation of lean body mass(kg) before and after the investigation had increased by 0.8kg in the case of the unskilled group and by 0.5kg in the case of the expert group. Lean body mass(kg) of the unskilled group increased by more than 0.3kg in comparison with the expert group. 5) Total body water before and after the unskilled group and expert group didn't change. In summation, swimming for one hour three times a week was found to reduce the FAT(%) and FAT mass(kg) of middle-aged women.