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Chun, Yoon-Keun,Ha, Joo-hun,Hong-Jung-Woo,Oh, Soo-Myung,Kim, Sung-Soo 경희대학교 동서의학연구소 1999 INTERNATIONAL SYMPOSIUM ON EAST-WEST MEDICINE Vol.1999 No.1
Yoon-Keun Chun¹,Joohun Ha□Hong-Jung Woo□, Soo Myung Oh□,Sung Soo Kim□ ¹Department of Molecular Biology, College of Medicine,²Department of Surgery, college of Medicine,³Department of Internal Medicine, College of Oriental Medicine,and ⁴East-Weat Medical Reserch Institute,Kyung Hee University, Seoul, Korea. The HBV DNA Amounts in Serum Have No relationship with ALT level and Hetergeneous Population Coexits in Chronic Hepatitis B Virus Infection. Proceedings of International Symposium on East-West Medicine, Seoul. 212-230, 1999. -Hepatitis B is caused by hepadnavirus. Hepatitis B virus replicates through 3.5kb pregenomic RNA intermediate which is regulated by core promoter. Pathogenesis of hepatitis B virus has been bilieved the result of host immune response. But recently many studies have reported that high level of viral replication caused by mutation in core promoter might result in severs hepatitis. But these studies were performed in vitro, not in vivo. So there is yet debate about which factor, viral of host factor, is more important in pathogenesis of hepatitis B virus. So we measured real viral replication level in 204 chronic hepatitis B patients by quantifying HBV DNA from sera by our novel PCR-based more sensitive method, and compared these results with ALT level measured from same sera, which indicates liver cell damage. Surprisingly there are no significant correlation between HBV DNA quantity and ALT level. Then we cloned core promoter region. In SSCP, we found that many viral mutants coexist in one patient. Base on SSCP result, we chose main viral core promoter type in each patients, which is thought to determine overall viral replication level in this patient. Main type of core promoter region of each 41 patients were directly sequenced. And with these we measured promoter activity by luciferase assay system and compared promoter activity with on another. We found tha there were some differences in promoter activity according to core promoter sequences. And we constructed replication-competent viral constructs with core promoter from 41 patients and Transfected these into HepG2 cell and measured HBV DNA by southern blot. There were also differences in HBV DNA quantity according to core promoter sequences. On these all results we investigated correlation between the effect of HBV core promoter on viral replication in vitro and HBN DNA quantity, ALT level from sera of each patients. We found there is no significant correlation among them. As a result, we concluded that in determining severity chronic hepatitis B patients, host factors of each patient is more important rather than replicative activity of virus itself.
단상 멀티레벨 능동전력필터를 위한 고조파 검지 기법 비교
김윤호(Yoon-Ho Kim),김수홍(Soo-Hong Kim),김성민(Sung-Min Kim),서강문(Kang-Moon Seo) 전력전자학회 2005 전력전자학술대회 논문집 Vol.- No.-
In this paper, harmonic detecting methods for the active power application are investigated. They are RDFT, Kalman Filter, Adaptive predictive filter, Instantaneous reactive power detecting method, Improved adaptive filter detecting method. The 5 harmonic detecting methods are simulated and their characteristics for the active filter application are compared using simulation results.
저서성 (底棲性) 대형무척추동물에 (大型無脊椎動物) 의한 금호강 (琴湖江) 수계의 (水系) 생물학적 수질평가
윤일병,공동수,이상협 ( Il Byong Yoon,Dong Soo Kong,Sang Hyeop Lee ) 한국하천호수학회 1992 생태와 환경 Vol.25 No.3
Keumho river is flowing across Taeku city, which is α-mesosaprobic according to annual and situal average level. Sillyong stream inflowing to upper branch is β-mesosaprobic, and Omok stream is α-mesosaprobic, and Namchon, Pulno, and Palkye stream were polysaprobic, respectively. Then, these streams impact on main branch. But Tonghwa stream is a little clean and dilutes a very polluted middle main branch. Among them, Namchon, Pulno, Pakye, and lower main branch are polysaprobic zones with McNaughton`s dominance DI above 0.8, Kno¨pp`s B.E.O.L. above 90, Pantle-Buck`s S above 3.2, Beck-Tsuda`s BI below 10, Shannon`s diversity below 1.5, Yoon-Kong`s TBS below 30. Therefore these zones seem to be target area to be ameliorated in Keumho basin. In the fluctuation of biotic indices, B.E.O.L., Saprobic index S, SI, dominance DI in last season of 1990 were lower than those in same period of 1991, but diversity H`, BI, and TBS were higher.
Soo-Yoon Sung(Soo-Yoon Sung),Jin Ho Song(Jin Ho Song),Byoung Hyuck Kim(Byoung Hyuck Kim),Yoo-Kang Kwak(Yoo-Kang Kwak),Kyung Su Kim(Kyung Su Kim),Gyu Sang Yoo(Gyu Sang Yoo),Hwa Kyung Byun(Hwa Kyung Byu 대한방사선종양학회 2024 Radiation Oncology Journal Vol.42 No.1
Advances in radiotherapy (RT) techniques, including intensity-modulated RT and image-guided RT, have allowed hypofractionation, increasing the fraction size over the conventional dose of 1.8–2.0 Gy. Hypofractionation offers advantages such as shorter treatment times, improved compliance, and under specific conditions, particularly in tumors with a low α/β ratio, higher efficacy. It was initially explored for use in RT for prostate cancer and adjuvant RT for breast cancer, and its application has been extended to various other malignancies. Hypofractionated RT (HFRT) may also be effective in patients who are unable to undergo conventional treatment owing to poor performance status, comorbidities, or old age. The treatment of brain tumors with HFRT is relatively common because brain stereotactic radiosurgery has been performed for over two decades. However, re-irradiation of recurrent lesions and treatment of elderly or frail patients are areas under investigation. HFRT for head and neck cancer has not been widely used because of concerns regarding late toxicity. Thus, we aimed to provide a comprehensive summary of the current evidence for HFRT for brain tumors and head and neck cancer and to offer practical recommendations to clinicians faced with the challenge of choosing new treatment options.
Sung Il Ahn,Yoon Hyuk Chang,Hea Soo Kwak 한국축산식품학회 2010 한국축산식품학회지 Vol.30 No.4
This study was carried out to optimize microencapsulation conditions for Inonotus obliquus extract powder with mediumchain triacylglycerol (MCT) using response surface methodology (RSM), and to determine the possibility of adding encapsulated I. obliquus extract to milk toward improving the functionality of milk. and to investigate the effects of added encapsulated I. obliquus extract on the physicochemical and sensory properties of the product. The microencapsulation efficiency of I. obliquus extract powder was investigated with respect to three variables (ratios of core material to coating material, amounts of water added, and spray pressure) in RSM. The optimal conditions for microencapsulation of I. obliquus extract powder were obtained from the ratio of core material to coating material (2.92:10) and the amount of water added (0.5 mL); the spray pressure had an insignificant effect on the microencapsulation (p
YOON, HYO-EUN,OH, SEONE-HEE,KIM, SOO-A,YOON, JUNG-HOON,AHN, SANG-GUN Spandidos Publications 2014 Oncology reports Vol.31 No.1
Pheophorbide a (Pa), a chlorophyll derivative, is a photosensitizer that can induce significant antitumor effects in several types of tumor cells. The present study investigated the mechanism of Pa-mediated photodynamic therapy (Pa-PDT) in the human skin cancer cell lines A431 and G361. PDT significantly inhibited the cell growth in a Pa-concentration-dependent manner. We observed increased expression of Beclin-1, LC3B and ATG5, which are markers of autophagy, after PDT treatment in A431 cells but not in G361 cells. In G361 cells, Pa-PDT strongly induced PARP cleavage and subsequent apoptosis, which was confirmed using Annexin V/Propidium iodide double staining. Pa-PDT predominantly exhibited its antitumor effects via activation of ERK1/2 and p38 in A431 and G361 cells, respectively. An in vivo study using the CAM xenograft model demonstrated that Pa-PDT strongly induced autophagy and apoptosis in A431-transplanted tumors and/or apoptosis in G361-transplanted tumors. These results may provide a basis for understanding the underlying mechanisms of Pa-PDT and for developing Pa-PDT as a therapy for skin cancer.
High‐Mobility n‐Type Organic Transistors Based on a Crystallized Diketopyrrolopyrrole Derivative
Yoon, Won Sik,Park, Sang Kyu,Cho, Illhun,Oh, Jeong‐,A,Kim, Jong H.,Park, Soo Young WILEY‐VCH Verlag 2013 Advanced functional materials Vol.23 No.28
<P><B>Abstract</B></P><P>A new high‐performing small molecule n‐channel semiconductor based on diketopyrrolopyrrole (DPP), 2,2′‐(5,5′‐(2,5‐bis(2‐ethylhexyl)‐3,6‐dioxo‐2,3,5,6‐tetrahydropyrrolo[3,4‐c]pyrrole‐1,4‐diyl)bis(thiophene‐5,2‐diyl))bis(methan‐1‐yl‐1‐ylidene)dimalononitrile (DPP‐T‐DCV), is successfully synthesized. The frontier molecular orbitals in this designed structure are elaborately tuned by introducing a strong electron‐accepting functionality (dicyanovinyl). The well‐defined lamellar structures of the crystals display a uniform terrace step height corresponding to a molecular monolayer in the solid‐state. As a result of this tuning and the remarkable crystallinity derived from the conformational planarity, organic field‐effect transistors (OFETs) based on dense‐packed solution‐processed single‐crystals of DPP‐T‐DCV exhibit an electron mobility (<I>μ</I><SUB>e</SUB>) up to 0.96 cm<SUP>2</SUP> V<SUP>−1</SUP> s<SUP>−1</SUP>, one of the highest values yet obtained for DPP derivative‐based n‐channel OFETs. Polycrystalline OFETs show promise (with an <I>μ</I><SUB>e</SUB> up to 0.64 cm<SUP>2</SUP> V<SUP>−1</SUP> s<SUP>−1</SUP>) for practical utility in organic device applications.</P>
Yoon, Chong-Hyeon,Kwon, Yong-Jin,Lee, Sang-Won,Park, Yong-Beom,Lee, Soo-Kon,Park, Min-Chan Springer 2013 Journal of clinical immunology Vol.33 No.1
<P>Liver X receptors (LXR) are nuclear receptors that play important roles in lipid metabolism and transport. LXR also suppress inflammatory responses in macrophages through a unique mechanism of transrepression. This study was performed to investigate whether the synthetic LXR agonist GW3965 can modulate the inflammatory status of fibroblast-like synoviocytes (FLS) from patients with rheumatoid arthritis (RA) and to identify the mechanism for their effect.</P>
Energy Consumption of the Brushing Process for PCB Manufacturing Based on a Friction Model
Yoon, Hae-Sung,Kim, Eun-Seob,Kim, Min-Soo,Lee, Gyu-Bong,Ahn, Sung-Hoon Korean Society for Precision Engineering 2014 International Journal of Precision Engineering and Vol.15 No.11
Industries are now required to use 'green' manufacturing due to emerging environmental concerns. In this study, the de-burring process for printed circuit board manufacturing was analyzed, and its energy consumption was examined based on a friction model. For de-burring of drilled micro-vias, a mechanical brushing process is typically used due to its performance and cost-effectiveness. However, it is very complex to analyze the energy consumption of a brushing process because a brush simply sweeps the surface with rotating metal wires, unlike conventional cutting processes. To construct an energy consumption model of a brushing process, its energy consumption was examined empirically considering a friction model. The brush was assumed to be an elastic body, and velocity strengthening and weakening of the friction coefficients were predicted. Experiments were performed to match the data, and the energy consumption model was validated. The power consumption of the brushing process showed a concave shape with respect to the rotational speed, and the overall power could be reduced by up to 40% by controlling the process parameters. The process parameters for the minimum energy consumption could be derived using the model considering local constraints such as burr height.
( Sang Soo Kang ),( Jeong Keun Choi ),( Il Seok Kim ),( Yeong Joon Yoon ),( Keun Man Shin ) 대한마취과학회 2010 Korean Journal of Anesthesiology Vol.59 No.4
Acute mesenteric ischemia and infarction is an emergent situation associated with high mortality, commonly due to emboli or thrombosis of the mesenteric arteries. Embolism to the mesenteric arteries is most frequently due to a dislodged thrombus from the left atrium, left ventricle, or cardiac valves. We report a case of 70-year-old female patient with an acute small bowel infarction due to a mesenteric artery embolism dislodged from a left atrial appendage detected by intraoperative transesophageal echocardiography and followed by anticoagulation therapy. (Korean J Anesthesiol 2010; 59: 279-282)