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( Yoon Jin Ma ),( Hahn Kim ),( Hyun Hwa Lee ) 한국의류학회 2012 한국의류학회지 Vol.36 No.12
This article examines how individual differences on the need for cognitive closure and demographics influence consumer perception and the usage of consumer reviews in online shopping. Data were randomly collected from 2,381 U.S. online consumer review users through an online survey. The findings from multiple regression analyses revealed the different effects of the need for cognitive closure dimensions (i.e., preference for order and structure, preference for predictability, discomfort with ambiguity, closed-mindedness, and decisiveness) and demographic characteristics on consumer attitudes, perceived online review influence, benefits, persuasiveness, and review usage behavior. Finally, practical implications and prospects for future research are discussed.
In vitro and vivo assessment of cytochrome P450-mediated herb-drug interaction of Ssang-hwa-tang
( Sang Yoon Lee ),( Ji Yoon Lee ),( Wonku Kang ),( Kwang Il Kwon ),( Soo Jin Oh ),( Jin Yeul Ma ),( Sang Kyum Kim ) 영남대학교 약품개발연구소 2013 영남대학교 약품개발연구소 연구업적집 Vol.23 No.0
We have evaluated the herb-drug interaction potential of Ssang-hwa-tang (SHT) mediated by cytochrome P450 (CYP) inhibition/induction. Further, the effects of fermentation on the CYP-mediated herb-drug interaction potential were determined. SHT showed inhibitory activity toward CYP1A2, but not 2A6, 2B6, 2C9, 2C19, 2D6, 2E1, and 3A4 in human liver microsomes. The results of the enzyme kinetic study suggested that the SHT-induced CYP1A2 inhibition is mixed reversible inhibition. The hepatic CYP expression and activity in rats treated with SHT were examined. The expression/activity of CYP2E1 increased as a result of SHT extract treatment (P<0.005 or P<0.001, respectively), which raises the possibility that SHT may increase the toxicity of environmental toxicants through the elevation of CYP2E1-mediated metabolic activation. SHT fermentation using Lactobacillus fermentum or Lactobacillus gasseri resulted in attenuation of the SHT-induced CYP1A2 inhibition, but not CYP2E1 induction, suggesting that changes in the chemical composition of SHT through fermentation can affect the inhibition of CYP1A2 activity. ⓒ2012 Elsevier Ltd, All rights reserved.ⓒ2012 Elsevier Ltd. All rights reserved.
Cytochrome P450-mediated herb-drug interaction potential of Galgeun-tang
( Sang Yoon Lee ),( Ji Yoon Lee ),( Wonku Kang ),( Kwang-il-kwon ),( Song Kyu Park ),( Soo Jin Oh ),( Jin Yeul Ma ),( Sang Kyum Kim ) 영남대학교 약품개발연구소 2013 영남대학교 약품개발연구소 연구업적집 Vol.23 No.0
We evaluated the herb-drug interaction potential of Galgeun-tang (GGT) extracts, mediated by cytochrome P450 (CYP) inhibition/induction. Further, the effects of fermentation on the CYP-mediated herb-drug interaction potential of GGT extracts were determined. As measured by LC-ESI/MS/MS, GGT extracts (0-300μg/mL) showed no inhibitory activity toward eight CYP isoforms (1A2, 2A6, 2B6, 2C9, 2C19, 2D6, 2E1, and 3A4) in pooled human liver microsomes, suggesting that GGT may have low potential for herb-drug interactions mediated by CYP inhibition. Hepatic CYP expression and activity in rats treated with GGT extracts twice per day for 1week was examined. Among the tested CYP isoforms (1A1, 1A2, 1B1, 2B1, 2C11, 2E1, 3A1, 3A2, and 4A1), CYP1B1 and 4A1 were increased by GGT extracts. Hepatic activities of 7-ethoxyresorufin-O-deethylase, 7-pentoxyresorufin-O-depentylase, and chlorzoxazone 6-hydroxylase, but not midazolam hydroxylase were also elevated. These results raise the possibility that GGT extracts may increase the toxicity of environmental toxicants through the elevating CYP-dependent metabolic activation. Interestingly, the increases in CYP1B1 and CYP4A1 levels, and 7-ethoxyresorufin-O-deethylase, 7-pentoxyresorufin-O-depentylase, and chlorzoxazone 6-hydroxylase activities were attenuated by fermentation of GGT extract using Lactobacillus plantarum KFRI 402, but not 144. Further studies are needed to identify the CYP regulatory component(s) from GGT and determination its metabolism. ⓒ2012 Elsevier Ltd. All rights reserved.
Inhibitory effects of Hwang-Ryun-Hae-Dok-Tang on cytochrome P450 in human liver microsomes
Lee, Sang Yoon,Jang, Himchan,Lee, Ji-Yoon,Ma, Jin Yeul,Oh, Soo Jin,Kim, Sang Kyum Informa UK Ltd. 2015 Xenobiotica Vol.45 No.2
<P>1. The herb-drug interaction potential of Hwang-Ryun-Hae-Dok-Tang (HR) extracts mediated by cytochrome P450 (CYP) inhibition was determined using human liver microsomes.</P><P>2. HR strongly inhibited CYP1A2 and moderately inhibited CYP2C19, CYP2D6, and CYP3A4 (testosterone) but not CYP2A6, CYP2B6, CYP2C8, CYP2C9, and CYP3A4 (midazolam).</P><P>3. The enzyme kinetic results suggest that CYP1A2 inhibition is competitively reversible (K<I><SUB>i</SUB></I>, 13.4 ± 1.8 μg/ml), and CYP2D6 inhibition is quasi-irreversible (K<I><SUB>I</SUB></I>, 0.234 ± 0.138 μg/ml; k<SUB>inact</SUB>, 0.067 ± 0.006 min<SUP>−1</SUP>).</P><P>4. Fermentation using <I>Lactobacillus acidophilus</I> attenuated the HR-induced inhibition of CYP2D6, but not the other isoforms.</P><P>5. Neither CYP1A2 nor CYP3A4 was markedly inhibited by berberine, palmatine, and geniposide—major components in HR—and CYP2D6 was inhibited by berberine (IC<SUB>50</SUB>, 13.8 μg/ml) in a metabolism-dependent manner.</P><P>6. The results suggest the possibility of HR-drug interaction through inhibition of CYP—particularly CYP2D6—which may be attenuated by fermentation using <I>L. acidophilus</I>.</P>
Ma, Ai-Feng,Seo, Hoe-Joo,Jin, Sung-Ho,Yoon, Ung-Chan,Hyun, Myeong-Ho,Kang, Sung-Kwon,Kim, Young-Inn Korean Chemical Society 2009 Bulletin of the Korean Chemical Society Vol.30 No.11
Three novel phosphorescent 2-phenylpyridine-based iridium(III) complexes, $[(ppy)_2Ir(P\^{}N)]PF6\;(1),\;[(dfppy)_2Ir(P\^{}N)]PF_6$ (2), and $[(dfmppy)_2 Ir(P\^{}N)]PF6$ (3), where $P\^{}N$ = 2-[(diphenylphosphino)methyl]pyridine (dppmp), were synthesized and characterized. The absorption, photoluminescence, cyclic voltammetry and thermal stability of the complexes were investigated. The complexes showed bright blue luminescences at wavelengths of 448 $\sim$ 500 nm at room temperature in $CHCl_3$ and revealed that the $\pi$-acceptor ability of the phosphorous atom in the ancillary dppmp ligand plays an important role in tuning emission color resulting in a blue-shift emission. The single crystal structure of $[(dfmppy))_2Ir(P\^N)]PF_6$ was determined using X-ray crystallography. The iridium metal center adopts a distorted octahedral structure coordinated to two dfmppy and one dppmp ligand, showing cis C-C and trans N-N chelate dispositions. There is a $\pi-\pi$ overlap between π electrons delocalized in the difluorophenyl rings.
Ma Yuanqiang,Jeong su Park,Wang Feng,Hwan Ma,Gyu rim Lee,Yeo jin Lee,Yoon-seok Roh 한국실험동물학회 2021 한국실험동물학회 학술발표대회 논문집 Vol.2021 No.7
Psoriasis, a chronic inflammation-mediated skin disease, affects 2-3% of the total populations in the world. It is characterized by keratinocytes hyperproliferation and immune cell infiltration. The JAK/STAT3 and JAK/STAT1 signaling pathways triggered by IL-6 and IFN- γ from dendritic cell and T lymphocytes, play important roles in psoriasis. Thus, blockade of JAK/STAT signaling will be potential strategy in psoriasis. CMX, an extract of Centipeda minima enriched in Brevilin A, Arnicolide D, Arnicolide C, and Microhelenin C which have already been reported in anti-inflammation, anti-cancer, antiallergy, and suppression of proliferation. We established chronic inflammatory and cell proliferating models in macrophages and keratinocytes with LPS (250ng/mL), rh-IL-6 (10ng/mL), or rh-IFN-γ (10ng/mL) to evaluate the effect of CMX. CCK-8 was used for cell proliferation assay, and the protein and RNA were collected and analyzed by western blot and RT-qPCR. We found that CMX inhibited pro-inflammatory cytokines production by inhibiting LPS-induced JAK1/2 and STAT1/3 phosphorylation in macrophages. Moreover, CMX down-regulated chemokines and cell proliferation in HaCaT cell induced by rh-IL-6 and rh-IFN-γ, respectively. Consistently, we demonstrated that reduction of chemokines expression and hyperproliferation was medicated by the regulation of IFN-γ-activated JAK/STAT1 and IL-6-activated JAK/STAT3 signaling. In conclusion, CMX inhibited JAK/STAT-mediated inflammatory responses and cell proliferation in macrophages and keratinocytes, consequently CMX may improve psoriasis development as an important therapeutic approach.
Yoon Jeong Lee,Kyung Ho Ma,Jeong Hoon Lee,Jin Tae Jung,Myeong Won Oh,Young Ho Yoon,Jong Won Han 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10
Salvia miltiorrhiza Bunge is a well known and important traditional medicinal herb because of its use in treating cardiovascular and cerebrovascular diseases. In this study, the antioxidant components and activity of ‘DASAN’, the first domestic cultivar of Salvia miltiorrhiza, were compared according to the cultivation period. The polyphenol content of ‘DASAN’ by cultivation period (1, 2 and 3 year) was 574.87, 343.41, and 331 mg/100 g, respectively. In addition, ABTS (255.73 mgAEAC/100 g), DPPH (245.83 mgAEAC/100 g) radical scavenging activity, and reducing activity(33.85 mgAEAC/100 g) of 1-year-olds were higher than those of 2 and 3-year-old. As the cultivation period increased, the antioxidant power showed a tendency to decrease, showing results similar to the results of analysis on the content of antioxidants. These results are considered to be useful data for setting optimal conditions for the cultivation period of ‘DASAN’ to help farmers. In addition, the results suggested that ‘DASAN’ could be considered as a new potential source of natural phenolic antioxidants for food, pharmaceutical, cosmetics or nutraceutical industries.