항통풍성 약물류가 Milk Xanthine Oxidase 활성에 미치는 영향

마광진,이경태,권창호 한국분자생물학회 1994 분자생물학뉴스 Vol.22 No.-

多樣한 黃芩藥鍼製劑의 安全性 및 效能에 關한 硏究

김호경,마진열,전원경,윤수영,강은정,주혜정,고병섭 한국한의학연구원 1997 한국한의학연구원논문집 Vol.3 No.1

In order to detect the safety and effect of various aqua-acupunctures from Scutellariae Radix, the modifications of boiling, filtration and dilution were employed for the manufacture of aqua-acupunctures. We injected 0.2cc of aqua-acupunctures into Joksamri(足三里) of rat, repeatedly. we compared subacute toxicity of them with saline group, distilled water(D.W.) group, acupuncture group and control group. The results were summarized as follows: 1. The groups were all healthy and alive, and there was no special abnormality in physical condition and autopsy. And there were not any toxic symptoms in repeating application of aqua-acupunctures to the rat, including changes of body weight, organ weight, haematological examination and serum biochemical test. 2. There was slight change of body weight in acupuncture group : We could see significance after 3 days (p<0.05) and after 7 days (p<0.001) in body weight loss. After 9 days, all tested groups were suppressed in body weight increment. 3. Result of organ weight: In Palking aqua-acupuncture(D-2 group), saline group and acupuncture group there were some statistical significance. Especially, acupuncture group revealed significant result in liver and spleen than aqua-acupunctures. From this result, we could suggest that the efficacy of acupuncture was preceded herbal medicine. 4. In serum biochemical test, we examined glucose(GLU), triglyceride(TG) and cholesterol(CHOL). In comparison with control group, the diluted 10 times of hwanggum aqua-acupuncture (× 10 group) was recognized significant decrease of glucose, but the diluted 100 times of Hwanggum aqua-acupuncture (× 100 group), D-2 group, saline group were confirmed significant increment. There was not any meaningful change of CHOL in all of tested group, excepting the acupuncture group was exhibited statistically significant decrease(p<0.05). In TG level all tested group except complex injection of standard compound (CPA group) and HG, there were significant value in statistically. The diluted solution was more significant decrease than Hwanggaum aqua-acupuncture(HG). The mutual relationship of components of aqua-acupuncture tended to decrease level of TG, regardless of its concentration. In acupuncture group, we gained some interesting result in meaningful decrease in TG. 5. Haematological examination showed significant increment of gramulocytes(GR) in all tested groups except Hwanggum aqua-acupuncture. And the diluted solutions of HG expressed very high increment of them(p<0.001). The GR and Mean Corpuscular Volume(MCV) of acupuncture group showed statistical significance.

주야 교대 근무가 편두통에 미치는 영향 : 한림대학교 의료원 간호사 연구 Hallym Medical Center Nurse Study

주민경,유경호,마효일,김윤중,김주용,송흥기,이병철 대한두통연구회 2004 두통 Vol.5 No.1

피질하 혈관성 치매 환자에서 협착성 뇌혈관 병변의 의의 : 자기공명 혈관조영술과 양전자방출단층촬영을 이용한 연구 MR Angiography and ^(18)FDG-PET Study

유경호,이병철,마효일,김윤중,정지향,나덕렬,강연욱 대한치매학회 2004 Dementia and Neurocognitive Disorders Vol.3 No.1

Background and Objective:Subcortical vascular dementia (SVD) incorporates small vessel disease as the primary vascular etiology, represents in MRI by lacunar infarct and deep white matter lesions. In clinical practice, a number of SVD patients present with various vascular risk factors for large artery disease (LAD) i.e., old age, hypertension, and diabetes. However the current diagnostic criteria for SVD did not include angiographic findings as a key feature. Therefore we tried to find out the frequency of large artery disease in SVD and to elucidate whether the presence of LAD affects clinico-radiological manifestations of SVD. Methods:Thirty three patients fulfilling 'Research criteria for SVD' by Erkinjuntti from 17 study centers were recruited. Of these 33 patients, 21 who underwent comprehensive neuropsychological test battery, MRI ^(18)FDG-PET, and MR angiography were classified into two subgroups according to the patterns of MRI abnormality:white matter dominant (WM) type (n=5) and multiple lacunar (LC) type (n=16). Clinical and neuropsychological profile and ^(18)FDG-PET findings of 21 SVD patients with and without LAD were compared. Results: Twelve (57%) of 21 SVD patients had mild stenotic lesions in intracranial large arteries:4 in middle cerebral artery, 8 in posterior cerebral artery, and 4 in vertebrobasilarj artery. There were no differences in vascular risk factors, characteristics of cognitive dysfunctions, and ^(18)FDG-PET findings between SVD with and without LAD. Conclusions:Our results showed that the presence of mild degree of large artery stenosis did not affect the clinical., neuropsychological profile and cerebral metabolism in PET. Therefore, the current 'Research criteria for SVaD' by Erkinjuntti could be used to diagnose SVD as a homogenous clinical group regardless of angiographic abnormalities.

Anti-Inflammatory and Analgesic Effects of Pyeongwisan on LPS-Stimulated Murine Macrophages and Mouse Models of Acetic Acid-Induced Writhing Response and Xylene-Induced Ear Edema

Oh, You-Chang,Jeong, Yun Hee,Cho, Won-Kyung,Ha, Jeong-Ho,Gu, Min Jung,Ma, Jin Yeul MDPI 2015 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Vol.16 No.1

<P>Pyeongwisan (PW) is an herbal medication used in traditional East Asian medicine to treat anorexia, abdominal distension, borborygmus and diarrhea caused by gastric catarrh, atony and dilatation. However, its effects on inflammation-related diseases are unknown. In this study, we investigated the biological effects of PW on lipopolysaccharide (LPS)-mediated inflammation in macrophages and on local inflammation <I>in vivo</I>. We investigated the biological effects of PW on the production of inflammatory mediators, pro-inflammatory cytokines and related products as well as the activation of nuclear factor kappa B (NF-κB) and mitogen-activated protein kinases (MAPKs) in LPS-stimulated macrophages. Additionally, we evaluated the analgesic effect on the acetic acid-induced writhing response and the inhibitory activity on xylene-induced ear edema in mice. PW showed anti-inflammatory effects by inhibiting the production of nitric oxide (NO), tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) and interleukin-1β (IL-1β). In addition, PW strongly suppressed inducible nitric oxide synthase (iNOS), a NO synthesis enzyme, induced heme oxygenase-1 (HO-1) expression and inhibited NF-κB activation and MAPK phosphorylation. Also, PW suppressed TNF-α, IL-6 and IL-1β cytokine production in LPS-stimulated peritoneal macrophage cells. Furthermore, PW showed an analgesic effect on the writhing response and an inhibitory effect on mice ear edema. We demonstrated the anti-inflammatory effects and inhibitory mechanism in macrophages as well as inhibitory activity of PW <I>in vivo</I> for the first time. Our results suggest the potential value of PW as an inflammatory therapeutic agent developed from a natural substance.</P>

뇌졸중 후 발생한 괴잉성욕에 대한 Cimetidine의 치료효과 : 증례보고

유경호,마효일,정승철,이병철 대한치매학회 2002 Dementia and Neurocognitive Disorders Vol.1 No.1

Most studies have agreed that there is a considerable decline in sexual activity following stroke. but the hypersexuality after stroke as a relatively isolated behavioral abnormality has been less frequently reported Hypersexuality has no proven treatment, although reports have described reductions in hypersexual behavior did not response to three medications were not uncommonly observed in clinical practice A 65-year-old right-handed male presented with acute left hemipararesis. His MRI showed a right middle cerebral artery infarct involving the temporal, parietal regions and the basal ganglia. Four weeks after stroke he showed abnormal behavior, such as incessantly holding and hugging the nursing staff without assent, but no increased orality or change in eating habits But several weeks after taking cimetidine. a histamine H₂-receptor antagonist. his sexual behavior showed a marked improvement This case demonstrates that cimetidine as a non-hormonal anti-androgenic effect decreased libido and hypersexual behavior without serious side effects in patients with cognitive decline after stroke Further studies that obviously define the response and long-term side effects of cimetidine are needed to confirm our observations.

칼슘제 수관살포가 참다래의 과실 품질과 저장에 미치는 영향

임경호,나양기,임동근,마경철,조윤섭,김월수,이상현,박용서 全南大學校 農業科學技術硏究所 2001 農業科學技術硏究 Vol.36 No.-

This study were carried out to improve Kiwifruit quality and storage life. Three kinds of calcium compound were sprayed and calcium content of fruits, weight loss during fruit storage and fruit quality were investigated. Calcium contents within leaves and fruit were lower in Clef-non treatment than that of control. The calcium content in fruit pericarp of Kalk-H and CaCl2 was 0.04 to 0.05% higher than that of control. Fruit weight and soluble solids content at harvest was a little higher but acidity and fruit hardness was lowered. Fruit weight loss of Kalk-H and CaCl2 treatment was 1.39 to 1.53% lower than that of control during storage. The soluble solids of ripen fruit was 1.0 to 1.3% higher in all treatment and 0.8% higher in Kalk-H treatment in 120 of after storage. Fruit hardness of control fruit was higher at harvest but that of CaCl2 treatmented fruit was 0.39㎏/φ 5㎜ higher in 120 days of storage.

비가림 및 망사 시설재배가 참다래의 수체생육 및 과실품질에 미치는 영향

나양기,마경철,임동근,김병삼,임경호,김월수,이상현,박용서 全南大學校 農業科學技術硏究所 2001 農業科學技術硏究 Vol.36 No.-

This studies were conducted to investigate the effects of rain shelter and netting on the tree growth, fruit set fruit quality of kiwifruit (Actinidia deliciosa). In rain shelter and net house, shoot falling wasn't occurred by strong wind, and fruit set, fruit weight and also fruit malformation, side flowering increased at the same time. In rain shelter house the increment temperature forced blooming date and increased shoot length, leaf number and diameter but in net house these tendencies were not observed. Relative light intensity of rain shelter house was higher than that of net house with standard of field culture (relative light intensity: 100%). Soluble solid content was higher in rain shelter house, and acid content was higher in net house. With the effect of rain sheltering the occurrence of bacterial bloom rot and canker significantly decreased in both rain shelter and net house but insect injury increased. These data showed that rain shelter house is more suitable for kiwi fruit culture.

휴경 연차에 따른 휴경지 군락내 식생 특성

강병화,심상인,마경호 한국환경농학회 2003 한국환경농학회지 Vol.22 No.1

휴경지의 식생 특성을 묵밭과 묵논과 같이 토양의 수분 상태가 다른 조건과 휴경 연차에 따라 조사하었다. 같은 묵논이라도 습한 상태로 휴경한 경우와 건조한 상태로 휴경한 경우 식생의 차이가 컸으며, 건조한 상태에서 다년생으로의 천이가 빠르게 일어났다. 천이 단계는 휴경 기간보다 휴경지의 토양 조건에 더욱 큰 영향을 받았다. 묵밭의 경우 휴경 2년차에 우점하였던 돌콩, 칡, 쑥, 새팥, 노랑물봉선 등은 휴경이 6년간 진전된 경우 칡, 억새, 돌콩, 쪽 등의 순으로 우점도가 변하였다. 논을 건답상태로 휴경한 경우 3년차에는 들깨풀, 돼지풀, 강아지풀 등이 주요 우점 초종이었으나 7년차에는 억새, 미국쑥부쟁이, 쇠치기풀 등이 우점하여 다년생으로 천이 되었다. 논을 습답 조건으로 휴경한 경우 수생 잡초가 우점하였다. 7년차에는 갈대, 돌콩, 부들, 고마리가 우점하였으나, 11년차에는 갈대, 줄, 고마리, 부들이 우점하는 초종이었다. 휴경지의 식물종 다양성은 건조한 토양 조건보다 다소 습한 조건의 토양에서 높게 나타났다. The present study was conducted to analyze the vegetational difference in fallowed fields at the different semi stages. Plant species were surveyed on the fields haviit different cropping history, soil moisture conditions, and the duration of set-aside. Effects of soil moisture condition and fallowing duration on the vegetational profiles of fallowed fields in the course of different send stages. In the fields fallowed for more than three years, a conspicuous feature of vegetations was the dominance of perennial species, which was less dominant in the fields fallowed for less than 3 years. The floristic composition of fallowed fields was dependent on the soil moisture condition. However, the influence of fallow history on vegetational composition was less than that of the soil moisture conditions. The dominant species occurred in fallowed upland (dry) fields were changed from Glycine NO, Persicaria thunhetgiana, and Artemisia princeps at 2-year-fallowed to Persicaria thunbergiana, Miscanthhus sinumsis, and Glycine sofa at 6-year-fallowed. In wet followed paddy fields, annual Mo sla pwnctulata, Ambrosia artenuisiifalia, and Setaria vifzdis, the dominant species at 3-year-fallowed, were substituted by perennial A iscanthus simnsis, Aster pilosus, and Hemarthria sibirica at 7-year-followed. When the succession continued for 11 years in wet fields, the vegetation was characterized by the domination of perennials such as Phragn tes com uanis, Tazania Walla, and Typha orientalis. It was suggested that the soil moisture condition was a strong determinant of the dominant species on early send conditions. In the fallowed paddy fields, the species diversity was relatively higher in the fields set-asided as wet condition compared to the fields followed as dry condition.

중증 대뇌반구경색 환자의 사망률과 초기 예후인자

나해리,강우열,정승철,유경호,마효일,이병철 대한노인병학회 2001 대한노인병학회지 Vol.5 No.2