Neonatal innate immunity and Toll-like receptor

윤혜선 대한소아청소년과학회 2010 Clinical and Experimental Pediatrics (CEP) Vol.53 No.12

The innate immune response is the first line of defense against microbial infections. Innate immunity is made up of the surface barrier, cellular immunity and humoral immunity. In newborn, immunologic function and demands are different to adults. Neonatal innate immunity specifically suppresses Th1-type immune responses, and not Th2-type immune responses, which are enhanced. And the impaired response of macrophages is associated with the defective innate immunity in newborn period. Toll-like receptors (TLRs) play a key roles in the detection of invading pathogens and in the induction of innate immune responses. In newborn, the expression of TLRs is age dependent, so preterm has low expression of TLRs. Also, there are defects in signaling pathways downstream of TLRs. As a consequence, the defects of TLRs activity cause the susceptibility to infection in the neonatal period.

소아천식의 치료

윤혜선 대한천식알레르기학회 1985 천식 및 알레르기 Vol.5 No.2

해피아트테라피 프로그램 참여경험이 전․의경의 심리적 안녕감, 군 생활 스트레스, 군 생활 적응, 자기효능감에 미치는 영향

윤혜선 한국무용과학회 2012 한국무용과학회지 Vol.28 No.-

Happy Arts Therapy(hereafter H.A.T.) program is the group counseling program through physical expression centered integration arts therapy. Since it has been introduced to help auxiliary police to adjust life of military in the Seoul Metropolitan Police Agency in 2005, more than 10,000 auxiliary police took part in this program so far. Thus, the purpose of this study is to investigate the effect of auxiliary police’s participation experience in H.A.T. program on psychological well-being, stress of military life, adjustment to military living and self-efficacy. To do this, standardized questionnaire was constructed and the survey was conducted targeting 420 auxiliary police who belonged to the Seoul Metropolitan Police Agency(Participation group of 210 and non-participation group of 210). The results are as follows. First, it showed that a group of auxiliary police with experience of participation in H.A.T. program had significantly higher psychological well-being, adjustment to military living and self-efficacy compared to other group without experience of participation. Stress of military life was significantly lower in a group with experience than that in other group without experience. Second, while the number of months for service was controlled, a group of auxiliary police with experience of participation in H.A.T. program and other group of non-participation were compared and analyzed. Psychological well-being, adjustment to military living and self-efficacy were significantly improved and stress of military life was significantly reduced in a group of participation. Third, within a group of auxiliary police with experience of participation in H.A.T. program, as the frequency of participation in program got increased, psychological well-being and self-efficacy were higher and it was effective on improvement on adjustment to military living. Stress of military life, on the other hand, was decreased. Fourth, as a result of the satisfaction of participants in H.A.T. program, it was shown that satisfaction of program was high. Taken all results together, H.A.T. program has the positive effect on psychological well-being, adjustment to military living, stress of military life and self-efficacy of auxiliary police. 해피아트테라피(Happy Arts Therapy: 이하 H.A.T.) 프로그램은 신체표현 중심의 통합예술치료를 통한 집단상담 프로그램이다. 2005년부터 서울지방경찰청 소속 전․의경들을 대상으로 군 생활 적응을 돕기 위한 프로그램으로 처음 도입되어 현재까지 전․의경 10만명 이상이 참여하였다. 이에 본 연구는 전․의경들의 H.A.T. 프로그램 참여경험이 심리적 안녕감, 군 생활 스트레스, 군 생활 적응, 자기효능감에 어떠한 영향을 미치는가를 규명하는데 그 목적이 있다. 이를 위해 서울지방경찰청 소속 전․의경 420명(참여집단 210명, 비 참여집단 210명)을 대상으로 정형화된 질문지를 구성하여 조사를 실시하였으며 그 결과는 다음과 같다. 첫째, H.A.T. 프로그램에 참여경험이 있는 전․의경 그룹이 참여경험이 없는 전․의경 그룹에 비해 심리적 안녕감과 군 생활 적응, 자기효능감은 유의한 차이로 높게 나타났고, 군 생활 스트레스는 유의한 차이로 낮게 나타났다. 둘째, 복무 개월 수를 통제한 상태에서 H.A.T. 프로그램 참여경험이 있는 전․의경 그룹과 비 참여자 그룹을 비교 분석한 결과, 참여자 그룹이 심리적 안녕감, 군 생활 적응, 자기효능감에서 유의한 차이로 향상된 것으로 나타났고, 군 생활 스트레스는 참여자 그룹이 유의한 차이로 감소된 것으로 나타났다. 셋째, H.A.T. 프로그램에 참여경험이 있는 전․의경 그룹 내에서 프로그램 참여 횟수가 많을수록 심리적 안녕감과 자기효능감이 높게 나타났고, 군 생활 적응 향상에도 효과적인 것으로 나타났다. 반면 군 생활 스트레스는 감소하는 것으로 나타났다. 넷째, H.A.T. 프로그램 참여자의 만족도를 실시한 결과 프로그램의 만족도가 높은 것으로 나타났다. 이상의 결과를 종합해보면, H.A.T. 프로그램은 전․의경들의 심리적 안녕감과 군 생활 스트레스 및 군 생활 적응, 자기효능감에 대해 긍정적인 영향을 미친다는 결론을 얻을 수 있다.

우유 알레르기

윤혜선 한국의학사 1992 診斷과治療 Vol.12 No.2

생산자 중심의 단체기록물 분류체계 개발에 관한 연구 민주통일민중운동연합을 중심으로

윤혜선,정연경,Yoon, Hye Seon,Chung, Yeon Kyoung 한국기록학회 2020 기록학연구 Vol.0 No.64

1999년 공공기록물 관리법이 제정되고 국내 기록관리는 주로 공공기록 관리 중심으로 이루어져 민간기록물 수집과 관리는 상대적으로 미흡하게 진행되어왔다. 본 연구는 1985년에 재야 여러 단체의 연합조직으로 창립되어 정권에 대항하여 활동하는 등 역사적 가치가 있지만 기록관리 및 이관 등이 제대로 이루어지지 않은 민주통일민중운동연합(이하 민통련)의 기록물을 바탕으로 민간 기록물의 생산자 중심의 단체컬렉션 분류체계를 개발하고자 하였다. 이를 위해 문헌연구, 기록물 내용 분석 및 재조직, 분류체계 개발, 전문가 평가를 실시하였는데 구체적인 연구방법은 다음과 같다. 첫째, 선행연구와 이론적 고찰을 통해서 매뉴스크립트 컬렉션에 적합한 분류 방법을 알아보고 민주화운동기념사업회 디지털 아카이브인 오픈아카이브의 분류체계를 분석하여 단체컬렉션 구성의 의의를 밝혔다. 둘째, 민통련의 설립배경, 활동 등을 분석하고, 기록의 생산적 특징인 시기, 유형, 내용을 분석하였다. 셋째, 전명혁(2004)의 민주화운동 단체를 바탕으로 나눈 범주를 기본으로 연관이 없는 주제 영역은 제외하거나 재정의하고, 새롭게 필요한 영역은 추가하였다. 넷째, 민통련 단체컬렉션의 분류체계를 생산자(조직), 생산 시기, 주제, 유형으로 만들고 전문가 평가를 받은 후, 이를 반영해서 민통련 분류체계의 최종안을 완성하였고 민통련 기록물에 적용하였다. 본 연구의 결과는 다양한 출처의 민통련 생산 기록을 재분류하여 해당기록으로의 접근과 활용이 용이한 분류체계를 개발함으로써 민통련 자료의 검색 효율성을 증진시킬 수 있을 것이다. 또한 단체 컬렉션 구성에 대한 하나의 사례로서 생산자 중심 분류의 기본 구조를 제시할 수 있을 것이다. RRecords management has focused largely on public records in south korea with a relatively low progress in the collection and management of private records with the enactment of Public Records Act in 1999. This study set out to categorize the records of the Coalition for Democratic Reunification and the People's Movement(DRPM) and develop them into a group collection. For this study, literature reviews, analysis and reorganization of records content, development of a classification system, and expert evaluation were carried out. The findings of this study will contribute to greater efficiency in the search of records about the DRPM by developing a classification system to recategorize its records of various sources and enable their easy access and utilization in a digital archive. In addition, the basic structure of producer-oriented classification can be suggested as an example of the organization of a group collection.

인공지능 기술을 윤리적으로 탐하다

윤혜선 한국인터넷자율정책기구 2018 KISO 저널 Vol.- No.33

Risk Factors for Neonatal Infections in Full-term Babies in South Korea

윤혜선,신윤정,기모란 연세대학교의과대학 2008 Yonsei medical journal Vol.49 No.4

Purpose: Since 1997, private postnatal care facilities (San-hu-jo-ri-won in Korean) have emerged to take the role of the family. As a result, neonates are now exposed to many people and are very vulnerable to infection. However, there has been no study on the influence of postnatal care facilities on neonatal infection. The aim of this study was to determine the risk factors of neonatal infection in full- term babies in Korea. Materials and Methods: We followed up 556 pregnant women and their babies for 4 weeks after their births at 2 hospitals in Seoul and Daejeon from October 2004 to September 2005. Among 512 full-term babies, 58 had infectious diseases. To determine the risk factors for infection, 53 infected neonates at 4-28 days of life and 413 healthy neonates were compared. Results: The incidence of neonatal infection at 4 to 28 days after birth was 10.5%. After adjusting the related factors, the number of siblings (OR=2.05, 95% CI=1.13-3.71 for 1 or more) and postnatal care facilities or home aides (OR=1.91, 95% CI=1.07-3.45) were significant risk factors. Formula or mixed feeding (OR=1.66, 95% CI=0.91-3.04) increased the risk of neonatal infection but it was not statistically significant. Conclusion: When the newborns had siblings, stayed at postnatal care facilities, or were cared for by home aides, the risk of neonatal infections significantly increased. Further research on the feeding effect on neonatal infection and evaluation of prevention efforts are needed.

[행복 일기] 행복을 타이핑하는 여자

윤혜선 샘터사 2009 월간 샘터 Vol.476 No.-

인공지능의 발전과 공진화를 위한 규제 패러다임의 모색

윤혜선 한국지능정보시스템학회 2018 한국지능정보시스템학회 학술대회논문집 Vol.2018 No.6

MICE 도시경쟁력 중요도 인식에 따른 개최도시 선호도 및 개최의사 연구

윤혜선,윤유식,김미성 한국이벤트컨벤션학회 2020 이벤트 컨벤션 연구 Vol.16 No.3

Purpose – The purpose of this study was to identify the importance of the urban competitiveness to the Organizer and Planner of the MICE industry and to verify the effect of the importance on the host city's preference and willingness to host. Research Design, data, and methodology – A total of 313 valid responses(189 organizers and 124 planners) were obtained and utilized for analysis through online and offline surveys of employees in the MICE field. The collected data were conducted using SPSS 25.0 to analyze the frequency, explore factors, reliability, correlate between variables, multiple regression, and independent sample T-Test analysis. Result – This study found that the factors that affect the host city's preference were meeting facilities, costs, and accessibility among the characteristics of MICE's recognition of the importance of urban competitiveness. It was also shown that the host city's preference has a positive effect on the host's intention. Lastly, T-tests showed that there are differences between the host and planners in competitiveness, preference and intention to host. Conclusions – The study provides practical implications and policy directions for securing urban competitiveness as a venue for MICE by identifying the importance of urban competitiveness, preference for host cities, and impact relationship between the host cities.