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High Frequency of Microsatellite Instability in Intestinal-type Gastric Cancer in Korean Patients
( Won Hyuk Choe ),( Sun Young Lee ),( Jun Haeng Lee ),( Sang Goon Shim ),( Young Ho Kim ),( Poong Lyul Rhee ),( Jong Chul Rhee ),( Chang Seok Ki ),( Jong Won Kim ),( Sang Yong Song ),( Jae J. Kim ) 대한내과학회 2005 The Korean Journal of Internal Medicine Vol.20 No.2
Dae-Hyuk Heo,Yu Min Kang,송경호,Jun-Won Seo,Jeong-Han Kim,June Young Chun,전강일,강창경,Song Mi Moon,Pyoeng Gyun Choe,Wan Beom Park,Ji Hwan Bang,Eu Suk Kim,Hong Bin Kim,Sang-Won Park,Won Sup Oh,Nam Joong Kim,M 대한의학회 2020 Journal of Korean medical science Vol.35 No.11
Background: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease with high mortality in East Asia. This study aimed to develop, for primary care providers, a prediction score using initial symptoms and basic laboratory blood tests to differentiate between SFTS and other endemic zoonoses in Korea. Methods: Patients aged ≥ 18 years diagnosed with endemic zoonoses during a 3-year period (between January 2015 and December 2017) were retrospectively enrolled from 4 tertiary university hospitals. A prediction score was built based on multivariate logistic regression analyses. Results: Of 84 patients, 35 with SFTS and 49 with other endemic zoonoses were enrolled. In multivariate logistic regression analysis, independent predictors of SFTS included neurologic symptoms (odds ratio [OR], 12.915; 95% confidence interval [CI], 2.173–76.747), diarrhea (OR, 10.306; 95% CI, 1.588–66.895), leukopenia (< 4,000/mm3 ) (OR, 19.400; 95% CI, 3.290– 114.408), and normal C-reactive protein (< 0.5 mg/dL) (OR, 24.739; 95% CI, 1.812–337.742). We set up a prediction score by assigning one point to each of these four predictors. A score of ≥ 2 had 82.9% sensitivity (95% CI, 71.7%–87.5%) and 95.9% specificity (95% CI, 88.0%–99.2%). The area under the curve of the clinical prediction score was 0.950 (95% CI, 0.903–0.997). Conclusion: This study finding suggests a simple and useful scoring system to predict SFTS in patients with endemic zoonoses. We expect this strategic approach to facilitate early differentiation of SFTS from other endemic zoonoses, especially by primary care providers, and to improve the clinical outcomes.
A Genetic Risk Score for Atrial Fibrillation Predicts the Response to Catheter Ablation
Won-Seok Choe,Jun Hyuk Kang,Eue-Keun Choi,Seung Yong Shin,Steven A. Lubitz,Patrick T. Ellinor,Seil Oh,Hong Euy Lim 대한심장학회 2019 Korean Circulation Journal Vol.49 No.4
Background and Objectives: The association of susceptibility loci for atrial fibrillation (AF) with AF recurrence after ablation has been reported, although with controversial results. In this prospective cohort analysis, we aimed to investigate whether a genetic risk score (GRS) can predict the rhythm outcomes after catheter ablation of AF. Methods: We determined the association between 20 AF-susceptible single nucleotide polymorphisms (SNPs) and AF recurrence after catheter ablation in 746 patients (74% males; age, 59±11 years; 56% paroxysmal AF). A GRS was calculated by summing the unweighted numbers of risk alleles of selected SNPs. A Cox proportional hazard model was used to identify the association between the GRS and risk of AF recurrence after catheter ablation. Results: AF recurrences after catheter ablation occurred in 168 (22.5%) subjects with a median follow-up of 23 months. The GRS was calculated using 5 SNPs (rs1448818, rs2200733, rs6843082, rs6838973 at chromosome 4q25 [PITX2] and rs2106261 at chromosome 16q22 [ZFHX3]), which showed modest associations with AF recurrence. The GRS was significantly associated with AF recurrence (hazard ratio [HR] per each score, 1.13; 95% confidence interval [CI], 1.03–1.24). Patients with intermediate (GRS 4–6) and high risks (GRS 7–10) showed HRs of 2.00 (95% CI, 0.99–4.04) and 2.66 (95% CI, 1.32–5.37), respectively, compared to patients with low risk (GRS 0–3). Conclusions: Our novel GRS using 5 AF-susceptible SNPs was strongly associated with AF recurrence after catheter ablation in Korean population, beyond clinical risk factors. Further efforts are warranted to construct a generalizable, robust genetic prediction model which can guide the optimal treatment strategies.
A New Scoring Method of the Mini-Mental Status Examination to Screen for Dementia
Choe, Jin Yeong,Han, Ji Won,Kim, Tae Hui,Kim, Jeong Lan,Moon, Seok Woo,Park, Joon Hyuk,Kim, Shin Gyeom,Kim, Bong-Jo,Kwak, Kyung-Phil,Ryu, Seung-Ho,Yoon, Jong Chul,Lee, Dong Young,Lee, Dong Woo,Lee, Se Karger 2014 DEMENTIA AND GERIATRIC COGNITIVE DISORDERS Vol.37 No.5
<P>Abstract</P><P><B><I>Background:</I></B> Although the Mini-Mental Status Examination (MMSE) is the most widely used screening instrument for dementia, it has several limitations. <B><I>Methods:</I></B> We developed and validated a new scoring method of the MMSE, namely the short form of the MMSE (MMSE-S). <B><I>Results:</I></B> The MMSE-S was more robust to demographic influences than the MMSE. The influence of education, in particular, was smaller in the MMSE-S compared to the MMSE (p < 0.01). The diagnostic accuracy of the MMSE-S for very mild to mild dementia was also better than that of the original MMSE (p < 0.0001). Its specificity, in particular, was higher than that of the original MMSE. In Korea, we could improve the post-test probability for dementia from 46.88 to 64.76% by employing the MMSE-S instead of the MMSE. We also provided optimal cut-off scores for dementia stratified by age, education, and gender, which may further improve the diagnostic accuracy of the MMSE-S for dementia. <B><I>Conclusion:</I></B> Due to its good accuracy and brevity, the MMSE-S may contribute to enhancing the cost-effectiveness of and accessibility to dementia screening as well as early diagnosis and treatment of dementia, particularly in low- and middle-income countries.</P><P>© 2014 S. Karger AG, Basel</P>
Comparisons of Liquidity Measures in the Stock Markets
Hyuk Choe,Cheol-Won Yang 한국재무학회 2008 한국재무학회 학술대회 Vol.2008 No.05
The notion of liquidity is widely used in the finance area, such as in the studies of market microstructure and asset pricing. However, there are so many liquidity measures that it is difficult for researchers to decide which measure they should adopt. There is no consensus on which measure is the most appropriate as well. This paper compares various liquidity measures to find which of these measures is the most appropriate in the stock market. Analyses are performed on the nonfinancial firms listed in the Korea Exchange and the NYSE/AMEX for the period 1993~2004. Two methodologies are employed. One is a correlation check that will reveal the internal consistency between measures. The other method is to investigate the relation between risk-adjusted returns and liquidity measures by using the asset pricing framework of Brennan, Chordia, and Subrahmanyam (1998) (BCS). This paper provides us several kinds of new knowledge about liquidity measures. First, most liquidity measures are highly correlated with each other, except for the Pastor and Stambaugh (2003) measure. Therefore, we do not need to be severely concerned about the conflicts of the liquidity measures. Second, the Amihud (2002) measure and its modified measure perform distinguishably well. Third, researchers are interested in a liquidity measure which can replace the high-frequency measure, such as the bid-ask spread. This paper concludes that the most reliable solution is the Amihud (2002) measure.
( Won Seok Choi ),( Tae Wan Kim ),( Ja Hyun Kim ),( Sang Hyuk Lee ),( Woon Je Hur ),( Young Gil Choe ),( Jung Ho Park ),( Chong Il Sohn ) 대한소화기기능성질환·운동학회 2013 Journal of Neurogastroenterology and Motility (JNM Vol.19 No.4
Background/Aims Globus is a foreign body sense in the throat without dysphagia, odynophagia, esophageal motility disorders, or gastroesophageal reflux. The etiology is unclear. Previous studies suggested that increased upper esophageal sphincter pressure, gastroesophageal reflux and hypertonicity of esophageal body were possible etiologies. This study was to quantify the upper esophageal sphincter (UES) pressure, contractile front velocity (CFV), proximal contractile integral (PCI), distal contractile integral (DCI) and transition zone (TZ) in patient with globus gastroesophageal reflux disease (GERD) without globus, and normal controls to suggest the correlation of specific high-resolution manometry (HRM) findings and globus. Methods Fifty-seven globus patients, 24 GERD patients and 7 normal controls were studied with HRM since 2009. We reviewed the reports, and selected 5 swallowing plots suitable for analysis in each report, analyzed each individual plot with ManoView. The 5 parameters from each plot in 57 globus patients were compared with that of 24 GERD patients and 7 normal controls. Results There was no significant difference in the UES pressure, CFV, PCI and DCI. TZ (using 30 mmHg isobaric contour) in globus showed significant difference compared with normal controls and GERD patients. The median values of TZ were 4.26 cm (interquartile range [IQR], 2.30-5.85) in globus patients, 5.91 cm (IQR, 3.97-7.62) in GERD patients and 2.26 cm (IQR, 1.22-2.92) in normal controls (P = 0.001). Conclusions HRM analysis suggested that UES pressure, CFV, PCI and DCI were not associated with globus. Instead increased length of TZ may be correlated with globus. Further study comparing HRM results in globus patients within larger population needs to confirm their correlation. (J Neurogastroenterol Motil 2013;19:473-478)