蒼耳子의 IC - 2 細胞에 대한 抗알러지 效果에 關한 硏究 ( 2 )

徐榮培,崔永奉,李龍求,李永喆 대한본초학회 2002 大韓本草學會誌 Vol.17 No.1

This study was carried out for the purpose of knowing the effect from anti-allergic action of B cells and the IC-2 mast cells the extraction from Xanthii Fructus(EXF). In order to know the effect of the cytotoxicity from extraction of Xanthii Fructus, we had to examine the safe density of EXF on lung fibroblast cells of the mouse (mLPCs). We also attempted to resolve the relationship cytotoxicity. The effect was on the organization of cytokine gene expression from the increas and divorce of the B cells and allergic acting by EXF, we found it necessary to examine the IC-2 cells and B cells. We examined the histamine release of IC-2 cells by ELISA method, we also examined the effect of EXF on the increase and divorce of the B cells by ^3H-thymidine uptake method. We then analyzed the release of IL-4, IgE and nitric oxide (NO). The results are as follows : 1. EXF did not show cytotoxicity against mLFCs. 2. According to the inspection on the effect on IC-2 cells gene expression by EXF, we found out the following results: EXF reduced IL-4, IL-6, GM-CSF, TNF-α gene expression and histamine release of IC-2 cells. The EXF inhibited signs of inflammation IC-2 cells.

山茱萸의 抗알러지 效果에 關한 硏究

徐榮培,吉基正,李龍求,李永喆 대한본초학회 2002 大韓本草學會誌 Vol.17 No.1

In order to investigate the anti-allergic effects of Corni Fructus extract(CFE) and about the expression of CD23, IgE, it was necessary for it to be activated by anti-CD40, rHRF. We then analyzed it from the flow cytometer. 1. CFE significantly decreased the expression of anti-CD23, IgE. 2. According to inspection of the inhibitory effect of CFE on the cell proliferation of B cells, IgE, IL-4, histamine release of B cells, we found out the following results: CFE reduced cell proliferation of B cells significantly, and reduced the immunoreaction directly in the B cells by the inhibitory effects on the IgE release of B cells. And CFE reduced the immunoreaction directly in the B cells by inhibitory effects on IL-4, histamine release of B cells.

紅花의 造血作用에 對한 實驗的 硏究

徐榮培,李龍求,李永喆,閔平基 대한본초학회 2002 大韓本草學會誌 Vol.17 No.1

In order to investigate the haematopoietic effects of Carthami Flos on various experiments were studied. The results were obtained as follows: 1. In the proliferous effect of bone marrow cells, water extracts of Carthami Flos played an important role on the proliferating bone marrow cells compared with control group at low density. 2. The water extracts of Carthami Flos promoted the proliferation of the bone marrow cells into cluster, BFU-E, CFU-GEMM and colony. 3. In the bone marrow cells treated with CTX, the water extracts of Carthami Flos promoted the SCF, EPO, IL-4, IL-6 gene expression, but gene expression of its receptors, c-kit, EPO-R, TPO, c-mpl, EKLF, GATA-1 were not promoted significantly. According to the above results, water extracts of Cathami Flos promoted not only the differentiation

상완골 근위부 분쇄 골절에서의 상완골 두 치환술

서중배,원중희,김용민,최의성,이호승,홍윤철 대한견.주관절학회 2000 大韓肩.주關節學會誌 Vol.3 No.2

太子蔘의 造血作用에 對한 實驗的 硏究

徐榮培,李龍求,李永喆,李太元 대한본초학회 2002 大韓本草學會誌 Vol.17 No.1

In order to investigate the hematopoietic effects of Pseudostellariae Radix various experiment about hematopoiesis were studied. The results were obtained as follows: 1. In the proliferous effect of bone marrow cells, water extracts of Pseudostellariae Radix played an important role on the proliferating bone marrow cells compared with control group. 2. The water extracts of Pseudostellariae Radix activated the bone marrow cells. 3. The water extracts of Pseudostellariae Radix promoted the proliferation of the bone marrow cells into cluster, BFU-E, CFU-GEMM. 4. In the bone marrow cells treated with CTX, the water extracts of Pseudostellariae Radix promoted the SCF, EPO, IL-4, IL-6 gene expression, but gene expression of its receptors, c-kit, EPO-R, TPO, c-mpl, EKLF, GATA-1 were not promoted significantly. According to the above results, water extracts of Pseudostellariae Radix promoted not only the differentiation of the bone marrow cells into CFU-GEMM which mother cell of erythrocytes, thrombocytes, monocytes and macrophages, but also the differentiation of the bone marrow cells into BFU-E. On the other hand, in the gene expression that have a lot of hematopoietic effects in the early differentiation of haematopoietic stem cells by promoting the gene expression of SCF, EPO, IL-4, IL-6 and so forth. Above results also demonstrates that the water extracts of Pseudostellariae Radix have somewhat meaningful effects in hematogenesis but not sufficient to explain its mechanisms about hematogenesis, therefore further deep studies should be accomplished about its mechanisms.

만성 요통 환자의 심리사회적 특성

김용민,원중희,최의성,서중배,이호승,허윤무 충북대학교 의학연구소 2001 忠北醫大學術誌 Vol.11 No.2

연구목적: 만성 요통 환자의 많은 수가 직업 등 주변 환경과 심리 상태의 영향을 받는 것으로 추정되나 그 연관성은 아직 논란이 많다. 본 연구에서는 설문 조사를 통하여 만성 요통 환자의 심리사회적 특성을 알아보고자 하였다. 대상 및 방법. 1997년 7월부터 1998년 12월까지 6주 이상 지속된 만성 요통으로 본원 정형외과 외래를 내원한 환자들 중 기질적 원인이 불명확한 62명의 환자들에서 직업, 유발요인, 치료 등 요통 관련 요소 설문과 Minnesota Multiphasic Personal Inventory (MMPI)를 실시하였다. 요통 관련 사항에는 통증의 기간, 정도, 통증이 유발 또는 심해지는 자세, 그리고 본인이 생각하는 요통의 원인 등을 포함하였다. MMPI는 전체 평균을 이용한 방법과 two-code 방법을 이용하여 평가하였다. 결과: 만성 요통환자의 직업 상 실내에서 앉아 일하는 직업이 가장 맡았으며 일정한 자세를 오래 유지하며 앉거나 서 있는 경우 증상이 악화되는 것으로 기술되었다. MMPI에서는 건강 염려증, 우울증, 히스테리의 세 척도의 평균이 55이상으로 상승되어 있었다. Two-code 방법에서는 92% (46/50)의 환자에서 위 세 척도 중 적어도 하나 이상 상승되어 있었다. 결론: 만성 요통 환자들에서 일상 생활의 자세와 직업이 요통의 발생 및 악화에 영향이 있을 것으로 보여졌다. MMPI를 통한 심리 인성 검사 상 건강 염려증, 우울증, 히스테리의 성향이 증가되어 있어 요통의 발생과 만성화에 심리적 요소가 영향을 미치는 것으로 보여졌다. 사회경제학적, 정신심리학적 요인이 만성 요통에 미치는 영향의 규명을 위한 다양하고 심도 있는 연구가 필요하다고 생각된다. Purpose : Socioeconomic and psychologic factors seem to affect incidence, severity, and chronicity of low back pain. Purpose of this study is to survey socioeconomic factors and document psychoneurotic traits via MMPI in chronic low back pain patients. Materials and Methods : From July 1997 to December 1998, questionnaire about low back pain-related factors such as duration, severity, posture, occupation etc. and MMPI were given to patients who visited our department for chronic low back pain()6weeks). 62 patients completed, and 50 of them completed MMPI. The answers were analyzed. MMPI scores were evaluated in mean±SD method and two-code method. Results : Sedentary workers were the most common. And symptoms were told to be elicited by long sitting or standing posture(job) . Hs, D, Hy scales of MMPI, which are know as "neurotic triad by two-code method was observed in 92% (46/50) . Conclusion : It seemed that job and posture had Important role in chronic low back pain. And, it seemed that chronic low back pain patients had some psychoneurotic traits especially in hypochondriasis, depression, and hysteria. More investigations to document the influences of socioeconomic and psychoneurotic factors in chronic low back pain seems to be necessary.

정신분열병 환자에서 가족력, 산과적 합병증 및 신체미세기형의 관련성에 관한 연구

안용민,김용식,정희연,신지용,윤세창,배안,이중서,주은정,이창인 大韓神經精神醫學會 1999 신경정신의학 Vol.38 No.2

연구목적 : 저자들은 태생기 동안에 받는 유전외적 요인, 즉 환경적 요인이 산발성 정신분열병 환자들의 발병에 크게 관여할 것이라고 가정하였다. 이를 검증하기 위하여 형제 중 1인 이상이 발병하여 가족력을 분명히 알 수 있는 정신분열병 환자군(이하 형제 환자군)과 가족력이 없는 산발성 정신분열병 환자군(이하 산발성 환자군) 및 정상대조군을 대상으로 산과적 합병증, 신체미세기형 및 정신분열병의 임상 양상을 비교하였다. 방 법 : 연구 대상은 형제 환자군 43명(남 22명, 여 21명), 산발성 환자군 43명(남 23명, 여 20명), 정상대조군 43명(남 20명, 여 23명)이었다. 산과적 합병증은 Lewis 척도를 이용하여 평가하였고 신체미세기형은 Waldrop 척도를 이용하여 측정하였다. 임상 양상으로서 발병 연령, 병전 기능 수준, 정신병리, 약물에 대한 반응, 회복시의 전반적 기능 수준, 지연성 운동장애의 유무를 평가하였다. 결 과 : 정상대조군과 정신분열병 환자군 전체를 비교하였을 때 산과적 합병증과 신체미세기형의 총점과 각 소항목의 점수에 차이가 없었다. 산발성 환자군과 형제 환자군을 비교하였을 때 산과적 합병증의 전체 점수에서는 유의한 차이가 없었으나, 출생 당시에 태아가 받은 스트레스 항목의 점수가 산발성 환자군에서 유의하게 높았다. 신체미세기형에서는 전체 점수 및 입의 미세기형 점수가 산발성 환자군에서 유의하게 높았다. 신체미세기형의 전체 점수가 4점 이상인 환자수도 산발성 환자군에서 높은 경향성을 보였다. 산과적 합병증과 신체미세기형 사이의 상호 연관성은 찾을 수 없었다. 정신분열병의 임상 양상 중에서는 Krawiecka 척도의 총점 및 양성 증상 점수와 회복시의 전반적 기능 수준만이 형제 환자군에 비해 산발성 환자군에서 유의하게 높았다. 성별에 따라서는 형제 환자군에서 남자 환자의 산과적 합병증이 유의하게 높았다. 결 론 : 본 연구를 통해 산과적 합병증 및 신체미세기형 연구가 정신분열병의 원인을 규명하기 위한 유용한 방법임이 시사되었지만, 가족력, 산과적 합병증 및 신체미세기형의 관련성에 대해서는 분명한 결론을 내리지 못하였다. The authors hypothesized that sporadic schizophrenic patients had more chances of receiving environmental insults during the fetal neural development compared with familial schizophrenics. We tested our hypothesis by comparing obstetric complications(OCs), minor physical anomalies(MPAs) and other clinical features, and examining the correlation between OCs and MPAs in schizophrenic patients who had one or more sibling with schizophrenia(sibling group) and sporadic schizophrenics(sporadic group) and normal controls. OCs were evaluated by the scale of Lewis, and MPAs were measured by the Waldrop scale. There were no significant difference in OCs and MPAs between schizophrenic and control groups. Sporadic group had significantly higher fetal distress, total Waldrop score and Waldrop score for mouth than sibling group. And there was a tendency that the number of subjects having the Waldrop score over 4 points was greater in the sporadic group. No significant correlation was observed between CCs and MPAs. The scores of initial psychopathology and post-treatment functioning were much higher in the sporadic group, but the other clinical feature showed no difference. Although male patients had more OCs than female patients in sibling group, no sex difference were observed as a whole. Our results suggest that, if the methodological weakness were complemented, OCs and MPAs would be useful tools in the search for the cause of schizophrenia.

환경농업조성지구내 용수원 및 채수시기별 수질비교

김찬용 ( Chan Yong Kim ),김창배 ( Chang Bae Kim ),김종수 ( Jong Soo Kim ),서영진 ( Young Jin Seo ),윤재탁 ( Jae Tak Yoon ) 한국환경농학회 2002 한국환경농학회지 Vol.21 No.3

A study was conducted to investigate the seasonal changes in water quality of watershed in the Agricultural Environment Promotion Zone. samples collected were 12 GW (ground water), 2 IW (irrigation water), 2 SW (stream water) in An-Doug City, 4 GW, 6 IW, 11 SW in Young-Yang Gun, and sampling was conducted separately during dry and rainy season. In the ground water, EC and ionic species, except pH, were higher than those in stream water, and especially NO_3-N concentration exceeded the limitation of drinking water. Concentration of ions decreased as the sampling depth was far from the soil surface. During a rainy season, the concentrations of NO_3-N and K In the stream water were slightly higher than those during season. COD was lower during dry season in Yong-Yang, while the trend was contrasted to An-Doug. These results suggest that ground water was polluted by fertilization and compost while streamwater was polluted by loss of soil and organic during the rainy season. Principal chemical components related with changing water quality were EC, NO_3^-, Ca, Mg, Na, CI^-, SO_4^- in ground water, whereas NH_4-N, K, Mg, CI^-, SO_4^- in stream water.

무증상 대퇴골두 무혈성 괴사의 증상발현

원중희,김용민,최의성,이호승,서중배,배병권 대한고관절학회 2001 Hip and Pelvis Vol.13 No.1

한국 전통복식이미지 제고에 관한 연구 - 이영희의 세계무대 진출을 중심으로 -

류지효(Ji Hyo Ryu),김용서(Yong Seo Kim),배수정(Soo Jeong Bae) 한국가정과학회 2001 한국가정과학회지 Vol.4 No.1

The purpose of this thesis is to investigate the way how the image of Korean costume could be introduced into the world fashion market, and appreciated by foreigners. For this purpose. I focus on analyzing the works of Lee. Yong-Hee presented in Pre^t-a`-Porter Paris Collection and interpreting the image of Korean costume in her works. I propose some imperative factors essential to promote the participating of Korean costume into the world fashion market. Firstly, the Korean costume should be reevaluated and moderated in a degree, to be acceptable or accessible to foreigners. Secondly, the commerciality is to be stressed in the light of fashion industry dealing with the practical function of the costume. Thirdly, Our open-mindness to other culture would also make our costume to be more prevalent in world fashion market paradoxically. The Seoul Collection in 2000 fall was opened by Korean government on the recognition that the fashion industry is highly productive and helpful not only in cultural basis but in economics.