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( Takeshi Hashimoto ),( Yoko Okada ),( Atsushi Yamanaka ),( Natsuhiko Ono ),( Keisuke Uryu ),( Isafumi Maru ) 한국운동영양학회 2020 Physical Activity and Nutrition (Phys Act Nutr) Vol.24 No.3
[Purpose] In vivo studies have demonstrated the ergogenic benefits of eleutherococcus senticosus (ES) supplementation. ES has been observed to enhance endurance capacity, improve cardiovascular function, and alter metabolic functions (e.g., increased fat utilization); however, the exact mechanisms involved remain unknown. We aimed to determine whether ES could effectively induce fat loss and improve muscle metabolic profiles through increases in lipolysis- and lipid metabolism-associated protein expression in 3T3-L1 adipocytes and C2C12 skeletal muscle cells, respectively, to uncover the direct effects of ES on adipocytes and skeletal muscle cells. [Methods] Different doses of ES extracts (0.2, 0.5, and 1.0 mg/mL) were added to cells (0.2 ES, 0.5 ES, and 1.0 ES, respectively) for 72 h and compared to the vehicle control (control). [Results] The intracellular triacylglycerol (TG) content significantly decreased (p < 0.05 for 0.2 ES, p < 0.01 for 0.5 ES and 1.0 ES) in 3T3-L1 cells. Adipose triglyceride lipase, which is involved in active lipolysis, was significantly higher in the 1.0 ES group than in the control group (p < 0.01) of 3T3-L1 adipocytes. In C2C12 cells, the mitochondrial protein voltage-dependent anion channel (VDAC) was significantly increased in the 1.0 ES group (p < 0.01). Furthermore, we found that 1.0 ES activated both 5' AMP-activated protein kinase (AMPK) and acetyl-CoA carboxylase (ACC) in skeletal muscle cells (p < 0.01). [Conclusion] These findings suggest that ES extracts decreased TG content, presumably by increasing lipase in adipocytes and metabolism-associated protein expression as well as mitochondrial biogenesis in muscle cells. These effects may corroborate previous in vivo findings regarding the ergogenic effects of ES supplementation.
Hashimoto, Takeshi The Korean Society of Marine Engineering 1996 한국마린엔지니어링학회지 Vol.20 No.3
In Asia countries the productions of ship building and marine engines have been increasing, specially Japanese marine industries have worked hard after 1960s and Korean ones after 1980s. Recently the other countries, as Taiwan and China, have been working so that these hour Asian countries are occuping the high level of shared ratio of productions for gross tonnages and horse powers, which are 74 and 64[%] of the world ones ($8.6\times10$+6[GT], $8.6\times10$+6[PS]) in 1994. Korean industries had the highest shared ratio of production of tanker vessel and 2 stroke diesel engine as 45[%]($2.2\times10$+6[GT]) and 37[%]($1.0\times10$+6[PS]) which were more than those of Japan as 34 and 16[%] in 1989 respectively. Some marine databases and their network links among Asian countries are proposed due to the posibility of collection and analyses with their own specifications by the marine industries and operators as well as Japanese ship reliability investigation works(SRIW) like SRIC in Japan. During 1966 and 1996 16 times of SRIW in Japan have been carried out by ship reliability investigation group(SRIG) in Japan. There have been collected and evaluated a great number of field data of failures and maintenances($700\times10$+3[occ], $1.6\times10$+6[MH}) during running hours($13.4\times10$+6[Hrs]), from which many kinds of evaluation indices could be gotten as the three indices of occurring rate$\lambda$(52.2[occ/1000Hrs]), average man-hour mh(2.29[MH/occ]) and manning index MI(119[MH/1000Hrs]). An estimation example having the three indices$\lambda$, mh and MI were shown by the SRIC 1990 Data Base in Japan for the two kinds of fuel oil suppling subsystems which are dual fuel oil one(DFOS) and mono fuel oil one(MFOS). Three indices MI, and mh for DFOS and MFOS results in 7.16 and 5.20[MH/1000Hrs], 2.63 and 2.06[occ/1000 Hrs]. Therefore the more simple subsystem MFOS can save approximately 30[%] of maintenance load. Finlly an utilization methods are shown for the SRIC in Japan by means of computer system and worlwide internet links.
Hashimoto, Hirokazu,Jiang, Wen,Yoshimura, Takeshi,Moon, Kyeong-Hye,Bok, Jinwoong,Ikenaka, Kazuhiro Elsevier 2018 Neurochemistry International Vol.119 No.-
<P><B>Abstract</B></P> <P>In the mouse neural tube, sonic hedgehog (Shh) secreted from the floor plate (FP) and the notochord (NC) regulates ventral patterning of the neural tube, and later is essential for the generation of oligodendrocyte precursor cells (OPCs). During early development, the NC is adjacent to the neural tube and induces ventral domains in it, including the FP. In the later stage of development, during gliogenesis in the spinal cord, the pMN domain receives strong Shh signaling input. While this is considered to be essential for the generation of OPCs, the actual role of this strong input in OPC generation remains unclear. Here we studied OPC generation in <I>bromi</I> mutant mice which show abnormal ciliary structure. Shh signaling occurs within cilia and has been reported to be weak in <I>bromi</I> mutants. At E11.5, accumulation of <I>Patched1</I> mRNA, a Shh signaling reporter, is observed in the pMN domain of wild type but not <I>bromi</I> mutants, whereas expression of <I>Gli1</I> mRNA, another Shh reporter, disappeared. Thus, Shh signaling input to the pMN domain at E12.5 was reduced in <I>bromi</I> mutant mice. In these mutants, induction of the FP structure was delayed and its size was reduced compared to wild type mice. Furthermore, while the p3 and pMN domains were induced, the length of the Nkx2.2-positive region and the number of Olig2-positive cells decreased. The number of OPCs was also significantly decreased in the E12.5 and E14.5 <I>bromi</I> mutant spinal cord. In contrast, motor neuron (MN) production, detected by HB9 expression, significantly increased. It is likely that the transition from MN production to OPC generation in the pMN domain is impaired in <I>bromi</I> mutant mice. These results suggest that strong Shh input to the pMN domain is not required for OPC generation but is essential for producing a sufficient number of OPCs.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Induction of the floor plate structure is attenuated in E12.5 <I>bromi</I> mutants. </LI> <LI> Shh signaling input to the pMN domain is insufficient in <I>bromi</I> mutants. </LI> <LI> Motor neuron generation increases at E12.5 by <I>bromi</I> mutation. </LI> <LI> Oligodendrocyte precursor cell number decreases in the embryonic <I>bromi</I> spinal cord. </LI> </UL> </P>
Takeshi Nakahara,Chikage Mitoma,Akiko Hashimoto-Hachiya,Masakazu Takahara,Gaku Tsuji,Hiroshi Uchi,Xianghong Yan,Junichi Hachisuka,Takahito Chiba,Hitokazu Esaki,Makiko Kido-Nakahara,Masutaka Furue 한국식품영양과학회 2015 Journal of medicinal food Vol.18 No.10
Opuntia ficus-indica (OFI) is a cactus species widely used as an anti-inflammatory, antilipidemic, and hypoglycemic agent. It has been shown that OFI extract (OFIE) inhibits oxidative stress in animal models of diabetes and hepatic disease; however, its antioxidant mechanism remains largely unknown. In this study, we demonstrated that OFIE exhibited potent antioxidant activity through the activation of nuclear factor erythroid 2-related factor 2 (NRF2) and the downstream antioxidant enzyme NAD(P)H:quinone oxidoreductase 1 (NQO1), which inhibited the generation of reactive oxygen species in keratinocytes challenged with tumor necrosis factor α or benzo[α]pyrene. The antioxidant capacity of OFIE was canceled in NRF2 knockdown keratinocytes. OFIE exerted this NRF2-NQO1 upregulation through activation of the aryl hydrocarbon receptor (AHR). Moreover, the ligation of AHR by OFIE upregulated the expression of epidermal barrier proteins: filaggrin and loricrin. OFIE also prevented TH2 cytokine-mediated downregulation of filaggrin and loricrin expression in an AHRdependent manner because it was canceled in AHR knockdown keratinocytes. Antioxidant OFIE is a potent activator of AHRNRF2-NQO1 signaling and may be beneficial in treating barrier-disrupted skin disorders.
Atsushi Goto,Takeshi Okamoto,Ryo Ogawa,Kouichi Hamabe,Shinichi Hashimoto,Jun Nishikawa,Taro Takami 대한소화기내시경학회 2022 Clinical Endoscopy Vol.55 No.4
Background/Aims: Intralesional steroid injections have been administered as prophylaxis for stenosis after esophageal endoscopicsubmucosal dissection. However, this method carries a risk of potential complications such as perforation because a fine needle is usedto directly puncture the postoperative ulcer. We devised a new method of steroid intralesional infusion using a spray tube and evaluatedits efficacy and safety. Methods: Intralesional steroid infusion using a spray tube was performed on 27 patients who underwent endoscopic submucosal dissectionfor superficial esophageal cancer with three-quarters or more of the lumen circumference resected. The presence or absence ofstenosis, complications, and the number of endoscopic balloon dilations (EBDs) performed were evaluated after treatment. Results: Although stenosis was not observed in 22 of the 27 patients, five patients had stenosis and dysphagia requiring EBD. The stenosisin these five patients was relieved after four EBDs. No complications related to intralesional steroid infusion using the spray tubewere observed. Conclusions: Intralesional steroid infusion using a spray tube is a simple and safe technique that is adequately effective in preventingstenosis (clinical trial number, UMIN000037567).
Circle Detection and Fitting Using Laser Range Finder for Positioning System
Xiangqi Huang,Takeshi Sasaki,Hideki Hashimoto,Fumihiro Inoue 제어로봇시스템학회 2010 제어로봇시스템학회 국제학술대회 논문집 Vol.2010 No.10
In this paper, inspired by RANSAC and Hough Transform voting procedure, a modified RANSAC algorithm of detection of cylindrical reference target using LRF for positioning system is proposed. Utilizing the orientation-invariant property of the circle, cylindrical shaped bar is chosen as the reference target of the positioning system. The given radius of the cylinder and convex arc shaped contour observed by LRF are two important constraints of the model of circle used in this positioning system. Simulation results prove that under given conditions the proposed circle detection algorithm works better than original RANSAC when occlusion and noise make the ratio of qualified inliers decrease. The reason is that a voting procedure can reduce the effect of noise and guarantee a more reliable model hypothesis. After extraction of enough inliers by proposed circle detection algorithm, maximum likelihood estimation is implemented to estimate the precise center position of the reference target.
Algorithm Evaluation Support Tools for Intelligent Space
Shaohua Zheng,Takeshi Sasaki,Hideki Hashimoto 제어로봇시스템학회 2009 제어로봇시스템학회 국제학술대회 논문집 Vol.2009 No.8
Intelligent Space is an environment in which a variety of sensors are distributed and installed. In this paper, the three tools to simulate Intelligent Space system, Environment Designer, Sensor Arranger and Simulation Runner are explained. They operate to make our simulator a powerful simulation platform for research and many other aims in Intelligent Space. In addition to simulation of the operation of Intelligent Space including information processing and mobile robot control, sensor arrangement is one of the main objectives of our platform. Beside of manual operation, amateur users are looking forward to more automatic functions. Because the arrangement of laser range finder is an important theme for Intelligent Space research, automatic laser range finder arrangement mode is proposed.