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( Wonjin Park ),( Yi-yong Baek ),( Joohwan Kim ),( Dong Hyun Jo ),( Seunghwan Choi ),( Jin Hyoung Kim ),( Taesam Kim ),( Suji Kim ),( Minsik Park ),( Ji Yoon Kim ),( Moo-ho Won ),( Kwon-soo Ha ),( Jeo 한국응용약물학회 2019 Biomolecules & Therapeutics(구 응용약물학회지) Vol.27 No.5
Vascular endothelial growth factor (VEGF) plays a pivotal role in pathologic ocular neovascularization and vascular leakage via activation of VEGF receptor 2 (VEGFR2). This study was undertaken to evaluate the therapeutic mechanisms and effects of the tetrapeptide Arg-Leu-Tyr-Glu (RLYE), a VEGFR2 inhibitor, in the development of vascular permeability and choroidal neovascularization (CNV). In cultured human retinal microvascular endothelial cells (HRMECs), treatment with RLYE blocked VEGF-Ainduced phosphorylation of VEGFR2, Akt, ERK, and endothelial nitric oxide synthase (eNOS), leading to suppression of VEGFA- mediated hyper-production of NO. Treatment with RLYE also inhibited VEGF-A-stimulated angiogenic processes (migration, proliferation, and tube formation) and the hyperpermeability of HRMECs, in addition to attenuating VEGF-A-induced angiogenesis and vascular permeability in mice. The anti-vascular permeability activity of RLYE was correlated with enhanced stability and positioning of the junction proteins VE-cadherin, β-catenin, claudin-5, and ZO-1, critical components of the cortical actin ring structure and retinal endothelial barrier, at the boundary between HRMECs stimulated with VEGF-A. Furthermore, intravitreally injected RLYE bound to retinal microvascular endothelium and inhibited laser-induced CNV in mice. These findings suggest that RLYE has potential as a therapeutic drug for the treatment of CNV by preventing VEGFR2-mediated vascular leakage and angiogenesis.
Park Minsik,김주환,Kim Taesam,Kim Suji,Park Wonjin,Ha Kwon-Soo,Cho Sung Hwan,원무호,이정형,권영근,김영명 생화학분자생물학회 2021 Experimental and molecular medicine Vol.53 No.-
Low-dose metronomic chemotherapy (LDMC) inhibits tumor angiogenesis and growth by targeting tumor-associated endothelial cells, but the molecular mechanism has not been fully elucidated. Here, we examined the functional role of regulated in development and DNA damage responses 1 (REDD1), an inhibitor of mammalian target of rapamycin complex 1 (mTORC1), in LDMC-mediated endothelial cell dysfunction. Low-dose doxorubicin (DOX) treatment induced REDD1 expression in cultured vascular and lymphatic endothelial cells and subsequently repressed the mRNA expression of mTORC1-dependent translation of vascular endothelial growth factor receptor (Vegfr)-2/3, resulting in the inhibition of VEGF-mediated angiogenesis and lymphangiogenesis. These regulatory effects of DOX-induced REDD1 expression were additionally confirmed by loss- and gain-of-function studies. Furthermore, LDMC with DOX significantly suppressed tumor angiogenesis, lymphangiogenesis, vascular permeability, growth, and metastasis in B16 melanoma-bearing wild-type but not Redd1-deficient mice. Altogether, our findings indicate that REDD1 is a crucial determinant of LDMC-mediated functional dysregulation of tumor vascular and lymphatic endothelial cells by translational repression of Vegfr-2/3 transcripts, supporting the potential therapeutic properties of REDD1 in highly progressive or metastatic tumors.
Capacity of Sectorized Distributed Networks Employing Adaptive Collaboration from Remote Antennas
PARK, Jonghyun,JANG, Ju Wook,PARK, Sang-Gyu,SUNG, Wonjin The Institute of Electronics, Information and Comm 2010 IEICE TRANSACTIONS ON COMMUNICATIONS - Vol.93 No.12
<P>Distributed networks employing collaborative transmission (CT) from remote antennas can provide improved system capacity and cell-edge performance, by using appropriate transmission strategies. When compared to conventional non-collaborative transmission (NCT) from one base station (BS), we show that CT from two adjacent BSs can be beneficial in terms of the capacity, even when the transmission rate is normalized by the number of collaborating BSs. We further demonstrate that performing adaptive transmission (AT) between NCT and CT based on the instantaneous channel conditions provide an additional gain in capacity. The exact amount of achievable gain is quantified by the closed-form formula for the capacity distribution, which is derived using the Jacobian transformation. The presented distribution is immediately applicable to 6-sectored distributed cellular network, for which we present numerical verification of the results.</P>
청각장애인을 위한 의사소통 지원 서비스의 문제점과 개선방안에 대한 전문가 인식 연구: 수어통역 및 문자통역을 중심으로
박정현 ( Park Junghyun ),정은경 ( Chung Eunkyung ),강기영 ( Kang Ki Young ),박원진 ( Park Wonjin ) 대구대학교 한국특수교육문제연구소 2020 특수교육저널 : 이론과 실천 Vol.21 No.4
[목적] 본 연구는 청각장애인 내부의 다양성을 고려하여, 수어를 제1언어로 사용하는 농인과 음성언어를 제1언어로 사용하는 난청인을 포괄하여 국내의 청각장애인을 위한 의사소통 지원 서비스와 관련된 전반적인 문제점과 개선방안을 파악하였다. [방법] 청각장애 관련 실천현장 및 학계에 종사하는 전문가 8명을 대상으로 일대일 심층면접을 통하여 자료를 수집하고, 귀납적 주제분석의 접근을 통해 자료를 분석하였다. Lincoln과 Guba(1985)가 제시한 네 가지 기준인 신뢰성, 전이가능성, 의존가능성, 확증성에 따라 연구의 엄격성을 확보하고자 노력하였다. [결과] 심층면접을 통해 국내 청각장애인을 위한 의사소통 지원서비스의 문제점과 개선방안에 대해 분석한 결과, 2개의 영역, 8개의 상위범주, 그리고 28개의 하위범주가 도출되었다. 현재 의사소통 지원 서비스의 문제점으로 크게 현행 수어통역센터의 한계, 의사소통 지원 서비스 제공 관련 구조적 장벽, 청각장애 당사자의 권리 옹호 부족이 언급되었고, 의사소통 지원 서비스의 개선방안으로 현행 수어통역 서비스 지원 개선, 청각장애 및 의사소통 지원 관련 기초자료 확보, 의사소통 지원체계 구축을 위한 정치적 활동 전개, 청각장애에 대한 인식 개선 교육 필요, 그리고 의사소통 지원 서비스의 확대 및 다양화가 제안되었다. [결론] 본 연구 결과를 바탕으로 첫째, 전문분야의 수어 연구, 현행 수어통역사 제도의 개선과 현행 수어통역 서비스의 질적 개선 및 양적 확대, 둘째, 난청인 협회의 조직과 문자통역 지원의 제도화, 셋째, 청각장애 관련 용어들의 재정립과 농인과 난청인의 욕구를 모두 반영한 통계자료 구축, 넷째, 청각장애인의 의사소통의 온전한 참여를 위한 환경을 구축하기 위한 다양한 지원방안 마련, 다섯째, 청각장애인의 생애주기별 의사소통 지원의 출발점으로서 초등·중등·고등교육을 받는 청각장애 학생들을 위한 다양한 의사소통 지원 서비스와 제도 마련을 제언하였다. [Purpose] Deaf and Hard of Hearing (D/HH) people have diverse communication needs depending on the first language they use (e.g., sign language, spoken language). This study aims to explore communication access services for D/HH people in South Korea, focusing on professionals’ perceptions on the problems of the services and recommendations for improvement. [Method] One-on-one in-depth interviews were conducted with eight professionals working in various fields related to D/HH population. Data were analyzed according to the inductive thematic analysis approach. Lincoln and Guba’s (1985) four criteria were used to maintain the rigor in this study. [Results] Results showed that there are eight higher-level categories and 28 lower-level categories in two domains. Problems with current communication access services include problems in current sign language interpreting centers, structural barriers related to providing communication access services, and lack of self-advocacy by D/HH people. Recommendations for improvements include improving current sign language interpreting services, collecting preliminary data on the D/HH population and communication access services, engagement of D/HH people in political activities for accessing communication, improving D/HH awareness, and expanding and diversifying communication access services. [Conclusion] This study suggests: improvements to current sign language interpreting services; institutionalizing communication access realtime translation services; redefinition of terminologies related to D/HH; creating D/HH friendly communication environments; and institutionalization of communication access services for D/HH students in elementary, secondary, and higher education (both in special and inclusive education).