High selective and stable performance of catalytic aromatization of alcohols and ethers over La/Zn/HZSM-5 catalysts

Youming Ni,Guangxing Li,Weiye Peng,Aiming Sun,Wanling Mo,Jianglin Hu,Tao Li 한국공업화학회 2010 Journal of Industrial and Engineering Chemistry Vol.16 No.4

The catalytic conversions of methanol, ethanol, dimethyl ether and diethyl ether to aromatic hydrocarbons (especially benzene, toluene and xylene) were achieved over 0.8%Zn/0.6%La/HZSM-5catalyst with a BTX selectivity as high as over 50% at reaction conditions of 710 K, WHSV 0.8 h1. The selectivity of BTX hydrocarbons in methanol aromatization reaction could remain 35% in 40 h. 2010 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved.

Slide Session : OS-GAS-05 ; Gastroenterology : 3-Mercaptopyruvate Sulfurtransferase Downregulation Ameliorates Hepatic Steatosis and Oxidative Stress Via Hydrogen Sulfi de Metabolism in Nonalcoholic Fatty Liver Disease

( Meng Li ),( Jiexia Ding ),( Xingyong Wan ),( Xi Jin ),( Shaohua Chen ),( Chaohui Yu ),( Youming Li ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

Background: The mitochondrial enzyme 3-mercaptopyruvate sulfurtransferase (MPST) is a source of endogenous hydrogen sul.de (H2S), a gaseous signaling molecule implicated in a wide range of physiological processes. The mechanisms of pathogenesis underlying nonalcoholic fatty liver disease (NAFLD) remain unclear. The possible role of MPST in the development of NAFLD has never been investigated. Methods: The NAFLD cell model was established by treating L02 cells with free fatty acid (FFA) overload. A variety of cellular and molecular approaches were used to study the effects of MPST on hepatic steatosis, oxidative stress and inflammation involved in NAFLD. Results: After culturing L02 cells by FFA for 24h, we detected the increased protein level of MPST. MPST knockdown in L02 cells resulted in a marked decrease of lipid accumulation and downregulation of SREBP-1 pathway and melioration of oxdiative stress, embodied in decreased level of H2O2, MDA and IL-6, meanwhile, increased levels of ATP and MMP. Unexpectedly, we observed a significantly increased level of H2S after knockdown of MPST. And the expression of CSE was enhanced when the MPST was decreased. When the level of H2S was decreased, the TG and H2O2 content within FFA-induced hepatocytes were greatly raised. Meanwhile, we demonstrated the reversed expression of SREBP-1/ ACC pathway with the reduced level of H2S. Conclusions: We showed that MPST knockdown could stimulate the compensatory process of CSE, causing the increasing of H2S which is recently considered as a novel antioxidant gas. The increased endogenous H2S could improve hepatocyte steatosis and partly improve the process of oxidative stress and in. ammatory state of steatosis hepatocytes. MPST is implicated in NAFLD via its important H2S metabolism. It provided new insight into the pathogenic mechanisms of NAFLD, pointing to potential target for therapeutic strategy.

Oxalate formation during hydrogen peroxide-reinforced oxygen delignification

Yingying Liu,Shujuan Ge,Youming Li,Bingyun Li,Hailong Li 한국공업화학회 2018 Journal of Industrial and Engineering Chemistry Vol.58 No.-

The effects of different process parameters (alkali dosage, hydrogen peroxide dosage, temperature, reaction time, and oxygen pressure) on oxalate formation during hydrogen peroxide-reinforced oxygen delignification (OP) of Eucalyptus kraft pulp were investigated in the present study. The relationships between oxalate formation and the dosages of both alkali and peroxide were found to be almost linear. Oxalate formation could be divided into “fast” and “slow” periods, depending on the reaction time. The best selectivity for the OP process was achieved using an alkali dosage of 2.0%, a hydrogen peroxide dosage of 2.0%, a temperature of 100 °C, an oxygen pressure of 0.6 MPa and a reaction time of 60 min. Oxalate formation was also, to some extent, reduced under these conditions. These results will be very helpful in optimizing the OP process, controlling oxalate formation and improving product quality.

Reliability-Based Iterative Proportionality-logic Decoding of LDPC Codes with Adaptive Decision

Youming Sun,Haiqiang Chen,Xiangcheng Li,Lingshan Luo,Tuanfa Qin 한국통신학회 2015 Journal of communications and networks Vol.17 No.3

In this paper, we present a reliability-based iterative proportionality-logic decoding algorithm for two classes of structured low-density parity-check (LDPC) codes. The main contributions of this paper include: 1) Syndromemessages instead of extrinsic messages are processed and exchanged between variable nodes and check nodes, which can reduce the decoding complexity; 2) a more flexible decision mechanism is developed in which the decision threshold can be self-adjusted during the iterative process. Such decision mechanism is particularly effective for decoding the majority-logic decodable codes; 3) only part of the variable nodes satisfying the pre-designed criterion are involved for the presented algorithm, which is in the proportionality-logic sense and can further reduce the computational complexity. Simulation results show that, when combined with factor correction techniques and appropriate proportionality parameter, the presented algorithm performs well and can achieve fast decoding convergence rate while maintaining relative low decoding complexity, especially for small quantized levels (3–4 bits). The presented algorithm provides a candidate for those application scenarios where the memory load and the energy consumption are extremely constrained.

3′‐Sialyllactose as an inhibitor of p65 phosphorylation ameliorates the progression of experimental rheumatoid arthritis

Kang, Li‐,Jung,Kwon, Eun‐,Soo,Lee, Kwang Min,Cho, Chanmi,Lee, Jae‐,In,Ryu, Young Bae,Youm, Tae Hyun,Jeon, Jimin,Cho, Mi Ra,Jeong, Seon‐,Yong,Lee, Sang‐,Rae,Kim, Wook,Yang John Wiley and Sons Inc. 2018 British journal of pharmacology Vol.175 No.23

<P><B>Background and Purpose</B></P><P>3′‐Sialyllactose (3′‐SL) is a safe compound that is present in high levels in human milk. Although it has anti‐inflammatory properties and supports immune homeostasis, its effect on collagen‐induced arthritis (CIA) is unknown. In this study, we investigated the prophylactic and therapeutic effect of 3′‐SL on the progression of rheumatoid arthritis (RA) in <I>in vitro</I> and <I>in vivo</I> models.</P><P><B>Experimental Approach</B></P><P>The anti‐arthritic effect of 3′‐SL was analysed with fibroblast‐like synoviocytes <I>in vitro</I> and an <I>in vivo</I> mouse model of CIA. RT‐PCR, Western blotting and ELISA were performed to evaluate its effects <I>in vitro</I>. Histological analysis of ankle and knee joints of mice with CIA was performed using immunohistochemistry, as well as safranin‐O and haematoxylin staining.</P><P><B>Key Results</B></P><P>3′‐SL markedly alleviated the severity of CIA in the mice by reducing paw swelling, clinical scores, incidence rate, serum levels of inflammatory cytokines and autoantibody production. Moreover, 3′‐SL reduced synovitis and pannus formation and suppressed cartilage destruction by blocking secretion of chemokines, pro‐inflammatory cytokines, https://en.wikipedia.org/wiki/Matrix_metalloproteinases and osteoclastogenesis <I>via</I> NF‐κB signalling. Notably, phosphorylation of p65, which is a key protein in the NF‐κB signalling pathway, was totally blocked by 3′‐SL in the RA models.</P><P><B>Conclusions and Implications</B></P><P>3′‐SL ameliorated pathogenesis of CIA by suppressing catabolic factor expression, proliferation of inflammatory immune cells and osteoclastogenesis. These effects were mediated <I>via</I> blockade of the NF‐κB signalling pathway. Therefore, 3′‐SL exerted prophylactic and therapeutic effects and could be a novel therapeutic agent for the treatment of RA.</P>

Design and Performance Study of Hybrid Channel-valved Magnetorheological Dampers

Yan Li,Xiaolong Yang,Jiehong Zhu,Youming Zhou 한국자기학회 2023 Journal of Magnetics Vol.28 No.1

In order to solve the problem of low damping force caused by low utilization of magnetic field in traditional magnetorheological dampers, a hybrid channel valve type magnetorheological damper with circular channel and disk channel are proposed. The main content of this paper is to design the basic structure of mixed channel valve magnetorheological damper. The mathematical model of damping force based on Bingham plastic model was established from the design of magnetic circuits. The two-dimensional simulation model of MR Damper was established by using EMAG module in ANSYS finite element analysis software, and the magnetic circuit of mixed channel valve MR Damper was simulated and analyzed. The results show that the output damping force of the hybrid channel valve-type magnetorheological damper is 18 KN and the adjustable coefficient is 14.52 with the current I of 3A, the number of coil turns of 560, the axial damping gap of 1 mm and the radial damping gap of 1.5 mm.

Design and Numerical Study of Hybrid Magnetic Source Disc-type Magnetorheological Valve

Xiaolong Yang,Yan Li,Youming Zhou,Shiying Zhou,Jiehong Zhu 한국자기학회 2023 Journal of Magnetics Vol.28 No.2

Magnetorheological valves are important components in hydraulic systems that provide precise position control. At present, the low-pressure drop performance of magnetorheological valves is the main problem limiting their application. To improve the pressure drop performance of magnetorheological valves, a hybrid magnetic source disc magnetorheological valve is proposed. The magnetic pressure drop model and viscous pressure drop model of the hybrid magnet source disc type magnetorheological valve based on the Bingham model are Derived. Magnetic field distributions in the damping channel of the hybrid magnet source disc type magnetorheological valve are obtained by using ANSYS finite element analysis software. The mathematical model of the relationship between pressure drop and magnetic induction intensity was established using Matlab software, and the effects of parameters such as effective current, axial damping gap, radial damping gap, and coil width on the pressure drop performance of disc-type magnetorheological valves with hybrid magnetic sources were numerically analyzed. The results show that the pressure drop of the disc magnetorheological valve with a hybrid magnetic source can reach 10.9935 MPa at the current I=3A, axial damping gap ga=1 mm, and radial damping gap gr=1.5 mm. Compared with the conventional disc magnetorheological valve, the pressure drop performance of the hybrid magnetic source disc magnetorheological valve is improved by 28 %, which provides ideas on how to improve the pressure drop performance of the magnetorheological valve.

Involvement of adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 in diallyl trisulfide-induced cytotoxicity in hepatocellular carcinoma cells

Guan Feng,Ding Youming,He Yikang,Li Lu,Yang Xinyu,Wang Changhua,Hu Mingbai 대한약리학회 2022 The Korean Journal of Physiology & Pharmacology Vol.26 No.6

It has been demonstrated that APPL1 (adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1) is involved in the regulation of several growth-related signaling pathways and thus closely associated with the development and progression of some cancers. Diallyl trisulfide (DAT), a garlic-derived bioactive compound, exerts selective cytotoxicity to various human cancer cells through interfering with pro-survival signaling pathways. However, whether and how DAT affects survival of human hepatocellular carcinoma (HCC) cells remain unclear. Herein, we tested the hypothesis of the involvement of APPL1 in DAT-induced cytotoxicity in HCC HepG2 cells. We found that Lys 63 (K63)-linked polyubiquitination of APPL1 was significantly decreased whereas phosphorylation of APPL1 at serine residues remained unchanged in DAT-treated HepG2 cells. Compared with wild-type APPL1, overexpression of APPL1 K63R mutant dramatically increased cell apoptosis and mitigated cell survival, along with a reduction of phosphorylation of STAT3, Akt, and Erk1/2. In addition, DAT administration markedly reduced protein levels of intracellular TNF receptor-associated factor 6 (TRAF6). Genetic inhibition of TRAF6 decreased K63-linked polyubiquitination of APPL1. Moreover, the cytotoxicity impacts of DAT on HepG2 cells were greatly attenuated by overexpression of wild-type APPL1. Taken together, these results suggest that APPL1 polyubiquitination probably mediates the inhibitory effects of DAT on survival of HepG2 cells by modulating STAT3, Akt, and Erk1/2 pathways.

Iterative Reliability-Based Modified Majority-Logic Decoding for Structured Binary LDPC Codes

Haiqiang Chen,Lingshan Luo,Youming Sun,Xiangcheng Li,Haibin Wan,Liping Luo,Tuanfa Qin 한국통신학회 2015 Journal of communications and networks Vol.17 No.4

In this paper, we present an iterative reliability-based modified majority-logic decoding algorithm for two classes of structured low-density parity-check codes. Different from the conventional modified one-step majority-logic decoding algorithms, we design a turbo-like iterative strategy to recover the performance degradation caused by the simply flipping operation. The main computational loads of the presented algorithminclude only binary logic and integer operations, resulting in low decoding complexity. Furthermore, by introducing the iterative set, a very small proportion (less than 6%) of variable nodes are involved in the reliability updating process, which can further reduce the computational complexity. Simulation results show that, combined with the factor correction technique and a well-designed non-uniform quantization scheme, the presented algorithm can achieve a significant performance improvement and a fast decoding speed, even with very small quantization levels (3–4 bits resolution). The presented algorithm provides a candidate for trade-offs between performance and complexity.

Mate recognition and antennal morphology of Octodonta nipae (Coleoptera: Chrysomelidae) adults

Lingfei Peng,Limin Chen,Jinlei Li,Youming Hou,Yigen Chen 한국응용곤충학회 2018 Journal of Asia-Pacific Entomology Vol.21 No.1

The nipa palm hispid beetle, Octodonta nipae (Maulik) has been killing palm trees since its introduction intoHainan province, China, from Malaysia in 2001. It continues to spread within Hainan province, northeast toFujian province, and northwest to Yunnan province within China. Knowledge on signals involved in mate locationand recognition could help develop effective integrated pest management programs. In the present study,we first experimentally proved that antennae were essential in success of O. nipae mating. We then excisedvarious segments/flagellomeres of adult male and female antennae and observed their mating behavior. Resultsrevealed that the 5th to 9th flagellomeres, especially those of males, were important for the mating success. Finally, in an attempt to elucidate the types of antennal sensilla accountable for the mating success, morphologyof O. nipae antennae was studied in detail with scanning electron microscopy. Six types of sensilla were distinguished:aporous sensilla trichodea (T1), multiporous sensilla trichodea (T2), aporous sensilla chaetica (Ch1),uniporous sensilla chaetica (Ch2), multiporous sensilla basiconica (B), and Böhm sensilla (Bm). Aporous sensillatrichodea is the most abundant; multiporous sensilla trichodea and sensilla basiconica are considered as olfactoryreceptors, and uniporous sensilla chaetica as gustatory receptor. Importance of flagellomeres 5–9 in matingsuccess seemed to correspond to the abundance of sensilla on these segments.