Idiopathic Hypertrophic Spinal Pachymeningitis with an Osteolytic Lesion

Jee, Tae Keun,Lee, Sun-Ho,Kim, Eun-Sang,Eoh, Whan The Korean Neurosurgical Society 2014 Journal of Korean neurosurgical society Vol.56 No.2

Idiopathic hypertrophic spinal pachymeningitis (IHSP) is a chronic, progressive, inflammatory disorder characterized by marked fibrosis of the spinal dura mater with unknown etiology. According to the location of the lesion, it might induce neurologic deficits by compression of spinal cord and nerve root. A 58-year old female with a 3-year history of progressive weakness in both lower extremities was referred to our institute. Spinal computed tomography (CT) scan showed an osteolytic lesion involving base of the C6 spinous process with adjacent epidural mass. Magnetic resonance imaging (MRI) revealed an epidural mass involving dorsal aspect of cervical spinal canal from C5 to C7 level, with low signal intensity on T1 and T2 weighted images and non-enhancement on T1 weighted-enhanced images. We decided to undertake surgical exploration. At the operation field, there was yellow colored, thickened fibrous tissue over the dura mater. The lesion was removed totally, and decompression of spinal cord was achieved. Symptoms improved partially after the operation. Histopathologically, fibrotic pachymeninges with scanty inflammatory cells was revealed, which was compatible with diagnosis of idiopathic hypertrophic pachymeningitis. Six months after operation, motor power grade of both lower extremities was normal on physical examination. However, the patient still complained of mild weakness in the right lower extremity. Although the nature of IHSP is generally indolent, decompressive surgery should be considered for the patient with definite or progressive neurologic symptoms in order to prevent further deterioration. In addition, IHSP can present as an osteolytic lesion. Differential diagnosis with neoplastic disease, including giant cell tumor, is important.

Fractionated Gamma Knife Radiosurgery for Benign Perioptic Tumors: Outcomes of 38 Patients in a Single Institute

Tae Keun Jee,Ho Jun Seol,Yong-Seok Im,공두식,남도현,Kwan Park,Hyung Jin Shin,이정일 대한뇌종양학회 2014 Brain Tumor Research and Treatment Vol.2 No.2

Background This study was performed to evaluate the efficacy and safety of fractionated Gamma Knife radiosurgery (GKRS) for perioptic lesions. Methods Thirty-eight patients with perioptic tumors were treated at our institute from May 2004 to December 2008. All patients had a lesion in close contact with the optic apparatus. Twenty-four of these patients had undergone surgical resection before fractionated GKRS. Radiation was delivered in four sessions with 12 hours intervals between sessions. The mean target volume was 3,851 mm3 and the median cumulative marginal dose was 20 Gy. The median follow-up was 38.2 months. Visual acuity and visual fields were analyzed according to visual impairment score using the German Ophthalmological Society guidelines. Results Tumor control was achieved in 35 (94.6%) of the 37 patients with available follow-up images. Progressive tumor growth was observed in two craniopharyngioma patients (5.4%). Favorable visual outcomes in the postoperative period were achieved in 94.7% of cases (36/38). Sixteen patients showed visual function after fractionated GKRS, twenty cases were stationary, and two patients showed visual function deterioration after GKRS. Conclusion GKRS is a safe and effective alternative to either surgery or fractionated radiotherapy for selected benign lesions that are adjacent to the optic apparatus.

Clinical Features and Treatment Outcome of Chordoid Meningiomas in a Single Institute

Jee, Tae Keun,Jo, Kyung-Il,Seol, Ho Jun,Kong, Doo-Sik,Lee, Jung-Il,Shin, Hyung Jin The Korean Neurosurgical Society 2014 Journal of Korean neurosurgical society Vol.56 No.3

Objective : Meningioma is the second most common primary central nervous system neoplasm. In contrast, chordoid meningioma is rare; due to the paucity of cases, little is known about its clinical features or treatment outcomes. The objectives of this study were to describe the clinical characteristics and outcomes for patients with chordoid meningioma. Methods : In total, 16 patients, with newly diagnosed chordoid meningioma who underwent surgical excision between 1999 and 2012 were included. We retrospectively evaluated the medical records, radiological findings, and pathological findings. The median follow-up period was 56.5 (range, 3-170) months. The MIB-1 labeling index ranged from 1 to 26.60% (median, 5.04). Results : Simpson grade I, II, and III resections were performed in four, nine, and three patients, respectively. The overall recurrence rate was 37.5%. Overall progression-free survival (PFS) after resection was 94.7 months (95% CI=62.9-126.6). Of the 4 patients with Simpson grade I resection, recurrence occurred in one patient. Among the Simpson grade II and III resection groups, eight patients underwent adjuvant radiation therapy and they showed significantly longer PFS (121 months, 95% CI=82.1-159.9) than the patients who underwent surgery alone (40.5 months, 95% CI=9.6-71.3) by the log-rank test (p<0.05). Conclusion : Chordoid meningiomas are difficult to manage and have a high rate of recurrence. Complete resection of the tumor is a key determinant of better outcomes. Adjuvant radiation therapy is recommended, eparticulary when Simpson grade I resection was not achieved.

ORIGINAL ARTICLE : Fractionated Gamma Knife Radiosurgery for Benign Perioptic Tumors: Outcomes of 38 Patients in a Single Institute

( Tae Keun Jee ),( Ho Jun Seol ),( Yong Seok Im ),( Doo Sik Kong ),( Do Hyun Nam ),( Kwan Park ),( Hyung Jin Shin ),( Jung Il Lee ) 대한뇌종양학회 대한신경종양학회 2014 Brain Tumor Research and Treatment Vol.2 No.2

Background This study was performed to evaluate the efficacy and safety of fractionated Gamma Knife radiosurgery (GKRS) for perioptic lesions. Methods Thirty-eight patients with perioptic tumors were treated at our institute from May 2004 to December 2008. All patients had a lesion in close contact with the optic apparatus. Twenty-four of these patients had undergone surgical resection before fractionated GKRS. Radiation was delivered in four sessions with 12 hours intervals between sessions. The mean target volume was 3,851 mm3 and the median cumulative marginal dose was 20 Gy. The median follow-up was 38.2 months. Visual acuity and visual fields were analyzed according to visual impairment score using the German Ophthalmological Society guidelines. Results Tumor control was achieved in 35 (94.6%) of the 37 patients with available follow-up images. Progressive tumor growth was observed in two craniopharyngioma patients (5.4%). Favorable visual outcomes in the postoperative period were achieved in 94.7% of cases (36/38). Sixteen patients showed visual function after fractionated GKRS, twenty cases were stationary, and two patients showed visual function deterioration after GKRS. Conclusion GKRS is a safe and effective alternative to either surgery or fractionated radiotherapy for selected benign lesions that are adjacent to the optic apparatus.

Stimulative Effects of Hominis Placental Pharmacopuncture Solution Combined with Zinc-oxide Nanoparticles on RAW 264.7 Cells - ZnO HPPS more easily stimulates RAW 264.7 cells -

Hong, Tae-Keun,Kim, Jee-Hye,Woo, Ju-Youn,Ha, Ki-Tae,Joo, Myung-Soo,Hahn, Yoon-Bong,Jeong, Han-Sol KOREAN PHARMACOPUNCTURE INSTITUTE 2012 Journal of pharmacopuncture Vol.15 No.3

Objectives: The purpose of this study is to examine whether Hominis Placental pharmacopuncture solution (HPPS) combined with zinc-oxide nanoparticles (ZnO NP) activates RAW 264.7 cells. Methods: We soaked ZnO nanoparticles in the Hominis Placenta pharmacopuncture solution, thereby making a combined form (ZnO NP HPPS). The effect of ZnO NP HPPS on the intracellular reactive oxygen species (ROS) production was measured by 2', 7'-dichlorofluorescin diacetate (DCFH-DA) assay. The effect of ZnO NP HPPS on NF-${\kappa}B$ was measured by using a luciferase assay. The effect of ZnO NP HPPS on the cytokine expression was assessed by semi-quantitative reverse transcriptase polymerase chain reaction (RT-PCR). The cellular uptake of ZnO NP HPPS was measured by using a flow cytometric analysis, and cellular structural alterations were analyzed by using transmission electron microscopy (TEM). Results: Neither the HPPS nor the ZnO NPs induced intracellular ROS production in RAW 264.7 cells. Neither of the materials activated NF-${\kappa}B$ or it's dependent genes, such as TNF-${\alpha}$, IL-1, and MCP-1. However, ZnO NP HPPS, the combined form of ZnO NPs and HPPS, did induce the intracellular ROS production, as well as prominently activating NF-${\kappa}B$ and it's dependent genes. Also, compared to ZnO NPs, it effectively increa-sed the uptake by RAW 264.7 cells. In addition, cellular structural alterations were observed in groups treated with ZnO NP HPPS. Conclusions: Neither ZnO NP nor HPPS activated RAW 264.7 cells, which is likely due to a low cellular uptake. The ZnO NP HPPS, however, significantly activated NF-${\kappa}B$ and up-regulated its dependent genes such as TNF-${\alpha}$, IL-1, and MCP-1. ZnO NP HPPS was also more easily taken into the RAW 264.7 cells than either ZnO NP or HPPS.

The detecion of African swine fever virus via hair plucking: An alternative non-invasive approach

Chae-Rin Park(Chae-Rin Park),Tae-Young Suh(Tae-Young Suh),Da-Hye Yi(Da-Hye Yi),Soo-Kyoung Lee(Soo-Kyoung Lee),Seong-Keun Hong(Seong-Keun Hong),Ki-Hyun Cho(Ki-Hyun Cho),Jee-Yong Park(Jee-Yong Park),Yon 한국예방수의학회 2022 한국예방수의학회 학술대회자료집 Vol.2022 No.-

전두엽에 발생한 신경절교종(Ganglioglioma) 1예 : 증례 보고

지연근,김태성,김광명,김국기,이봉암,임언,지제근 대한신경외과학회 1983 Journal of Korean neurosurgical society Vol.12 No.2

A case of ganglioglioma is presented. A 2-year-old Korean male was admitted with chief complaint of generalized seizure from the age of 15 days. Neurologically, delayed speech development and mild monoparesis of right upper extremity he had. Brain CT revealed the ill defined round calcific density on left frontal lobe with mild dilatation of frontal horn of left lateral ventricle. EEG showed the single and poly spike wave on left cerebral hemisphere. The tumor mass was grayish white in color and rubbery hard in consistency with relatively good demarcation from the adjacent normal brain cortex. Histological diagnosis was a ganglioglioma with calcification. Following subtotal removal, the patient had an uneventful recovery.

경추외상 환자의 임상적 고찰

지연근,김태성,김광명,김국기,이봉암,임언 대한신경외과학회 1983 Journal of Korean neurosurgical society Vol.12 No.4

Thirty two cases of the cervical spinal injury have been collected except those which associated with the injury on the other sites, such as head or internal organs. Nine cases of them were managed with surgery by anterior and/or posterior approaches The others were only immobilized by traction. Independent of operative method, we acquired slight to moderate improvement in all operative cases. Two cases with skeletal traction, however, became more aggravated. Indication of operation has much controversies as yet. A Major problem at present falls on the difficulty of functional recovery.

연구보문 : 생태환경 ; 농업환경 분야의 미래유망기술 및 전략기술에 관한 우선순위 재설정

조근태 ( Keun Tae Cho ),주진호 ( Jin Ho Joo ),옥용식 ( Yong Sik Ok ),신봉철 ( Bong Chul Shin ),김지용 ( Jee Yong Kim ),이종인 ( Jong In Lee ) 한국환경농학회 2008 한국환경농학회지 Vol.27 No.4

The objective of this study was to set priority for future core technologies in agricultural and environmental science using analytic hierarchy process(AHP). Forty-six technologies were derived by specialist meetings. Evaluation criteria, for setting the priority were decided as `technology`, `marketability`, and `public`. Eighteen specialists in agricultural and environmental science answered to the questionnaire for AHP. As the results, `technology` was decided as the most important evaluation criterion. The `Feasibility` in `technology` criterion, `Market Growth` in `marketability` criterion, and `Impact to other industry` in `public` criterion were decided as sub-criteria in each criterion. The most important technology was `Risk assessment of toxic heavy metals and establishment of accreditation criteria for environmentally friendly agricultural products.

간호학과 학생의 신체변형장애에 관한 연구

김지욱(Jee-Wook Kim),김수영(Soo-Young Kim),강문희(Moon-Hee Gang),이선우(Sun-Woo Lee),김정란(Jeong-Lan Kim),왕성근(Seong-Keun Wang),신윤오(Yun-O Shin),이태경(Tae-Kyung Lee),지익성(Ik-Seung Chee) 대한생물치료정신의학회 2007 생물치료정신의학 Vol.13 No.2

Objectives:The purposes of this study were to examine prevalence, characteristics and comorbidity of BDD in Korean nurse college students. Methods:Korean versions of BDDE-SR, MOCI, BDI, SES, LSAS were applied to 607 Korean nurse college students. Results:1) Five factors were extracted in BDDE-SR by factor analysis with the Varimax rotation. They were‘preoccupation, distress, embarrassment factor’,‘avoidance factor’,‘checking, comparing, camouflaging factor’,‘dissatisfaction factor’,‘importance factor’. 2) Sex differences in dissatisfied body parts on whole body, head hair, whole face, genitals, breasts were significant by chi-square test. 3) Eighteen participants(2.97%) were satisfied with DSM-IV criteria A and B of body dysmorphic disorder(BDD group). 4) The most dissatisfied body part was entire leg, eye, nose, waist-abdomen, calves in BDD group. 5) Differences between BDD group and non-BDD group on age and weight were significant by Mann-Whitney U-tests. 6) Differences between BDD group and non-BDD group on BDI, MOCI, LSAS-anxiety scale, LSAS-avoidance scale, SES were significant by Mann- Whitney U-tests. 7) Differences between men and female on BDDE-SR factor 1, BDDE-SR factor 2, BDDE-SR factor 3, BDDE-SR total factors, LSAS-avoidance scale were significant by Mann-Whitney U-tests. 8) Using multiple regression analysis the most contributing variance toward the total factor score of BDDE-SR of participants was BDI, and others were BMI, LSAS-anxiety scale, age, MOCI, SES in order of contribution. Conclusion:Our results indicate that BDD is a common disorder and is highly associated with depression, anxiety, obsessive-compulsive disorder symptoms, poor self-esteem. The authors suggest that future researches should be directed to obtaining clinical data of the patients with BDD. 목적 : 저자들은 대전지역 간호학과 학생을 대상으로 신체 변형장애의 임상 특성과 관련 심리적 변인을 알아보기 위해 연구하였다. 방법 : 한국판 신체변형장애 척도, 한국판 Maudsley 강박행동 질문지, 한국판 Beck 우울증 척도, 한국판 자아존중감 척도, 한국판 Liebowitz 사회 불안 척도를 607명의 간호학과 학생에게 시행하였다. 결과 : BDD군은 18명(2.97%)이었으며 가장 마음에 들지 않는 신체 부위로 다리 전체, 눈, 코, 허리-배, 종아리 순을 보고하였다. non-BDD군보다 BDD군에서 우울감, 강박증, 자존심 저하, 사회 불안-회피 성향이 유의미하게 높았다. 간호학과 학생 전체를 대상으로 신체 변형장애 성향에 가장 영향을 주는 변인은 우울감이었으며 BMI, 사회 불안 성향, 연령, 강박증, 자존감 순이었다. 여학생의 경우 신체변형장애 성향에 영향을 주는 변인은 우울감, BMI, 사회 불안 성향, 연령, 강박증, 자존감 순이었다. 남학생의 경우 신체변형장애 성향에 영향을 주는 변인은 우울감, 강박증 순이었다. 결론 : 본 연구는 향후 신체변형장애 연구에 유용한 자료로 사용될 수 있을 것이다. 그러나 많지 않은 표본수를 감안할 때 우리의 연구를 실증하기 위해 보다 많은 표본을 대상으로 연구가 시행되어야 할 것이며 신체변형장애 환자들에 대한 임상 특성에 대한 연구가 필요할 것이다.